TY  - JOUR
AU  - Krajišnik, Danina
AU  - Daković, Aleksandra
AU  - Malenović, Anđelija
AU  - Milojević-Rakić, Maja
AU  - Dondur, Vera
AU  - Radulović, Željka
AU  - Milić, Jela
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1905
AB  - Results on adsorption of diclofenac sodium (DS) by modified natural zeolite composites at three levels (10,20 and 30 mmol/100 g) of cationic surfactant-hexadecyltrimethylammonium bromide (HB), in a buffer solution, were compared. Characterization of composites before and after drug adsorption was performed by determination of electrokinetic mobility, FTIR and thermal analysis. The results indicated interactions between drug and carriers. The pharmaceutical performance of cationic surfactant-modified zeolites as drug formulation excipients was evaluated by in vitro dissolution experiments. The results were compared with the drug release from corresponding physical mixtures. Prolonged drug release over a period of 8 h (up to 30%) was achieved with both groups of samples. Furthermore, DS release reached up to 85% from physical mixtures containing drug amount closer to a therapeutic dose.
PB  - Elsevier Science BV, Amsterdam
T2  - Applied Clay Science
T1  - Investigation of adsorption and release of diclofenac sodium by modified zeolites composites
SP  - 322
EP  - 326
DO  - 10.1016/j.clay.2013.08.011
ER  - 

@article{
author = "Krajišnik, Danina and Daković, Aleksandra and Malenović, Anđelija and Milojević-Rakić, Maja and Dondur, Vera and Radulović, Željka and Milić, Jela",
year = "2013",
abstract = "Results on adsorption of diclofenac sodium (DS) by modified natural zeolite composites at three levels (10,20 and 30 mmol/100 g) of cationic surfactant-hexadecyltrimethylammonium bromide (HB), in a buffer solution, were compared. Characterization of composites before and after drug adsorption was performed by determination of electrokinetic mobility, FTIR and thermal analysis. The results indicated interactions between drug and carriers. The pharmaceutical performance of cationic surfactant-modified zeolites as drug formulation excipients was evaluated by in vitro dissolution experiments. The results were compared with the drug release from corresponding physical mixtures. Prolonged drug release over a period of 8 h (up to 30%) was achieved with both groups of samples. Furthermore, DS release reached up to 85% from physical mixtures containing drug amount closer to a therapeutic dose.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Applied Clay Science",
title = "Investigation of adsorption and release of diclofenac sodium by modified zeolites composites",
pages = "322-326",
doi = "10.1016/j.clay.2013.08.011"
}

Krajišnik, D., Daković, A., Malenović, A., Milojević-Rakić, M., Dondur, V., Radulović, Ž.,& Milić, J.. (2013). Investigation of adsorption and release of diclofenac sodium by modified zeolites composites. in Applied Clay Science
Elsevier Science BV, Amsterdam., 322-326.
https://doi.org/10.1016/j.clay.2013.08.011

Krajišnik D, Daković A, Malenović A, Milojević-Rakić M, Dondur V, Radulović Ž, Milić J. Investigation of adsorption and release of diclofenac sodium by modified zeolites composites. in Applied Clay Science. 2013;:322-326.
doi:10.1016/j.clay.2013.08.011 .

Krajišnik, Danina, Daković, Aleksandra, Malenović, Anđelija, Milojević-Rakić, Maja, Dondur, Vera, Radulović, Željka, Milić, Jela, "Investigation of adsorption and release of diclofenac sodium by modified zeolites composites" in Applied Clay Science (2013):322-326,
https://doi.org/10.1016/j.clay.2013.08.011 . .