TY  - JOUR
AU  - Obradović, Dragana
AU  - Anđelić, Tamara
AU  - Ninković, Milica
AU  - Dejanović, Bratislav
AU  - Kotur-Stevuljević, Jelena
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3748
AB  - Objectives: The aim of our study was to analyze oxidative stress (OS) markers in multiple sclerosis (MS) patients during relapse and remission and to evaluate the effects of corticosteroid relapse treatment on oxidative status, and also to determine possible relationship between OS markers and relapse disability recovery after corticosteroid treatment. Methods: Our study included 118 MS patients, (59 relapse/59 remission) 70 females and 48 males, mean age 40.2 ± 9.4 years, and 88 matched healthy controls. Undergoing disease-modifying therapy (DMT) was present in 30.5% of relapse and 88% of remission MS patients. We analyzed in plasma/serum the following: pro-oxidative–antioxidative balance (PAB), nitrates and nitrites (NO3 + NO2), malondialdehyde (MDA), advanced oxidation protein products (AOPP) superoxide dismutase (SOD), catalase (CAT), uric acid, bilirubin, albumin, and transferrin in all patients and additionally after corticosteroid relapse treatment. Neurological disability was measured using the Extended Disability Status Scale (EDSS). Results: Better clinical recovery after relapse treatment was associated with increased baseline SOD, decreased AOPP, and ongoing DMT (all p < 0.05). There was no difference between OS markers in relapse and remission. MS patients had higher MDA, NO3 + NO2, PAB, SOD, CAT, lower AOPP, uric acid, albumin, bilirubin, and transferrin compared to controls (all p < 0.05). Corticosteroids caused significant decrease of all OS markers (all p < 0.05). Conclusion: Increased baseline antioxidative activity of SOD and decreased baseline levels of pro-oxidant AOPP along with ongoing DMT were related to better clinical recovery after corticosteroid relapse treatment. Increase of pro-oxidants and antioxidant enzyme activity in relapse and remission confirms ongoing oxidative injury irrelevant of MS clinical presentation.
PB  - Springer-Verlag Italia s.r.l.
T2  - Neurological Sciences
T1  - Superoxide dismutase (SOD), advanced oxidation protein products (AOPP), and disease-modifying treatment are related to better relapse recovery after corticosteroid treatment in multiple sclerosis
DO  - 10.1007/s10072-020-04928-y
ER  - 

@article{
author = "Obradović, Dragana and Anđelić, Tamara and Ninković, Milica and Dejanović, Bratislav and Kotur-Stevuljević, Jelena",
year = "2020",
abstract = "Objectives: The aim of our study was to analyze oxidative stress (OS) markers in multiple sclerosis (MS) patients during relapse and remission and to evaluate the effects of corticosteroid relapse treatment on oxidative status, and also to determine possible relationship between OS markers and relapse disability recovery after corticosteroid treatment. Methods: Our study included 118 MS patients, (59 relapse/59 remission) 70 females and 48 males, mean age 40.2 ± 9.4 years, and 88 matched healthy controls. Undergoing disease-modifying therapy (DMT) was present in 30.5% of relapse and 88% of remission MS patients. We analyzed in plasma/serum the following: pro-oxidative–antioxidative balance (PAB), nitrates and nitrites (NO3 + NO2), malondialdehyde (MDA), advanced oxidation protein products (AOPP) superoxide dismutase (SOD), catalase (CAT), uric acid, bilirubin, albumin, and transferrin in all patients and additionally after corticosteroid relapse treatment. Neurological disability was measured using the Extended Disability Status Scale (EDSS). Results: Better clinical recovery after relapse treatment was associated with increased baseline SOD, decreased AOPP, and ongoing DMT (all p < 0.05). There was no difference between OS markers in relapse and remission. MS patients had higher MDA, NO3 + NO2, PAB, SOD, CAT, lower AOPP, uric acid, albumin, bilirubin, and transferrin compared to controls (all p < 0.05). Corticosteroids caused significant decrease of all OS markers (all p < 0.05). Conclusion: Increased baseline antioxidative activity of SOD and decreased baseline levels of pro-oxidant AOPP along with ongoing DMT were related to better clinical recovery after corticosteroid relapse treatment. Increase of pro-oxidants and antioxidant enzyme activity in relapse and remission confirms ongoing oxidative injury irrelevant of MS clinical presentation.",
publisher = "Springer-Verlag Italia s.r.l.",
journal = "Neurological Sciences",
title = "Superoxide dismutase (SOD), advanced oxidation protein products (AOPP), and disease-modifying treatment are related to better relapse recovery after corticosteroid treatment in multiple sclerosis",
doi = "10.1007/s10072-020-04928-y"
}

Obradović, D., Anđelić, T., Ninković, M., Dejanović, B.,& Kotur-Stevuljević, J.. (2020). Superoxide dismutase (SOD), advanced oxidation protein products (AOPP), and disease-modifying treatment are related to better relapse recovery after corticosteroid treatment in multiple sclerosis. in Neurological Sciences
Springer-Verlag Italia s.r.l...
https://doi.org/10.1007/s10072-020-04928-y

Obradović D, Anđelić T, Ninković M, Dejanović B, Kotur-Stevuljević J. Superoxide dismutase (SOD), advanced oxidation protein products (AOPP), and disease-modifying treatment are related to better relapse recovery after corticosteroid treatment in multiple sclerosis. in Neurological Sciences. 2020;.
doi:10.1007/s10072-020-04928-y .

Obradović, Dragana, Anđelić, Tamara, Ninković, Milica, Dejanović, Bratislav, Kotur-Stevuljević, Jelena, "Superoxide dismutase (SOD), advanced oxidation protein products (AOPP), and disease-modifying treatment are related to better relapse recovery after corticosteroid treatment in multiple sclerosis" in Neurological Sciences (2020),
https://doi.org/10.1007/s10072-020-04928-y . .

TY  - CONF
AU  - Anđelić, Tamara
AU  - Mijušković, Mirjana
AU  - Kotur-Stevuljević, Jelena
AU  - Milenković, M.
AU  - Obradović, D.
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3089
PB  - Sage Publications Ltd, London
C3  - Multiple Sclerosis Journal
T1  - Markers of oxidative stress - correlation with vitamin D3 and smoking in multiple sclerosis (MS) patients
VL  - 24
IS  - Supplement 2
SP  - 1017
EP  - 1017
DO  - 10.1177/1352458518799980
ER  - 

@conference{
author = "Anđelić, Tamara and Mijušković, Mirjana and Kotur-Stevuljević, Jelena and Milenković, M. and Obradović, D.",
year = "2018",
publisher = "Sage Publications Ltd, London",
journal = "Multiple Sclerosis Journal",
title = "Markers of oxidative stress - correlation with vitamin D3 and smoking in multiple sclerosis (MS) patients",
volume = "24",
number = "Supplement 2",
pages = "1017-1017",
doi = "10.1177/1352458518799980"
}

Anđelić, T., Mijušković, M., Kotur-Stevuljević, J., Milenković, M.,& Obradović, D.. (2018). Markers of oxidative stress - correlation with vitamin D3 and smoking in multiple sclerosis (MS) patients. in Multiple Sclerosis Journal
Sage Publications Ltd, London., 24(Supplement 2), 1017-1017.
https://doi.org/10.1177/1352458518799980

Anđelić T, Mijušković M, Kotur-Stevuljević J, Milenković M, Obradović D. Markers of oxidative stress - correlation with vitamin D3 and smoking in multiple sclerosis (MS) patients. in Multiple Sclerosis Journal. 2018;24(Supplement 2):1017-1017.
doi:10.1177/1352458518799980 .

Anđelić, Tamara, Mijušković, Mirjana, Kotur-Stevuljević, Jelena, Milenković, M., Obradović, D., "Markers of oxidative stress - correlation with vitamin D3 and smoking in multiple sclerosis (MS) patients" in Multiple Sclerosis Journal, 24, no. Supplement 2 (2018):1017-1017,
https://doi.org/10.1177/1352458518799980 . .

TY  - CONF
AU  - Obradović, D.
AU  - Anđelić, Tamara
AU  - Raicević, R.
AU  - Kotur-Stevuljević, Jelena
AU  - Dejanović, Bratislav
AU  - Milojević, A.
AU  - Ninković, Milica
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3232
PB  - Wiley, Hoboken
C3  - European Journal of Neurology
T1  - Oxidative stress parameters in relapsing-Remitting Multiple Sclerosis (RRMS) patients before and after corticosteroid therapy
VL  - 25
IS  - Supplement 2
SP  - 187
EP  - 187
DO  - 10.1111/ene.13699
ER  - 

@conference{
author = "Obradović, D. and Anđelić, Tamara and Raicević, R. and Kotur-Stevuljević, Jelena and Dejanović, Bratislav and Milojević, A. and Ninković, Milica",
year = "2018",
publisher = "Wiley, Hoboken",
journal = "European Journal of Neurology",
title = "Oxidative stress parameters in relapsing-Remitting Multiple Sclerosis (RRMS) patients before and after corticosteroid therapy",
volume = "25",
number = "Supplement 2",
pages = "187-187",
doi = "10.1111/ene.13699"
}

Obradović, D., Anđelić, T., Raicević, R., Kotur-Stevuljević, J., Dejanović, B., Milojević, A.,& Ninković, M.. (2018). Oxidative stress parameters in relapsing-Remitting Multiple Sclerosis (RRMS) patients before and after corticosteroid therapy. in European Journal of Neurology
Wiley, Hoboken., 25(Supplement 2), 187-187.
https://doi.org/10.1111/ene.13699

Obradović D, Anđelić T, Raicević R, Kotur-Stevuljević J, Dejanović B, Milojević A, Ninković M. Oxidative stress parameters in relapsing-Remitting Multiple Sclerosis (RRMS) patients before and after corticosteroid therapy. in European Journal of Neurology. 2018;25(Supplement 2):187-187.
doi:10.1111/ene.13699 .

Obradović, D., Anđelić, Tamara, Raicević, R., Kotur-Stevuljević, Jelena, Dejanović, Bratislav, Milojević, A., Ninković, Milica, "Oxidative stress parameters in relapsing-Remitting Multiple Sclerosis (RRMS) patients before and after corticosteroid therapy" in European Journal of Neurology, 25, no. Supplement 2 (2018):187-187,
https://doi.org/10.1111/ene.13699 . .

TY  - JOUR
AU  - Mijušković, Mirjana
AU  - Stanojević, Ivan
AU  - Milović, Novak
AU  - Cerović, Snežana
AU  - Petrović, Dejan
AU  - Maksić, Đoko
AU  - Kovacević, Božidar
AU  - Anđelić, Tamara
AU  - Aleksić, Predrag
AU  - Terzić, Brankica
AU  - Đukić, Mirjana
AU  - Vojvodić, Danilo
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3231
AB  - The objective of this prospective follow-up trial was to ascertain whether the urinary kidney injury molecule-1 (uKIM-1) associates with tumor tissue (tKIM-1) expression and with the pathological characteristics of clear renal cell carcinoma (cRCC) in radically nephrectomized (RN) and/or in partially nephrectomized (PN) patients with cRCC, pre- and postoperatively. This clinical study included 40 patients subjected to RN/PN (cRCC group) and 30 healthy volunteers (control group). Urinary KIM-1 was determined by ELISA TIM-1/KIM-1 kit and normalized by urinary creatinine. Immunohistochemical staining (monoclonal anti-human anti-TIM-1/KIM-1/HAVCR antibody) was used for semiquantitative analysis of the tKIM-1 expression and expressed as a score (% KIM-1 positively stained tubules). Both markers were interpreted in terms of the tumor characteristics comprising tumor size, Fuhrman grade, pathological (pT) stage, tumor/nodes/metastasis (TNM) stage, lymphovascular invasion and type of surgery RN/PN. Preoperative uKIM-1 was significantly higher in the cRCC group compared to controls, such as uKIM-1 was statistically higher in RN than in PN patients. Postoperatively, uKIM-1 decreased to control values. Expression of tKIM-1 was documented in all nephrectomized patients. Significant associations were achieved between uKIM-1 and tKIM-1 and with considered tumor characteristics, especially with tumor size and grade. Based on the accomplished associations, we found uKIM-1 as a highly sensitive marker for cRCC diagnosis. The clinical trial registration number: 1110-2012.
PB  - Springer, Dordrecht
T2  - International Urology and Nephrology
T1  - Tissue and urinary KIM-1 relate to tumor characteristics in patients with clear renal cell carcinoma
VL  - 50
IS  - 1
SP  - 63
EP  - 70
DO  - 10.1007/s11255-017-1724-6
ER  - 

@article{
author = "Mijušković, Mirjana and Stanojević, Ivan and Milović, Novak and Cerović, Snežana and Petrović, Dejan and Maksić, Đoko and Kovacević, Božidar and Anđelić, Tamara and Aleksić, Predrag and Terzić, Brankica and Đukić, Mirjana and Vojvodić, Danilo",
year = "2018",
abstract = "The objective of this prospective follow-up trial was to ascertain whether the urinary kidney injury molecule-1 (uKIM-1) associates with tumor tissue (tKIM-1) expression and with the pathological characteristics of clear renal cell carcinoma (cRCC) in radically nephrectomized (RN) and/or in partially nephrectomized (PN) patients with cRCC, pre- and postoperatively. This clinical study included 40 patients subjected to RN/PN (cRCC group) and 30 healthy volunteers (control group). Urinary KIM-1 was determined by ELISA TIM-1/KIM-1 kit and normalized by urinary creatinine. Immunohistochemical staining (monoclonal anti-human anti-TIM-1/KIM-1/HAVCR antibody) was used for semiquantitative analysis of the tKIM-1 expression and expressed as a score (% KIM-1 positively stained tubules). Both markers were interpreted in terms of the tumor characteristics comprising tumor size, Fuhrman grade, pathological (pT) stage, tumor/nodes/metastasis (TNM) stage, lymphovascular invasion and type of surgery RN/PN. Preoperative uKIM-1 was significantly higher in the cRCC group compared to controls, such as uKIM-1 was statistically higher in RN than in PN patients. Postoperatively, uKIM-1 decreased to control values. Expression of tKIM-1 was documented in all nephrectomized patients. Significant associations were achieved between uKIM-1 and tKIM-1 and with considered tumor characteristics, especially with tumor size and grade. Based on the accomplished associations, we found uKIM-1 as a highly sensitive marker for cRCC diagnosis. The clinical trial registration number: 1110-2012.",
publisher = "Springer, Dordrecht",
journal = "International Urology and Nephrology",
title = "Tissue and urinary KIM-1 relate to tumor characteristics in patients with clear renal cell carcinoma",
volume = "50",
number = "1",
pages = "63-70",
doi = "10.1007/s11255-017-1724-6"
}

Mijušković, M., Stanojević, I., Milović, N., Cerović, S., Petrović, D., Maksić, Đ., Kovacević, B., Anđelić, T., Aleksić, P., Terzić, B., Đukić, M.,& Vojvodić, D.. (2018). Tissue and urinary KIM-1 relate to tumor characteristics in patients with clear renal cell carcinoma. in International Urology and Nephrology
Springer, Dordrecht., 50(1), 63-70.
https://doi.org/10.1007/s11255-017-1724-6

Mijušković M, Stanojević I, Milović N, Cerović S, Petrović D, Maksić Đ, Kovacević B, Anđelić T, Aleksić P, Terzić B, Đukić M, Vojvodić D. Tissue and urinary KIM-1 relate to tumor characteristics in patients with clear renal cell carcinoma. in International Urology and Nephrology. 2018;50(1):63-70.
doi:10.1007/s11255-017-1724-6 .

Mijušković, Mirjana, Stanojević, Ivan, Milović, Novak, Cerović, Snežana, Petrović, Dejan, Maksić, Đoko, Kovacević, Božidar, Anđelić, Tamara, Aleksić, Predrag, Terzić, Brankica, Đukić, Mirjana, Vojvodić, Danilo, "Tissue and urinary KIM-1 relate to tumor characteristics in patients with clear renal cell carcinoma" in International Urology and Nephrology, 50, no. 1 (2018):63-70,
https://doi.org/10.1007/s11255-017-1724-6 . .

TY  - CONF
AU  - Mijušković, Mirjana
AU  - Stanojević, Ivan
AU  - Cerović, Snežana
AU  - Petrović, Dejan
AU  - Terzić, Brankica
AU  - Kovacević, Božidar
AU  - Anđelić, Tamara
AU  - Aleksić, Predrag
AU  - Đukić, Mirjana
AU  - Vojvodić, Danilo
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2939
PB  - Oxford Univ Press, Oxford
C3  - Nephrology Dialysis Transplantation
T1  - Tissue and urinary kim-1 relate with tumor characteristics in patients with clear renal cell carcinoma
VL  - 32
IS  - Supplement 3
SP  - iii438
EP  - iii438
DO  - 10.1093/ndt/gfx161.MP028
ER  - 

@conference{
author = "Mijušković, Mirjana and Stanojević, Ivan and Cerović, Snežana and Petrović, Dejan and Terzić, Brankica and Kovacević, Božidar and Anđelić, Tamara and Aleksić, Predrag and Đukić, Mirjana and Vojvodić, Danilo",
year = "2017",
publisher = "Oxford Univ Press, Oxford",
journal = "Nephrology Dialysis Transplantation",
title = "Tissue and urinary kim-1 relate with tumor characteristics in patients with clear renal cell carcinoma",
volume = "32",
number = "Supplement 3",
pages = "iii438-iii438",
doi = "10.1093/ndt/gfx161.MP028"
}

Mijušković, M., Stanojević, I., Cerović, S., Petrović, D., Terzić, B., Kovacević, B., Anđelić, T., Aleksić, P., Đukić, M.,& Vojvodić, D.. (2017). Tissue and urinary kim-1 relate with tumor characteristics in patients with clear renal cell carcinoma. in Nephrology Dialysis Transplantation
Oxford Univ Press, Oxford., 32(Supplement 3), iii438-iii438.
https://doi.org/10.1093/ndt/gfx161.MP028

Mijušković M, Stanojević I, Cerović S, Petrović D, Terzić B, Kovacević B, Anđelić T, Aleksić P, Đukić M, Vojvodić D. Tissue and urinary kim-1 relate with tumor characteristics in patients with clear renal cell carcinoma. in Nephrology Dialysis Transplantation. 2017;32(Supplement 3):iii438-iii438.
doi:10.1093/ndt/gfx161.MP028 .

Mijušković, Mirjana, Stanojević, Ivan, Cerović, Snežana, Petrović, Dejan, Terzić, Brankica, Kovacević, Božidar, Anđelić, Tamara, Aleksić, Predrag, Đukić, Mirjana, Vojvodić, Danilo, "Tissue and urinary kim-1 relate with tumor characteristics in patients with clear renal cell carcinoma" in Nephrology Dialysis Transplantation, 32, no. Supplement 3 (2017):iii438-iii438,
https://doi.org/10.1093/ndt/gfx161.MP028 . .

TY  - JOUR
AU  - Mijušković, Mirjana
AU  - Stanojević, Ivan
AU  - Milović, Novak
AU  - Cerović, Snežana
AU  - Petrović, Dejan
AU  - Jovanović, Dragan
AU  - Aleksić, Predrag
AU  - Kovačević, Božidar
AU  - Anđelić, Tamara
AU  - Terzić, Brankica
AU  - Đukić, Mirjana
AU  - Vojvodić, Danilo
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2676
AB  - Background/Aim. Kidney injury molecule-1 (KIM-1) and aquaporin-1 (AQP-1) are potential early urinary biomarkers of clear renal cell carcinoma (cRCC). The aim of this study was to ascertain relationship between the urine concentrations KIM-1 and AQP-1 with tumor size, grade, pT stage and type of operation (radical or partial nephrectomy) in patients with cRCC. Methods. Urinary concentrations of urinary KIM-1 (uKIM-1) and urinary AQP-1 (uAQP-1) were determined by commercially available ELISA kits. The analysis included 40 patients undergoing partial or radical nephrectomy for cRCC and 40 age- and sex-matched healthy adult volunteers. Results. The median preoperative concentrations of KIM-1 in the cRCC group [0.724 ± 1.120 ng/mg urinary creatinine (Ucr)] were significantly greater compared with controls (healthy volunteers) (0.210 ± 0.082 ng/mgUcr) (p = 0.0227). Postoperatively, uKIM-1 concentration decreased significantly to control values (0.177 ± 0.099 ng/mgUcr vs 0.210 ± 0.082 ng/mgUcr, respectively). The size, grade and stage of tumor were correlated positively with preoperative uKIM-1 concentrations. Contrary to these results, concentrations of uAQP-1 in the cRCC group were significantly lower (0.111 ± 0.092 ng/mgUcr) compared with the control group (0.202 ± 0.078 ng/mgUcr) (p = 0.0014). Postoperatively, the concentrations of uAQP-1 increased progressively up to control values, approximately. We find no significant correlation between preoperative uAQP-1 concentrations and tumor size, grade and stage. Conclusion. uKIM-1 was found to be a reliable diagnostic marker of cRCC, based on its significantly increased values before and decreased values after the nephrectomy.
AB  - Uvod/Cilj. Molekul oštećenja bubrega-1 (KIM-1) i akvaporin-1 (AQP-1) su potencijalni rani biomarkeri karcinoma svetlih ćelija (cRCC). Cilj ove studije bio je da se utvrdi povezanost između koncentracija KIM-1 i AQP-1 u urinu i veličine, gradusa, stadijuma i vrste operacije (radikalna ili parcijalna nefrektomija) kod bolesnika sa cRCC. Metode. Urinarne koncentracije KIM-1 i AQP-1 određene su primenom komercijalnih ELISA kitova. Analizom je bilo obuhvaćeno 40 bolesnika koji su bili podvrgnuti parcijalnoj ili radikalnoj nefrektomiji zbog tumora bubrega i 40 zdravih odraslih ispitanika. Grupe su bile komparabilne po polu i godinama života. Rezultati. Srednja preoperativna koncentracija urinarnog KIM-1 (uKIM-1) u cRCC grupi [0,724 ± 1,120 ng/mg kreatinia u urinu (Ucr)] bila je statistički značajno viša u poređenju sa koncentracijom u kontrolnoj grupi (0,210 ± 0,082 ng/mgUcr ) (p = 0,0227). Postoperativno, koncentracija uKIM-1 značajno je padala i približavala se vrednosti u kontrolnoj grupi (0,177 ± 0,099 ng/mgUcr nasuprot 0,210 ± 0,082 ng/mgUcr). Veličina, gradus i stadijum tumora bili su u pozitivnoj korelaciji sa preoperativnim koncentracijama uKIM-1. Nasuprot ovim rezultatima, koncentracija urinarnog AQP-1 (uAQP-1) u cRCC grupi bila je značajno niža (0,111 ± 0,092 ng/mgUcr) u poređenju sa kontrolnom grupom zdravih osoba (0,202 ± 0,078 ng/mgUcr) (p = 0,0014). Postoperativno, koncentracija uAQP-1 progresivno se povećavala, približno do vrednosti u kontrolnoj grupi. Nismo našli značajnu korelaciju između preoperativnih koncentracija uAQP-1 i veličine, gradusa i stadijuma tumora. Zaključak. uKIM-1 bi mogao biti dodatni pouzdani dijagnostički marker za cRRC na osnovu njegove značajno više preoperativne koncentracije i sniženja vrednosti nakon nefrektomije.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Urinary KIM-1 and AQP-1 in patients with clear renal cell carcinoma: Potential noninvasive biomarkers
T1  - Molekul oštećenja bubrega-1 (KIM-1) i akvaporin-1 (AQP-1) u urinu kod bolesnika sa karcinomom svetlih ćelija bubrega - potencijalni neiznvazivni biomarkeri
VL  - 73
IS  - 3
SP  - 266
EP  - 272
DO  - 10.2298/VSP150124006M
ER  - 

@article{
author = "Mijušković, Mirjana and Stanojević, Ivan and Milović, Novak and Cerović, Snežana and Petrović, Dejan and Jovanović, Dragan and Aleksić, Predrag and Kovačević, Božidar and Anđelić, Tamara and Terzić, Brankica and Đukić, Mirjana and Vojvodić, Danilo",
year = "2016",
abstract = "Background/Aim. Kidney injury molecule-1 (KIM-1) and aquaporin-1 (AQP-1) are potential early urinary biomarkers of clear renal cell carcinoma (cRCC). The aim of this study was to ascertain relationship between the urine concentrations KIM-1 and AQP-1 with tumor size, grade, pT stage and type of operation (radical or partial nephrectomy) in patients with cRCC. Methods. Urinary concentrations of urinary KIM-1 (uKIM-1) and urinary AQP-1 (uAQP-1) were determined by commercially available ELISA kits. The analysis included 40 patients undergoing partial or radical nephrectomy for cRCC and 40 age- and sex-matched healthy adult volunteers. Results. The median preoperative concentrations of KIM-1 in the cRCC group [0.724 ± 1.120 ng/mg urinary creatinine (Ucr)] were significantly greater compared with controls (healthy volunteers) (0.210 ± 0.082 ng/mgUcr) (p = 0.0227). Postoperatively, uKIM-1 concentration decreased significantly to control values (0.177 ± 0.099 ng/mgUcr vs 0.210 ± 0.082 ng/mgUcr, respectively). The size, grade and stage of tumor were correlated positively with preoperative uKIM-1 concentrations. Contrary to these results, concentrations of uAQP-1 in the cRCC group were significantly lower (0.111 ± 0.092 ng/mgUcr) compared with the control group (0.202 ± 0.078 ng/mgUcr) (p = 0.0014). Postoperatively, the concentrations of uAQP-1 increased progressively up to control values, approximately. We find no significant correlation between preoperative uAQP-1 concentrations and tumor size, grade and stage. Conclusion. uKIM-1 was found to be a reliable diagnostic marker of cRCC, based on its significantly increased values before and decreased values after the nephrectomy., Uvod/Cilj. Molekul oštećenja bubrega-1 (KIM-1) i akvaporin-1 (AQP-1) su potencijalni rani biomarkeri karcinoma svetlih ćelija (cRCC). Cilj ove studije bio je da se utvrdi povezanost između koncentracija KIM-1 i AQP-1 u urinu i veličine, gradusa, stadijuma i vrste operacije (radikalna ili parcijalna nefrektomija) kod bolesnika sa cRCC. Metode. Urinarne koncentracije KIM-1 i AQP-1 određene su primenom komercijalnih ELISA kitova. Analizom je bilo obuhvaćeno 40 bolesnika koji su bili podvrgnuti parcijalnoj ili radikalnoj nefrektomiji zbog tumora bubrega i 40 zdravih odraslih ispitanika. Grupe su bile komparabilne po polu i godinama života. Rezultati. Srednja preoperativna koncentracija urinarnog KIM-1 (uKIM-1) u cRCC grupi [0,724 ± 1,120 ng/mg kreatinia u urinu (Ucr)] bila je statistički značajno viša u poređenju sa koncentracijom u kontrolnoj grupi (0,210 ± 0,082 ng/mgUcr ) (p = 0,0227). Postoperativno, koncentracija uKIM-1 značajno je padala i približavala se vrednosti u kontrolnoj grupi (0,177 ± 0,099 ng/mgUcr nasuprot 0,210 ± 0,082 ng/mgUcr). Veličina, gradus i stadijum tumora bili su u pozitivnoj korelaciji sa preoperativnim koncentracijama uKIM-1. Nasuprot ovim rezultatima, koncentracija urinarnog AQP-1 (uAQP-1) u cRCC grupi bila je značajno niža (0,111 ± 0,092 ng/mgUcr) u poređenju sa kontrolnom grupom zdravih osoba (0,202 ± 0,078 ng/mgUcr) (p = 0,0014). Postoperativno, koncentracija uAQP-1 progresivno se povećavala, približno do vrednosti u kontrolnoj grupi. Nismo našli značajnu korelaciju između preoperativnih koncentracija uAQP-1 i veličine, gradusa i stadijuma tumora. Zaključak. uKIM-1 bi mogao biti dodatni pouzdani dijagnostički marker za cRRC na osnovu njegove značajno više preoperativne koncentracije i sniženja vrednosti nakon nefrektomije.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Urinary KIM-1 and AQP-1 in patients with clear renal cell carcinoma: Potential noninvasive biomarkers, Molekul oštećenja bubrega-1 (KIM-1) i akvaporin-1 (AQP-1) u urinu kod bolesnika sa karcinomom svetlih ćelija bubrega - potencijalni neiznvazivni biomarkeri",
volume = "73",
number = "3",
pages = "266-272",
doi = "10.2298/VSP150124006M"
}

Mijušković, M., Stanojević, I., Milović, N., Cerović, S., Petrović, D., Jovanović, D., Aleksić, P., Kovačević, B., Anđelić, T., Terzić, B., Đukić, M.,& Vojvodić, D.. (2016). Urinary KIM-1 and AQP-1 in patients with clear renal cell carcinoma: Potential noninvasive biomarkers. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 73(3), 266-272.
https://doi.org/10.2298/VSP150124006M

Mijušković M, Stanojević I, Milović N, Cerović S, Petrović D, Jovanović D, Aleksić P, Kovačević B, Anđelić T, Terzić B, Đukić M, Vojvodić D. Urinary KIM-1 and AQP-1 in patients with clear renal cell carcinoma: Potential noninvasive biomarkers. in Vojnosanitetski pregled. 2016;73(3):266-272.
doi:10.2298/VSP150124006M .

Mijušković, Mirjana, Stanojević, Ivan, Milović, Novak, Cerović, Snežana, Petrović, Dejan, Jovanović, Dragan, Aleksić, Predrag, Kovačević, Božidar, Anđelić, Tamara, Terzić, Brankica, Đukić, Mirjana, Vojvodić, Danilo, "Urinary KIM-1 and AQP-1 in patients with clear renal cell carcinoma: Potential noninvasive biomarkers" in Vojnosanitetski pregled, 73, no. 3 (2016):266-272,
https://doi.org/10.2298/VSP150124006M . .

TY  - JOUR
AU  - Perić, Aneta
AU  - Šurbatović, Maja
AU  - Vezmar-Kovačević, Sandra
AU  - Antunović, Mirjana
AU  - Veljović, Milić
AU  - Đorđević, Dragan
AU  - Anđelić, Tamara
AU  - Zeba, Snježana
AU  - Dobrić, Silva
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2262
AB  - Background/Aim. Critically ill patients are at very high risk of developing severe infections in intensive care units (ICUs). Procalcitonin (PCT) levels are eleveted in the circulation in patients with bacterial sepsis and PCT might be useful in guiding antibiotic treatment. The aim of this study was to estimate factors influencing patients survival and treatment cost in ICU with special emphasis on the impact of PCT serum levels use in guiding antimicrobial therapy. Methods. The study was conducted from August 2010 to May 2012 in the Intensive Therapy Unit, Clinic of Anesthesiology and Intensive Therapy, Military Medical Academy (MMA), Belgrade, Serbia. All adult critically ill patients with sepsis and/or trauma admitted in the ICU were included in the study. This study included only the cost of antimicrobial therapy in the ICU and the cost for PCT analysis. We used prices valid in the MMA for the year 2012. PCT in serum was measured by homogeneous immunoassay on a Brahms Kryptor analyzer. Results. A total of 102 patients were enrolled. The mean patients age was 55 ± 19 years and 61.8% of patients were male. The mean length of stay (LOS) in the ICU was 12 ± 21 days. There was a statistically significant difference (p  lt  0.001) between the sepsis and trauma group regarding outcome (higher mortality rate was in the sepsis group, particularly in the patients with peritonitis who were mostly women). The patients younger than 70 years had better chance of survival. LOS, the use of carbapenems and PCT-measurement influenced the cost of therapy in the ICU. Conclusions. The obtained results show that age, the diagnosis and gender were the main predictors of survival of critically ill patients in the ICU. The cost of ICU stay was dependent on LOS, use of carbapenems and PCT measurement although the influence of these three factors on the outcome in the patients did not reach a statistical significance.
AB  - Uvod/Cilj. Kritično oboleli pacijenti imaju veliki rizik od razvoja teških infekcija u jedinicama intenzivne terapije (JIT). Nivo prokalcitonina (PCT) u cirkulaciji je povišen kod bolesnika sa bakterijskom sepsom, tako da PCT može biti koristan u praćenju antibiotske terapije. Cilj ove studije bio je da se ustanove faktori koji utiču na ishod i troškove lečenja u JIT u našoj ustanovi sa posebnim naglaskom na uticaj korišćenja serumskog nivoa PCT u vođenju antimikrobne terapije. Metode. Studija je sprovedena od avgusta 2010. godine do maja 2012. godine u Jedinici intenzivne terapije Klinike za anesteziologiju i intenzivnu terapiju Vojnomedicinske akademije (VMA) u Beogradu, Srbija. Svi kritično oboleli sa sepsom i/ili traumom koji su primljeni u JIT bili su uključeni u studiju. Studijom su obuhvaćeni samo troškovi antimikrobne terapije u JIT i troškovi PCT analize. Koristili smo cenovnik VMA za 2012. godinu. PCT u serumu je meren tehnikom homogenog imunoeseja na Brams Kriptor analizatoru. Rezultati. Studijom su bila obuhvaćena 102 bolesnika. Prosečna starost bolesnika iznosila je 55 ± 19 godina, a 61,8% bolesnika bili su muškarci. Prosečna dužina boravka u JIT (lenght of stay LOS) iznosila je 12 ± 21 dana. Postojala je statistički značajna razlika (p  lt  0.001) između ishoda lečenja u grupi sa sepsom u odnosu na grupu sa traumom. Bolesnici mlađi od 70 godina imali su bolju šansu da prežive. Dužina boravka, upotreba karbapenema i merenje PCT uticali su na cenu terapije u JIT. Zaključak. Dobijeni rezultati pokazuju da su godine života, dijagnoza i pol bili glavni prediktori preživljavanja kritično obolelih u JIT. Cena terapije zavisila je od dužine boravka u JIT, upotrebe karbapenema i merenja PCT, ali uticaj ovih faktora na ishod lečenja nije dostigao statističku značajnost.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Factors influencing antibiotic treatment cost and outcome in critically ill patients: A 'real-life' study
T1  - Faktori koji utiču na cenu antibiotske terapije i ishod kod kritično obolelih pacijenata - 'real-life' studija
VL  - 71
IS  - 12
SP  - 1102
EP  - 1108
DO  - 10.2298/VSP1412102P
ER  - 

@article{
author = "Perić, Aneta and Šurbatović, Maja and Vezmar-Kovačević, Sandra and Antunović, Mirjana and Veljović, Milić and Đorđević, Dragan and Anđelić, Tamara and Zeba, Snježana and Dobrić, Silva",
year = "2014",
abstract = "Background/Aim. Critically ill patients are at very high risk of developing severe infections in intensive care units (ICUs). Procalcitonin (PCT) levels are eleveted in the circulation in patients with bacterial sepsis and PCT might be useful in guiding antibiotic treatment. The aim of this study was to estimate factors influencing patients survival and treatment cost in ICU with special emphasis on the impact of PCT serum levels use in guiding antimicrobial therapy. Methods. The study was conducted from August 2010 to May 2012 in the Intensive Therapy Unit, Clinic of Anesthesiology and Intensive Therapy, Military Medical Academy (MMA), Belgrade, Serbia. All adult critically ill patients with sepsis and/or trauma admitted in the ICU were included in the study. This study included only the cost of antimicrobial therapy in the ICU and the cost for PCT analysis. We used prices valid in the MMA for the year 2012. PCT in serum was measured by homogeneous immunoassay on a Brahms Kryptor analyzer. Results. A total of 102 patients were enrolled. The mean patients age was 55 ± 19 years and 61.8% of patients were male. The mean length of stay (LOS) in the ICU was 12 ± 21 days. There was a statistically significant difference (p  lt  0.001) between the sepsis and trauma group regarding outcome (higher mortality rate was in the sepsis group, particularly in the patients with peritonitis who were mostly women). The patients younger than 70 years had better chance of survival. LOS, the use of carbapenems and PCT-measurement influenced the cost of therapy in the ICU. Conclusions. The obtained results show that age, the diagnosis and gender were the main predictors of survival of critically ill patients in the ICU. The cost of ICU stay was dependent on LOS, use of carbapenems and PCT measurement although the influence of these three factors on the outcome in the patients did not reach a statistical significance., Uvod/Cilj. Kritično oboleli pacijenti imaju veliki rizik od razvoja teških infekcija u jedinicama intenzivne terapije (JIT). Nivo prokalcitonina (PCT) u cirkulaciji je povišen kod bolesnika sa bakterijskom sepsom, tako da PCT može biti koristan u praćenju antibiotske terapije. Cilj ove studije bio je da se ustanove faktori koji utiču na ishod i troškove lečenja u JIT u našoj ustanovi sa posebnim naglaskom na uticaj korišćenja serumskog nivoa PCT u vođenju antimikrobne terapije. Metode. Studija je sprovedena od avgusta 2010. godine do maja 2012. godine u Jedinici intenzivne terapije Klinike za anesteziologiju i intenzivnu terapiju Vojnomedicinske akademije (VMA) u Beogradu, Srbija. Svi kritično oboleli sa sepsom i/ili traumom koji su primljeni u JIT bili su uključeni u studiju. Studijom su obuhvaćeni samo troškovi antimikrobne terapije u JIT i troškovi PCT analize. Koristili smo cenovnik VMA za 2012. godinu. PCT u serumu je meren tehnikom homogenog imunoeseja na Brams Kriptor analizatoru. Rezultati. Studijom su bila obuhvaćena 102 bolesnika. Prosečna starost bolesnika iznosila je 55 ± 19 godina, a 61,8% bolesnika bili su muškarci. Prosečna dužina boravka u JIT (lenght of stay LOS) iznosila je 12 ± 21 dana. Postojala je statistički značajna razlika (p  lt  0.001) između ishoda lečenja u grupi sa sepsom u odnosu na grupu sa traumom. Bolesnici mlađi od 70 godina imali su bolju šansu da prežive. Dužina boravka, upotreba karbapenema i merenje PCT uticali su na cenu terapije u JIT. Zaključak. Dobijeni rezultati pokazuju da su godine života, dijagnoza i pol bili glavni prediktori preživljavanja kritično obolelih u JIT. Cena terapije zavisila je od dužine boravka u JIT, upotrebe karbapenema i merenja PCT, ali uticaj ovih faktora na ishod lečenja nije dostigao statističku značajnost.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Factors influencing antibiotic treatment cost and outcome in critically ill patients: A 'real-life' study, Faktori koji utiču na cenu antibiotske terapije i ishod kod kritično obolelih pacijenata - 'real-life' studija",
volume = "71",
number = "12",
pages = "1102-1108",
doi = "10.2298/VSP1412102P"
}

Perić, A., Šurbatović, M., Vezmar-Kovačević, S., Antunović, M., Veljović, M., Đorđević, D., Anđelić, T., Zeba, S.,& Dobrić, S.. (2014). Factors influencing antibiotic treatment cost and outcome in critically ill patients: A 'real-life' study. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 71(12), 1102-1108.
https://doi.org/10.2298/VSP1412102P

Perić A, Šurbatović M, Vezmar-Kovačević S, Antunović M, Veljović M, Đorđević D, Anđelić T, Zeba S, Dobrić S. Factors influencing antibiotic treatment cost and outcome in critically ill patients: A 'real-life' study. in Vojnosanitetski pregled. 2014;71(12):1102-1108.
doi:10.2298/VSP1412102P .

Perić, Aneta, Šurbatović, Maja, Vezmar-Kovačević, Sandra, Antunović, Mirjana, Veljović, Milić, Đorđević, Dragan, Anđelić, Tamara, Zeba, Snježana, Dobrić, Silva, "Factors influencing antibiotic treatment cost and outcome in critically ill patients: A 'real-life' study" in Vojnosanitetski pregled, 71, no. 12 (2014):1102-1108,
https://doi.org/10.2298/VSP1412102P . .