TY  - JOUR
AU  - Joković, Danilo
AU  - Milosavljević, Filip
AU  - Stojanović, Zvezdana
AU  - Šupić, Gordana
AU  - Vojvodić, Danilo
AU  - Uzelac, Bojana
AU  - Jukić, Marin
AU  - Petković Ćurčin, Aleksandra
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4080
AB  - The inter-individual variability in CYP2C19-mediated metabolism may affect the antidepressant treatment. The aim of this study is to evaluate differences in antidepressant efficacy and tolerability between different CYP2C19 metabolizer categories in inpatients suffering from major depressive disorder. The cohort was divided into experimental groups based on CYP2C19 genotype and it contained 24 slow (SMs), 41 normal (NMs), and 37 fast metabolizers (FMs). Efficacy and tolerability were assessed at baseline, and after two and four weeks as a follow- up. The primary efficacy measurement was the change from baseline in Hamilton’s Depression Rating Scale (HAMD), while the primary tolerability measurement was the Toronto Side-Effects Scale (TSES) intensity scores at the last visit. The reduction in HAMD score was 36% less pronounced and response rate was exceedingly less prevalent (75% lower) in SMs, compared with NMs. The TSES intensity score was increased in SMs, compared with NMs, by 43% for central nervous system and by 22% for gastrointestinal adverse drug reactions. No sig- nificant differences in measured parameters were observed between NMs and FMs. Compared with NM and RM, lower antidepressant efficacy and tolerability was observed in SMs; this association is likely connected with the lower SM capacity to metabolize antidepressant drugs.
PB  - Elsevier Ireland Ltd
T2  - Psychiatry Research
T1  - CYP2C19 slow metabolizer phenotype is associated with lower antidepressant efficacy and tolerability
VL  - 312
DO  - 10.1016/j.psychres.2022.114535
ER  - 

@article{
author = "Joković, Danilo and Milosavljević, Filip and Stojanović, Zvezdana and Šupić, Gordana and Vojvodić, Danilo and Uzelac, Bojana and Jukić, Marin and Petković Ćurčin, Aleksandra",
year = "2022",
abstract = "The inter-individual variability in CYP2C19-mediated metabolism may affect the antidepressant treatment. The aim of this study is to evaluate differences in antidepressant efficacy and tolerability between different CYP2C19 metabolizer categories in inpatients suffering from major depressive disorder. The cohort was divided into experimental groups based on CYP2C19 genotype and it contained 24 slow (SMs), 41 normal (NMs), and 37 fast metabolizers (FMs). Efficacy and tolerability were assessed at baseline, and after two and four weeks as a follow- up. The primary efficacy measurement was the change from baseline in Hamilton’s Depression Rating Scale (HAMD), while the primary tolerability measurement was the Toronto Side-Effects Scale (TSES) intensity scores at the last visit. The reduction in HAMD score was 36% less pronounced and response rate was exceedingly less prevalent (75% lower) in SMs, compared with NMs. The TSES intensity score was increased in SMs, compared with NMs, by 43% for central nervous system and by 22% for gastrointestinal adverse drug reactions. No sig- nificant differences in measured parameters were observed between NMs and FMs. Compared with NM and RM, lower antidepressant efficacy and tolerability was observed in SMs; this association is likely connected with the lower SM capacity to metabolize antidepressant drugs.",
publisher = "Elsevier Ireland Ltd",
journal = "Psychiatry Research",
title = "CYP2C19 slow metabolizer phenotype is associated with lower antidepressant efficacy and tolerability",
volume = "312",
doi = "10.1016/j.psychres.2022.114535"
}

Joković, D., Milosavljević, F., Stojanović, Z., Šupić, G., Vojvodić, D., Uzelac, B., Jukić, M.,& Petković Ćurčin, A.. (2022). CYP2C19 slow metabolizer phenotype is associated with lower antidepressant efficacy and tolerability. in Psychiatry Research
Elsevier Ireland Ltd., 312.
https://doi.org/10.1016/j.psychres.2022.114535

Joković D, Milosavljević F, Stojanović Z, Šupić G, Vojvodić D, Uzelac B, Jukić M, Petković Ćurčin A. CYP2C19 slow metabolizer phenotype is associated with lower antidepressant efficacy and tolerability. in Psychiatry Research. 2022;312.
doi:10.1016/j.psychres.2022.114535 .

Joković, Danilo, Milosavljević, Filip, Stojanović, Zvezdana, Šupić, Gordana, Vojvodić, Danilo, Uzelac, Bojana, Jukić, Marin, Petković Ćurčin, Aleksandra, "CYP2C19 slow metabolizer phenotype is associated with lower antidepressant efficacy and tolerability" in Psychiatry Research, 312 (2022),
https://doi.org/10.1016/j.psychres.2022.114535 . .

TY  - JOUR
AU  - Taso, Ervin
AU  - Rakić, Mia
AU  - Bajić, Vladimir
AU  - Petković-Ćurčin, Aleksandra
AU  - Stanojević, Ivan
AU  - Đukić, Mirjana
AU  - Struillou, Xavier
AU  - Vojvodić, Danilo
AU  - Banović, Tatjana
AU  - Kanjevac, Tatjana
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3794
AB  - Profiling of biomarkers of physiological process represents an integrative part in optimisation of diagnostic markers in order to adjust the diagnostic ranges to the potential effects of the local factors such occlusal forces in case of periodontal tissues. The objective of this study was estimation of IL-1β, IL-2, IL-4, IL-5, IL- 6, IL-9, IL-10, IL-12, IL-13, IL-17, IL-22, TNFα and IFNγ concentrations in gingival crevicular fluid samples (GCF) between different groups of teeth. Two hundred fifty-nine systemically healthy non-smokers having at least one vital tooth without restorations, with healthy periodontal tissues, were clinically examined and the GCF sample was retrieved. The cytokine levels were estimated using flow cytometry and compared between central incisors (CI), lateral incisors, canines, first premolars, second premolars, first molars and second molars. Cytokine profiles varied between different groups of teeth with tendency of increase in proinflammatory cytokines from anterior teeth toward molars. Molars might be considered teeth with natural predisposition for faster bone resorption while the adjustment of diagnostic range of periodontal biomarkers for anterior or posterior teeth should be considered within diagnostic context. Cytokine profiles varied between different groups of teeth with tendency of increase in proinflammatory cytokines from anterior teeth toward molars. Molars might be considered teeth with natural predisposition for faster bone resorption while the adjustment of diagnostic range of periodontal biomarkers for anterior or posterior teeth should be considered within diagnostic context.
AB  - Profilisanje biomarkera fiziološkog procesa predstavlja integrativni deo optimalizacije dijagnostičkih markera, kako bi se dijagnostički rasponi prilagodili potencijalnim uticajima lokalnih faktora poput okluzijskih sila u slučaju parodontalnih tkiva. Cilj ove studije bila je procena koncentracija IL-1b, IL-2, IL-4, IL-5, IL-6, IL-9, IL-10, IL-12, IL-13, IL-17, IL- 22, TNFα i IFNγ u uzorcima gingivalne tečnosti (GT) kod različitih grupa zuba. Klinički je pregledano dvesta pedeset devet sistemski zdravih nepušača sa najmanje jednim vitalnim zubom bez restauracija, sa zdravim parodontalnim tkivima, i uzet je GT uzorak. Nivoi citokina procenjeni su protočnom citometrijom i upoređeni između centralnih sekutića (CS), bočnih sekutića, očnjaka, prvih i drugih premolara, kao i prvih i drugih kutnjaka. Profil citokina varirao je između različitih grupa zuba sa tendencijom povećanja pro-upalnih citokina od prednjih zuba do kutnjaka. Molari se mogu smatrati zubima sa prirodnom predispozicijom za bržu resorpciju kosti, dok bi podešavanje dijagnostičkog raspona parodontalnih biomarkera za prednje ili zadnje zube trebalo razmotriti unutar dijagnostičkog konteksta.
PB  - University of Kragujevac, Faculty of Science
T2  - Serbian Journal of Experimental and Clinical Research
T1  - Variation of the cytokine profiles in gingival crevicular fluid between different groups of periodontally healthy teeth
T1  - Varijacija profila citokina u gingivalnoj zglobnoj tečnosti između različitih grupa parodontalno zdravih zuba
VL  - 21
IS  - 4
SP  - 333
EP  - 341
DO  - 10.2478/sjecr-2019-0015
ER  - 

@article{
author = "Taso, Ervin and Rakić, Mia and Bajić, Vladimir and Petković-Ćurčin, Aleksandra and Stanojević, Ivan and Đukić, Mirjana and Struillou, Xavier and Vojvodić, Danilo and Banović, Tatjana and Kanjevac, Tatjana",
year = "2020",
abstract = "Profiling of biomarkers of physiological process represents an integrative part in optimisation of diagnostic markers in order to adjust the diagnostic ranges to the potential effects of the local factors such occlusal forces in case of periodontal tissues. The objective of this study was estimation of IL-1β, IL-2, IL-4, IL-5, IL- 6, IL-9, IL-10, IL-12, IL-13, IL-17, IL-22, TNFα and IFNγ concentrations in gingival crevicular fluid samples (GCF) between different groups of teeth. Two hundred fifty-nine systemically healthy non-smokers having at least one vital tooth without restorations, with healthy periodontal tissues, were clinically examined and the GCF sample was retrieved. The cytokine levels were estimated using flow cytometry and compared between central incisors (CI), lateral incisors, canines, first premolars, second premolars, first molars and second molars. Cytokine profiles varied between different groups of teeth with tendency of increase in proinflammatory cytokines from anterior teeth toward molars. Molars might be considered teeth with natural predisposition for faster bone resorption while the adjustment of diagnostic range of periodontal biomarkers for anterior or posterior teeth should be considered within diagnostic context. Cytokine profiles varied between different groups of teeth with tendency of increase in proinflammatory cytokines from anterior teeth toward molars. Molars might be considered teeth with natural predisposition for faster bone resorption while the adjustment of diagnostic range of periodontal biomarkers for anterior or posterior teeth should be considered within diagnostic context., Profilisanje biomarkera fiziološkog procesa predstavlja integrativni deo optimalizacije dijagnostičkih markera, kako bi se dijagnostički rasponi prilagodili potencijalnim uticajima lokalnih faktora poput okluzijskih sila u slučaju parodontalnih tkiva. Cilj ove studije bila je procena koncentracija IL-1b, IL-2, IL-4, IL-5, IL-6, IL-9, IL-10, IL-12, IL-13, IL-17, IL- 22, TNFα i IFNγ u uzorcima gingivalne tečnosti (GT) kod različitih grupa zuba. Klinički je pregledano dvesta pedeset devet sistemski zdravih nepušača sa najmanje jednim vitalnim zubom bez restauracija, sa zdravim parodontalnim tkivima, i uzet je GT uzorak. Nivoi citokina procenjeni su protočnom citometrijom i upoređeni između centralnih sekutića (CS), bočnih sekutića, očnjaka, prvih i drugih premolara, kao i prvih i drugih kutnjaka. Profil citokina varirao je između različitih grupa zuba sa tendencijom povećanja pro-upalnih citokina od prednjih zuba do kutnjaka. Molari se mogu smatrati zubima sa prirodnom predispozicijom za bržu resorpciju kosti, dok bi podešavanje dijagnostičkog raspona parodontalnih biomarkera za prednje ili zadnje zube trebalo razmotriti unutar dijagnostičkog konteksta.",
publisher = "University of Kragujevac, Faculty of Science",
journal = "Serbian Journal of Experimental and Clinical Research",
title = "Variation of the cytokine profiles in gingival crevicular fluid between different groups of periodontally healthy teeth, Varijacija profila citokina u gingivalnoj zglobnoj tečnosti između različitih grupa parodontalno zdravih zuba",
volume = "21",
number = "4",
pages = "333-341",
doi = "10.2478/sjecr-2019-0015"
}

Taso, E., Rakić, M., Bajić, V., Petković-Ćurčin, A., Stanojević, I., Đukić, M., Struillou, X., Vojvodić, D., Banović, T.,& Kanjevac, T.. (2020). Variation of the cytokine profiles in gingival crevicular fluid between different groups of periodontally healthy teeth. in Serbian Journal of Experimental and Clinical Research
University of Kragujevac, Faculty of Science., 21(4), 333-341.
https://doi.org/10.2478/sjecr-2019-0015

Taso E, Rakić M, Bajić V, Petković-Ćurčin A, Stanojević I, Đukić M, Struillou X, Vojvodić D, Banović T, Kanjevac T. Variation of the cytokine profiles in gingival crevicular fluid between different groups of periodontally healthy teeth. in Serbian Journal of Experimental and Clinical Research. 2020;21(4):333-341.
doi:10.2478/sjecr-2019-0015 .

Taso, Ervin, Rakić, Mia, Bajić, Vladimir, Petković-Ćurčin, Aleksandra, Stanojević, Ivan, Đukić, Mirjana, Struillou, Xavier, Vojvodić, Danilo, Banović, Tatjana, Kanjevac, Tatjana, "Variation of the cytokine profiles in gingival crevicular fluid between different groups of periodontally healthy teeth" in Serbian Journal of Experimental and Clinical Research, 21, no. 4 (2020):333-341,
https://doi.org/10.2478/sjecr-2019-0015 . .

TY  - JOUR
AU  - Taso, Ervin
AU  - Stefanović, Vladimir
AU  - Stevanović, Ivana
AU  - Vojvodić, Danilo
AU  - Topić, Aleksandra
AU  - Petković-Ćurčin, Aleksandra
AU  - Obradović-Đuričić, Kosovka
AU  - Marković, Aleksa
AU  - Đukić, Mirjana
AU  - Vujanović, Dragana
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3219
AB  - Biocompatibility of dental materials (DM) can be evaluated by gingival crevicular fluid (GCF) oxidative stress (OS) status. The goal of the study was to ascertain influence of dental caries degree, teeth position, and type and amount of applied DM on GCF OS profile. For this purpose, we tested six DMs that were sealed in one session: amalgam (Amg), composites: Tetric EvoCeram and Beautifil (BF), phosphate cement-zinc phosphate and polycarboxylate cements zinc polycarboxylate cements, and glass ionomer cement (GIC). The study included 88 dental outpatients. Follow-up was scheduled at 7th and 30th day. Oxidative stress parameters (malondialdehyde (MDA) and glutathione (GSH) levels and total superoxide dismutase (tSOD) activity) were measured before (0th day) and after the treatment (7th and 30th day) in GCF. Control teeth were mirror-positioned healthy teeth. The DM accomplished the following effects (listed in descending order): increase of GSH in GCF was realized by ZPoC > BF > GIC > Amg; tSOD activity increase by ZPoC > BF > Amg; and MDA decrease by ZPoC > ZPhC > Amg > TEC. Dental caries provokes insignificant rise of OS in GCF. ZPoC and ZPhC showed the highest antioxidant effect, contrary to GIC. Restorations with antioxidant properties may reduce gum diseases initiated by caries lesion, what is of great clinical relevance in dentistry.
PB  - Hindawi Ltd, London
T2  - Oxidative Medicine and Cellular Longevity
T1  - Influence of Dental Restorations on Oxidative Stress in Gingival Crevicular Fluid
DO  - 10.1155/2018/1823189
ER  - 

@article{
author = "Taso, Ervin and Stefanović, Vladimir and Stevanović, Ivana and Vojvodić, Danilo and Topić, Aleksandra and Petković-Ćurčin, Aleksandra and Obradović-Đuričić, Kosovka and Marković, Aleksa and Đukić, Mirjana and Vujanović, Dragana",
year = "2018",
abstract = "Biocompatibility of dental materials (DM) can be evaluated by gingival crevicular fluid (GCF) oxidative stress (OS) status. The goal of the study was to ascertain influence of dental caries degree, teeth position, and type and amount of applied DM on GCF OS profile. For this purpose, we tested six DMs that were sealed in one session: amalgam (Amg), composites: Tetric EvoCeram and Beautifil (BF), phosphate cement-zinc phosphate and polycarboxylate cements zinc polycarboxylate cements, and glass ionomer cement (GIC). The study included 88 dental outpatients. Follow-up was scheduled at 7th and 30th day. Oxidative stress parameters (malondialdehyde (MDA) and glutathione (GSH) levels and total superoxide dismutase (tSOD) activity) were measured before (0th day) and after the treatment (7th and 30th day) in GCF. Control teeth were mirror-positioned healthy teeth. The DM accomplished the following effects (listed in descending order): increase of GSH in GCF was realized by ZPoC > BF > GIC > Amg; tSOD activity increase by ZPoC > BF > Amg; and MDA decrease by ZPoC > ZPhC > Amg > TEC. Dental caries provokes insignificant rise of OS in GCF. ZPoC and ZPhC showed the highest antioxidant effect, contrary to GIC. Restorations with antioxidant properties may reduce gum diseases initiated by caries lesion, what is of great clinical relevance in dentistry.",
publisher = "Hindawi Ltd, London",
journal = "Oxidative Medicine and Cellular Longevity",
title = "Influence of Dental Restorations on Oxidative Stress in Gingival Crevicular Fluid",
doi = "10.1155/2018/1823189"
}

Taso, E., Stefanović, V., Stevanović, I., Vojvodić, D., Topić, A., Petković-Ćurčin, A., Obradović-Đuričić, K., Marković, A., Đukić, M.,& Vujanović, D.. (2018). Influence of Dental Restorations on Oxidative Stress in Gingival Crevicular Fluid. in Oxidative Medicine and Cellular Longevity
Hindawi Ltd, London..
https://doi.org/10.1155/2018/1823189

Taso E, Stefanović V, Stevanović I, Vojvodić D, Topić A, Petković-Ćurčin A, Obradović-Đuričić K, Marković A, Đukić M, Vujanović D. Influence of Dental Restorations on Oxidative Stress in Gingival Crevicular Fluid. in Oxidative Medicine and Cellular Longevity. 2018;.
doi:10.1155/2018/1823189 .

Taso, Ervin, Stefanović, Vladimir, Stevanović, Ivana, Vojvodić, Danilo, Topić, Aleksandra, Petković-Ćurčin, Aleksandra, Obradović-Đuričić, Kosovka, Marković, Aleksa, Đukić, Mirjana, Vujanović, Dragana, "Influence of Dental Restorations on Oxidative Stress in Gingival Crevicular Fluid" in Oxidative Medicine and Cellular Longevity (2018),
https://doi.org/10.1155/2018/1823189 . .

TY  - JOUR
AU  - Stefanović, Vladimir
AU  - Taso, Ervin
AU  - Petković-Ćurčin, Aleksandra
AU  - Đukić, Mirjana
AU  - Gardašević, Milka
AU  - Rakić, Mia
AU  - Xavier, Struillou
AU  - Jović, Milena
AU  - Miller, Karolina
AU  - Stanojević, Ivan
AU  - Vojvodić, Danilo
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2668
AB  - Background/Aim. Several cytokines and lymphokines (IL1β, ENA78, IL6, TNFα, IL8 and S100A8) are expressed during dental pulp inflammation. Analysis of gingival crevicular fluid (GCF) offers a non-invasive means of studying general host response in oral cavity. Although GCF levels of various mediators could reflect the state of inflammation both in dental pulp and gingiva adjacent to a tooth, GCF samples of those without significant gingivitis could be interpreted as reflection of pulpal process. The aim of this study was to investigate IL9 GCF values in patients with dental caries and to assess possible influence of various dental fillings materials on local IL9 production. Methods. The study group included 90 patients, aged 18-70, with inclusion and exclusion criteria in the prospective clinical study. Of the 6 types of material used for the restoration of prepared cavities, 3 were intended for temporary and 3 for definitive restoration. According to dental fillings weight, all the participants were divided into 3 groups: those with fillings lighter than 0.50 g, those with 0.50-1.00 g, and those with fillings heavier than 1.00 g. Samples were taken from gingival sulcus using the filter paper technique. Clinical parameters were determined by bleeding index, plaque index (Silness-Lou, 0-3), gingival index (0-3), and gingival sulcus depth. Cytokine concentrations were assessed using commercially available cytomix. Results. According to the weight of dental fillings, there was a clear decreament trend of IL9 values meaning that dental defects greater than 1.00 g of dental filling were associated with lower GCF IL9 concentration. The IL9 values correlated with the degree of gingival index and depth of gingival sulcus, being higher with more advanced gingivitis and more pronounced anatomical changes in the tooth edge. Different filling materials exerted various local IL9 responses. Zink polycarbonate cement and amalgam fillings induced a significant and long-lasting local IL9 decrement, while the use of Tetric EvoCeram and GMA-BISK significantly increased IL9 levels. Conclusion. The obtained results indicate that IL9 GCF could be regarded as a measure of odontoblasts' response to the extensity of dental caries. The type of material used for dental fillings could profoundly alter biological function of gingival and pulpal cells. Also, the results obtained in this study suggest that some materials could even enhance wound repair by modulating macrophage activation.
AB  - Uvod/Cilj. Jedan broj citokina i limfokina (IL1β, ENA78, IL6, TNFα, IL8 I S100A8) izlučuje se tokom upale zubne pulpe. Analiza gingivalne sulkusne tečnosti (gingival crevicular fluid - GCF) omogućava neinvazivno proučavanje opšteg odgovora pacijenta na lokalne promene u usnoj duplji. Iako nivoi GCF mogu da odražavaju stanje upale kako u zubnoj pulpi, tako i u gingivi susednog zuba, uzorci GCF zuba bez značajnijeg gingivitisa mogli bi se tumačiti kao pokazatelji procesa u pulpi. Cilj ovog istraživanja bio je da se ispitaju nivoi IL9 u GCF kod pacijenata sa zubnim karijesom i da se utvrdi eventualni uticaj različitih materijala za zubne ispune na lokalnu proizvodnju IL9. Metode. U studiju je bilo uključeno 90 pacijenata, starih od 18 do 70 godina, uz primenu kriterijuma za uključivanje/isključivanje za prospektivne kliničke studije. Od ukupno šest materijala za punjenje pripremljenih kaviteta, tri je korišćeno za privremenu i tri za trajnu ispunu. Prema težini zubnog ispuna, pacijenti su bili podeljeni na tri grupe: oni sa ispunama lakšim od 0,50 g, sa ispunama od 0,50 do 1,00 g i sa ispunama težim od 1,00 g. Uzorci su uzimani iz gingivalnog sulkusa primenom tehnike filter papira. Korišćeni klinički parametri bili su indeks krvarenja, plak indeks (Silness-Lou, 0-3), gingivalni indeks (0-3) i dubina gingivalnog sulkusa. Koncentracije citokina određene su komercijalnim citomiksom. Rezultati. Težina zubne ispune ukazivala je na tendenciju opadanja vrednosti IL9, što je značilo da je veće oštećenje zuba, sa zubnom ispunom težom od 1,00 g, praćeno nižom koncentracijom IL9 u GCF. Vrednosti IL9 bile su u korelaciji sa stepenom gingivalnog indeksa i dubinom gingivalnog sulkusa, pogotovu u poodmaklom gingivitisu i izraženijim anatomskim promenama ivica zuba. Različite ispune izazivale su različite lokalne sekrecije IL9. Cink-polikarbonatni cement i amalgamska ispuna izazvale su značajan i dugotrajan pad nivoa lokalnog IL9, dok je primena tetrik-evocerama i GMA-BISK znatno povisila nivoe IL9. Zaključak. Rezultati dobijeni u ovoj studiji ukazuju da se IL9 u GCF može koristiti kao mera za reakciju odontoblasta na veličinu karijesa. Tip zubne ispune može da promeni biološku funkciju ćelija gingive i pulpe. Rezultati ove studije, takođe, ukazuju i na to da neke vrste ispuna mogu čak da ubrzaju zarastanje rane modulacijom aktivnosti makrofaga.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Influence of dental filling material type on the concentration of interleukin 9 in the samples of gingival crevicular fluid
T1  - Uticaj tipa materijala za plombiranje zuba na koncentraciju interleukina 9 u uzorcima gingivalne sulkusne tečnosti
VL  - 73
IS  - 8
SP  - 728
EP  - 734
DO  - 10.2298/VSP140227054S
ER  - 

@article{
author = "Stefanović, Vladimir and Taso, Ervin and Petković-Ćurčin, Aleksandra and Đukić, Mirjana and Gardašević, Milka and Rakić, Mia and Xavier, Struillou and Jović, Milena and Miller, Karolina and Stanojević, Ivan and Vojvodić, Danilo",
year = "2016",
abstract = "Background/Aim. Several cytokines and lymphokines (IL1β, ENA78, IL6, TNFα, IL8 and S100A8) are expressed during dental pulp inflammation. Analysis of gingival crevicular fluid (GCF) offers a non-invasive means of studying general host response in oral cavity. Although GCF levels of various mediators could reflect the state of inflammation both in dental pulp and gingiva adjacent to a tooth, GCF samples of those without significant gingivitis could be interpreted as reflection of pulpal process. The aim of this study was to investigate IL9 GCF values in patients with dental caries and to assess possible influence of various dental fillings materials on local IL9 production. Methods. The study group included 90 patients, aged 18-70, with inclusion and exclusion criteria in the prospective clinical study. Of the 6 types of material used for the restoration of prepared cavities, 3 were intended for temporary and 3 for definitive restoration. According to dental fillings weight, all the participants were divided into 3 groups: those with fillings lighter than 0.50 g, those with 0.50-1.00 g, and those with fillings heavier than 1.00 g. Samples were taken from gingival sulcus using the filter paper technique. Clinical parameters were determined by bleeding index, plaque index (Silness-Lou, 0-3), gingival index (0-3), and gingival sulcus depth. Cytokine concentrations were assessed using commercially available cytomix. Results. According to the weight of dental fillings, there was a clear decreament trend of IL9 values meaning that dental defects greater than 1.00 g of dental filling were associated with lower GCF IL9 concentration. The IL9 values correlated with the degree of gingival index and depth of gingival sulcus, being higher with more advanced gingivitis and more pronounced anatomical changes in the tooth edge. Different filling materials exerted various local IL9 responses. Zink polycarbonate cement and amalgam fillings induced a significant and long-lasting local IL9 decrement, while the use of Tetric EvoCeram and GMA-BISK significantly increased IL9 levels. Conclusion. The obtained results indicate that IL9 GCF could be regarded as a measure of odontoblasts' response to the extensity of dental caries. The type of material used for dental fillings could profoundly alter biological function of gingival and pulpal cells. Also, the results obtained in this study suggest that some materials could even enhance wound repair by modulating macrophage activation., Uvod/Cilj. Jedan broj citokina i limfokina (IL1β, ENA78, IL6, TNFα, IL8 I S100A8) izlučuje se tokom upale zubne pulpe. Analiza gingivalne sulkusne tečnosti (gingival crevicular fluid - GCF) omogućava neinvazivno proučavanje opšteg odgovora pacijenta na lokalne promene u usnoj duplji. Iako nivoi GCF mogu da odražavaju stanje upale kako u zubnoj pulpi, tako i u gingivi susednog zuba, uzorci GCF zuba bez značajnijeg gingivitisa mogli bi se tumačiti kao pokazatelji procesa u pulpi. Cilj ovog istraživanja bio je da se ispitaju nivoi IL9 u GCF kod pacijenata sa zubnim karijesom i da se utvrdi eventualni uticaj različitih materijala za zubne ispune na lokalnu proizvodnju IL9. Metode. U studiju je bilo uključeno 90 pacijenata, starih od 18 do 70 godina, uz primenu kriterijuma za uključivanje/isključivanje za prospektivne kliničke studije. Od ukupno šest materijala za punjenje pripremljenih kaviteta, tri je korišćeno za privremenu i tri za trajnu ispunu. Prema težini zubnog ispuna, pacijenti su bili podeljeni na tri grupe: oni sa ispunama lakšim od 0,50 g, sa ispunama od 0,50 do 1,00 g i sa ispunama težim od 1,00 g. Uzorci su uzimani iz gingivalnog sulkusa primenom tehnike filter papira. Korišćeni klinički parametri bili su indeks krvarenja, plak indeks (Silness-Lou, 0-3), gingivalni indeks (0-3) i dubina gingivalnog sulkusa. Koncentracije citokina određene su komercijalnim citomiksom. Rezultati. Težina zubne ispune ukazivala je na tendenciju opadanja vrednosti IL9, što je značilo da je veće oštećenje zuba, sa zubnom ispunom težom od 1,00 g, praćeno nižom koncentracijom IL9 u GCF. Vrednosti IL9 bile su u korelaciji sa stepenom gingivalnog indeksa i dubinom gingivalnog sulkusa, pogotovu u poodmaklom gingivitisu i izraženijim anatomskim promenama ivica zuba. Različite ispune izazivale su različite lokalne sekrecije IL9. Cink-polikarbonatni cement i amalgamska ispuna izazvale su značajan i dugotrajan pad nivoa lokalnog IL9, dok je primena tetrik-evocerama i GMA-BISK znatno povisila nivoe IL9. Zaključak. Rezultati dobijeni u ovoj studiji ukazuju da se IL9 u GCF može koristiti kao mera za reakciju odontoblasta na veličinu karijesa. Tip zubne ispune može da promeni biološku funkciju ćelija gingive i pulpe. Rezultati ove studije, takođe, ukazuju i na to da neke vrste ispuna mogu čak da ubrzaju zarastanje rane modulacijom aktivnosti makrofaga.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Influence of dental filling material type on the concentration of interleukin 9 in the samples of gingival crevicular fluid, Uticaj tipa materijala za plombiranje zuba na koncentraciju interleukina 9 u uzorcima gingivalne sulkusne tečnosti",
volume = "73",
number = "8",
pages = "728-734",
doi = "10.2298/VSP140227054S"
}

Stefanović, V., Taso, E., Petković-Ćurčin, A., Đukić, M., Gardašević, M., Rakić, M., Xavier, S., Jović, M., Miller, K., Stanojević, I.,& Vojvodić, D.. (2016). Influence of dental filling material type on the concentration of interleukin 9 in the samples of gingival crevicular fluid. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 73(8), 728-734.
https://doi.org/10.2298/VSP140227054S

Stefanović V, Taso E, Petković-Ćurčin A, Đukić M, Gardašević M, Rakić M, Xavier S, Jović M, Miller K, Stanojević I, Vojvodić D. Influence of dental filling material type on the concentration of interleukin 9 in the samples of gingival crevicular fluid. in Vojnosanitetski pregled. 2016;73(8):728-734.
doi:10.2298/VSP140227054S .

Stefanović, Vladimir, Taso, Ervin, Petković-Ćurčin, Aleksandra, Đukić, Mirjana, Gardašević, Milka, Rakić, Mia, Xavier, Struillou, Jović, Milena, Miller, Karolina, Stanojević, Ivan, Vojvodić, Danilo, "Influence of dental filling material type on the concentration of interleukin 9 in the samples of gingival crevicular fluid" in Vojnosanitetski pregled, 73, no. 8 (2016):728-734,
https://doi.org/10.2298/VSP140227054S . .

TY  - JOUR
AU  - Todorović, Tatjana
AU  - Vujanović, Dragana
AU  - Dozić, Ivan
AU  - Petković-Ćurčin, Aleksandra
PY  - 2008
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1087
AB  - Lead manifests toxic effects in almost all organs and tissues, especially in: the nervous system, hematopoietic system, kidney and liver. This metal has a special affinity for deposition in hard tissue, i.e., bones and teeth. It is generally believed that the main mechanism of its toxicity relies on its interaction with bioelements, especially with Ca and Mg. This article analyses the influence of Pb poisoning on Ca and Mg content in hard tissues, (mandible, femur, teeth and skull) of female and young rats. Experiments were carried out on 60 female rats, AO breed, and on 80 of their young rats (offspring). Female rats were divided into three groups: the first one was a control group, the second one received 100 mg/kg Pb2+ kg b.wt. per day in drinking water, the third one received 30 mg/kg Pb2+ kg b.wt. per day in drinking water. Young rats (offspring) were divided into the same respective three groups. Lead, calcium and magnesium content in hard tissues (mandible, femur, teeth-incisors and skull) was determined by flame atomic absorption spectrophotometry in mineralized samples. There was a statistically significant Pb deposition in all analyzed female and young rat hard tissues. Ca and Mg contents were significantly reduced in all female and young rat hard tissues. These results show that Pb poisoning causes a significant reduction in Ca and Mg content in animal hard tissues, which is probably the consequence of competitive antagonism between Pb and Ca and Mg.
PB  - John Libbey Eurotext Ltd, Montrouge
T2  - Magnesium Research
T1  - Calcium and magnesium content in hard tissues of rats under condition of subchronic lead intoxication
VL  - 21
IS  - 1
SP  - 43
EP  - 50
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1087
ER  - 

@article{
author = "Todorović, Tatjana and Vujanović, Dragana and Dozić, Ivan and Petković-Ćurčin, Aleksandra",
year = "2008",
abstract = "Lead manifests toxic effects in almost all organs and tissues, especially in: the nervous system, hematopoietic system, kidney and liver. This metal has a special affinity for deposition in hard tissue, i.e., bones and teeth. It is generally believed that the main mechanism of its toxicity relies on its interaction with bioelements, especially with Ca and Mg. This article analyses the influence of Pb poisoning on Ca and Mg content in hard tissues, (mandible, femur, teeth and skull) of female and young rats. Experiments were carried out on 60 female rats, AO breed, and on 80 of their young rats (offspring). Female rats were divided into three groups: the first one was a control group, the second one received 100 mg/kg Pb2+ kg b.wt. per day in drinking water, the third one received 30 mg/kg Pb2+ kg b.wt. per day in drinking water. Young rats (offspring) were divided into the same respective three groups. Lead, calcium and magnesium content in hard tissues (mandible, femur, teeth-incisors and skull) was determined by flame atomic absorption spectrophotometry in mineralized samples. There was a statistically significant Pb deposition in all analyzed female and young rat hard tissues. Ca and Mg contents were significantly reduced in all female and young rat hard tissues. These results show that Pb poisoning causes a significant reduction in Ca and Mg content in animal hard tissues, which is probably the consequence of competitive antagonism between Pb and Ca and Mg.",
publisher = "John Libbey Eurotext Ltd, Montrouge",
journal = "Magnesium Research",
title = "Calcium and magnesium content in hard tissues of rats under condition of subchronic lead intoxication",
volume = "21",
number = "1",
pages = "43-50",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1087"
}

Todorović, T., Vujanović, D., Dozić, I.,& Petković-Ćurčin, A.. (2008). Calcium and magnesium content in hard tissues of rats under condition of subchronic lead intoxication. in Magnesium Research
John Libbey Eurotext Ltd, Montrouge., 21(1), 43-50.
https://hdl.handle.net/21.15107/rcub_farfar_1087

Todorović T, Vujanović D, Dozić I, Petković-Ćurčin A. Calcium and magnesium content in hard tissues of rats under condition of subchronic lead intoxication. in Magnesium Research. 2008;21(1):43-50.
https://hdl.handle.net/21.15107/rcub_farfar_1087 .

Todorović, Tatjana, Vujanović, Dragana, Dozić, Ivan, Petković-Ćurčin, Aleksandra, "Calcium and magnesium content in hard tissues of rats under condition of subchronic lead intoxication" in Magnesium Research, 21, no. 1 (2008):43-50,
https://hdl.handle.net/21.15107/rcub_farfar_1087 .