TY  - JOUR
AU  - Jančić-Stojanović, Biljana
AU  - Malenović, Anđelija
AU  - Marković, Slavko
AU  - Ivanović, Darko
AU  - Medenica, Mirjana
PY  - 2010
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1371
AB  - An RP-HPLC method has been optimized and validated for the simultaneous determination of hydrocortisone acetate and of lidocaine in suppositories. For the method optimization, response surface methodology was applied, and the obtained model was tested using analysis of variance. The optimal separations were conducted on a Beckman-Coulter 150 x 4.6 mm, 5 pm particle-size column at 20 degrees C. The mobile phase was methanol-water (65 + 35, v/v), pH adjusted to 2.5 with 85% orthophosphoric acid, with a flow rate of 1.0 mL/min. UV detection was performed at 250 nm. Phenobarbital was used as an internal standard. The method was validated for selectivity, linearity, precision, and robustness.
PB  - AOAC Int, Gaithersburg
T2  - Journal of AOAC International
T1  - Optimization and Validation of an RP-HPLC Method for Analysis of Hydrocortisone Acetate and Lidocaine in Suppositories
VL  - 93
IS  - 1
SP  - 102
EP  - 107
DO  - 10.1093/jaoac/93.1.102
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1371
ER  - 

@article{
author = "Jančić-Stojanović, Biljana and Malenović, Anđelija and Marković, Slavko and Ivanović, Darko and Medenica, Mirjana",
year = "2010",
abstract = "An RP-HPLC method has been optimized and validated for the simultaneous determination of hydrocortisone acetate and of lidocaine in suppositories. For the method optimization, response surface methodology was applied, and the obtained model was tested using analysis of variance. The optimal separations were conducted on a Beckman-Coulter 150 x 4.6 mm, 5 pm particle-size column at 20 degrees C. The mobile phase was methanol-water (65 + 35, v/v), pH adjusted to 2.5 with 85% orthophosphoric acid, with a flow rate of 1.0 mL/min. UV detection was performed at 250 nm. Phenobarbital was used as an internal standard. The method was validated for selectivity, linearity, precision, and robustness.",
publisher = "AOAC Int, Gaithersburg",
journal = "Journal of AOAC International",
title = "Optimization and Validation of an RP-HPLC Method for Analysis of Hydrocortisone Acetate and Lidocaine in Suppositories",
volume = "93",
number = "1",
pages = "102-107",
doi = "10.1093/jaoac/93.1.102",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1371"
}

Jančić-Stojanović, B., Malenović, A., Marković, S., Ivanović, D.,& Medenica, M.. (2010). Optimization and Validation of an RP-HPLC Method for Analysis of Hydrocortisone Acetate and Lidocaine in Suppositories. in Journal of AOAC International
AOAC Int, Gaithersburg., 93(1), 102-107.
https://doi.org/10.1093/jaoac/93.1.102
https://hdl.handle.net/21.15107/rcub_farfar_1371

Jančić-Stojanović B, Malenović A, Marković S, Ivanović D, Medenica M. Optimization and Validation of an RP-HPLC Method for Analysis of Hydrocortisone Acetate and Lidocaine in Suppositories. in Journal of AOAC International. 2010;93(1):102-107.
doi:10.1093/jaoac/93.1.102
https://hdl.handle.net/21.15107/rcub_farfar_1371 .

Jančić-Stojanović, Biljana, Malenović, Anđelija, Marković, Slavko, Ivanović, Darko, Medenica, Mirjana, "Optimization and Validation of an RP-HPLC Method for Analysis of Hydrocortisone Acetate and Lidocaine in Suppositories" in Journal of AOAC International, 93, no. 1 (2010):102-107,
https://doi.org/10.1093/jaoac/93.1.102 .,
https://hdl.handle.net/21.15107/rcub_farfar_1371 .

TY  - JOUR
AU  - Letica, Jelena
AU  - Marković, Slavko
AU  - Zirojević, Jelena
AU  - Nikolić, Katarina
AU  - Agbaba, Danica
PY  - 2010
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1334
AB  - An RP-HPLC method for simultaneous separation and quantification of pantoprazole and its five main impurities in pharmaceutical formulations was developed and validated. The separation was accomplished on a Zorbax Eclipse XDB C18 column (5 mu m particle size, 150 x 4.6 mm id) using a gradient with mobile phase A [buffer-acetonitrile (70 + 30, v/v)], and mobile phase B [buffer-acetonitrile (30 + 70, v/v)]. The buffer was 0.01 M ammonium acetate solution with addition of 1 mL triethylamine/L of the solution, adjusted to pH 4.5 with orthophosphoric acid. The eluent flow rate was 1 mL/min, the temperature of the column was 30 C, and the eluate was monitored at 290 nm. Linearity (r = 0.999), recovery (97.6-105.8%), RSD (0.55-1.90%), and LOQ (0.099-1.48 mu g/mL) were evaluated and found to be satisfactory. The proposed method can be used for simultaneous identification and quantification of the analyzed compounds in pharmaceutical formulations.
PB  - AOAC Int, Gaithersburg
T2  - Journal of AOAC International
T1  - High-Performance Liquid Chromatographic Determination of Pantoprazole and Its Main Impurities in Pharmaceuticals
VL  - 93
IS  - 4
SP  - 1121
EP  - 1128
DO  - 10.1093/jaoac/93.4.1121
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1334
ER  - 

@article{
author = "Letica, Jelena and Marković, Slavko and Zirojević, Jelena and Nikolić, Katarina and Agbaba, Danica",
year = "2010",
abstract = "An RP-HPLC method for simultaneous separation and quantification of pantoprazole and its five main impurities in pharmaceutical formulations was developed and validated. The separation was accomplished on a Zorbax Eclipse XDB C18 column (5 mu m particle size, 150 x 4.6 mm id) using a gradient with mobile phase A [buffer-acetonitrile (70 + 30, v/v)], and mobile phase B [buffer-acetonitrile (30 + 70, v/v)]. The buffer was 0.01 M ammonium acetate solution with addition of 1 mL triethylamine/L of the solution, adjusted to pH 4.5 with orthophosphoric acid. The eluent flow rate was 1 mL/min, the temperature of the column was 30 C, and the eluate was monitored at 290 nm. Linearity (r = 0.999), recovery (97.6-105.8%), RSD (0.55-1.90%), and LOQ (0.099-1.48 mu g/mL) were evaluated and found to be satisfactory. The proposed method can be used for simultaneous identification and quantification of the analyzed compounds in pharmaceutical formulations.",
publisher = "AOAC Int, Gaithersburg",
journal = "Journal of AOAC International",
title = "High-Performance Liquid Chromatographic Determination of Pantoprazole and Its Main Impurities in Pharmaceuticals",
volume = "93",
number = "4",
pages = "1121-1128",
doi = "10.1093/jaoac/93.4.1121",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1334"
}

Letica, J., Marković, S., Zirojević, J., Nikolić, K.,& Agbaba, D.. (2010). High-Performance Liquid Chromatographic Determination of Pantoprazole and Its Main Impurities in Pharmaceuticals. in Journal of AOAC International
AOAC Int, Gaithersburg., 93(4), 1121-1128.
https://doi.org/10.1093/jaoac/93.4.1121
https://hdl.handle.net/21.15107/rcub_farfar_1334

Letica J, Marković S, Zirojević J, Nikolić K, Agbaba D. High-Performance Liquid Chromatographic Determination of Pantoprazole and Its Main Impurities in Pharmaceuticals. in Journal of AOAC International. 2010;93(4):1121-1128.
doi:10.1093/jaoac/93.4.1121
https://hdl.handle.net/21.15107/rcub_farfar_1334 .

Letica, Jelena, Marković, Slavko, Zirojević, Jelena, Nikolić, Katarina, Agbaba, Danica, "High-Performance Liquid Chromatographic Determination of Pantoprazole and Its Main Impurities in Pharmaceuticals" in Journal of AOAC International, 93, no. 4 (2010):1121-1128,
https://doi.org/10.1093/jaoac/93.4.1121 .,
https://hdl.handle.net/21.15107/rcub_farfar_1334 .

TY  - JOUR
AU  - Nikolić, Katarina
AU  - Ivković, Branka
AU  - Besović, Željka
AU  - Marković, Slavko
AU  - Agbaba, Danica
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1202
AB  - A new and accurate HPLC method using beta-cyclodextrin chemically bonded to spherical silica particles as chiral stationary phase (CSP) was developed and validated for determination of S-clopidogrel and its impurities R-enantiomer and S-acid as a hydrolytic product. The effects of acetonitrile and methanol content in the mobile phase and temperature on the resolution and retention of enantiomers were investigated. A satisfactory resolution of S-clopidogrel active form and its impurities was achieved on ChiraDex(R) column (5 mu m, 4 x 250 mm) at a flow rate of 1.0 ml/min and 17 degrees C using acetonitrile, methanol and 0.01 M potassium dihydrogen phosphate solution (15:5:80 v/v/v) as mobile phase. The detection wavelength was set at 220 nm. The method was validated in terms of accuracy, precision, linearity, and robustness. The limit of detection for R-enantiomer and S-acid were 0.75 and 0.09 mu g/ml, respectively, injection volume being 20 mu l. Finally, the molecular modeling of the inclusion complexes between the analytes and beta-cyclodextrin was performed to investigate the mechanism of the enantiorecognition and to study the quantitative structure-retention relationships. Chirality 21:878-885, 2009.
PB  - Wiley, Hoboken
T2  - Chirality
T1  - A Validated Enantiospecific Method for Determination and Purity Assay of Clopridogrel
VL  - 21
IS  - 10
SP  - 878
EP  - 885
DO  - 10.1002/chir.20681
ER  - 

@article{
author = "Nikolić, Katarina and Ivković, Branka and Besović, Željka and Marković, Slavko and Agbaba, Danica",
year = "2009",
abstract = "A new and accurate HPLC method using beta-cyclodextrin chemically bonded to spherical silica particles as chiral stationary phase (CSP) was developed and validated for determination of S-clopidogrel and its impurities R-enantiomer and S-acid as a hydrolytic product. The effects of acetonitrile and methanol content in the mobile phase and temperature on the resolution and retention of enantiomers were investigated. A satisfactory resolution of S-clopidogrel active form and its impurities was achieved on ChiraDex(R) column (5 mu m, 4 x 250 mm) at a flow rate of 1.0 ml/min and 17 degrees C using acetonitrile, methanol and 0.01 M potassium dihydrogen phosphate solution (15:5:80 v/v/v) as mobile phase. The detection wavelength was set at 220 nm. The method was validated in terms of accuracy, precision, linearity, and robustness. The limit of detection for R-enantiomer and S-acid were 0.75 and 0.09 mu g/ml, respectively, injection volume being 20 mu l. Finally, the molecular modeling of the inclusion complexes between the analytes and beta-cyclodextrin was performed to investigate the mechanism of the enantiorecognition and to study the quantitative structure-retention relationships. Chirality 21:878-885, 2009.",
publisher = "Wiley, Hoboken",
journal = "Chirality",
title = "A Validated Enantiospecific Method for Determination and Purity Assay of Clopridogrel",
volume = "21",
number = "10",
pages = "878-885",
doi = "10.1002/chir.20681"
}

Nikolić, K., Ivković, B., Besović, Ž., Marković, S.,& Agbaba, D.. (2009). A Validated Enantiospecific Method for Determination and Purity Assay of Clopridogrel. in Chirality
Wiley, Hoboken., 21(10), 878-885.
https://doi.org/10.1002/chir.20681

Nikolić K, Ivković B, Besović Ž, Marković S, Agbaba D. A Validated Enantiospecific Method for Determination and Purity Assay of Clopridogrel. in Chirality. 2009;21(10):878-885.
doi:10.1002/chir.20681 .

Nikolić, Katarina, Ivković, Branka, Besović, Željka, Marković, Slavko, Agbaba, Danica, "A Validated Enantiospecific Method for Determination and Purity Assay of Clopridogrel" in Chirality, 21, no. 10 (2009):878-885,
https://doi.org/10.1002/chir.20681 . .

TY  - JOUR
AU  - Miseljić, Branislava
AU  - Popović, Gordana
AU  - Agbaba, Danica
AU  - Marković, Slavko
AU  - Simonovska, Breda
AU  - Vovk, Irena
PY  - 2008
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1077
AB  - A gradient reversed-phase column high-performance liquid chromatographic method was developed for the detection and quantification of norfloxacin and its major impurities in norfloxacin-containing pharmaceuticals. Chromatographic separations were performed under the following experimental conditions: column, Zorbax SB RP-18 (5 mu m, 250 x 4.6 mm); injection volume, 20 mu L; mobile phase, 0.05 M NaH2PO4 (pH 2.5)-acetonitrile (87 + 13) for 16 min and (58 + 42) for 9 min (stepwise gradient); and flow rate, 1.3 mL/min. All analyses were performed at 25 degrees C, and the eluate was monitored at 275 nm using a diode array detector. Linearity (correlation coefficient = 0.999), recovery (99.3-101.8%), relative standard deviation (0.2-0.7%), and quantitation limit (0.12-0.47 mu g/mL) were evaluated and found to be satisfactory. The method is simple, rapid, and convenient for purity control of norfloxacin in both raw materials and dosage forms.
PB  - AOAC Int, Gaithersburg
T2  - Journal of AOAC International
T1  - Column high-performance liquid chromatographic determination of norfloxacin and its main impurities in pharmaceuticals
VL  - 91
IS  - 2
SP  - 332
EP  - 338
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1077
ER  - 

@article{
author = "Miseljić, Branislava and Popović, Gordana and Agbaba, Danica and Marković, Slavko and Simonovska, Breda and Vovk, Irena",
year = "2008",
abstract = "A gradient reversed-phase column high-performance liquid chromatographic method was developed for the detection and quantification of norfloxacin and its major impurities in norfloxacin-containing pharmaceuticals. Chromatographic separations were performed under the following experimental conditions: column, Zorbax SB RP-18 (5 mu m, 250 x 4.6 mm); injection volume, 20 mu L; mobile phase, 0.05 M NaH2PO4 (pH 2.5)-acetonitrile (87 + 13) for 16 min and (58 + 42) for 9 min (stepwise gradient); and flow rate, 1.3 mL/min. All analyses were performed at 25 degrees C, and the eluate was monitored at 275 nm using a diode array detector. Linearity (correlation coefficient = 0.999), recovery (99.3-101.8%), relative standard deviation (0.2-0.7%), and quantitation limit (0.12-0.47 mu g/mL) were evaluated and found to be satisfactory. The method is simple, rapid, and convenient for purity control of norfloxacin in both raw materials and dosage forms.",
publisher = "AOAC Int, Gaithersburg",
journal = "Journal of AOAC International",
title = "Column high-performance liquid chromatographic determination of norfloxacin and its main impurities in pharmaceuticals",
volume = "91",
number = "2",
pages = "332-338",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1077"
}

Miseljić, B., Popović, G., Agbaba, D., Marković, S., Simonovska, B.,& Vovk, I.. (2008). Column high-performance liquid chromatographic determination of norfloxacin and its main impurities in pharmaceuticals. in Journal of AOAC International
AOAC Int, Gaithersburg., 91(2), 332-338.
https://hdl.handle.net/21.15107/rcub_farfar_1077

Miseljić B, Popović G, Agbaba D, Marković S, Simonovska B, Vovk I. Column high-performance liquid chromatographic determination of norfloxacin and its main impurities in pharmaceuticals. in Journal of AOAC International. 2008;91(2):332-338.
https://hdl.handle.net/21.15107/rcub_farfar_1077 .

Miseljić, Branislava, Popović, Gordana, Agbaba, Danica, Marković, Slavko, Simonovska, Breda, Vovk, Irena, "Column high-performance liquid chromatographic determination of norfloxacin and its main impurities in pharmaceuticals" in Journal of AOAC International, 91, no. 2 (2008):332-338,
https://hdl.handle.net/21.15107/rcub_farfar_1077 .