TY  - JOUR
AU  - Osmokrović, Andrea
AU  - Jančić, Ivan
AU  - Janković-Castvan, Ivona
AU  - Petrović, Predrag
AU  - Milenković, Marina
AU  - Obradović, Bojana
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3308
AB  - Composites based on Zn-alginate hydrogels in the form of beads were produced by extrusion of a suspension containing 0.5 % w/w of alginate and 20 % w/w of activated charcoal (AC) with the intent to simultaneously release two active agents, Zn2+ and AC particles, in a physiological-like environment. The obtained composite beads were analyzed by FE-SEM and characterized regarding textural parameters, as well as Zn2+ and AC release kinetics in the physiological saline solution. Zn(2+)ions were quickly released reaching the equilibrium concentration within the first hour in the contrary to the release of AC particles, which was described by internal diffusion with the apparent diffusion coefficient of approximately 10(-13) m(2) s(-1). Potential functionality of the obtained beads was evaluated regarding antibacterial activity in suspensions of the standard bacterial strain Escherichia coli 25922. The observed strong bactericidal effects were related to the quick release of Zn2+ that was not affected by AC. Thus, taking into account results of this study, as well as high sorption capacity of alginate hydrogel, efficiency of AC to adsorb malodor and tissue degradation products and positive effects of Zn2+ on wound healing, the obtained composites have shown promising potentials for applications as multifunctional wound dressings.
PB  - Savez hemijskih inženjera, Beograd
T2  - Hemijska industrija
T1  - Novel composite zinc-alginate hydrogels with activated charcoal aimed for potential applications in multifunctional primary wound dressings
VL  - 73
IS  - 1
SP  - 37
EP  - 46
DO  - 10.2298/HEMIND180629003O
ER  - 

@article{
author = "Osmokrović, Andrea and Jančić, Ivan and Janković-Castvan, Ivona and Petrović, Predrag and Milenković, Marina and Obradović, Bojana",
year = "2019",
abstract = "Composites based on Zn-alginate hydrogels in the form of beads were produced by extrusion of a suspension containing 0.5 % w/w of alginate and 20 % w/w of activated charcoal (AC) with the intent to simultaneously release two active agents, Zn2+ and AC particles, in a physiological-like environment. The obtained composite beads were analyzed by FE-SEM and characterized regarding textural parameters, as well as Zn2+ and AC release kinetics in the physiological saline solution. Zn(2+)ions were quickly released reaching the equilibrium concentration within the first hour in the contrary to the release of AC particles, which was described by internal diffusion with the apparent diffusion coefficient of approximately 10(-13) m(2) s(-1). Potential functionality of the obtained beads was evaluated regarding antibacterial activity in suspensions of the standard bacterial strain Escherichia coli 25922. The observed strong bactericidal effects were related to the quick release of Zn2+ that was not affected by AC. Thus, taking into account results of this study, as well as high sorption capacity of alginate hydrogel, efficiency of AC to adsorb malodor and tissue degradation products and positive effects of Zn2+ on wound healing, the obtained composites have shown promising potentials for applications as multifunctional wound dressings.",
publisher = "Savez hemijskih inženjera, Beograd",
journal = "Hemijska industrija",
title = "Novel composite zinc-alginate hydrogels with activated charcoal aimed for potential applications in multifunctional primary wound dressings",
volume = "73",
number = "1",
pages = "37-46",
doi = "10.2298/HEMIND180629003O"
}

Osmokrović, A., Jančić, I., Janković-Castvan, I., Petrović, P., Milenković, M.,& Obradović, B.. (2019). Novel composite zinc-alginate hydrogels with activated charcoal aimed for potential applications in multifunctional primary wound dressings. in Hemijska industrija
Savez hemijskih inženjera, Beograd., 73(1), 37-46.
https://doi.org/10.2298/HEMIND180629003O

Osmokrović A, Jančić I, Janković-Castvan I, Petrović P, Milenković M, Obradović B. Novel composite zinc-alginate hydrogels with activated charcoal aimed for potential applications in multifunctional primary wound dressings. in Hemijska industrija. 2019;73(1):37-46.
doi:10.2298/HEMIND180629003O .

Osmokrović, Andrea, Jančić, Ivan, Janković-Castvan, Ivona, Petrović, Predrag, Milenković, Marina, Obradović, Bojana, "Novel composite zinc-alginate hydrogels with activated charcoal aimed for potential applications in multifunctional primary wound dressings" in Hemijska industrija, 73, no. 1 (2019):37-46,
https://doi.org/10.2298/HEMIND180629003O . .