TY  - JOUR
AU  - Karlicić, Vukoica
AU  - Vuković, Jelena
AU  - Stanojević, Ivan
AU  - Sotirović, Jelena
AU  - Perić, Alexandra
AU  - Jović, Milena
AU  - Cvijanović, Vlado
AU  - Đukić, Mirjana
AU  - Banović, Tatjana
AU  - Vojvodić, Danilo
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2641
AB  - Purpose: Advanced lung carcinoma is charasterized with fast disease progression. Interleukin (IL)10 and transforming growth factor (TGF)b1 are immunosuppressive mediators and their role in lung carcinoma pathogenesis and in the antitumor response has not yet been elucidated. The purpose of this study was to correlate IL10 and TGFb1 levels in the serum and lung tumor microcirculation with clinical stage, disease extent, histological features and TNM stage. Methods: The study included 41 lung cancer patients in clinical stage III and IV. Histological type was determined immunohistochemically, while tumor size, localization and dissemination were determined radiologically by multislice computerized tomography (MSCT). IL10 and TGFb1 levels were quantified with commercial flow cytometric test in serum and lung tumor microcirculation samples. Results: Non small cell lung cancer (NSCLC) patients had significantly elevated TGFb1 while small cell lung cancer (SCLC) patients had significantly increased IL10 in tumor microcirculation. IL10 was significantly elevated in patients with the largest tumors, as well as in patients with III clinical stage and without metastases, both in the serum and tumor microcirculation. TGFb1 was significantly increased in serum and tumor microcirculation in patients with larger tumors. We found significant correlation between these two immunosuppressive cytokines, IL10 and TGFbl, in tumor microcirculation but not in patient serum samples. Conclusion: IL10 and TGFb1 in systemic and tumor microcirculation are significantly associated with particular histological type of lung cancer, tumor size and degree of disease extent.
PB  - Balkan Union of Oncology (B.U.ON.)
T2  - Journal of BUON
T1  - Association of locally produced IL10 and TGFb1 with tumor size, histological type and presence of metastases in patients with lung carcinoma
VL  - 21
IS  - 5
SP  - 1210
EP  - 1218
UR  - https://hdl.handle.net/21.15107/rcub_farfar_2641
ER  - 

@article{
author = "Karlicić, Vukoica and Vuković, Jelena and Stanojević, Ivan and Sotirović, Jelena and Perić, Alexandra and Jović, Milena and Cvijanović, Vlado and Đukić, Mirjana and Banović, Tatjana and Vojvodić, Danilo",
year = "2016",
abstract = "Purpose: Advanced lung carcinoma is charasterized with fast disease progression. Interleukin (IL)10 and transforming growth factor (TGF)b1 are immunosuppressive mediators and their role in lung carcinoma pathogenesis and in the antitumor response has not yet been elucidated. The purpose of this study was to correlate IL10 and TGFb1 levels in the serum and lung tumor microcirculation with clinical stage, disease extent, histological features and TNM stage. Methods: The study included 41 lung cancer patients in clinical stage III and IV. Histological type was determined immunohistochemically, while tumor size, localization and dissemination were determined radiologically by multislice computerized tomography (MSCT). IL10 and TGFb1 levels were quantified with commercial flow cytometric test in serum and lung tumor microcirculation samples. Results: Non small cell lung cancer (NSCLC) patients had significantly elevated TGFb1 while small cell lung cancer (SCLC) patients had significantly increased IL10 in tumor microcirculation. IL10 was significantly elevated in patients with the largest tumors, as well as in patients with III clinical stage and without metastases, both in the serum and tumor microcirculation. TGFb1 was significantly increased in serum and tumor microcirculation in patients with larger tumors. We found significant correlation between these two immunosuppressive cytokines, IL10 and TGFbl, in tumor microcirculation but not in patient serum samples. Conclusion: IL10 and TGFb1 in systemic and tumor microcirculation are significantly associated with particular histological type of lung cancer, tumor size and degree of disease extent.",
publisher = "Balkan Union of Oncology (B.U.ON.)",
journal = "Journal of BUON",
title = "Association of locally produced IL10 and TGFb1 with tumor size, histological type and presence of metastases in patients with lung carcinoma",
volume = "21",
number = "5",
pages = "1210-1218",
url = "https://hdl.handle.net/21.15107/rcub_farfar_2641"
}

Karlicić, V., Vuković, J., Stanojević, I., Sotirović, J., Perić, A., Jović, M., Cvijanović, V., Đukić, M., Banović, T.,& Vojvodić, D.. (2016). Association of locally produced IL10 and TGFb1 with tumor size, histological type and presence of metastases in patients with lung carcinoma. in Journal of BUON
Balkan Union of Oncology (B.U.ON.)., 21(5), 1210-1218.
https://hdl.handle.net/21.15107/rcub_farfar_2641

Karlicić V, Vuković J, Stanojević I, Sotirović J, Perić A, Jović M, Cvijanović V, Đukić M, Banović T, Vojvodić D. Association of locally produced IL10 and TGFb1 with tumor size, histological type and presence of metastases in patients with lung carcinoma. in Journal of BUON. 2016;21(5):1210-1218.
https://hdl.handle.net/21.15107/rcub_farfar_2641 .

Karlicić, Vukoica, Vuković, Jelena, Stanojević, Ivan, Sotirović, Jelena, Perić, Alexandra, Jović, Milena, Cvijanović, Vlado, Đukić, Mirjana, Banović, Tatjana, Vojvodić, Danilo, "Association of locally produced IL10 and TGFb1 with tumor size, histological type and presence of metastases in patients with lung carcinoma" in Journal of BUON, 21, no. 5 (2016):1210-1218,
https://hdl.handle.net/21.15107/rcub_farfar_2641 .