TY  - JOUR
AU  - Perić, Aneta
AU  - Šurbatović, Maja
AU  - Vezmar-Kovačević, Sandra
AU  - Antunović, Mirjana
AU  - Veljović, Milić
AU  - Krstić-Lečić, Ivana
AU  - Đorđević, Dragan
AU  - Kilibarda, Vesna
AU  - Zeba, Snježana
AU  - Dobrić, Silva
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2473
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Beta-lactam antibiotics use in intensive care units: The pathophysiological, pharmacokinetic, pharmacodynamic and pharmacoeconomic approach
T1  - Upotreba beta-laktamskih antibiotika u jedinicama intenzivne terapije - patofiziološki, farmakokinetički, farmakodinamički i farmakoekonomski pristup
VL  - 72
IS  - 2
SP  - 175
EP  - 180
DO  - 10.2298/VSP1502175P
ER  - 

@article{
author = "Perić, Aneta and Šurbatović, Maja and Vezmar-Kovačević, Sandra and Antunović, Mirjana and Veljović, Milić and Krstić-Lečić, Ivana and Đorđević, Dragan and Kilibarda, Vesna and Zeba, Snježana and Dobrić, Silva",
year = "2015",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Beta-lactam antibiotics use in intensive care units: The pathophysiological, pharmacokinetic, pharmacodynamic and pharmacoeconomic approach, Upotreba beta-laktamskih antibiotika u jedinicama intenzivne terapije - patofiziološki, farmakokinetički, farmakodinamički i farmakoekonomski pristup",
volume = "72",
number = "2",
pages = "175-180",
doi = "10.2298/VSP1502175P"
}

Perić, A., Šurbatović, M., Vezmar-Kovačević, S., Antunović, M., Veljović, M., Krstić-Lečić, I., Đorđević, D., Kilibarda, V., Zeba, S.,& Dobrić, S.. (2015). Beta-lactam antibiotics use in intensive care units: The pathophysiological, pharmacokinetic, pharmacodynamic and pharmacoeconomic approach. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 72(2), 175-180.
https://doi.org/10.2298/VSP1502175P

Perić A, Šurbatović M, Vezmar-Kovačević S, Antunović M, Veljović M, Krstić-Lečić I, Đorđević D, Kilibarda V, Zeba S, Dobrić S. Beta-lactam antibiotics use in intensive care units: The pathophysiological, pharmacokinetic, pharmacodynamic and pharmacoeconomic approach. in Vojnosanitetski pregled. 2015;72(2):175-180.
doi:10.2298/VSP1502175P .

Perić, Aneta, Šurbatović, Maja, Vezmar-Kovačević, Sandra, Antunović, Mirjana, Veljović, Milić, Krstić-Lečić, Ivana, Đorđević, Dragan, Kilibarda, Vesna, Zeba, Snježana, Dobrić, Silva, "Beta-lactam antibiotics use in intensive care units: The pathophysiological, pharmacokinetic, pharmacodynamic and pharmacoeconomic approach" in Vojnosanitetski pregled, 72, no. 2 (2015):175-180,
https://doi.org/10.2298/VSP1502175P . .

TY  - JOUR
AU  - Perić, Aneta
AU  - Šurbatović, Maja
AU  - Vezmar-Kovačević, Sandra
AU  - Antunović, Mirjana
AU  - Veljović, Milić
AU  - Đorđević, Dragan
AU  - Anđelić, Tamara
AU  - Zeba, Snježana
AU  - Dobrić, Silva
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2262
AB  - Background/Aim. Critically ill patients are at very high risk of developing severe infections in intensive care units (ICUs). Procalcitonin (PCT) levels are eleveted in the circulation in patients with bacterial sepsis and PCT might be useful in guiding antibiotic treatment. The aim of this study was to estimate factors influencing patients survival and treatment cost in ICU with special emphasis on the impact of PCT serum levels use in guiding antimicrobial therapy. Methods. The study was conducted from August 2010 to May 2012 in the Intensive Therapy Unit, Clinic of Anesthesiology and Intensive Therapy, Military Medical Academy (MMA), Belgrade, Serbia. All adult critically ill patients with sepsis and/or trauma admitted in the ICU were included in the study. This study included only the cost of antimicrobial therapy in the ICU and the cost for PCT analysis. We used prices valid in the MMA for the year 2012. PCT in serum was measured by homogeneous immunoassay on a Brahms Kryptor analyzer. Results. A total of 102 patients were enrolled. The mean patients age was 55 ± 19 years and 61.8% of patients were male. The mean length of stay (LOS) in the ICU was 12 ± 21 days. There was a statistically significant difference (p  lt  0.001) between the sepsis and trauma group regarding outcome (higher mortality rate was in the sepsis group, particularly in the patients with peritonitis who were mostly women). The patients younger than 70 years had better chance of survival. LOS, the use of carbapenems and PCT-measurement influenced the cost of therapy in the ICU. Conclusions. The obtained results show that age, the diagnosis and gender were the main predictors of survival of critically ill patients in the ICU. The cost of ICU stay was dependent on LOS, use of carbapenems and PCT measurement although the influence of these three factors on the outcome in the patients did not reach a statistical significance.
AB  - Uvod/Cilj. Kritično oboleli pacijenti imaju veliki rizik od razvoja teških infekcija u jedinicama intenzivne terapije (JIT). Nivo prokalcitonina (PCT) u cirkulaciji je povišen kod bolesnika sa bakterijskom sepsom, tako da PCT može biti koristan u praćenju antibiotske terapije. Cilj ove studije bio je da se ustanove faktori koji utiču na ishod i troškove lečenja u JIT u našoj ustanovi sa posebnim naglaskom na uticaj korišćenja serumskog nivoa PCT u vođenju antimikrobne terapije. Metode. Studija je sprovedena od avgusta 2010. godine do maja 2012. godine u Jedinici intenzivne terapije Klinike za anesteziologiju i intenzivnu terapiju Vojnomedicinske akademije (VMA) u Beogradu, Srbija. Svi kritično oboleli sa sepsom i/ili traumom koji su primljeni u JIT bili su uključeni u studiju. Studijom su obuhvaćeni samo troškovi antimikrobne terapije u JIT i troškovi PCT analize. Koristili smo cenovnik VMA za 2012. godinu. PCT u serumu je meren tehnikom homogenog imunoeseja na Brams Kriptor analizatoru. Rezultati. Studijom su bila obuhvaćena 102 bolesnika. Prosečna starost bolesnika iznosila je 55 ± 19 godina, a 61,8% bolesnika bili su muškarci. Prosečna dužina boravka u JIT (lenght of stay LOS) iznosila je 12 ± 21 dana. Postojala je statistički značajna razlika (p  lt  0.001) između ishoda lečenja u grupi sa sepsom u odnosu na grupu sa traumom. Bolesnici mlađi od 70 godina imali su bolju šansu da prežive. Dužina boravka, upotreba karbapenema i merenje PCT uticali su na cenu terapije u JIT. Zaključak. Dobijeni rezultati pokazuju da su godine života, dijagnoza i pol bili glavni prediktori preživljavanja kritično obolelih u JIT. Cena terapije zavisila je od dužine boravka u JIT, upotrebe karbapenema i merenja PCT, ali uticaj ovih faktora na ishod lečenja nije dostigao statističku značajnost.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Factors influencing antibiotic treatment cost and outcome in critically ill patients: A 'real-life' study
T1  - Faktori koji utiču na cenu antibiotske terapije i ishod kod kritično obolelih pacijenata - 'real-life' studija
VL  - 71
IS  - 12
SP  - 1102
EP  - 1108
DO  - 10.2298/VSP1412102P
ER  - 

@article{
author = "Perić, Aneta and Šurbatović, Maja and Vezmar-Kovačević, Sandra and Antunović, Mirjana and Veljović, Milić and Đorđević, Dragan and Anđelić, Tamara and Zeba, Snježana and Dobrić, Silva",
year = "2014",
abstract = "Background/Aim. Critically ill patients are at very high risk of developing severe infections in intensive care units (ICUs). Procalcitonin (PCT) levels are eleveted in the circulation in patients with bacterial sepsis and PCT might be useful in guiding antibiotic treatment. The aim of this study was to estimate factors influencing patients survival and treatment cost in ICU with special emphasis on the impact of PCT serum levels use in guiding antimicrobial therapy. Methods. The study was conducted from August 2010 to May 2012 in the Intensive Therapy Unit, Clinic of Anesthesiology and Intensive Therapy, Military Medical Academy (MMA), Belgrade, Serbia. All adult critically ill patients with sepsis and/or trauma admitted in the ICU were included in the study. This study included only the cost of antimicrobial therapy in the ICU and the cost for PCT analysis. We used prices valid in the MMA for the year 2012. PCT in serum was measured by homogeneous immunoassay on a Brahms Kryptor analyzer. Results. A total of 102 patients were enrolled. The mean patients age was 55 ± 19 years and 61.8% of patients were male. The mean length of stay (LOS) in the ICU was 12 ± 21 days. There was a statistically significant difference (p  lt  0.001) between the sepsis and trauma group regarding outcome (higher mortality rate was in the sepsis group, particularly in the patients with peritonitis who were mostly women). The patients younger than 70 years had better chance of survival. LOS, the use of carbapenems and PCT-measurement influenced the cost of therapy in the ICU. Conclusions. The obtained results show that age, the diagnosis and gender were the main predictors of survival of critically ill patients in the ICU. The cost of ICU stay was dependent on LOS, use of carbapenems and PCT measurement although the influence of these three factors on the outcome in the patients did not reach a statistical significance., Uvod/Cilj. Kritično oboleli pacijenti imaju veliki rizik od razvoja teških infekcija u jedinicama intenzivne terapije (JIT). Nivo prokalcitonina (PCT) u cirkulaciji je povišen kod bolesnika sa bakterijskom sepsom, tako da PCT može biti koristan u praćenju antibiotske terapije. Cilj ove studije bio je da se ustanove faktori koji utiču na ishod i troškove lečenja u JIT u našoj ustanovi sa posebnim naglaskom na uticaj korišćenja serumskog nivoa PCT u vođenju antimikrobne terapije. Metode. Studija je sprovedena od avgusta 2010. godine do maja 2012. godine u Jedinici intenzivne terapije Klinike za anesteziologiju i intenzivnu terapiju Vojnomedicinske akademije (VMA) u Beogradu, Srbija. Svi kritično oboleli sa sepsom i/ili traumom koji su primljeni u JIT bili su uključeni u studiju. Studijom su obuhvaćeni samo troškovi antimikrobne terapije u JIT i troškovi PCT analize. Koristili smo cenovnik VMA za 2012. godinu. PCT u serumu je meren tehnikom homogenog imunoeseja na Brams Kriptor analizatoru. Rezultati. Studijom su bila obuhvaćena 102 bolesnika. Prosečna starost bolesnika iznosila je 55 ± 19 godina, a 61,8% bolesnika bili su muškarci. Prosečna dužina boravka u JIT (lenght of stay LOS) iznosila je 12 ± 21 dana. Postojala je statistički značajna razlika (p  lt  0.001) između ishoda lečenja u grupi sa sepsom u odnosu na grupu sa traumom. Bolesnici mlađi od 70 godina imali su bolju šansu da prežive. Dužina boravka, upotreba karbapenema i merenje PCT uticali su na cenu terapije u JIT. Zaključak. Dobijeni rezultati pokazuju da su godine života, dijagnoza i pol bili glavni prediktori preživljavanja kritično obolelih u JIT. Cena terapije zavisila je od dužine boravka u JIT, upotrebe karbapenema i merenja PCT, ali uticaj ovih faktora na ishod lečenja nije dostigao statističku značajnost.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Factors influencing antibiotic treatment cost and outcome in critically ill patients: A 'real-life' study, Faktori koji utiču na cenu antibiotske terapije i ishod kod kritično obolelih pacijenata - 'real-life' studija",
volume = "71",
number = "12",
pages = "1102-1108",
doi = "10.2298/VSP1412102P"
}

Perić, A., Šurbatović, M., Vezmar-Kovačević, S., Antunović, M., Veljović, M., Đorđević, D., Anđelić, T., Zeba, S.,& Dobrić, S.. (2014). Factors influencing antibiotic treatment cost and outcome in critically ill patients: A 'real-life' study. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 71(12), 1102-1108.
https://doi.org/10.2298/VSP1412102P

Perić A, Šurbatović M, Vezmar-Kovačević S, Antunović M, Veljović M, Đorđević D, Anđelić T, Zeba S, Dobrić S. Factors influencing antibiotic treatment cost and outcome in critically ill patients: A 'real-life' study. in Vojnosanitetski pregled. 2014;71(12):1102-1108.
doi:10.2298/VSP1412102P .

Perić, Aneta, Šurbatović, Maja, Vezmar-Kovačević, Sandra, Antunović, Mirjana, Veljović, Milić, Đorđević, Dragan, Anđelić, Tamara, Zeba, Snježana, Dobrić, Silva, "Factors influencing antibiotic treatment cost and outcome in critically ill patients: A 'real-life' study" in Vojnosanitetski pregled, 71, no. 12 (2014):1102-1108,
https://doi.org/10.2298/VSP1412102P . .

TY  - JOUR
AU  - Perić, Aneta
AU  - Toskić-Radojičić, Marija
AU  - Vezmar-Kovačević, Sandra
AU  - Miljković, Branislava
AU  - Antunović, Mirjana
AU  - Bojić, Vedrana
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2049
AB  - Introduction and objectives: Non-steroidal anti-inflammatory drugs (NSAIDs) are associated with anti-inflammatory, analgetic and antipyretic properties and are used in the treatment of acute mild to moderate pain, chronic pain and inflammatory conditions and fever. The aim of the study was to analyze the consumption of NSAIDs, purpose of use, length of therapy, adverse effects and patient's perception about efficacy and safety of the drugs. All patients, who had a NSAID prescribed, were included in the study. Method: The research was done in the Military Medical Academy, Belgrade, Serbia from June to December 2008. A questionnaire filled with the assistance of a pharmacist, contained questions about co morbidities, use and adverse effects of NSAIDs. All patients with at least one NSAID prespription (diclofenac, ibuprofen, flurbiprofen, naproxen, piroxicam, tenoxicam, meloxicam) were included in the study. The responses were statistically processed using the /-test. Results: 160 patients were included in the study. The majority of the patients (59.4%) used one NSAID in tablet form (48.8%). The most frequent used were diclofenac and ibuprofen. 51.9% suffered from rheumatic diseases for more than 5 years. Every other patient used both NSAIDs and gastroprotective drugs, most often ranitidine (58.1%). Conclusion: The results show that rheumatic diseases are often present in older patients and that treatment with NSAIDs lasts longer than five years. Mild gastric problems have been recorded as adverse effects of NSAIDs, most often nausea and pain in the stomach. This is probably due to the frequent use of diclofenac and ibuprofen, drugs with low or moderate risk for gastric toxicity as well as the concomitant use of H2-antagonists and proton pump inhibitors.
AB  - Uvod i cilj rada: Nesteroidni antiinflamatorni lekovi (NSAIL) ispoljavaju antiinflamatorno, analgetičko i antipiretičko dejstvo i primenjuju se kod akutnih bolova blagog do umerenog intenziteta, hroničnih bolnih i zapaljenskih stanja, te povišene telesne temperature. Cilj ove studije bio je da se analizira vanbolnička potrošnja NSAIL, način primene, dužina terapije i neželjene reakcije, kao i iskustva pacijenata u vezi sa efikasnošću i bezbednošću lekova. U studiju su uključeni svi pacijenti kojima je propisan NSAIL. Metode: Istraživanje je sprovedeno u Vojnomedicinskoj akademiji u Beogradu, u periodu od juna do decembra 2008. godine. Pacijenti su, uz pomoć farmaceuta, popunjavali upitnik koji se sastojao od pitanja vezanih za pridružena oboljenja, upotrebu i neželjene efekte NSAIL. U studiju su uključeni svi pacijenti kojima je na recept bio propisan neki od NSAIL (diklofenak, ibuprofen, flurbiprofen, naproksen, piroksikam, tenoksikam, meloksikam). Odgovori su statistički obrađeni primenom x2-testa. Rezultati: U studiji je učestvovalo 160 pacijenata. Većina pacijenata (59,4%) je koristila jedan NSAIL, 48,8% ispitanika je primenjivalo lek u obliku tablete. Diklofenak i ibuprofen su najčešće korišćeni lekovi. U ispitivanoj grupi pacijenata, 51,9% pacijenata je bolovalo od reumatične bolesti duže od 5 godina. Svaki drugi pacijent je istovremeno primenjivao NSAIL i gastroprotektivni lek, najčešće ranitidin (58,1%). Zaključak: Rezultati pokazuju da se NSAIL često primenjuju duže od pet godina, u lečenju reumatičnih bolesti koje su zastupljene kod starijih pacijenata. Najčešći neželjeni efekti NSAIL su blagi gastrointestinalni problemi, nauzeja i bol u stomaku. Ovo se objašnjava time što se najviše koriste diklofenak i ibuprofen, lekovi koji imaju slab ili umeren rizik za ispoljavanje gastričnih neželjenih efekata, ali i zbog istovremene primene NSAIL i H2-blokatora/inhibitora protonske pumpe.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - Use of non-steroidal anti-inflammatory drugs in outpatients in Serbia: Observational study
T1  - Vanbolnička primena nesteroidnih anti-inflamatornih lekova u Srbiji - opservaciona studija
VL  - 63
IS  - 5
SP  - 431
EP  - 442
UR  - https://hdl.handle.net/21.15107/rcub_farfar_2049
ER  - 

@article{
author = "Perić, Aneta and Toskić-Radojičić, Marija and Vezmar-Kovačević, Sandra and Miljković, Branislava and Antunović, Mirjana and Bojić, Vedrana",
year = "2013",
abstract = "Introduction and objectives: Non-steroidal anti-inflammatory drugs (NSAIDs) are associated with anti-inflammatory, analgetic and antipyretic properties and are used in the treatment of acute mild to moderate pain, chronic pain and inflammatory conditions and fever. The aim of the study was to analyze the consumption of NSAIDs, purpose of use, length of therapy, adverse effects and patient's perception about efficacy and safety of the drugs. All patients, who had a NSAID prescribed, were included in the study. Method: The research was done in the Military Medical Academy, Belgrade, Serbia from June to December 2008. A questionnaire filled with the assistance of a pharmacist, contained questions about co morbidities, use and adverse effects of NSAIDs. All patients with at least one NSAID prespription (diclofenac, ibuprofen, flurbiprofen, naproxen, piroxicam, tenoxicam, meloxicam) were included in the study. The responses were statistically processed using the /-test. Results: 160 patients were included in the study. The majority of the patients (59.4%) used one NSAID in tablet form (48.8%). The most frequent used were diclofenac and ibuprofen. 51.9% suffered from rheumatic diseases for more than 5 years. Every other patient used both NSAIDs and gastroprotective drugs, most often ranitidine (58.1%). Conclusion: The results show that rheumatic diseases are often present in older patients and that treatment with NSAIDs lasts longer than five years. Mild gastric problems have been recorded as adverse effects of NSAIDs, most often nausea and pain in the stomach. This is probably due to the frequent use of diclofenac and ibuprofen, drugs with low or moderate risk for gastric toxicity as well as the concomitant use of H2-antagonists and proton pump inhibitors., Uvod i cilj rada: Nesteroidni antiinflamatorni lekovi (NSAIL) ispoljavaju antiinflamatorno, analgetičko i antipiretičko dejstvo i primenjuju se kod akutnih bolova blagog do umerenog intenziteta, hroničnih bolnih i zapaljenskih stanja, te povišene telesne temperature. Cilj ove studije bio je da se analizira vanbolnička potrošnja NSAIL, način primene, dužina terapije i neželjene reakcije, kao i iskustva pacijenata u vezi sa efikasnošću i bezbednošću lekova. U studiju su uključeni svi pacijenti kojima je propisan NSAIL. Metode: Istraživanje je sprovedeno u Vojnomedicinskoj akademiji u Beogradu, u periodu od juna do decembra 2008. godine. Pacijenti su, uz pomoć farmaceuta, popunjavali upitnik koji se sastojao od pitanja vezanih za pridružena oboljenja, upotrebu i neželjene efekte NSAIL. U studiju su uključeni svi pacijenti kojima je na recept bio propisan neki od NSAIL (diklofenak, ibuprofen, flurbiprofen, naproksen, piroksikam, tenoksikam, meloksikam). Odgovori su statistički obrađeni primenom x2-testa. Rezultati: U studiji je učestvovalo 160 pacijenata. Većina pacijenata (59,4%) je koristila jedan NSAIL, 48,8% ispitanika je primenjivalo lek u obliku tablete. Diklofenak i ibuprofen su najčešće korišćeni lekovi. U ispitivanoj grupi pacijenata, 51,9% pacijenata je bolovalo od reumatične bolesti duže od 5 godina. Svaki drugi pacijent je istovremeno primenjivao NSAIL i gastroprotektivni lek, najčešće ranitidin (58,1%). Zaključak: Rezultati pokazuju da se NSAIL često primenjuju duže od pet godina, u lečenju reumatičnih bolesti koje su zastupljene kod starijih pacijenata. Najčešći neželjeni efekti NSAIL su blagi gastrointestinalni problemi, nauzeja i bol u stomaku. Ovo se objašnjava time što se najviše koriste diklofenak i ibuprofen, lekovi koji imaju slab ili umeren rizik za ispoljavanje gastričnih neželjenih efekata, ali i zbog istovremene primene NSAIL i H2-blokatora/inhibitora protonske pumpe.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Use of non-steroidal anti-inflammatory drugs in outpatients in Serbia: Observational study, Vanbolnička primena nesteroidnih anti-inflamatornih lekova u Srbiji - opservaciona studija",
volume = "63",
number = "5",
pages = "431-442",
url = "https://hdl.handle.net/21.15107/rcub_farfar_2049"
}

Perić, A., Toskić-Radojičić, M., Vezmar-Kovačević, S., Miljković, B., Antunović, M.,& Bojić, V.. (2013). Use of non-steroidal anti-inflammatory drugs in outpatients in Serbia: Observational study. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 63(5), 431-442.
https://hdl.handle.net/21.15107/rcub_farfar_2049

Perić A, Toskić-Radojičić M, Vezmar-Kovačević S, Miljković B, Antunović M, Bojić V. Use of non-steroidal anti-inflammatory drugs in outpatients in Serbia: Observational study. in Arhiv za farmaciju. 2013;63(5):431-442.
https://hdl.handle.net/21.15107/rcub_farfar_2049 .

Perić, Aneta, Toskić-Radojičić, Marija, Vezmar-Kovačević, Sandra, Miljković, Branislava, Antunović, Mirjana, Bojić, Vedrana, "Use of non-steroidal anti-inflammatory drugs in outpatients in Serbia: Observational study" in Arhiv za farmaciju, 63, no. 5 (2013):431-442,
https://hdl.handle.net/21.15107/rcub_farfar_2049 .

TY  - JOUR
AU  - Mirković, Dušica
AU  - Ibrić, Svetlana
AU  - Antunović, Mirjana
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2052
AB  - Background/Aim. Parenteral nutrition as a specific aspect of providing nutritients still remains a permanent topic of both theoretical and experimental research. Total parenteral nutrition (TPN) admixtures have complex contents making difficult to maintain their stability. The most critical parameter is the diameter of a lipid droplet, i.e. droplet size distribution. It is recommended that droplet size should not be more than 5 􀆬m and that the presence of greater droplets should not exceed the value of 0.05%. Lipid droplets size is affected particularly by electrolyte addition, especially polyvalent cations. There is a danger of the added electrolytes interaction with lipid droplets which leads to their aggregation and negative effects upon the admixtures stability. The aim of this study was to assess the effect of added electrolyte and lipid phase quantity on the admixture stability. Methods. Electrolytes were added to the studied admixture of a defined basic formulation contents in accordance with recommendations from the literature. Droplets size measurements were performed using the method of laser diffraction with a laser particles analyzer. Effects of independent variables were calculated and evaluated using commercial software. Na+, K+, Ca2+ and Mg2+ concentrations, as well as the quantity of fat phase were chosen as studied factors, i.e. independent variables. The system response, or dependent variable was the median of droplets size. Each of the factors was varied at two levels, higher (+1) and lower (-1), according to the 25-2 fractional factorial design. Results. The study suggested the presence of relative uniformity of the results of all the measurements regardless of the quantity of added electrolytes and lipid phase. It was shown that undoubtedly there is the influence of 2-valent cations (calcium and magnesium) upon lipid droplets size, which is in a direct correlation with theoretical assumption. Conclusion. Within a 72-hour testing period there was no significant increase in droplet size, i.e. the studied admixtures remained stable considering droplet size median as the criterion of stability.
AB  - Uvod/Cilj. Parenteralna ishrana, kao specifičan vid nadoknade hranljivih materija, i dalje predstavlja stalnu temu teorijskog i eksperimentalnog izučavanja. Složeni sastav smeše za totalnu parenteralnu ishranu (TPI) otežava održanje njihove stabilnosti. Najkritičniji parameter je dijametar lipidnih kapi, odnosno raspodela veličina kapi. Postoji preporuka da veličina kapi ne bi trebalo da prelazi 5 μm i da zastupljenost većih kapi ne prelazi vrednost od 0,05%. Na veličinu lipidnih kapi poseban uticaj ima dodavanje elektrolita, naročito viševalentnih katjona. Postoji opasnost da dodati elektroliti interreaguju sa lipidnim kapima, što dovodi do njihovog spajanja i ima negativan uticaj na stabilnost smeša. Cilj ovog rada bio je da se istraži kako dodati elektroliti i količina lipidne faze utiču na stabilnost ovih smeša. Metode. Ispitivanoj smeši sa definisanim sastavom osnovne formulacije izrađenoj u bolničkoj apoteci, dodavani su elektroliti na osnovu preporuka iz literature. Merenje veličine kapi vršeno je metodom laserske difrakcije pomoću laserskog analizatora čestica. Uticaj nezavisno promenljivih je procenjen i izračunat primenom komercijalnog softvera. Kao nezavisno promenljive, u svojstvu ispitivanih faktora izabrani su koncentracije Na+, K+, Ca2+ i Mg2+, kao i količina masne faze. Odgovor sistema, ili zavisno promenljiva veličina, bila je medijana veličine kapi. Svaki od faktora variran je na dva nivoa, gornji (+1) i donji (-1), odnosno primenjen je 25-2 frakcioni faktorijalni dizajn. Rezultati. Istraživanje je pokazalo da nezavisno od količine dodatih elektrolita i količine lipidne faze postoji relativna ujednačenost rezultata za sva merenja. Analiza pojedinačnih faktora ukazuje na nesumnjiv uticaj dvovalentnih katjona (kalcijuma i magnezijuma) na veličinu lipidnih kapi, što je u direktnoj korelaciji sa teoretskim postavkama. Zaključak: Tokom ispitivanog 72-časovnog perioda nije bilo značajnog povećanja veličine kapi, odnosno ispitivana smeša ostala je stabilna sa stanovišta medijane veličine kapi kao kriterijuma stabilnosti.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Quality assessment of total parenteral nutrition admixtures by the use of fractional factorial design
T1  - Analiza kvaliteta smeša za totalnu parenteralnu ishranu primenom delimičnog faktorijalnog dizajna
VL  - 70
IS  - 4
SP  - 374
EP  - 379
DO  - 10.2298/VSP1304374M
ER  - 

@article{
author = "Mirković, Dušica and Ibrić, Svetlana and Antunović, Mirjana",
year = "2013",
abstract = "Background/Aim. Parenteral nutrition as a specific aspect of providing nutritients still remains a permanent topic of both theoretical and experimental research. Total parenteral nutrition (TPN) admixtures have complex contents making difficult to maintain their stability. The most critical parameter is the diameter of a lipid droplet, i.e. droplet size distribution. It is recommended that droplet size should not be more than 5 􀆬m and that the presence of greater droplets should not exceed the value of 0.05%. Lipid droplets size is affected particularly by electrolyte addition, especially polyvalent cations. There is a danger of the added electrolytes interaction with lipid droplets which leads to their aggregation and negative effects upon the admixtures stability. The aim of this study was to assess the effect of added electrolyte and lipid phase quantity on the admixture stability. Methods. Electrolytes were added to the studied admixture of a defined basic formulation contents in accordance with recommendations from the literature. Droplets size measurements were performed using the method of laser diffraction with a laser particles analyzer. Effects of independent variables were calculated and evaluated using commercial software. Na+, K+, Ca2+ and Mg2+ concentrations, as well as the quantity of fat phase were chosen as studied factors, i.e. independent variables. The system response, or dependent variable was the median of droplets size. Each of the factors was varied at two levels, higher (+1) and lower (-1), according to the 25-2 fractional factorial design. Results. The study suggested the presence of relative uniformity of the results of all the measurements regardless of the quantity of added electrolytes and lipid phase. It was shown that undoubtedly there is the influence of 2-valent cations (calcium and magnesium) upon lipid droplets size, which is in a direct correlation with theoretical assumption. Conclusion. Within a 72-hour testing period there was no significant increase in droplet size, i.e. the studied admixtures remained stable considering droplet size median as the criterion of stability., Uvod/Cilj. Parenteralna ishrana, kao specifičan vid nadoknade hranljivih materija, i dalje predstavlja stalnu temu teorijskog i eksperimentalnog izučavanja. Složeni sastav smeše za totalnu parenteralnu ishranu (TPI) otežava održanje njihove stabilnosti. Najkritičniji parameter je dijametar lipidnih kapi, odnosno raspodela veličina kapi. Postoji preporuka da veličina kapi ne bi trebalo da prelazi 5 μm i da zastupljenost većih kapi ne prelazi vrednost od 0,05%. Na veličinu lipidnih kapi poseban uticaj ima dodavanje elektrolita, naročito viševalentnih katjona. Postoji opasnost da dodati elektroliti interreaguju sa lipidnim kapima, što dovodi do njihovog spajanja i ima negativan uticaj na stabilnost smeša. Cilj ovog rada bio je da se istraži kako dodati elektroliti i količina lipidne faze utiču na stabilnost ovih smeša. Metode. Ispitivanoj smeši sa definisanim sastavom osnovne formulacije izrađenoj u bolničkoj apoteci, dodavani su elektroliti na osnovu preporuka iz literature. Merenje veličine kapi vršeno je metodom laserske difrakcije pomoću laserskog analizatora čestica. Uticaj nezavisno promenljivih je procenjen i izračunat primenom komercijalnog softvera. Kao nezavisno promenljive, u svojstvu ispitivanih faktora izabrani su koncentracije Na+, K+, Ca2+ i Mg2+, kao i količina masne faze. Odgovor sistema, ili zavisno promenljiva veličina, bila je medijana veličine kapi. Svaki od faktora variran je na dva nivoa, gornji (+1) i donji (-1), odnosno primenjen je 25-2 frakcioni faktorijalni dizajn. Rezultati. Istraživanje je pokazalo da nezavisno od količine dodatih elektrolita i količine lipidne faze postoji relativna ujednačenost rezultata za sva merenja. Analiza pojedinačnih faktora ukazuje na nesumnjiv uticaj dvovalentnih katjona (kalcijuma i magnezijuma) na veličinu lipidnih kapi, što je u direktnoj korelaciji sa teoretskim postavkama. Zaključak: Tokom ispitivanog 72-časovnog perioda nije bilo značajnog povećanja veličine kapi, odnosno ispitivana smeša ostala je stabilna sa stanovišta medijane veličine kapi kao kriterijuma stabilnosti.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Quality assessment of total parenteral nutrition admixtures by the use of fractional factorial design, Analiza kvaliteta smeša za totalnu parenteralnu ishranu primenom delimičnog faktorijalnog dizajna",
volume = "70",
number = "4",
pages = "374-379",
doi = "10.2298/VSP1304374M"
}

Mirković, D., Ibrić, S.,& Antunović, M.. (2013). Quality assessment of total parenteral nutrition admixtures by the use of fractional factorial design. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 70(4), 374-379.
https://doi.org/10.2298/VSP1304374M

Mirković D, Ibrić S, Antunović M. Quality assessment of total parenteral nutrition admixtures by the use of fractional factorial design. in Vojnosanitetski pregled. 2013;70(4):374-379.
doi:10.2298/VSP1304374M .

Mirković, Dušica, Ibrić, Svetlana, Antunović, Mirjana, "Quality assessment of total parenteral nutrition admixtures by the use of fractional factorial design" in Vojnosanitetski pregled, 70, no. 4 (2013):374-379,
https://doi.org/10.2298/VSP1304374M . .

TY  - JOUR
AU  - Perić, Aneta
AU  - Toskić-Radojičić, Marija
AU  - Dobrić, Silva
AU  - Damjanov, Nemanja
AU  - Miljković, Branislava
AU  - Antunović, Mirjana
AU  - Vezmar, Sandra
PY  - 2010
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1366
AB  - Rationale In developed countries, cyclooxygenase 2 (COX-2) inhibitors were shown to be less costly than the combination of non-steroidal anti-inflammatory drugs (NSAIDs) and proton pump inhibitors (PPIs) in treatment of patients with high risk of serious gastrointestinal (GI) adverse effects. It is questionable if such results apply to developing countries where health service costs are lower and there is high discrepancy between generic and patent protected drug prices. We analysed the direct cost of treatment with generic NSAIDs in combination with PPIs versus branded COX-2 inhibitors in patients with high risk of serious GI adverse effects from the perspective of the public health service in Serbia. Methods Total cost of treatment of serious GI complications and the use of NSAID+PPI versus COX-2 inhibitors were calculated. A model for estimation of cost of treatment of NSAID+PPI versus COX-2 inhibitors which included the probability of developing serious GI adverse effects was developed. Results Total cost of treatment of serious GI adverse effects resulted in an average of $814/patient. Considering the relative risk of such adverse effects for patients with four or more risk factors, the least costly treatment over 6 months was the use of celecoxib ($487). Compared with diclofenac+omeprazole, cost savings were estimated at $59 and $22 per patient with celecoxib and etoricoxib, respectively. Conclusion Cost savings may be achieved by using COX-2 inhibitors in patients at high risk of GI adverse effects even in countries with moderate health care service expenditures. Such possibility requires further investigation.
PB  - Wiley-Blackwell, Malden
T2  - Journal of Evaluation in Clinical Practice
T1  - Are COX-2 inhibitors preferable to combined NSAID and PPI in countries with moderate health service expenditures?
VL  - 16
IS  - 6
SP  - 1090
EP  - 1095
DO  - 10.1111/j.1365-2753.2009.01258.x
ER  - 

@article{
author = "Perić, Aneta and Toskić-Radojičić, Marija and Dobrić, Silva and Damjanov, Nemanja and Miljković, Branislava and Antunović, Mirjana and Vezmar, Sandra",
year = "2010",
abstract = "Rationale In developed countries, cyclooxygenase 2 (COX-2) inhibitors were shown to be less costly than the combination of non-steroidal anti-inflammatory drugs (NSAIDs) and proton pump inhibitors (PPIs) in treatment of patients with high risk of serious gastrointestinal (GI) adverse effects. It is questionable if such results apply to developing countries where health service costs are lower and there is high discrepancy between generic and patent protected drug prices. We analysed the direct cost of treatment with generic NSAIDs in combination with PPIs versus branded COX-2 inhibitors in patients with high risk of serious GI adverse effects from the perspective of the public health service in Serbia. Methods Total cost of treatment of serious GI complications and the use of NSAID+PPI versus COX-2 inhibitors were calculated. A model for estimation of cost of treatment of NSAID+PPI versus COX-2 inhibitors which included the probability of developing serious GI adverse effects was developed. Results Total cost of treatment of serious GI adverse effects resulted in an average of $814/patient. Considering the relative risk of such adverse effects for patients with four or more risk factors, the least costly treatment over 6 months was the use of celecoxib ($487). Compared with diclofenac+omeprazole, cost savings were estimated at $59 and $22 per patient with celecoxib and etoricoxib, respectively. Conclusion Cost savings may be achieved by using COX-2 inhibitors in patients at high risk of GI adverse effects even in countries with moderate health care service expenditures. Such possibility requires further investigation.",
publisher = "Wiley-Blackwell, Malden",
journal = "Journal of Evaluation in Clinical Practice",
title = "Are COX-2 inhibitors preferable to combined NSAID and PPI in countries with moderate health service expenditures?",
volume = "16",
number = "6",
pages = "1090-1095",
doi = "10.1111/j.1365-2753.2009.01258.x"
}

Perić, A., Toskić-Radojičić, M., Dobrić, S., Damjanov, N., Miljković, B., Antunović, M.,& Vezmar, S.. (2010). Are COX-2 inhibitors preferable to combined NSAID and PPI in countries with moderate health service expenditures?. in Journal of Evaluation in Clinical Practice
Wiley-Blackwell, Malden., 16(6), 1090-1095.
https://doi.org/10.1111/j.1365-2753.2009.01258.x

Perić A, Toskić-Radojičić M, Dobrić S, Damjanov N, Miljković B, Antunović M, Vezmar S. Are COX-2 inhibitors preferable to combined NSAID and PPI in countries with moderate health service expenditures?. in Journal of Evaluation in Clinical Practice. 2010;16(6):1090-1095.
doi:10.1111/j.1365-2753.2009.01258.x .

Perić, Aneta, Toskić-Radojičić, Marija, Dobrić, Silva, Damjanov, Nemanja, Miljković, Branislava, Antunović, Mirjana, Vezmar, Sandra, "Are COX-2 inhibitors preferable to combined NSAID and PPI in countries with moderate health service expenditures?" in Journal of Evaluation in Clinical Practice, 16, no. 6 (2010):1090-1095,
https://doi.org/10.1111/j.1365-2753.2009.01258.x . .