Perić, M.

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  • Perić, M. (6)
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Author's Bibliography

The effect of P1075 on the isolated human saphenous vein

Gojković-Bukarica, Ljiljana; Novaković, Aleksandra; Beleslin-Cokić, Bojana B.; Marković-Lipkovski, Jasmina; Perić, M.; Nezić, D.; Kanjuh, Vladimir

(Wiley-Blackwell Publishing, Inc, Malden, 2010)

TY  - CONF
AU  - Gojković-Bukarica, Ljiljana
AU  - Novaković, Aleksandra
AU  - Beleslin-Cokić, Bojana B.
AU  - Marković-Lipkovski, Jasmina
AU  - Perić, M.
AU  - Nezić, D.
AU  - Kanjuh, Vladimir
PY  - 2010
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1390
PB  - Wiley-Blackwell Publishing, Inc, Malden
C3  - European Journal of Clinical Investigation
T1  - The effect of P1075 on the isolated human saphenous vein
VL  - 40
IS  - Suppl. 1
SP  - 5
EP  - 5
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1390
ER  - 
@conference{
author = "Gojković-Bukarica, Ljiljana and Novaković, Aleksandra and Beleslin-Cokić, Bojana B. and Marković-Lipkovski, Jasmina and Perić, M. and Nezić, D. and Kanjuh, Vladimir",
year = "2010",
publisher = "Wiley-Blackwell Publishing, Inc, Malden",
journal = "European Journal of Clinical Investigation",
title = "The effect of P1075 on the isolated human saphenous vein",
volume = "40",
number = "Suppl. 1",
pages = "5-5",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1390"
}
Gojković-Bukarica, L., Novaković, A., Beleslin-Cokić, B. B., Marković-Lipkovski, J., Perić, M., Nezić, D.,& Kanjuh, V.. (2010). The effect of P1075 on the isolated human saphenous vein. in European Journal of Clinical Investigation
Wiley-Blackwell Publishing, Inc, Malden., 40(Suppl. 1), 5-5.
https://hdl.handle.net/21.15107/rcub_farfar_1390
Gojković-Bukarica L, Novaković A, Beleslin-Cokić BB, Marković-Lipkovski J, Perić M, Nezić D, Kanjuh V. The effect of P1075 on the isolated human saphenous vein. in European Journal of Clinical Investigation. 2010;40(Suppl. 1):5-5.
https://hdl.handle.net/21.15107/rcub_farfar_1390 .
Gojković-Bukarica, Ljiljana, Novaković, Aleksandra, Beleslin-Cokić, Bojana B., Marković-Lipkovski, Jasmina, Perić, M., Nezić, D., Kanjuh, Vladimir, "The effect of P1075 on the isolated human saphenous vein" in European Journal of Clinical Investigation, 40, no. Suppl. 1 (2010):5-5,
https://hdl.handle.net/21.15107/rcub_farfar_1390 .

Cardioprotective effect of red wine

Novaković, Aleksandra; Gojković-Bukarica, Ljiljana; Nezić, D.; Perić, M.; Kanjuh, Vladimir

(Elsevier Ireland Ltd, Clare, 2010)

TY  - CONF
AU  - Novaković, Aleksandra
AU  - Gojković-Bukarica, Ljiljana
AU  - Nezić, D.
AU  - Perić, M.
AU  - Kanjuh, Vladimir
PY  - 2010
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1411
PB  - Elsevier Ireland Ltd, Clare
C3  - Atherosclerosis Supplements
T1  - Cardioprotective effect of red wine
VL  - 11
IS  - 2
SP  - 27
EP  - 28
DO  - 10.1016/S1567-5688(10)70120-3
ER  - 
@conference{
author = "Novaković, Aleksandra and Gojković-Bukarica, Ljiljana and Nezić, D. and Perić, M. and Kanjuh, Vladimir",
year = "2010",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Atherosclerosis Supplements",
title = "Cardioprotective effect of red wine",
volume = "11",
number = "2",
pages = "27-28",
doi = "10.1016/S1567-5688(10)70120-3"
}
Novaković, A., Gojković-Bukarica, L., Nezić, D., Perić, M.,& Kanjuh, V.. (2010). Cardioprotective effect of red wine. in Atherosclerosis Supplements
Elsevier Ireland Ltd, Clare., 11(2), 27-28.
https://doi.org/10.1016/S1567-5688(10)70120-3
Novaković A, Gojković-Bukarica L, Nezić D, Perić M, Kanjuh V. Cardioprotective effect of red wine. in Atherosclerosis Supplements. 2010;11(2):27-28.
doi:10.1016/S1567-5688(10)70120-3 .
Novaković, Aleksandra, Gojković-Bukarica, Ljiljana, Nezić, D., Perić, M., Kanjuh, Vladimir, "Cardioprotective effect of red wine" in Atherosclerosis Supplements, 11, no. 2 (2010):27-28,
https://doi.org/10.1016/S1567-5688(10)70120-3 . .

Cardioprotective effect of red wine

Novaković, Aleksandra; Gojković-Bukarica, Ljiljana; Nezić, D.; Perić, M.

(Lippincott Williams & Wilkins, Philadelphia, 2008)

TY  - CONF
AU  - Novaković, Aleksandra
AU  - Gojković-Bukarica, Ljiljana
AU  - Nezić, D.
AU  - Perić, M.
PY  - 2008
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1100
PB  - Lippincott Williams & Wilkins, Philadelphia
C3  - Circulation
T1  - Cardioprotective effect of red wine
VL  - 118
IS  - 12
SP  - e171
EP  - e171
DO  - 10.1161/CIRCULATIONAHA.108.189874
ER  - 
@conference{
author = "Novaković, Aleksandra and Gojković-Bukarica, Ljiljana and Nezić, D. and Perić, M.",
year = "2008",
publisher = "Lippincott Williams & Wilkins, Philadelphia",
journal = "Circulation",
title = "Cardioprotective effect of red wine",
volume = "118",
number = "12",
pages = "e171-e171",
doi = "10.1161/CIRCULATIONAHA.108.189874"
}
Novaković, A., Gojković-Bukarica, L., Nezić, D.,& Perić, M.. (2008). Cardioprotective effect of red wine. in Circulation
Lippincott Williams & Wilkins, Philadelphia., 118(12), e171-e171.
https://doi.org/10.1161/CIRCULATIONAHA.108.189874
Novaković A, Gojković-Bukarica L, Nezić D, Perić M. Cardioprotective effect of red wine. in Circulation. 2008;118(12):e171-e171.
doi:10.1161/CIRCULATIONAHA.108.189874 .
Novaković, Aleksandra, Gojković-Bukarica, Ljiljana, Nezić, D., Perić, M., "Cardioprotective effect of red wine" in Circulation, 118, no. 12 (2008):e171-e171,
https://doi.org/10.1161/CIRCULATIONAHA.108.189874 . .
2

Human internal thoracic artery relaxed by resveratrol

Novaković, Aleksandra; Gojković-Bukarica, Ljiljana; Perić, M.; Nezić, D.

(Savez farmaceutskih udruženja Srbije, Beograd, 2006)

TY  - CONF
AU  - Novaković, Aleksandra
AU  - Gojković-Bukarica, Ljiljana
AU  - Perić, M.
AU  - Nezić, D.
PY  - 2006
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/745
PB  - Savez farmaceutskih udruženja Srbije, Beograd
C3  - Arhiv za farmaciju
T1  - Human internal thoracic artery relaxed by resveratrol
T1  - Relaksacija humane unutrašnje torakalne arterije prouzrokovana rezveratrolom
VL  - 56
IS  - 4
SP  - 390
EP  - 391
UR  - https://hdl.handle.net/21.15107/rcub_farfar_745
ER  - 
@conference{
author = "Novaković, Aleksandra and Gojković-Bukarica, Ljiljana and Perić, M. and Nezić, D.",
year = "2006",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Human internal thoracic artery relaxed by resveratrol, Relaksacija humane unutrašnje torakalne arterije prouzrokovana rezveratrolom",
volume = "56",
number = "4",
pages = "390-391",
url = "https://hdl.handle.net/21.15107/rcub_farfar_745"
}
Novaković, A., Gojković-Bukarica, L., Perić, M.,& Nezić, D.. (2006). Human internal thoracic artery relaxed by resveratrol. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 56(4), 390-391.
https://hdl.handle.net/21.15107/rcub_farfar_745
Novaković A, Gojković-Bukarica L, Perić M, Nezić D. Human internal thoracic artery relaxed by resveratrol. in Arhiv za farmaciju. 2006;56(4):390-391.
https://hdl.handle.net/21.15107/rcub_farfar_745 .
Novaković, Aleksandra, Gojković-Bukarica, Ljiljana, Perić, M., Nezić, D., "Human internal thoracic artery relaxed by resveratrol" in Arhiv za farmaciju, 56, no. 4 (2006):390-391,
https://hdl.handle.net/21.15107/rcub_farfar_745 .

Endothelium-dependent relaxation of internal mammary artery produced by resveratrol

Novaković, Aleksandra; Gojković-Bukarica, Ljiljana; Perić, M.; Nežić, D.; Đukanović, B.; Lešić, A.; Bumbaširević, M.; Marković-Lipkovski, Jasmina

(Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd, 2006)

TY  - JOUR
AU  - Novaković, Aleksandra
AU  - Gojković-Bukarica, Ljiljana
AU  - Perić, M.
AU  - Nežić, D.
AU  - Đukanović, B.
AU  - Lešić, A.
AU  - Bumbaširević, M.
AU  - Marković-Lipkovski, Jasmina
PY  - 2006
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/871
AB  - Resveratrol, a polyphenol present in wine, has been thought to be responsible for cardiovascular benefits associated with moderate wine consumption. It is also present in the plant Polygonum Cuspidatum. The mechanism of cardiovascular benefits probably includes vasorelaxation, antioxidant and anti-platelet effects of resveratrol. The mechanisms by which resveratrol causes vasodilatation are uncertain. The aim of this study was to investigate the mechanism(s) of resveratrol induced vasorelaxation in human internal mammary artery (HIMA) with endothelium. HIMA rings were precontracted by phenylephrine. Resveratrol induced relaxation of the HIMA rings with endothelium. LNAME, an inhibitor of NO synthase, and methylene blue, an inhibitor of guanylate cyclase, abolished relaxation of HIMA induced by resveratrol. Highly selective blocker of ATP-sensitive K channels, glibenclamide as well as a nonselective blocker of big Ca-sensitive K+ channels, charybdotoxin did not block resveratrol-induced relaxation of HIMA. 4-Aminopyridine and margatoxin, blockers of voltage-gated K+ (KV) channels, abolished endothelium-dependent relaxation of HIMA, induced by resveratrol. In conclusion, we have shown that resveratrol induces relaxation of HIMA with endothelium. It seems that NO and smooth muscle KV channels are included in this relaxation.
AB  - Smatra se da rezveratrol kao jedna polifenolna komponenta prisutna u značajnim količinama u crnom vinu, smanjuje rizik od razvoja ateroskleroze i koronarne bolesti. U mehanizam kardioprotektivnog delovanja verovatno su uključ eni antioksidativno, antitrombocitno i vazodilatatorno delovanje rezveratrola. Mehanizam vazodilatacije još uvek nije poznat, pa je cilj ovog rada bio da se ispitaju efekti i mehanizam vazorelaksantnog delovanja rezveratrola na humanoj unutraš njoj torakalnoj arteriji sa endotelom. Unutrašnja torakalna arterija je prekontrahovana fenilefrinom. Rezveratrol je koncentracijski-zavisno relaksirao unutrašnju torakalnu arteriju čoveka. L-NAME, inhibitor NO sintaze, i metilensko plavo, inhibitor solubilne gvanilat ciklaze, su antagonizovali relaksaciju unutrašnje torakalne arterije sa intaktnim endotelom, prouzrokovanu rezveratrolom. Visoko selektivni blokator ATP-senzitivnih K+ kanala, glibenklamid, kao i neselektivni blokator velikih Ca-senzitivnih K+ kanala, karibdotoksin nisu antagonizovali rezveratrolom indukovanu relaksaciju unutrašnje torakalne arterije. 4-Aminopiridin i margatoksin, blokatori voltažnih K+ kanala su antagonizovali relaksaciju prouzrokovanu rezveratrolom. Na osnovu ovih činjenica se može zaključiti da je endotel-zavisna relaksacija unutrašnje torakalne arterije čoveka, prouzrokovana rezveratrolom, verovatno posredovana NO. Izgleda, da su 4-aminopiriin- i margatoksin-senzitivni K-kanali smešteni u membrani vaskularnih glatko-mišićnih ćelija humane unutrašnje torakalne arterije, uključeni u mehanizam endotel-zavisne relaksacije prouzrokovane rezveratrolom.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta veterinaria
T1  - Endothelium-dependent relaxation of internal mammary artery produced by resveratrol
T1  - Endotel-zavisna relaksacija unutrašnje torakalne arterije prouzrokovana rezveratrolom
VL  - 56
IS  - 2-3
SP  - 203
EP  - 213
DO  - 10.2298/AVB0603203N
ER  - 
@article{
author = "Novaković, Aleksandra and Gojković-Bukarica, Ljiljana and Perić, M. and Nežić, D. and Đukanović, B. and Lešić, A. and Bumbaširević, M. and Marković-Lipkovski, Jasmina",
year = "2006",
abstract = "Resveratrol, a polyphenol present in wine, has been thought to be responsible for cardiovascular benefits associated with moderate wine consumption. It is also present in the plant Polygonum Cuspidatum. The mechanism of cardiovascular benefits probably includes vasorelaxation, antioxidant and anti-platelet effects of resveratrol. The mechanisms by which resveratrol causes vasodilatation are uncertain. The aim of this study was to investigate the mechanism(s) of resveratrol induced vasorelaxation in human internal mammary artery (HIMA) with endothelium. HIMA rings were precontracted by phenylephrine. Resveratrol induced relaxation of the HIMA rings with endothelium. LNAME, an inhibitor of NO synthase, and methylene blue, an inhibitor of guanylate cyclase, abolished relaxation of HIMA induced by resveratrol. Highly selective blocker of ATP-sensitive K channels, glibenclamide as well as a nonselective blocker of big Ca-sensitive K+ channels, charybdotoxin did not block resveratrol-induced relaxation of HIMA. 4-Aminopyridine and margatoxin, blockers of voltage-gated K+ (KV) channels, abolished endothelium-dependent relaxation of HIMA, induced by resveratrol. In conclusion, we have shown that resveratrol induces relaxation of HIMA with endothelium. It seems that NO and smooth muscle KV channels are included in this relaxation., Smatra se da rezveratrol kao jedna polifenolna komponenta prisutna u značajnim količinama u crnom vinu, smanjuje rizik od razvoja ateroskleroze i koronarne bolesti. U mehanizam kardioprotektivnog delovanja verovatno su uključ eni antioksidativno, antitrombocitno i vazodilatatorno delovanje rezveratrola. Mehanizam vazodilatacije još uvek nije poznat, pa je cilj ovog rada bio da se ispitaju efekti i mehanizam vazorelaksantnog delovanja rezveratrola na humanoj unutraš njoj torakalnoj arteriji sa endotelom. Unutrašnja torakalna arterija je prekontrahovana fenilefrinom. Rezveratrol je koncentracijski-zavisno relaksirao unutrašnju torakalnu arteriju čoveka. L-NAME, inhibitor NO sintaze, i metilensko plavo, inhibitor solubilne gvanilat ciklaze, su antagonizovali relaksaciju unutrašnje torakalne arterije sa intaktnim endotelom, prouzrokovanu rezveratrolom. Visoko selektivni blokator ATP-senzitivnih K+ kanala, glibenklamid, kao i neselektivni blokator velikih Ca-senzitivnih K+ kanala, karibdotoksin nisu antagonizovali rezveratrolom indukovanu relaksaciju unutrašnje torakalne arterije. 4-Aminopiridin i margatoksin, blokatori voltažnih K+ kanala su antagonizovali relaksaciju prouzrokovanu rezveratrolom. Na osnovu ovih činjenica se može zaključiti da je endotel-zavisna relaksacija unutrašnje torakalne arterije čoveka, prouzrokovana rezveratrolom, verovatno posredovana NO. Izgleda, da su 4-aminopiriin- i margatoksin-senzitivni K-kanali smešteni u membrani vaskularnih glatko-mišićnih ćelija humane unutrašnje torakalne arterije, uključeni u mehanizam endotel-zavisne relaksacije prouzrokovane rezveratrolom.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta veterinaria",
title = "Endothelium-dependent relaxation of internal mammary artery produced by resveratrol, Endotel-zavisna relaksacija unutrašnje torakalne arterije prouzrokovana rezveratrolom",
volume = "56",
number = "2-3",
pages = "203-213",
doi = "10.2298/AVB0603203N"
}
Novaković, A., Gojković-Bukarica, L., Perić, M., Nežić, D., Đukanović, B., Lešić, A., Bumbaširević, M.,& Marković-Lipkovski, J.. (2006). Endothelium-dependent relaxation of internal mammary artery produced by resveratrol. in Acta veterinaria
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 56(2-3), 203-213.
https://doi.org/10.2298/AVB0603203N
Novaković A, Gojković-Bukarica L, Perić M, Nežić D, Đukanović B, Lešić A, Bumbaširević M, Marković-Lipkovski J. Endothelium-dependent relaxation of internal mammary artery produced by resveratrol. in Acta veterinaria. 2006;56(2-3):203-213.
doi:10.2298/AVB0603203N .
Novaković, Aleksandra, Gojković-Bukarica, Ljiljana, Perić, M., Nežić, D., Đukanović, B., Lešić, A., Bumbaširević, M., Marković-Lipkovski, Jasmina, "Endothelium-dependent relaxation of internal mammary artery produced by resveratrol" in Acta veterinaria, 56, no. 2-3 (2006):203-213,
https://doi.org/10.2298/AVB0603203N . .
1
1
1

Reactivity of arterial and vein bypass grafts to potential pharmalogical spasmogens

Novaković, Aleksandra; Gojković-Bukarica, Ljiljana; Kažić, Tomislav M.; Sajić, Zoran; Đukanović, Boško P.; Perić, M.; Kanjuh, Vladimir

(Savez farmaceutskih udruženja Srbije, Beograd, 2002)

TY  - CONF
AU  - Novaković, Aleksandra
AU  - Gojković-Bukarica, Ljiljana
AU  - Kažić, Tomislav M.
AU  - Sajić, Zoran
AU  - Đukanović, Boško P.
AU  - Perić, M.
AU  - Kanjuh, Vladimir
PY  - 2002
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/405
PB  - Savez farmaceutskih udruženja Srbije, Beograd
C3  - Arhiv za farmaciju
T1  - Reactivity of arterial and vein bypass grafts to potential pharmalogical spasmogens
T1  - Reaktivnost arterijskih i venskih bajpas graftova na potencijalne farmakološke spazmogene
VL  - 52
IS  - 4
SP  - 630
EP  - 631
UR  - https://hdl.handle.net/21.15107/rcub_farfar_405
ER  - 
@conference{
author = "Novaković, Aleksandra and Gojković-Bukarica, Ljiljana and Kažić, Tomislav M. and Sajić, Zoran and Đukanović, Boško P. and Perić, M. and Kanjuh, Vladimir",
year = "2002",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Reactivity of arterial and vein bypass grafts to potential pharmalogical spasmogens, Reaktivnost arterijskih i venskih bajpas graftova na potencijalne farmakološke spazmogene",
volume = "52",
number = "4",
pages = "630-631",
url = "https://hdl.handle.net/21.15107/rcub_farfar_405"
}
Novaković, A., Gojković-Bukarica, L., Kažić, T. M., Sajić, Z., Đukanović, B. P., Perić, M.,& Kanjuh, V.. (2002). Reactivity of arterial and vein bypass grafts to potential pharmalogical spasmogens. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 52(4), 630-631.
https://hdl.handle.net/21.15107/rcub_farfar_405
Novaković A, Gojković-Bukarica L, Kažić TM, Sajić Z, Đukanović BP, Perić M, Kanjuh V. Reactivity of arterial and vein bypass grafts to potential pharmalogical spasmogens. in Arhiv za farmaciju. 2002;52(4):630-631.
https://hdl.handle.net/21.15107/rcub_farfar_405 .
Novaković, Aleksandra, Gojković-Bukarica, Ljiljana, Kažić, Tomislav M., Sajić, Zoran, Đukanović, Boško P., Perić, M., Kanjuh, Vladimir, "Reactivity of arterial and vein bypass grafts to potential pharmalogical spasmogens" in Arhiv za farmaciju, 52, no. 4 (2002):630-631,
https://hdl.handle.net/21.15107/rcub_farfar_405 .

The antivasoconstrictor effect of P1075 on the isolated human saphenous vein

Gojković-Bukarica, Ljiljana; Kazić, T; Beleslin Cokić, B; Novaković, Aleksandra; Perić, M; Sajić, Zoran; Bojić, M; Đukanović, B; Kanjuh, Vladimir

(BMJ Publishing Group, 2000)

TY  - JOUR
AU  - Gojković-Bukarica, Ljiljana
AU  - Kazić, T
AU  - Beleslin Cokić, B
AU  - Novaković, Aleksandra
AU  - Perić, M
AU  - Sajić, Zoran
AU  - Bojić, M
AU  - Đukanović, B
AU  - Kanjuh, Vladimir
PY  - 2000
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/275
AB  - To investigate whether the antivasoconstrictor effect of P1075, a potassium channel openers, could be partly due to modulation of neurotransmitter release from adrenergic nerve endings we analysed the presynaptic and postsynaptic effects of P1075 on the isolated human saphenous vein (HSV). The HSV rings were contracted by electrical field stimulation (EFS) or by exogenous noradrenaline (10 μM; NA). The repetitive transmural EFS was carried out at 20 Hz with square wave pulses of 0.3 ms duration and supramaximal voltage. The contraction of the HSV in response to transmural EFS recorded in our experiments are neurogenic in nature, as this effect was abolished by tetrodotoxin (1 μM). We have also found that phentolamine (1 μM) inhibited almost completly (90 ″ 2%) the HSV contractions to EFS suggesting that this response was mediated by NA release from perivascular sympathetic nerve endings activating postjuncional α adrenoceptors. P1075 (0.01-10 μM) induced a concentration-dependent inhibition of both neurogenic contractions, and contractions evoked by exogenous NA of the HSV with pEC 50 values of of 6.48 ″ 0.05 and 6.36″ 0.08. The difference between the pEC 50 values (r) was not statistically significant (P > 0.05). These results suggest that the antivasoconstrictor effect of P1075 on the HSV might be postsynaptic, and associated with opening of the smooth muscle potassium channels.
PB  - BMJ Publishing Group
T2  - Heart
T1  - The antivasoconstrictor effect of P1075 on the isolated human saphenous vein
VL  - 83
IS  - SUPPL. 2
UR  - https://hdl.handle.net/21.15107/rcub_farfar_275
ER  - 
@article{
author = "Gojković-Bukarica, Ljiljana and Kazić, T and Beleslin Cokić, B and Novaković, Aleksandra and Perić, M and Sajić, Zoran and Bojić, M and Đukanović, B and Kanjuh, Vladimir",
year = "2000",
abstract = "To investigate whether the antivasoconstrictor effect of P1075, a potassium channel openers, could be partly due to modulation of neurotransmitter release from adrenergic nerve endings we analysed the presynaptic and postsynaptic effects of P1075 on the isolated human saphenous vein (HSV). The HSV rings were contracted by electrical field stimulation (EFS) or by exogenous noradrenaline (10 μM; NA). The repetitive transmural EFS was carried out at 20 Hz with square wave pulses of 0.3 ms duration and supramaximal voltage. The contraction of the HSV in response to transmural EFS recorded in our experiments are neurogenic in nature, as this effect was abolished by tetrodotoxin (1 μM). We have also found that phentolamine (1 μM) inhibited almost completly (90 ″ 2%) the HSV contractions to EFS suggesting that this response was mediated by NA release from perivascular sympathetic nerve endings activating postjuncional α adrenoceptors. P1075 (0.01-10 μM) induced a concentration-dependent inhibition of both neurogenic contractions, and contractions evoked by exogenous NA of the HSV with pEC 50 values of of 6.48 ″ 0.05 and 6.36″ 0.08. The difference between the pEC 50 values (r) was not statistically significant (P > 0.05). These results suggest that the antivasoconstrictor effect of P1075 on the HSV might be postsynaptic, and associated with opening of the smooth muscle potassium channels.",
publisher = "BMJ Publishing Group",
journal = "Heart",
title = "The antivasoconstrictor effect of P1075 on the isolated human saphenous vein",
volume = "83",
number = "SUPPL. 2",
url = "https://hdl.handle.net/21.15107/rcub_farfar_275"
}
Gojković-Bukarica, L., Kazić, T., Beleslin Cokić, B., Novaković, A., Perić, M., Sajić, Z., Bojić, M., Đukanović, B.,& Kanjuh, V.. (2000). The antivasoconstrictor effect of P1075 on the isolated human saphenous vein. in Heart
BMJ Publishing Group., 83(SUPPL. 2).
https://hdl.handle.net/21.15107/rcub_farfar_275
Gojković-Bukarica L, Kazić T, Beleslin Cokić B, Novaković A, Perić M, Sajić Z, Bojić M, Đukanović B, Kanjuh V. The antivasoconstrictor effect of P1075 on the isolated human saphenous vein. in Heart. 2000;83(SUPPL. 2).
https://hdl.handle.net/21.15107/rcub_farfar_275 .
Gojković-Bukarica, Ljiljana, Kazić, T, Beleslin Cokić, B, Novaković, Aleksandra, Perić, M, Sajić, Zoran, Bojić, M, Đukanović, B, Kanjuh, Vladimir, "The antivasoconstrictor effect of P1075 on the isolated human saphenous vein" in Heart, 83, no. SUPPL. 2 (2000),
https://hdl.handle.net/21.15107/rcub_farfar_275 .