Husinec, Suren

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950092aa-dd08-4d3c-89ff-d51091e1f664
  • Husinec, Suren (12)
Projects

Author's Bibliography

Study of the intramolecular Heck reaction: synthesis of the bicyclic core of corialstonidine

Tasić, Gordana; Maslak, Veselin; Husinec, Suren; Todorović, Nina; Savić, Vladimir

(Pergamon-Elsevier Science Ltd, Oxford, 2015)

TY  - JOUR
AU  - Tasić, Gordana
AU  - Maslak, Veselin
AU  - Husinec, Suren
AU  - Todorović, Nina
AU  - Savić, Vladimir
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2375
AB  - The intramolecular Heck reaction has been examined for the preparation of the core bicyclic structure of corialstonidine. Initial attempts to cyclise a vinyl iodide moiety onto a cyclic allyl alcohol were complicated by various side reactions. However, the corresponding process performed under reductive conditions on a conjugated ketone, obtained from the cyclic allyl alcohol, afforded the desired bicyclo[3.2.1] derivative. This compound possesses the skeletal features of the carbocyclic fragment of corialstonidine and is suitable for further transformations aimed towards the synthesis of the natural product or its derivatives.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Tetrahedron-Asymmetry
T1  - Study of the intramolecular Heck reaction: synthesis of the bicyclic core of corialstonidine
VL  - 56
IS  - 19
SP  - 2529
EP  - 2532
DO  - 10.1016/j.tetlet.2015.03.129
ER  - 
@article{
author = "Tasić, Gordana and Maslak, Veselin and Husinec, Suren and Todorović, Nina and Savić, Vladimir",
year = "2015",
abstract = "The intramolecular Heck reaction has been examined for the preparation of the core bicyclic structure of corialstonidine. Initial attempts to cyclise a vinyl iodide moiety onto a cyclic allyl alcohol were complicated by various side reactions. However, the corresponding process performed under reductive conditions on a conjugated ketone, obtained from the cyclic allyl alcohol, afforded the desired bicyclo[3.2.1] derivative. This compound possesses the skeletal features of the carbocyclic fragment of corialstonidine and is suitable for further transformations aimed towards the synthesis of the natural product or its derivatives.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Tetrahedron-Asymmetry",
title = "Study of the intramolecular Heck reaction: synthesis of the bicyclic core of corialstonidine",
volume = "56",
number = "19",
pages = "2529-2532",
doi = "10.1016/j.tetlet.2015.03.129"
}
Tasić, G., Maslak, V., Husinec, S., Todorović, N.,& Savić, V.. (2015). Study of the intramolecular Heck reaction: synthesis of the bicyclic core of corialstonidine. in Tetrahedron-Asymmetry
Pergamon-Elsevier Science Ltd, Oxford., 56(19), 2529-2532.
https://doi.org/10.1016/j.tetlet.2015.03.129
Tasić G, Maslak V, Husinec S, Todorović N, Savić V. Study of the intramolecular Heck reaction: synthesis of the bicyclic core of corialstonidine. in Tetrahedron-Asymmetry. 2015;56(19):2529-2532.
doi:10.1016/j.tetlet.2015.03.129 .
Tasić, Gordana, Maslak, Veselin, Husinec, Suren, Todorović, Nina, Savić, Vladimir, "Study of the intramolecular Heck reaction: synthesis of the bicyclic core of corialstonidine" in Tetrahedron-Asymmetry, 56, no. 19 (2015):2529-2532,
https://doi.org/10.1016/j.tetlet.2015.03.129 . .
4
4
4

Organocatalysis in Synthesis of Pyrrolidine Derivatives via Cycloaddition Reactions of Azomethine Ylides

Ranđelović, Jelena; Simić, Milena; Tasić, Gordana; Husinec, Suren; Savić, Vladimir

(Bentham Science Publ Ltd, Sharjah, 2014)

TY  - JOUR
AU  - Ranđelović, Jelena
AU  - Simić, Milena
AU  - Tasić, Gordana
AU  - Husinec, Suren
AU  - Savić, Vladimir
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2090
AB  - Cycloaddition reactions of azomethine ylides are the most direct way to synthesise pyrrolidine derivatives. They have been studied for several decades and have become an indispensable tool in synthesis of pyrrolidines and pyrrolidine derived natural products. Amongst many methods for generating azomethine ylides, various processes involving imines derived from amino acid esters have been the most frequently studied. The use of Lewis acids to promote imine-ylide-cycloaddition sequence under mild conditions, in recent years, has led to the development of highly stereoselective metal catalysed methodologies for the preparation of pyrrolidine derivatives. In the last few years, the concept of organocatalysis has been incorporated in cycloaddition reactions of azomethine ylides providing an alternative access to chiral pyrrolidines. Several classes of typical organocatalysts such as prolines, phosphoric acids, thioureas, guanidines and sulphuric acid derivatives have been used for these purposes. Various mechanistic pathways have been proposed, based on either the activation of only one reacting partner, 1,3-dipole (imine) or dipolarophile (alkene), or both of them simultaneously. While the first three classes of organocatalysts appear to afford pyrrolidines, generally, in good yields and with high levels of stereoselectivity, guanidines and sulphuric acid derivatives are less efficient, but also the least studied catalyst group. A whole range of electron deficient dipolarophiles (alkenes) have been used in these cycloaddition processes, while, regarding the dipole precursor imine, aromatic aldimines seem to be more efficient than their aliphatic equivalents. There is no doubt that the recent progress in organocatalytic cycloadditions of azomethine ylides created new possibilities for synthesis of pyrrolidine derivatives and enriched this useful synthetic methodology.
PB  - Bentham Science Publ Ltd, Sharjah
T2  - Current Organic Chemistry
T1  - Organocatalysis in Synthesis of Pyrrolidine Derivatives via Cycloaddition Reactions of Azomethine Ylides
VL  - 18
IS  - 9
SP  - 1073
EP  - 1096
DO  - 10.2174/1385272819999140404130229
ER  - 
@article{
author = "Ranđelović, Jelena and Simić, Milena and Tasić, Gordana and Husinec, Suren and Savić, Vladimir",
year = "2014",
abstract = "Cycloaddition reactions of azomethine ylides are the most direct way to synthesise pyrrolidine derivatives. They have been studied for several decades and have become an indispensable tool in synthesis of pyrrolidines and pyrrolidine derived natural products. Amongst many methods for generating azomethine ylides, various processes involving imines derived from amino acid esters have been the most frequently studied. The use of Lewis acids to promote imine-ylide-cycloaddition sequence under mild conditions, in recent years, has led to the development of highly stereoselective metal catalysed methodologies for the preparation of pyrrolidine derivatives. In the last few years, the concept of organocatalysis has been incorporated in cycloaddition reactions of azomethine ylides providing an alternative access to chiral pyrrolidines. Several classes of typical organocatalysts such as prolines, phosphoric acids, thioureas, guanidines and sulphuric acid derivatives have been used for these purposes. Various mechanistic pathways have been proposed, based on either the activation of only one reacting partner, 1,3-dipole (imine) or dipolarophile (alkene), or both of them simultaneously. While the first three classes of organocatalysts appear to afford pyrrolidines, generally, in good yields and with high levels of stereoselectivity, guanidines and sulphuric acid derivatives are less efficient, but also the least studied catalyst group. A whole range of electron deficient dipolarophiles (alkenes) have been used in these cycloaddition processes, while, regarding the dipole precursor imine, aromatic aldimines seem to be more efficient than their aliphatic equivalents. There is no doubt that the recent progress in organocatalytic cycloadditions of azomethine ylides created new possibilities for synthesis of pyrrolidine derivatives and enriched this useful synthetic methodology.",
publisher = "Bentham Science Publ Ltd, Sharjah",
journal = "Current Organic Chemistry",
title = "Organocatalysis in Synthesis of Pyrrolidine Derivatives via Cycloaddition Reactions of Azomethine Ylides",
volume = "18",
number = "9",
pages = "1073-1096",
doi = "10.2174/1385272819999140404130229"
}
Ranđelović, J., Simić, M., Tasić, G., Husinec, S.,& Savić, V.. (2014). Organocatalysis in Synthesis of Pyrrolidine Derivatives via Cycloaddition Reactions of Azomethine Ylides. in Current Organic Chemistry
Bentham Science Publ Ltd, Sharjah., 18(9), 1073-1096.
https://doi.org/10.2174/1385272819999140404130229
Ranđelović J, Simić M, Tasić G, Husinec S, Savić V. Organocatalysis in Synthesis of Pyrrolidine Derivatives via Cycloaddition Reactions of Azomethine Ylides. in Current Organic Chemistry. 2014;18(9):1073-1096.
doi:10.2174/1385272819999140404130229 .
Ranđelović, Jelena, Simić, Milena, Tasić, Gordana, Husinec, Suren, Savić, Vladimir, "Organocatalysis in Synthesis of Pyrrolidine Derivatives via Cycloaddition Reactions of Azomethine Ylides" in Current Organic Chemistry, 18, no. 9 (2014):1073-1096,
https://doi.org/10.2174/1385272819999140404130229 . .
31
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32

Indirect N-vinylation of indoles via isomerisation of N-allyl derivatives: synthesis of (+/-)-debromoarborescidine B

Tasić, Gordana; Simić, Milena; Popović, Stanimir; Husinec, Suren; Maslak, Veselin; Savić, Vladimir

(Pergamon-Elsevier Science Ltd, Oxford, 2013)

TY  - JOUR
AU  - Tasić, Gordana
AU  - Simić, Milena
AU  - Popović, Stanimir
AU  - Husinec, Suren
AU  - Maslak, Veselin
AU  - Savić, Vladimir
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1973
AB  - Double bond migration in N-allylindoles has been investigated as a method to access N-vinyl derivatives of this heterocycle. The optimal reaction conditions employed t-BuOK or NaH in DMSO as the solvent at room temperature to afford the products in yields ranging from 51 to 99%. Although in some cases a high degree of stereoselectivity was observed, preferential formation of either the Z- or E-isomer was not predictable. The developed methodology was employed in the synthesis of (+/-)-debromoarborescidine B.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Tetrahedron-Asymmetry
T1  - Indirect N-vinylation of indoles via isomerisation of N-allyl derivatives: synthesis of (+/-)-debromoarborescidine B
VL  - 54
IS  - 34
SP  - 4536
EP  - 4539
DO  - 10.1016/j.tetlet.2013.06.069
ER  - 
@article{
author = "Tasić, Gordana and Simić, Milena and Popović, Stanimir and Husinec, Suren and Maslak, Veselin and Savić, Vladimir",
year = "2013",
abstract = "Double bond migration in N-allylindoles has been investigated as a method to access N-vinyl derivatives of this heterocycle. The optimal reaction conditions employed t-BuOK or NaH in DMSO as the solvent at room temperature to afford the products in yields ranging from 51 to 99%. Although in some cases a high degree of stereoselectivity was observed, preferential formation of either the Z- or E-isomer was not predictable. The developed methodology was employed in the synthesis of (+/-)-debromoarborescidine B.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Tetrahedron-Asymmetry",
title = "Indirect N-vinylation of indoles via isomerisation of N-allyl derivatives: synthesis of (+/-)-debromoarborescidine B",
volume = "54",
number = "34",
pages = "4536-4539",
doi = "10.1016/j.tetlet.2013.06.069"
}
Tasić, G., Simić, M., Popović, S., Husinec, S., Maslak, V.,& Savić, V.. (2013). Indirect N-vinylation of indoles via isomerisation of N-allyl derivatives: synthesis of (+/-)-debromoarborescidine B. in Tetrahedron-Asymmetry
Pergamon-Elsevier Science Ltd, Oxford., 54(34), 4536-4539.
https://doi.org/10.1016/j.tetlet.2013.06.069
Tasić G, Simić M, Popović S, Husinec S, Maslak V, Savić V. Indirect N-vinylation of indoles via isomerisation of N-allyl derivatives: synthesis of (+/-)-debromoarborescidine B. in Tetrahedron-Asymmetry. 2013;54(34):4536-4539.
doi:10.1016/j.tetlet.2013.06.069 .
Tasić, Gordana, Simić, Milena, Popović, Stanimir, Husinec, Suren, Maslak, Veselin, Savić, Vladimir, "Indirect N-vinylation of indoles via isomerisation of N-allyl derivatives: synthesis of (+/-)-debromoarborescidine B" in Tetrahedron-Asymmetry, 54, no. 34 (2013):4536-4539,
https://doi.org/10.1016/j.tetlet.2013.06.069 . .
9
6
8

A highly regioselective, protecting group controlled, synthesis of bicyclic compounds via Pd-catalysed intramolecular cyclisations

Tasić, Gordana; Ranđelović, Jelena; Vusurović, Nikola; Maslak, Veselin; Husinec, Suren; Savić, Vladimir

(Pergamon-Elsevier Science Ltd, Oxford, 2013)

TY  - JOUR
AU  - Tasić, Gordana
AU  - Ranđelović, Jelena
AU  - Vusurović, Nikola
AU  - Maslak, Veselin
AU  - Husinec, Suren
AU  - Savić, Vladimir
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1924
AB  - Intramolecular Pd-catalysed cyclisation reactions for the preparation of bicyclic compounds have been studied as a model system towards the synthesis of corialstonine and corialstonidine. Significant differences in reactivity have been observed for the cyclic allyl alcohols possessing O-protected and free OH functionalities. Cyclisation via the intramolecular Heck reaction, for both derivatives, proved to be highly regioselective and while the O-protected compound favoured the exo mode of cyclisation, the unprotected alcohol preferred the endo cyclisation pathway. Brief computational studies were carried out in order to obtain further insight into these processes.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Tetrahedron-Asymmetry
T1  - A highly regioselective, protecting group controlled, synthesis of bicyclic compounds via Pd-catalysed intramolecular cyclisations
VL  - 54
IS  - 18
SP  - 2243
EP  - 2246
DO  - 10.1016/j.tetlet.2013.02.068
ER  - 
@article{
author = "Tasić, Gordana and Ranđelović, Jelena and Vusurović, Nikola and Maslak, Veselin and Husinec, Suren and Savić, Vladimir",
year = "2013",
abstract = "Intramolecular Pd-catalysed cyclisation reactions for the preparation of bicyclic compounds have been studied as a model system towards the synthesis of corialstonine and corialstonidine. Significant differences in reactivity have been observed for the cyclic allyl alcohols possessing O-protected and free OH functionalities. Cyclisation via the intramolecular Heck reaction, for both derivatives, proved to be highly regioselective and while the O-protected compound favoured the exo mode of cyclisation, the unprotected alcohol preferred the endo cyclisation pathway. Brief computational studies were carried out in order to obtain further insight into these processes.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Tetrahedron-Asymmetry",
title = "A highly regioselective, protecting group controlled, synthesis of bicyclic compounds via Pd-catalysed intramolecular cyclisations",
volume = "54",
number = "18",
pages = "2243-2246",
doi = "10.1016/j.tetlet.2013.02.068"
}
Tasić, G., Ranđelović, J., Vusurović, N., Maslak, V., Husinec, S.,& Savić, V.. (2013). A highly regioselective, protecting group controlled, synthesis of bicyclic compounds via Pd-catalysed intramolecular cyclisations. in Tetrahedron-Asymmetry
Pergamon-Elsevier Science Ltd, Oxford., 54(18), 2243-2246.
https://doi.org/10.1016/j.tetlet.2013.02.068
Tasić G, Ranđelović J, Vusurović N, Maslak V, Husinec S, Savić V. A highly regioselective, protecting group controlled, synthesis of bicyclic compounds via Pd-catalysed intramolecular cyclisations. in Tetrahedron-Asymmetry. 2013;54(18):2243-2246.
doi:10.1016/j.tetlet.2013.02.068 .
Tasić, Gordana, Ranđelović, Jelena, Vusurović, Nikola, Maslak, Veselin, Husinec, Suren, Savić, Vladimir, "A highly regioselective, protecting group controlled, synthesis of bicyclic compounds via Pd-catalysed intramolecular cyclisations" in Tetrahedron-Asymmetry, 54, no. 18 (2013):2243-2246,
https://doi.org/10.1016/j.tetlet.2013.02.068 . .
4
4
4

Synthesis of Allyl Acetates via Palladium-Catalysed Functionalisation of Allenes and 1,3-Dienes

Husinec, Suren; Petković, Miloš; Savić, Vladimir; Simić, Milena

(Georg Thieme Verlag Kg, Stuttgart, 2012)

TY  - JOUR
AU  - Husinec, Suren
AU  - Petković, Miloš
AU  - Savić, Vladimir
AU  - Simić, Milena
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1724
AB  - pi-Allylpalladium intermediates are known to participate efficiently in transformations involving nucleophilic species. Exploring these processes, we have developed a method for the preparation of allyl acetates via palladium-catalysed functionalisation of allenes and 1,3-dienes. Reactions of aryl iodides with either of these two classes of compounds and excess sodium acetate in the presence of Pd(OAc) (2) and Ph3P as the catalytic system afforded the respective allyl acetates in moderate to good yields. The scope of this process has been investigated. The described method is an addition to the synthetic repertoire for the preparation of allyl acetates, and may be useful, in particular, for the synthesis of structurally complex compounds of this type.
PB  - Georg Thieme Verlag Kg, Stuttgart
T2  - Synthesis
T1  - Synthesis of Allyl Acetates via Palladium-Catalysed Functionalisation of Allenes and 1,3-Dienes
VL  - 44
IS  - 3
SP  - 399
EP  - 408
DO  - 10.1055/s-0031-1289658
ER  - 
@article{
author = "Husinec, Suren and Petković, Miloš and Savić, Vladimir and Simić, Milena",
year = "2012",
abstract = "pi-Allylpalladium intermediates are known to participate efficiently in transformations involving nucleophilic species. Exploring these processes, we have developed a method for the preparation of allyl acetates via palladium-catalysed functionalisation of allenes and 1,3-dienes. Reactions of aryl iodides with either of these two classes of compounds and excess sodium acetate in the presence of Pd(OAc) (2) and Ph3P as the catalytic system afforded the respective allyl acetates in moderate to good yields. The scope of this process has been investigated. The described method is an addition to the synthetic repertoire for the preparation of allyl acetates, and may be useful, in particular, for the synthesis of structurally complex compounds of this type.",
publisher = "Georg Thieme Verlag Kg, Stuttgart",
journal = "Synthesis",
title = "Synthesis of Allyl Acetates via Palladium-Catalysed Functionalisation of Allenes and 1,3-Dienes",
volume = "44",
number = "3",
pages = "399-408",
doi = "10.1055/s-0031-1289658"
}
Husinec, S., Petković, M., Savić, V.,& Simić, M.. (2012). Synthesis of Allyl Acetates via Palladium-Catalysed Functionalisation of Allenes and 1,3-Dienes. in Synthesis
Georg Thieme Verlag Kg, Stuttgart., 44(3), 399-408.
https://doi.org/10.1055/s-0031-1289658
Husinec S, Petković M, Savić V, Simić M. Synthesis of Allyl Acetates via Palladium-Catalysed Functionalisation of Allenes and 1,3-Dienes. in Synthesis. 2012;44(3):399-408.
doi:10.1055/s-0031-1289658 .
Husinec, Suren, Petković, Miloš, Savić, Vladimir, Simić, Milena, "Synthesis of Allyl Acetates via Palladium-Catalysed Functionalisation of Allenes and 1,3-Dienes" in Synthesis, 44, no. 3 (2012):399-408,
https://doi.org/10.1055/s-0031-1289658 . .
17
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23

Annulations of isoquinoline and beta-carboline ring systems: synthesis of 8-oxoprotoberberine derivatives

Husinec, Suren; Savić, Vladimir; Simić, Milena; Tešević, Vele; Vidović, Dragoslav

(Pergamon-Elsevier Science Ltd, Oxford, 2011)

TY  - JOUR
AU  - Husinec, Suren
AU  - Savić, Vladimir
AU  - Simić, Milena
AU  - Tešević, Vele
AU  - Vidović, Dragoslav
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1567
AB  - Annulation processes of isoquinoline and p-carboline compounds have been investigated leading to synthetic routes for the preparation of 8-oxoprotoberberine derivatives. The key steps combined a diene formation/Diels-Alder cycloaddition reaction to afford the targeted polycyclic skeletons. Further oxidative transformations of the cycloadducts produced the 8-oxoprotoberberine type products. The alkaloids of this class are important natural products with a wide range of biological activity and the synthethic methodology described in this paper could prove to be useful for the preparation of the D-ring functionalised derivatives.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Tetrahedron-Asymmetry
T1  - Annulations of isoquinoline and beta-carboline ring systems: synthesis of 8-oxoprotoberberine derivatives
VL  - 52
IS  - 21
SP  - 2733
EP  - 2736
DO  - 10.1016/j.tetlet.2011.03.085
ER  - 
@article{
author = "Husinec, Suren and Savić, Vladimir and Simić, Milena and Tešević, Vele and Vidović, Dragoslav",
year = "2011",
abstract = "Annulation processes of isoquinoline and p-carboline compounds have been investigated leading to synthetic routes for the preparation of 8-oxoprotoberberine derivatives. The key steps combined a diene formation/Diels-Alder cycloaddition reaction to afford the targeted polycyclic skeletons. Further oxidative transformations of the cycloadducts produced the 8-oxoprotoberberine type products. The alkaloids of this class are important natural products with a wide range of biological activity and the synthethic methodology described in this paper could prove to be useful for the preparation of the D-ring functionalised derivatives.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Tetrahedron-Asymmetry",
title = "Annulations of isoquinoline and beta-carboline ring systems: synthesis of 8-oxoprotoberberine derivatives",
volume = "52",
number = "21",
pages = "2733-2736",
doi = "10.1016/j.tetlet.2011.03.085"
}
Husinec, S., Savić, V., Simić, M., Tešević, V.,& Vidović, D.. (2011). Annulations of isoquinoline and beta-carboline ring systems: synthesis of 8-oxoprotoberberine derivatives. in Tetrahedron-Asymmetry
Pergamon-Elsevier Science Ltd, Oxford., 52(21), 2733-2736.
https://doi.org/10.1016/j.tetlet.2011.03.085
Husinec S, Savić V, Simić M, Tešević V, Vidović D. Annulations of isoquinoline and beta-carboline ring systems: synthesis of 8-oxoprotoberberine derivatives. in Tetrahedron-Asymmetry. 2011;52(21):2733-2736.
doi:10.1016/j.tetlet.2011.03.085 .
Husinec, Suren, Savić, Vladimir, Simić, Milena, Tešević, Vele, Vidović, Dragoslav, "Annulations of isoquinoline and beta-carboline ring systems: synthesis of 8-oxoprotoberberine derivatives" in Tetrahedron-Asymmetry, 52, no. 21 (2011):2733-2736,
https://doi.org/10.1016/j.tetlet.2011.03.085 . .
10
9
10

A Base Promoted Cyclization of N-Propargylaminopyridines. Synthesis of Imidazo[1,2-a]pyridine Derivatives

Husinec, Suren; Marković, Rade; Petković, Miloš; Nasufović, Veselin; Savić, Vladimir

(Amer Chemical Soc, Washington, 2011)

TY  - JOUR
AU  - Husinec, Suren
AU  - Marković, Rade
AU  - Petković, Miloš
AU  - Nasufović, Veselin
AU  - Savić, Vladimir
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1527
AB  - A base promoted cyclization of the protected N-propargylaminopyridines was shown to be an efficient method for the preparation of imidazo[1,2-a] pyridine derivatives. The reactions were carried out with a small excess of base, at room temperature or slightly above producing the heterocyclic products in moderate to good yields. The stereoelectronic properties of substituents on the pyridine ring were shown to influence the cyclization process.
PB  - Amer Chemical Soc, Washington
T2  - Organic Letters
T1  - A Base Promoted Cyclization of N-Propargylaminopyridines. Synthesis of Imidazo[1,2-a]pyridine Derivatives
VL  - 13
IS  - 9
SP  - 2286
EP  - 2289
DO  - 10.1021/ol200508x
ER  - 
@article{
author = "Husinec, Suren and Marković, Rade and Petković, Miloš and Nasufović, Veselin and Savić, Vladimir",
year = "2011",
abstract = "A base promoted cyclization of the protected N-propargylaminopyridines was shown to be an efficient method for the preparation of imidazo[1,2-a] pyridine derivatives. The reactions were carried out with a small excess of base, at room temperature or slightly above producing the heterocyclic products in moderate to good yields. The stereoelectronic properties of substituents on the pyridine ring were shown to influence the cyclization process.",
publisher = "Amer Chemical Soc, Washington",
journal = "Organic Letters",
title = "A Base Promoted Cyclization of N-Propargylaminopyridines. Synthesis of Imidazo[1,2-a]pyridine Derivatives",
volume = "13",
number = "9",
pages = "2286-2289",
doi = "10.1021/ol200508x"
}
Husinec, S., Marković, R., Petković, M., Nasufović, V.,& Savić, V.. (2011). A Base Promoted Cyclization of N-Propargylaminopyridines. Synthesis of Imidazo[1,2-a]pyridine Derivatives. in Organic Letters
Amer Chemical Soc, Washington., 13(9), 2286-2289.
https://doi.org/10.1021/ol200508x
Husinec S, Marković R, Petković M, Nasufović V, Savić V. A Base Promoted Cyclization of N-Propargylaminopyridines. Synthesis of Imidazo[1,2-a]pyridine Derivatives. in Organic Letters. 2011;13(9):2286-2289.
doi:10.1021/ol200508x .
Husinec, Suren, Marković, Rade, Petković, Miloš, Nasufović, Veselin, Savić, Vladimir, "A Base Promoted Cyclization of N-Propargylaminopyridines. Synthesis of Imidazo[1,2-a]pyridine Derivatives" in Organic Letters, 13, no. 9 (2011):2286-2289,
https://doi.org/10.1021/ol200508x . .
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54

Palladium-catalysed synthesis of allyl acetates from allenes

Husinec, Suren; Jadranin, Milka; Marković, Rade; Petković, Miloš; Savić, Vladimir; Todorović, Nina

(Pergamon-Elsevier Science Ltd, Oxford, 2010)

TY  - JOUR
AU  - Husinec, Suren
AU  - Jadranin, Milka
AU  - Marković, Rade
AU  - Petković, Miloš
AU  - Savić, Vladimir
AU  - Todorović, Nina
PY  - 2010
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1382
AB  - Allyl acetates were synthesised from allenes utilising methodology based on the general reactivity of pi-allyl palladium intermediates which participate efficiently in transformations involving nucleophiles. Reactions of allenes and aryl iodides in the presence of AcONa and Pd(OAc)(2)/PPh(3) as the catalytic system afforded allyl acetates in moderate to good yields. Monosubstituted allenes, depending on their structure, produced either a separable mixture of two regioisomeric products or a single regioisomer. As allylic acetates can be easily hydrolysed, the methodology is applicable for the synthesis of allyl alcohols as well.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Tetrahedron-Asymmetry
T1  - Palladium-catalysed synthesis of allyl acetates from allenes
VL  - 51
IS  - 31
SP  - 4066
EP  - 4068
DO  - 10.1016/j.tetlet.2010.05.136
ER  - 
@article{
author = "Husinec, Suren and Jadranin, Milka and Marković, Rade and Petković, Miloš and Savić, Vladimir and Todorović, Nina",
year = "2010",
abstract = "Allyl acetates were synthesised from allenes utilising methodology based on the general reactivity of pi-allyl palladium intermediates which participate efficiently in transformations involving nucleophiles. Reactions of allenes and aryl iodides in the presence of AcONa and Pd(OAc)(2)/PPh(3) as the catalytic system afforded allyl acetates in moderate to good yields. Monosubstituted allenes, depending on their structure, produced either a separable mixture of two regioisomeric products or a single regioisomer. As allylic acetates can be easily hydrolysed, the methodology is applicable for the synthesis of allyl alcohols as well.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Tetrahedron-Asymmetry",
title = "Palladium-catalysed synthesis of allyl acetates from allenes",
volume = "51",
number = "31",
pages = "4066-4068",
doi = "10.1016/j.tetlet.2010.05.136"
}
Husinec, S., Jadranin, M., Marković, R., Petković, M., Savić, V.,& Todorović, N.. (2010). Palladium-catalysed synthesis of allyl acetates from allenes. in Tetrahedron-Asymmetry
Pergamon-Elsevier Science Ltd, Oxford., 51(31), 4066-4068.
https://doi.org/10.1016/j.tetlet.2010.05.136
Husinec S, Jadranin M, Marković R, Petković M, Savić V, Todorović N. Palladium-catalysed synthesis of allyl acetates from allenes. in Tetrahedron-Asymmetry. 2010;51(31):4066-4068.
doi:10.1016/j.tetlet.2010.05.136 .
Husinec, Suren, Jadranin, Milka, Marković, Rade, Petković, Miloš, Savić, Vladimir, Todorović, Nina, "Palladium-catalysed synthesis of allyl acetates from allenes" in Tetrahedron-Asymmetry, 51, no. 31 (2010):4066-4068,
https://doi.org/10.1016/j.tetlet.2010.05.136 . .
10
12
12

Stereoselective cyclo-addition reactions of azomethine ylides catalysed by in situ generated Ag(I)/bisphosphine complexes

Grigg, Ronald; Husinec, Suren; Savić, Vladimir

(Srpsko hemijsko društvo, Beograd, 2010)

TY  - JOUR
AU  - Grigg, Ronald
AU  - Husinec, Suren
AU  - Savić, Vladimir
PY  - 2010
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1417
AB  - Stereoselective cyclo-addition reactions of azomethine ylides promoted by in situ generated Ag(I)/bisphosphine complexes were studied. Under the optimized conditions, the pyrrolidine products were isolated in up to 84 % yield and with up to 71% e.e. The effects of various reaction variables on the stereoselectivity were also investigated.
AB  - Proučavane su stereoselektivne cikloadicione reakcije azometinskih ilida katalizovane kompleksima srebra i bisfosfinskog liganda generisanih in situ. Pirolidinski derivati izolovani su u dobrim prinosima i sa enantioselektivnošću do 71%. Proučavani su takođe i efekti reakcionih uslova na stereoselektivnost ovih reakcija.
PB  - Srpsko hemijsko društvo, Beograd
T2  - Journal of the Serbian Chemical Society
T1  - Stereoselective cyclo-addition reactions of azomethine ylides catalysed by in situ generated Ag(I)/bisphosphine complexes
T1  - Stereoselektivne cikloadicione reakcije azometinskih ilida katalizovane in situ generisanim Ag(I)/bisfosfinskim kompleksima
VL  - 75
IS  - 1
SP  - 1
EP  - 9
DO  - 10.2298/JSC1001001G
ER  - 
@article{
author = "Grigg, Ronald and Husinec, Suren and Savić, Vladimir",
year = "2010",
abstract = "Stereoselective cyclo-addition reactions of azomethine ylides promoted by in situ generated Ag(I)/bisphosphine complexes were studied. Under the optimized conditions, the pyrrolidine products were isolated in up to 84 % yield and with up to 71% e.e. The effects of various reaction variables on the stereoselectivity were also investigated., Proučavane su stereoselektivne cikloadicione reakcije azometinskih ilida katalizovane kompleksima srebra i bisfosfinskog liganda generisanih in situ. Pirolidinski derivati izolovani su u dobrim prinosima i sa enantioselektivnošću do 71%. Proučavani su takođe i efekti reakcionih uslova na stereoselektivnost ovih reakcija.",
publisher = "Srpsko hemijsko društvo, Beograd",
journal = "Journal of the Serbian Chemical Society",
title = "Stereoselective cyclo-addition reactions of azomethine ylides catalysed by in situ generated Ag(I)/bisphosphine complexes, Stereoselektivne cikloadicione reakcije azometinskih ilida katalizovane in situ generisanim Ag(I)/bisfosfinskim kompleksima",
volume = "75",
number = "1",
pages = "1-9",
doi = "10.2298/JSC1001001G"
}
Grigg, R., Husinec, S.,& Savić, V.. (2010). Stereoselective cyclo-addition reactions of azomethine ylides catalysed by in situ generated Ag(I)/bisphosphine complexes. in Journal of the Serbian Chemical Society
Srpsko hemijsko društvo, Beograd., 75(1), 1-9.
https://doi.org/10.2298/JSC1001001G
Grigg R, Husinec S, Savić V. Stereoselective cyclo-addition reactions of azomethine ylides catalysed by in situ generated Ag(I)/bisphosphine complexes. in Journal of the Serbian Chemical Society. 2010;75(1):1-9.
doi:10.2298/JSC1001001G .
Grigg, Ronald, Husinec, Suren, Savić, Vladimir, "Stereoselective cyclo-addition reactions of azomethine ylides catalysed by in situ generated Ag(I)/bisphosphine complexes" in Journal of the Serbian Chemical Society, 75, no. 1 (2010):1-9,
https://doi.org/10.2298/JSC1001001G . .
2
2
2

TLC Retention Behavior of Brodifacoum, Bromadiolone, and Coumatetralyl and their Impurities on Different Adsorbents

Tosti, Tomislav; Rakić, Gordana; Natić, Maja; Milojković-Opsenica, Dušanka; Husinec, Suren; Savić, Vladimir; Tešić, Živoslav

(Akademiai Kiado Zrt, Budapest, 2009)

TY  - JOUR
AU  - Tosti, Tomislav
AU  - Rakić, Gordana
AU  - Natić, Maja
AU  - Milojković-Opsenica, Dušanka
AU  - Husinec, Suren
AU  - Savić, Vladimir
AU  - Tešić, Živoslav
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1199
AB  - The chromatographic behavior of three biocidal technical materials, rodenticide active ingredients brodifacoum, bromadiolone, and coumatetralyl, and impurities present in the technical material was investigated by both normal-phase (NP) and reversed-phase (RP) planar chromatography. The research was carried out using thin-layers of silica gel, alumina, cellulose, and C-18 silica. Several solvents on their own or in various combinations and proportions were used for separation. The optimum chromatographic systems for separation of the substances from each other and from their impurities were selected. Under reversed-phase chromatographic (RPC) conditions a linear correlation between R-M values and mobile phase composition was established. From results obtained, the lipophilicity R-M(o) and C-0 were determined. Possible separation mechanisms are discussed on the basis of the established retention behavior.
PB  - Akademiai Kiado Zrt, Budapest
T2  - Journal of Planar Chromatography - Modern TLC
T1  - TLC Retention Behavior of Brodifacoum, Bromadiolone, and Coumatetralyl and their Impurities on Different Adsorbents
VL  - 22
IS  - 5
SP  - 333
EP  - 343
DO  - 10.1556/JPC.22.2009.5.4
ER  - 
@article{
author = "Tosti, Tomislav and Rakić, Gordana and Natić, Maja and Milojković-Opsenica, Dušanka and Husinec, Suren and Savić, Vladimir and Tešić, Živoslav",
year = "2009",
abstract = "The chromatographic behavior of three biocidal technical materials, rodenticide active ingredients brodifacoum, bromadiolone, and coumatetralyl, and impurities present in the technical material was investigated by both normal-phase (NP) and reversed-phase (RP) planar chromatography. The research was carried out using thin-layers of silica gel, alumina, cellulose, and C-18 silica. Several solvents on their own or in various combinations and proportions were used for separation. The optimum chromatographic systems for separation of the substances from each other and from their impurities were selected. Under reversed-phase chromatographic (RPC) conditions a linear correlation between R-M values and mobile phase composition was established. From results obtained, the lipophilicity R-M(o) and C-0 were determined. Possible separation mechanisms are discussed on the basis of the established retention behavior.",
publisher = "Akademiai Kiado Zrt, Budapest",
journal = "Journal of Planar Chromatography - Modern TLC",
title = "TLC Retention Behavior of Brodifacoum, Bromadiolone, and Coumatetralyl and their Impurities on Different Adsorbents",
volume = "22",
number = "5",
pages = "333-343",
doi = "10.1556/JPC.22.2009.5.4"
}
Tosti, T., Rakić, G., Natić, M., Milojković-Opsenica, D., Husinec, S., Savić, V.,& Tešić, Ž.. (2009). TLC Retention Behavior of Brodifacoum, Bromadiolone, and Coumatetralyl and their Impurities on Different Adsorbents. in Journal of Planar Chromatography - Modern TLC
Akademiai Kiado Zrt, Budapest., 22(5), 333-343.
https://doi.org/10.1556/JPC.22.2009.5.4
Tosti T, Rakić G, Natić M, Milojković-Opsenica D, Husinec S, Savić V, Tešić Ž. TLC Retention Behavior of Brodifacoum, Bromadiolone, and Coumatetralyl and their Impurities on Different Adsorbents. in Journal of Planar Chromatography - Modern TLC. 2009;22(5):333-343.
doi:10.1556/JPC.22.2009.5.4 .
Tosti, Tomislav, Rakić, Gordana, Natić, Maja, Milojković-Opsenica, Dušanka, Husinec, Suren, Savić, Vladimir, Tešić, Živoslav, "TLC Retention Behavior of Brodifacoum, Bromadiolone, and Coumatetralyl and their Impurities on Different Adsorbents" in Journal of Planar Chromatography - Modern TLC, 22, no. 5 (2009):333-343,
https://doi.org/10.1556/JPC.22.2009.5.4 . .
3
3
4

Chiral catalysts in the stereoselective synthesis of pyrrolidine derivatives via metallo-azomethine ylides

Husinec, Suren; Savić, Vladimir

(Pergamon-Elsevier Science Ltd, Oxford, 2005)

TY  - JOUR
AU  - Husinec, Suren
AU  - Savić, Vladimir
PY  - 2005
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/580
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Therapeutic Advances in Drug Safety
T1  - Chiral catalysts in the stereoselective synthesis of pyrrolidine derivatives via metallo-azomethine ylides
VL  - 16
IS  - 12
SP  - 2047
EP  - 2061
DO  - 10.1016/j.tetasy.2005.05.020
ER  - 
@article{
author = "Husinec, Suren and Savić, Vladimir",
year = "2005",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Therapeutic Advances in Drug Safety",
title = "Chiral catalysts in the stereoselective synthesis of pyrrolidine derivatives via metallo-azomethine ylides",
volume = "16",
number = "12",
pages = "2047-2061",
doi = "10.1016/j.tetasy.2005.05.020"
}
Husinec, S.,& Savić, V.. (2005). Chiral catalysts in the stereoselective synthesis of pyrrolidine derivatives via metallo-azomethine ylides. in Therapeutic Advances in Drug Safety
Pergamon-Elsevier Science Ltd, Oxford., 16(12), 2047-2061.
https://doi.org/10.1016/j.tetasy.2005.05.020
Husinec S, Savić V. Chiral catalysts in the stereoselective synthesis of pyrrolidine derivatives via metallo-azomethine ylides. in Therapeutic Advances in Drug Safety. 2005;16(12):2047-2061.
doi:10.1016/j.tetasy.2005.05.020 .
Husinec, Suren, Savić, Vladimir, "Chiral catalysts in the stereoselective synthesis of pyrrolidine derivatives via metallo-azomethine ylides" in Therapeutic Advances in Drug Safety, 16, no. 12 (2005):2047-2061,
https://doi.org/10.1016/j.tetasy.2005.05.020 . .
6
184
154
163

The synthesis of some unsaturated 4-substituted-g-lactones

Husinec, Suren; Savić, Vladimir

(Srpsko hemijsko društvo, Beograd, 2000)

TY  - JOUR
AU  - Husinec, Suren
AU  - Savić, Vladimir
PY  - 2000
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/259
AB  - The synthesis of conjugated and nonconjugated unsaturated 4-substituted lactones of type 1 and 2 are described. The type 1 lactone was prepared by a two step procedure employing Bredereck's reagent. The type 2 lactone was synthesized by combining the Claisen-Ireland rearrangement and selenolactonisation.
AB  - Razvijeni su relativno jednostavni sintetski putevi za dobijanje konjugovanih i nekonjugovanih d-laktona koji imaju strukture tipa 1 i 2. Lakton tipa 1 je sintetisan uvođenjem egzociklične dvostruke veze uz korišćenje Bredereck-ovog reagensa, dok je lakton tipa 2 dobijen primenom Claisen-Ireland-ovog premeštanja i selenolaktonizacije.
PB  - Srpsko hemijsko društvo, Beograd
T2  - Journal of the Serbian Chemical Society
T1  - The synthesis of some unsaturated 4-substituted-g-lactones
T1  - Sinteza nekih nezasićenih 4-supstituisanih-g-laktona
VL  - 65
IS  - 2
SP  - 87
EP  - 93
UR  - https://hdl.handle.net/21.15107/rcub_farfar_259
ER  - 
@article{
author = "Husinec, Suren and Savić, Vladimir",
year = "2000",
abstract = "The synthesis of conjugated and nonconjugated unsaturated 4-substituted lactones of type 1 and 2 are described. The type 1 lactone was prepared by a two step procedure employing Bredereck's reagent. The type 2 lactone was synthesized by combining the Claisen-Ireland rearrangement and selenolactonisation., Razvijeni su relativno jednostavni sintetski putevi za dobijanje konjugovanih i nekonjugovanih d-laktona koji imaju strukture tipa 1 i 2. Lakton tipa 1 je sintetisan uvođenjem egzociklične dvostruke veze uz korišćenje Bredereck-ovog reagensa, dok je lakton tipa 2 dobijen primenom Claisen-Ireland-ovog premeštanja i selenolaktonizacije.",
publisher = "Srpsko hemijsko društvo, Beograd",
journal = "Journal of the Serbian Chemical Society",
title = "The synthesis of some unsaturated 4-substituted-g-lactones, Sinteza nekih nezasićenih 4-supstituisanih-g-laktona",
volume = "65",
number = "2",
pages = "87-93",
url = "https://hdl.handle.net/21.15107/rcub_farfar_259"
}
Husinec, S.,& Savić, V.. (2000). The synthesis of some unsaturated 4-substituted-g-lactones. in Journal of the Serbian Chemical Society
Srpsko hemijsko društvo, Beograd., 65(2), 87-93.
https://hdl.handle.net/21.15107/rcub_farfar_259
Husinec S, Savić V. The synthesis of some unsaturated 4-substituted-g-lactones. in Journal of the Serbian Chemical Society. 2000;65(2):87-93.
https://hdl.handle.net/21.15107/rcub_farfar_259 .
Husinec, Suren, Savić, Vladimir, "The synthesis of some unsaturated 4-substituted-g-lactones" in Journal of the Serbian Chemical Society, 65, no. 2 (2000):87-93,
https://hdl.handle.net/21.15107/rcub_farfar_259 .