TY  - JOUR
AU  - Brzaković, B. B.
AU  - Vezmar-Kovačević, Sandra
AU  - Vučićević, Katarina
AU  - Miljković, Branislava
AU  - Martinović, Žarko J.
AU  - Pokrajac, Milena
AU  - Prostran, Milica
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1634
AB  - What is known and Objective: Lamotrigine metabolism may be substantially altered with concomitant administration of valproic acid and/or carbamazepine. Such alterations may require the adjustment of lamotrigine dose to ensure optimal treatment efficacy and safety. Methods: The extent of lamotrigine interactions was investigated dependent on age, gender, weight and dose of concomitant carbamazepine and/or valproic acid in 65 patients with epilepsy. Lamotrigine plasma steady-state oral clearance (CLss/F) and area under the curve (AUCss) were calculated from the dose of drug, average steady-state concentration (Css) and interval of administration. Multiple regression analysis was used for the identification and quantification of factors that influenced lamotrigine pharmacokinetics. Results and Discussion: Age and dose of carbamazepine and valproic acid had significant influence on lamotrigine CLss/F and AUCss. Carbamazepine was associated with a dose-dependent increase and valproic acid with a dose-dependent decrease of lamotrigine metabolism rate. The effect of carbamazepine was more pronounced. Younger patients were expected to metabolize lamotrigine more rapidly whereas overweight patients may be less susceptible to interactions. Gender had no influence on lamotrigine pharmacokinetics. What is new and Conclusion: The efficacy and safety of lamotrigine may be altered by concomitant administration of carbamazepine and valproic acid. The models developed may be useful for estimating doses of lamotrigine for individual patients to minimize clinically significant interactions. Therapeutic monitoring is advisable when those drugs are used concomitantly.
PB  - Wiley-Blackwell, Hoboken
T2  - Journal of Clinical Pharmacy and Therapeutics
T1  - Impact of age, weight and concomitant treatment on lamotrigine pharmacokinetics
VL  - 37
IS  - 6
SP  - 693
EP  - 697
DO  - 10.1111/j.1365-2710.2012.01351.x
ER  - 

@article{
author = "Brzaković, B. B. and Vezmar-Kovačević, Sandra and Vučićević, Katarina and Miljković, Branislava and Martinović, Žarko J. and Pokrajac, Milena and Prostran, Milica",
year = "2012",
abstract = "What is known and Objective: Lamotrigine metabolism may be substantially altered with concomitant administration of valproic acid and/or carbamazepine. Such alterations may require the adjustment of lamotrigine dose to ensure optimal treatment efficacy and safety. Methods: The extent of lamotrigine interactions was investigated dependent on age, gender, weight and dose of concomitant carbamazepine and/or valproic acid in 65 patients with epilepsy. Lamotrigine plasma steady-state oral clearance (CLss/F) and area under the curve (AUCss) were calculated from the dose of drug, average steady-state concentration (Css) and interval of administration. Multiple regression analysis was used for the identification and quantification of factors that influenced lamotrigine pharmacokinetics. Results and Discussion: Age and dose of carbamazepine and valproic acid had significant influence on lamotrigine CLss/F and AUCss. Carbamazepine was associated with a dose-dependent increase and valproic acid with a dose-dependent decrease of lamotrigine metabolism rate. The effect of carbamazepine was more pronounced. Younger patients were expected to metabolize lamotrigine more rapidly whereas overweight patients may be less susceptible to interactions. Gender had no influence on lamotrigine pharmacokinetics. What is new and Conclusion: The efficacy and safety of lamotrigine may be altered by concomitant administration of carbamazepine and valproic acid. The models developed may be useful for estimating doses of lamotrigine for individual patients to minimize clinically significant interactions. Therapeutic monitoring is advisable when those drugs are used concomitantly.",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Journal of Clinical Pharmacy and Therapeutics",
title = "Impact of age, weight and concomitant treatment on lamotrigine pharmacokinetics",
volume = "37",
number = "6",
pages = "693-697",
doi = "10.1111/j.1365-2710.2012.01351.x"
}

Brzaković, B. B., Vezmar-Kovačević, S., Vučićević, K., Miljković, B., Martinović, Ž. J., Pokrajac, M.,& Prostran, M.. (2012). Impact of age, weight and concomitant treatment on lamotrigine pharmacokinetics. in Journal of Clinical Pharmacy and Therapeutics
Wiley-Blackwell, Hoboken., 37(6), 693-697.
https://doi.org/10.1111/j.1365-2710.2012.01351.x

Brzaković BB, Vezmar-Kovačević S, Vučićević K, Miljković B, Martinović ŽJ, Pokrajac M, Prostran M. Impact of age, weight and concomitant treatment on lamotrigine pharmacokinetics. in Journal of Clinical Pharmacy and Therapeutics. 2012;37(6):693-697.
doi:10.1111/j.1365-2710.2012.01351.x .

Brzaković, B. B., Vezmar-Kovačević, Sandra, Vučićević, Katarina, Miljković, Branislava, Martinović, Žarko J., Pokrajac, Milena, Prostran, Milica, "Impact of age, weight and concomitant treatment on lamotrigine pharmacokinetics" in Journal of Clinical Pharmacy and Therapeutics, 37, no. 6 (2012):693-697,
https://doi.org/10.1111/j.1365-2710.2012.01351.x . .