TY  - JOUR
AU  - Jocić, B.
AU  - Zečević, Mira
AU  - Živanović, Lj.
AU  - Licanski, A.
PY  - 2007
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/982
AB  - An isocratic reversed-phase high-performance liquid chromatographic method was developed and validated for the analysis of a novel antimigraine drug, rizatriptan benzoate, in a dosage form along with its two impurities, L-749.019 and L-783.540. The method used a C-18 XTerra (TM) ( 150 x 3.9 mm), 5 mm column. The mobile phase consisted of a mixture of methanol, TEA (1%) and 10 mM KH2PO4 ( 5: 9.5: 85.5 v/v) at a flow rate of 1.2 ml min(-1) ( pH of the water phase was adjusted to 5.5 with 85% orthophosphoric acid). Column temperature was 20 degrees C and the detection was performed at 225 nm. The central composite design technique and the response surface method were used in the robustness test considerations. The method was applied satisfactorily to the analysis of commercial rizatriptan formulation.
PB  - Taylor & Francis Inc, Philadelphia
T2  - Analytical Letters
T1  - A chemometrical approach to optimization and validation of an HPLC assay for rizatriptan and its impurities in tablets
VL  - 40
IS  - 12
SP  - 2301
EP  - 2316
DO  - 10.1080/00032710701575959
ER  - 

@article{
author = "Jocić, B. and Zečević, Mira and Živanović, Lj. and Licanski, A.",
year = "2007",
abstract = "An isocratic reversed-phase high-performance liquid chromatographic method was developed and validated for the analysis of a novel antimigraine drug, rizatriptan benzoate, in a dosage form along with its two impurities, L-749.019 and L-783.540. The method used a C-18 XTerra (TM) ( 150 x 3.9 mm), 5 mm column. The mobile phase consisted of a mixture of methanol, TEA (1%) and 10 mM KH2PO4 ( 5: 9.5: 85.5 v/v) at a flow rate of 1.2 ml min(-1) ( pH of the water phase was adjusted to 5.5 with 85% orthophosphoric acid). Column temperature was 20 degrees C and the detection was performed at 225 nm. The central composite design technique and the response surface method were used in the robustness test considerations. The method was applied satisfactorily to the analysis of commercial rizatriptan formulation.",
publisher = "Taylor & Francis Inc, Philadelphia",
journal = "Analytical Letters",
title = "A chemometrical approach to optimization and validation of an HPLC assay for rizatriptan and its impurities in tablets",
volume = "40",
number = "12",
pages = "2301-2316",
doi = "10.1080/00032710701575959"
}

Jocić, B., Zečević, M., Živanović, Lj.,& Licanski, A.. (2007). A chemometrical approach to optimization and validation of an HPLC assay for rizatriptan and its impurities in tablets. in Analytical Letters
Taylor & Francis Inc, Philadelphia., 40(12), 2301-2316.
https://doi.org/10.1080/00032710701575959

Jocić B, Zečević M, Živanović L, Licanski A. A chemometrical approach to optimization and validation of an HPLC assay for rizatriptan and its impurities in tablets. in Analytical Letters. 2007;40(12):2301-2316.
doi:10.1080/00032710701575959 .

Jocić, B., Zečević, Mira, Živanović, Lj., Licanski, A., "A chemometrical approach to optimization and validation of an HPLC assay for rizatriptan and its impurities in tablets" in Analytical Letters, 40, no. 12 (2007):2301-2316,
https://doi.org/10.1080/00032710701575959 . .

TY  - JOUR
AU  - Savić, G.
AU  - Zečević, Mira
AU  - Jocić, B.
AU  - Živanović, Lj.
PY  - 2007
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/978
PB  - Vieweg, Wiesbaden
T2  - Chromatographia
T1  - Validation of an HPLC method for the determination of valclecoxib and its degradation product: a mixture of alpha- and beta-n-lactosyl sulfonamide anomers (vol 66, pg 29, 2007)
VL  - 66
IS  - 3-4
SP  - 297
EP  - 297
DO  - 10.1365/s10337-007-0328-1
ER  - 

@article{
author = "Savić, G. and Zečević, Mira and Jocić, B. and Živanović, Lj.",
year = "2007",
publisher = "Vieweg, Wiesbaden",
journal = "Chromatographia",
title = "Validation of an HPLC method for the determination of valclecoxib and its degradation product: a mixture of alpha- and beta-n-lactosyl sulfonamide anomers (vol 66, pg 29, 2007)",
volume = "66",
number = "3-4",
pages = "297-297",
doi = "10.1365/s10337-007-0328-1"
}

Savić, G., Zečević, M., Jocić, B.,& Živanović, Lj.. (2007). Validation of an HPLC method for the determination of valclecoxib and its degradation product: a mixture of alpha- and beta-n-lactosyl sulfonamide anomers (vol 66, pg 29, 2007). in Chromatographia
Vieweg, Wiesbaden., 66(3-4), 297-297.
https://doi.org/10.1365/s10337-007-0328-1

Savić G, Zečević M, Jocić B, Živanović L. Validation of an HPLC method for the determination of valclecoxib and its degradation product: a mixture of alpha- and beta-n-lactosyl sulfonamide anomers (vol 66, pg 29, 2007). in Chromatographia. 2007;66(3-4):297-297.
doi:10.1365/s10337-007-0328-1 .

Savić, G., Zečević, Mira, Jocić, B., Živanović, Lj., "Validation of an HPLC method for the determination of valclecoxib and its degradation product: a mixture of alpha- and beta-n-lactosyl sulfonamide anomers (vol 66, pg 29, 2007)" in Chromatographia, 66, no. 3-4 (2007):297-297,
https://doi.org/10.1365/s10337-007-0328-1 . .

TY  - JOUR
AU  - Savić, G.
AU  - Zečević, Mira
AU  - Jocić, B.
AU  - Živanović, Lj.
PY  - 2007
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/975
AB  - An HPLC method has been developed for the separation of valdecoxib and a degradation product consisting of alpha and beta-N-lactosyl sulfonamide, i.e. alpha and beta anomers (SC-77852). Best results were achieved with a Chromolith Performance RP-18e column (100 mm x 4.6 mm), macropore size 2 pm, mesopore size 13 nm, with an eluent of methanol:water containing a 1% solution of TEA (36:64 v/v), pH 7.4 (adjusted with 85% orthophosphoric acid), at 22 degrees C. Detection was at 220 nm. The method was validated for its selectivity, linearity, precision (repeatability) and robustness. Quantitation and detection limits were determined for both valdecoxib and SC-77852. Method robustness was further evaluated by performing 2 3 full factorial design experiments. The final step, optimisation of the variables, was performed using response surface design. The validated method was used for assay of valdecoxib and SC77852 in Bextra((R)) film-coated tablets.
PB  - Vieweg, Wiesbaden
T2  - Chromatographia
T1  - Validation of an HPLC method for the determination of valdecoxib and its degradation product: a mixture of alpha- and beta-n-lactosyl sulfonamide anomers
VL  - 66
IS  - 1-2
SP  - 29
EP  - 35
DO  - 10.1365/s10337-007-0276-9
ER  - 

@article{
author = "Savić, G. and Zečević, Mira and Jocić, B. and Živanović, Lj.",
year = "2007",
abstract = "An HPLC method has been developed for the separation of valdecoxib and a degradation product consisting of alpha and beta-N-lactosyl sulfonamide, i.e. alpha and beta anomers (SC-77852). Best results were achieved with a Chromolith Performance RP-18e column (100 mm x 4.6 mm), macropore size 2 pm, mesopore size 13 nm, with an eluent of methanol:water containing a 1% solution of TEA (36:64 v/v), pH 7.4 (adjusted with 85% orthophosphoric acid), at 22 degrees C. Detection was at 220 nm. The method was validated for its selectivity, linearity, precision (repeatability) and robustness. Quantitation and detection limits were determined for both valdecoxib and SC-77852. Method robustness was further evaluated by performing 2 3 full factorial design experiments. The final step, optimisation of the variables, was performed using response surface design. The validated method was used for assay of valdecoxib and SC77852 in Bextra((R)) film-coated tablets.",
publisher = "Vieweg, Wiesbaden",
journal = "Chromatographia",
title = "Validation of an HPLC method for the determination of valdecoxib and its degradation product: a mixture of alpha- and beta-n-lactosyl sulfonamide anomers",
volume = "66",
number = "1-2",
pages = "29-35",
doi = "10.1365/s10337-007-0276-9"
}

Savić, G., Zečević, M., Jocić, B.,& Živanović, Lj.. (2007). Validation of an HPLC method for the determination of valdecoxib and its degradation product: a mixture of alpha- and beta-n-lactosyl sulfonamide anomers. in Chromatographia
Vieweg, Wiesbaden., 66(1-2), 29-35.
https://doi.org/10.1365/s10337-007-0276-9

Savić G, Zečević M, Jocić B, Živanović L. Validation of an HPLC method for the determination of valdecoxib and its degradation product: a mixture of alpha- and beta-n-lactosyl sulfonamide anomers. in Chromatographia. 2007;66(1-2):29-35.
doi:10.1365/s10337-007-0276-9 .

Savić, G., Zečević, Mira, Jocić, B., Živanović, Lj., "Validation of an HPLC method for the determination of valdecoxib and its degradation product: a mixture of alpha- and beta-n-lactosyl sulfonamide anomers" in Chromatographia, 66, no. 1-2 (2007):29-35,
https://doi.org/10.1365/s10337-007-0276-9 . .

TY  - JOUR
AU  - Zečević, Mira
AU  - Stanković, Z
AU  - Živanović, L
AU  - Jocić, B
PY  - 2006
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/815
AB  - The novel, rapid high performance liquid chromatographic method for the determination of tramadol hydrochloride and its three impurities was developed and validated. The method can simultaneously assay potassium sorbate, used as preservative. and saccharin sodium, used as sweetener in tramadol pharmaceutical formulation. The separation was carried out on a C-18 XTerra (TM) (150 mm x 4.6 mm, 5 mm) column using acetonitrile-0.015 M Na2HPO4 buffer (2:8, v/v) as mobile phase (pH value 3.0 was adjusted with orthophosphoric acid) at a flow rate 1.0 ml min(-1), temperature of the column 20 degrees C and UV detection at 218 nm. The method was found to be linear (r > 0.999) in the range of 0.05-0.8 mg ml(-1) for tramadol hydrochloride, 0.1-1.2 mg ml(-1) for impurities B and C and for impurity A (r > 0.995) in the range 0.15-2.4 mg ml(-1). The low RSD values indicate good precision and high recovery values indicate excellent accuracy of the HPLC method. Developed method was successfully applied to the determination of tramadol hydrochloride. its investigated impurities and potassium sorbate in commercial formulation. The recovery of tramadol hydrochloride was 98.25% and RSD was 1.80%. The method is rapid and sensitive enough to be used to analyse Trodon((R)) oral drops.
PB  - Elsevier Science BV, Amsterdam
T2  - Journal of Chromatography A
T1  - Validation of a high-performance liquid chromatographic method for the simultaneous determination of tramadol and its impurities in oral drops as a pharmaceutical formulation
VL  - 1119
IS  - 1-2
SP  - 251
EP  - 256
DO  - 10.1016/j.chroma.2005.11.105
ER  - 

@article{
author = "Zečević, Mira and Stanković, Z and Živanović, L and Jocić, B",
year = "2006",
abstract = "The novel, rapid high performance liquid chromatographic method for the determination of tramadol hydrochloride and its three impurities was developed and validated. The method can simultaneously assay potassium sorbate, used as preservative. and saccharin sodium, used as sweetener in tramadol pharmaceutical formulation. The separation was carried out on a C-18 XTerra (TM) (150 mm x 4.6 mm, 5 mm) column using acetonitrile-0.015 M Na2HPO4 buffer (2:8, v/v) as mobile phase (pH value 3.0 was adjusted with orthophosphoric acid) at a flow rate 1.0 ml min(-1), temperature of the column 20 degrees C and UV detection at 218 nm. The method was found to be linear (r > 0.999) in the range of 0.05-0.8 mg ml(-1) for tramadol hydrochloride, 0.1-1.2 mg ml(-1) for impurities B and C and for impurity A (r > 0.995) in the range 0.15-2.4 mg ml(-1). The low RSD values indicate good precision and high recovery values indicate excellent accuracy of the HPLC method. Developed method was successfully applied to the determination of tramadol hydrochloride. its investigated impurities and potassium sorbate in commercial formulation. The recovery of tramadol hydrochloride was 98.25% and RSD was 1.80%. The method is rapid and sensitive enough to be used to analyse Trodon((R)) oral drops.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Journal of Chromatography A",
title = "Validation of a high-performance liquid chromatographic method for the simultaneous determination of tramadol and its impurities in oral drops as a pharmaceutical formulation",
volume = "1119",
number = "1-2",
pages = "251-256",
doi = "10.1016/j.chroma.2005.11.105"
}

Zečević, M., Stanković, Z., Živanović, L.,& Jocić, B.. (2006). Validation of a high-performance liquid chromatographic method for the simultaneous determination of tramadol and its impurities in oral drops as a pharmaceutical formulation. in Journal of Chromatography A
Elsevier Science BV, Amsterdam., 1119(1-2), 251-256.
https://doi.org/10.1016/j.chroma.2005.11.105

Zečević M, Stanković Z, Živanović L, Jocić B. Validation of a high-performance liquid chromatographic method for the simultaneous determination of tramadol and its impurities in oral drops as a pharmaceutical formulation. in Journal of Chromatography A. 2006;1119(1-2):251-256.
doi:10.1016/j.chroma.2005.11.105 .

Zečević, Mira, Stanković, Z, Živanović, L, Jocić, B, "Validation of a high-performance liquid chromatographic method for the simultaneous determination of tramadol and its impurities in oral drops as a pharmaceutical formulation" in Journal of Chromatography A, 1119, no. 1-2 (2006):251-256,
https://doi.org/10.1016/j.chroma.2005.11.105 . .