TY  - JOUR
AU  - Rmandić, Milena
AU  - Stajić, Ana
AU  - Jančić, Jasna
AU  - Samardžić, Janko
AU  - Jović, Nebojša
AU  - Malenović, Anđelija
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4262
AB  - In this research, a UHPLC–MS/MS method was developed and validated for the deter-
mination of zonisamide in dried plasma spots (DPS) and dried blood spots (DBS). Detection of
zonisamide and internal standard, 1-(2,3-dichlorphenyl)piperazine, was carried out in ESI+ mode by
monitoring two MRM transitions per analyte. Total run time, less than 2.5 min, was achieved using
Acquity UPLC BEH Amide (2.1 × 100 mm, 1.7 μm particle size) column with mobile phase com-
prising acetonitrile–water (85:15%, v/v) with 0.075% formic acid. The flow rate was 0.225 mL/min,
the column temperature was 30 ◦C and the injection volume was 3 μL. Desolvation temperature,
desolvation gas flow rate, ion source temperature and cone gas flow rate were set by the IntelliStart
software tool in combination with tuning. All of the Guthrie cards were scanned, and DPS/DBS
areas were determined by the image processing tool. The influence of hematocrit values (20–60%)
on accuracy and precision was evaluated to determine the range within which method for DBSs is
free from Hct or dependency is within acceptable limits. The validated method was applied to the
determination of zonisamide levels in DPS and DBS samples obtained from patients confirming its
suitability for clinical application. Finally, the distribution of zonisamide into the red blood cells was
estimated by correlating its DPS and DBS levels.
PB  - MDPI
T2  - Molecules
T1  - Quantification of Zonisamide in Dried Blood Spots and Dried Plasma Spots by UPLC–MS/MS: Application to Clinical Practice
VL  - 27
IS  - 15
DO  - 10.3390/molecules27154899
ER  - 

@article{
author = "Rmandić, Milena and Stajić, Ana and Jančić, Jasna and Samardžić, Janko and Jović, Nebojša and Malenović, Anđelija",
year = "2022",
abstract = "In this research, a UHPLC–MS/MS method was developed and validated for the deter-
mination of zonisamide in dried plasma spots (DPS) and dried blood spots (DBS). Detection of
zonisamide and internal standard, 1-(2,3-dichlorphenyl)piperazine, was carried out in ESI+ mode by
monitoring two MRM transitions per analyte. Total run time, less than 2.5 min, was achieved using
Acquity UPLC BEH Amide (2.1 × 100 mm, 1.7 μm particle size) column with mobile phase com-
prising acetonitrile–water (85:15%, v/v) with 0.075% formic acid. The flow rate was 0.225 mL/min,
the column temperature was 30 ◦C and the injection volume was 3 μL. Desolvation temperature,
desolvation gas flow rate, ion source temperature and cone gas flow rate were set by the IntelliStart
software tool in combination with tuning. All of the Guthrie cards were scanned, and DPS/DBS
areas were determined by the image processing tool. The influence of hematocrit values (20–60%)
on accuracy and precision was evaluated to determine the range within which method for DBSs is
free from Hct or dependency is within acceptable limits. The validated method was applied to the
determination of zonisamide levels in DPS and DBS samples obtained from patients confirming its
suitability for clinical application. Finally, the distribution of zonisamide into the red blood cells was
estimated by correlating its DPS and DBS levels.",
publisher = "MDPI",
journal = "Molecules",
title = "Quantification of Zonisamide in Dried Blood Spots and Dried Plasma Spots by UPLC–MS/MS: Application to Clinical Practice",
volume = "27",
number = "15",
doi = "10.3390/molecules27154899"
}

Rmandić, M., Stajić, A., Jančić, J., Samardžić, J., Jović, N.,& Malenović, A.. (2022). Quantification of Zonisamide in Dried Blood Spots and Dried Plasma Spots by UPLC–MS/MS: Application to Clinical Practice. in Molecules
MDPI., 27(15).
https://doi.org/10.3390/molecules27154899

Rmandić M, Stajić A, Jančić J, Samardžić J, Jović N, Malenović A. Quantification of Zonisamide in Dried Blood Spots and Dried Plasma Spots by UPLC–MS/MS: Application to Clinical Practice. in Molecules. 2022;27(15).
doi:10.3390/molecules27154899 .

Rmandić, Milena, Stajić, Ana, Jančić, Jasna, Samardžić, Janko, Jović, Nebojša, Malenović, Anđelija, "Quantification of Zonisamide in Dried Blood Spots and Dried Plasma Spots by UPLC–MS/MS: Application to Clinical Practice" in Molecules, 27, no. 15 (2022),
https://doi.org/10.3390/molecules27154899 . .

TY  - CONF
AU  - Rmandić, Milena
AU  - Dotsikas, Yannis
AU  - Stajić, Ana
AU  - Malenović, Anđelija
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4703
PB  - MSBM
C3  - XIII Mass Spectrometry in Biotechnology and Medicine (MSBM). July 7-13, 2019, Dubrovnik, Croatia.
T1  - Development of UHPLC- MS/MS Bioanalytical Method for Determination of Zonisamide in the Samples Collected in the Form of Dried Plasma Spots
SP  - 46
EP  - 46
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4703
ER  - 

@conference{
author = "Rmandić, Milena and Dotsikas, Yannis and Stajić, Ana and Malenović, Anđelija",
year = "2019",
publisher = "MSBM",
journal = "XIII Mass Spectrometry in Biotechnology and Medicine (MSBM). July 7-13, 2019, Dubrovnik, Croatia.",
title = "Development of UHPLC- MS/MS Bioanalytical Method for Determination of Zonisamide in the Samples Collected in the Form of Dried Plasma Spots",
pages = "46-46",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4703"
}

Rmandić, M., Dotsikas, Y., Stajić, A.,& Malenović, A.. (2019). Development of UHPLC- MS/MS Bioanalytical Method for Determination of Zonisamide in the Samples Collected in the Form of Dried Plasma Spots. in XIII Mass Spectrometry in Biotechnology and Medicine (MSBM). July 7-13, 2019, Dubrovnik, Croatia.
MSBM., 46-46.
https://hdl.handle.net/21.15107/rcub_farfar_4703

Rmandić M, Dotsikas Y, Stajić A, Malenović A. Development of UHPLC- MS/MS Bioanalytical Method for Determination of Zonisamide in the Samples Collected in the Form of Dried Plasma Spots. in XIII Mass Spectrometry in Biotechnology and Medicine (MSBM). July 7-13, 2019, Dubrovnik, Croatia.. 2019;:46-46.
https://hdl.handle.net/21.15107/rcub_farfar_4703 .

Rmandić, Milena, Dotsikas, Yannis, Stajić, Ana, Malenović, Anđelija, "Development of UHPLC- MS/MS Bioanalytical Method for Determination of Zonisamide in the Samples Collected in the Form of Dried Plasma Spots" in XIII Mass Spectrometry in Biotechnology and Medicine (MSBM). July 7-13, 2019, Dubrovnik, Croatia. (2019):46-46,
https://hdl.handle.net/21.15107/rcub_farfar_4703 .

TY  - JOUR
AU  - Stajić, Ana
AU  - Maksić, Jelena
AU  - Maksić, Đoko
AU  - Forsdahl, Guro
AU  - Medenica, Mirjana
AU  - Jančić-Stojanović, Biljana
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3080
AB  - Aim: An ultra pressure liquid chromatography (UPLC)/MS/MS method for vancomycin and teicoplanin determination in human plasma was developed in accordance with analytical quality by design (AQbD) concept and fully validated. Materials & methods: Chromatographic separation was performed on ACQUITY UPLC C-18 charge surface hybrid (CSH) column (2.1 mm x 50 mm, 1.7 mu m particle size) in gradient mode and the mobile phase consisted of 0.1% formic acid in water and pure acetonitrile. The experimental design methodology was used for the definition of optimal chromatographic and protein precipitation conditions. Results: The linearity ranges were 0.05-10 mu g ml(-1) for vancomycin and 0.5-200 mu g ml(-1) for total teicoplanin. The relative standard deviations for precision estimation were below 15% and the accuracy was within 85-115% for all quality control levels. Conclusion: The method was utilized for glycopeptide antibiotics bioanalysis.
PB  - Future Sci Ltd, London
T2  - Bioanalysis
T1  - Analytical Quality by Design-based development and validation of ultra pressure liquid chromatography/MS/MS method for glycopeptide antibiotics determination in human plasma
VL  - 10
IS  - 22
SP  - 1861
EP  - 1876
DO  - 10.4155/bio-2018-0181
ER  - 

@article{
author = "Stajić, Ana and Maksić, Jelena and Maksić, Đoko and Forsdahl, Guro and Medenica, Mirjana and Jančić-Stojanović, Biljana",
year = "2018",
abstract = "Aim: An ultra pressure liquid chromatography (UPLC)/MS/MS method for vancomycin and teicoplanin determination in human plasma was developed in accordance with analytical quality by design (AQbD) concept and fully validated. Materials & methods: Chromatographic separation was performed on ACQUITY UPLC C-18 charge surface hybrid (CSH) column (2.1 mm x 50 mm, 1.7 mu m particle size) in gradient mode and the mobile phase consisted of 0.1% formic acid in water and pure acetonitrile. The experimental design methodology was used for the definition of optimal chromatographic and protein precipitation conditions. Results: The linearity ranges were 0.05-10 mu g ml(-1) for vancomycin and 0.5-200 mu g ml(-1) for total teicoplanin. The relative standard deviations for precision estimation were below 15% and the accuracy was within 85-115% for all quality control levels. Conclusion: The method was utilized for glycopeptide antibiotics bioanalysis.",
publisher = "Future Sci Ltd, London",
journal = "Bioanalysis",
title = "Analytical Quality by Design-based development and validation of ultra pressure liquid chromatography/MS/MS method for glycopeptide antibiotics determination in human plasma",
volume = "10",
number = "22",
pages = "1861-1876",
doi = "10.4155/bio-2018-0181"
}

Stajić, A., Maksić, J., Maksić, Đ., Forsdahl, G., Medenica, M.,& Jančić-Stojanović, B.. (2018). Analytical Quality by Design-based development and validation of ultra pressure liquid chromatography/MS/MS method for glycopeptide antibiotics determination in human plasma. in Bioanalysis
Future Sci Ltd, London., 10(22), 1861-1876.
https://doi.org/10.4155/bio-2018-0181

Stajić A, Maksić J, Maksić Đ, Forsdahl G, Medenica M, Jančić-Stojanović B. Analytical Quality by Design-based development and validation of ultra pressure liquid chromatography/MS/MS method for glycopeptide antibiotics determination in human plasma. in Bioanalysis. 2018;10(22):1861-1876.
doi:10.4155/bio-2018-0181 .

Stajić, Ana, Maksić, Jelena, Maksić, Đoko, Forsdahl, Guro, Medenica, Mirjana, Jančić-Stojanović, Biljana, "Analytical Quality by Design-based development and validation of ultra pressure liquid chromatography/MS/MS method for glycopeptide antibiotics determination in human plasma" in Bioanalysis, 10, no. 22 (2018):1861-1876,
https://doi.org/10.4155/bio-2018-0181 . .

TY  - JOUR
AU  - Terzić, Jelena
AU  - Popović, Igor
AU  - Tumpa, Anja
AU  - Stajić, Ana
AU  - Jančić-Stojanović, Biljana
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3022
PB  - Elsevier Science BV, Amsterdam
T2  - Journal of Pharmaceutical and Biomedical Analysis
T1  - Application of Analytical Quality by Design concept for bilastine and its degradation impurities determination by hydrophilic interaction liquid chromatographic method (vol 125, pg 385, 2016)
VL  - 138
SP  - 386
EP  - 386
DO  - 10.1016/j.jpba.2017.02.016
ER  - 

@article{
author = "Terzić, Jelena and Popović, Igor and Tumpa, Anja and Stajić, Ana and Jančić-Stojanović, Biljana",
year = "2017",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Journal of Pharmaceutical and Biomedical Analysis",
title = "Application of Analytical Quality by Design concept for bilastine and its degradation impurities determination by hydrophilic interaction liquid chromatographic method (vol 125, pg 385, 2016)",
volume = "138",
pages = "386-386",
doi = "10.1016/j.jpba.2017.02.016"
}

Terzić, J., Popović, I., Tumpa, A., Stajić, A.,& Jančić-Stojanović, B.. (2017). Application of Analytical Quality by Design concept for bilastine and its degradation impurities determination by hydrophilic interaction liquid chromatographic method (vol 125, pg 385, 2016). in Journal of Pharmaceutical and Biomedical Analysis
Elsevier Science BV, Amsterdam., 138, 386-386.
https://doi.org/10.1016/j.jpba.2017.02.016

Terzić J, Popović I, Tumpa A, Stajić A, Jančić-Stojanović B. Application of Analytical Quality by Design concept for bilastine and its degradation impurities determination by hydrophilic interaction liquid chromatographic method (vol 125, pg 385, 2016). in Journal of Pharmaceutical and Biomedical Analysis. 2017;138:386-386.
doi:10.1016/j.jpba.2017.02.016 .

Terzić, Jelena, Popović, Igor, Tumpa, Anja, Stajić, Ana, Jančić-Stojanović, Biljana, "Application of Analytical Quality by Design concept for bilastine and its degradation impurities determination by hydrophilic interaction liquid chromatographic method (vol 125, pg 385, 2016)" in Journal of Pharmaceutical and Biomedical Analysis, 138 (2017):386-386,
https://doi.org/10.1016/j.jpba.2017.02.016 . .

TY  - JOUR
AU  - Tumpa, Anja
AU  - Stajić, Ana
AU  - Jančić-Stojanović, Biljana
AU  - Medenica, Mirjana
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2958
AB  - This paper deals with the development of hydrophilic interaction liquid chromatography (HILIC) method with gradient elution, in accordance with Analytical Quality by Design (AQbD) methodology, for the first time. The method is developed for olanzapine and its seven related substances. Following step by step AQbD methodology, firstly as critical process parameters (CPPs) temperature, starting content of aqueous phase and duration of linear gradient are recognized, and as critical quality attributes (CQAs) separation criterion S of critical pairs of substances are investigated. Rechtschaffen design is used for the creation of models that describe the dependence between CPPs and CQAs. The design space that is obtained at the end is used for choosing the optimal conditions (set point). The method is fully validated at the end to verify the adequacy of the chosen optimal conditions and applied to real samples.
PB  - Elsevier Science BV, Amsterdam
T2  - Journal of Pharmaceutical and Biomedical Analysis
T1  - Quality by Design in the development of hydrophilic interaction liquid chromatography method with gradient elution for the analysis of olanzapine
VL  - 134
SP  - 18
EP  - 26
DO  - 10.1016/j.jpba.2016.11.010
ER  - 

@article{
author = "Tumpa, Anja and Stajić, Ana and Jančić-Stojanović, Biljana and Medenica, Mirjana",
year = "2017",
abstract = "This paper deals with the development of hydrophilic interaction liquid chromatography (HILIC) method with gradient elution, in accordance with Analytical Quality by Design (AQbD) methodology, for the first time. The method is developed for olanzapine and its seven related substances. Following step by step AQbD methodology, firstly as critical process parameters (CPPs) temperature, starting content of aqueous phase and duration of linear gradient are recognized, and as critical quality attributes (CQAs) separation criterion S of critical pairs of substances are investigated. Rechtschaffen design is used for the creation of models that describe the dependence between CPPs and CQAs. The design space that is obtained at the end is used for choosing the optimal conditions (set point). The method is fully validated at the end to verify the adequacy of the chosen optimal conditions and applied to real samples.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Journal of Pharmaceutical and Biomedical Analysis",
title = "Quality by Design in the development of hydrophilic interaction liquid chromatography method with gradient elution for the analysis of olanzapine",
volume = "134",
pages = "18-26",
doi = "10.1016/j.jpba.2016.11.010"
}

Tumpa, A., Stajić, A., Jančić-Stojanović, B.,& Medenica, M.. (2017). Quality by Design in the development of hydrophilic interaction liquid chromatography method with gradient elution for the analysis of olanzapine. in Journal of Pharmaceutical and Biomedical Analysis
Elsevier Science BV, Amsterdam., 134, 18-26.
https://doi.org/10.1016/j.jpba.2016.11.010

Tumpa A, Stajić A, Jančić-Stojanović B, Medenica M. Quality by Design in the development of hydrophilic interaction liquid chromatography method with gradient elution for the analysis of olanzapine. in Journal of Pharmaceutical and Biomedical Analysis. 2017;134:18-26.
doi:10.1016/j.jpba.2016.11.010 .

Tumpa, Anja, Stajić, Ana, Jančić-Stojanović, Biljana, Medenica, Mirjana, "Quality by Design in the development of hydrophilic interaction liquid chromatography method with gradient elution for the analysis of olanzapine" in Journal of Pharmaceutical and Biomedical Analysis, 134 (2017):18-26,
https://doi.org/10.1016/j.jpba.2016.11.010 . .

TY  - JOUR
AU  - Stajić, Ana
AU  - Jančić-Stojanović, Biljana
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2935
AB  - Background. Teicoplanin and vancomycin are glycopeptide antibiotics currently in use for treatment of multidrug-resistant bacterial infections. Scope and Approach. Severe undesirable effects, such as ototoxicity, nephrotoxicity and neutropenia have been reported for vancomycin and teicoplanin, which necessitates monitoring the concentration of these two drugs in different biological samples. In order to obtain precise and accurate results, sensitive, reliable and fast methods are necessary. The main aim of this mini review is to give a clear and concise overview of the recently developed, validated, novel and improved methods for glycopeptide antibiotic analyses in various biological matrices. Also, the variability of the matrices requires optimal and effective sample preparation procedures to be developed, and so these are discussed. Key Findings and Conclusions. Different liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods have been described for quantitative determination of glycopeptide antibiotics in various biological matrices. It was shown that protein precipitation was a convenient method for sample preparation despite the high number of novel sample preparation methods.
AB  - Uvod. Teikoplanin i vankomicin su antibiotici glikopeptidne strukture koji se trenutno koriste u terapiji multirezistentnih bakterijskih infekcija. Cilj i pristup. Ozbiljni neželjeni efekti vankomicina i teikoplanina kao što su ototoksičnost, nefrotoksičnost i neutropenija zahtevaju njihovo praćenje u različitim tipovima biološkog materijala. Osetljiva, pouzdana i brza metoda potrebna je u cilju dobijanja tačnih i preciznih podataka o koncentraciji pomenutih jedinjenja. Cilj ovog pregleda je da da jasan i kratak prikaz o razvijenim i validiranim novim, ili unapređenim metodama za analizu glikopeptidnih antibiotika u različitim biološkim matriksima. Takođe, u radu su opisane i metode pripreme uzorka upravo zbog raznovrsnosti biološkog materijala. Ključni nalazi i zaključak. Opisane su raznovrsne LC-MS/MS metode za određivanje glikopeptidnih antibiotika u biološkom materijalu. Primećeno je da je precipitacija proteina pogodna metoda pripreme uzorka bez obzira na broj novijih metoda pripreme koje se koriste.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Veterinarski glasnik
T1  - Overview of the analytical methods for vancomycin and/or teicoplanin determination in biological matrices
T1  - Pregled analitičkih metoda za određivanje vankomicina i teikoplanina u biološkom materijalu
VL  - 71
IS  - 2
SP  - 87
EP  - 97
DO  - 10.2298/VETGL1702087S
ER  - 

@article{
author = "Stajić, Ana and Jančić-Stojanović, Biljana",
year = "2017",
abstract = "Background. Teicoplanin and vancomycin are glycopeptide antibiotics currently in use for treatment of multidrug-resistant bacterial infections. Scope and Approach. Severe undesirable effects, such as ototoxicity, nephrotoxicity and neutropenia have been reported for vancomycin and teicoplanin, which necessitates monitoring the concentration of these two drugs in different biological samples. In order to obtain precise and accurate results, sensitive, reliable and fast methods are necessary. The main aim of this mini review is to give a clear and concise overview of the recently developed, validated, novel and improved methods for glycopeptide antibiotic analyses in various biological matrices. Also, the variability of the matrices requires optimal and effective sample preparation procedures to be developed, and so these are discussed. Key Findings and Conclusions. Different liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods have been described for quantitative determination of glycopeptide antibiotics in various biological matrices. It was shown that protein precipitation was a convenient method for sample preparation despite the high number of novel sample preparation methods., Uvod. Teikoplanin i vankomicin su antibiotici glikopeptidne strukture koji se trenutno koriste u terapiji multirezistentnih bakterijskih infekcija. Cilj i pristup. Ozbiljni neželjeni efekti vankomicina i teikoplanina kao što su ototoksičnost, nefrotoksičnost i neutropenija zahtevaju njihovo praćenje u različitim tipovima biološkog materijala. Osetljiva, pouzdana i brza metoda potrebna je u cilju dobijanja tačnih i preciznih podataka o koncentraciji pomenutih jedinjenja. Cilj ovog pregleda je da da jasan i kratak prikaz o razvijenim i validiranim novim, ili unapređenim metodama za analizu glikopeptidnih antibiotika u različitim biološkim matriksima. Takođe, u radu su opisane i metode pripreme uzorka upravo zbog raznovrsnosti biološkog materijala. Ključni nalazi i zaključak. Opisane su raznovrsne LC-MS/MS metode za određivanje glikopeptidnih antibiotika u biološkom materijalu. Primećeno je da je precipitacija proteina pogodna metoda pripreme uzorka bez obzira na broj novijih metoda pripreme koje se koriste.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Veterinarski glasnik",
title = "Overview of the analytical methods for vancomycin and/or teicoplanin determination in biological matrices, Pregled analitičkih metoda za određivanje vankomicina i teikoplanina u biološkom materijalu",
volume = "71",
number = "2",
pages = "87-97",
doi = "10.2298/VETGL1702087S"
}

Stajić, A.,& Jančić-Stojanović, B.. (2017). Overview of the analytical methods for vancomycin and/or teicoplanin determination in biological matrices. in Veterinarski glasnik
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 71(2), 87-97.
https://doi.org/10.2298/VETGL1702087S

Stajić A, Jančić-Stojanović B. Overview of the analytical methods for vancomycin and/or teicoplanin determination in biological matrices. in Veterinarski glasnik. 2017;71(2):87-97.
doi:10.2298/VETGL1702087S .

Stajić, Ana, Jančić-Stojanović, Biljana, "Overview of the analytical methods for vancomycin and/or teicoplanin determination in biological matrices" in Veterinarski glasnik, 71, no. 2 (2017):87-97,
https://doi.org/10.2298/VETGL1702087S . .

TY  - JOUR
AU  - Stajić, Ana
AU  - Anđelković, Marija
AU  - Dikić, Nenad
AU  - Rasić, J.
AU  - Vukašinović-Vesić, Milica
AU  - Ivanović, D.
AU  - Jančić-Stojanović, Biljana
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2869
AB  - From 1st January 2017 higenamine was added on the WADA (World Anti-doping Agency) Prohibited list under S3 group beta-2 agonists as at all times banned substance for the athletes. The main origine of higenamine (or norcoclaurine) are different plants including Nandina domestica, Aconitum carmichaelii, Asarum heterotropioides, Galium divaricatum, Annona squamosa, Nelumbo nucifera etc. Higenamine main use is related to weight loss and it could be found (un)labeled in different dietary supplements. The objective of this study was development of sensitive and reliable UHPLC/MS/MS method for determination of higenamine in various dietary supplement samples. In order to obtain high method sensitivity, hydrophilic interaction liquid chromatography (HILIC) mode was applied. Separation was carried out on UHPLC Acquity BEH HILIC analytical column (2.1 mm x 100 mm, 1.7 mu m particle size). Mobile phase consisted of 0.1% formic acid in water and acetonitrile, respectively, was mixed in ratio of 30:70, v/v. Flow rate was set at 0.2 mL min(-1). Quercetin was used as an internal standard. ESI (+) source ionization mode using multi reaction monitoring (MRM) mode was utilized and three ion transitions of higenamine were followed 272.08 -> 107.01, 272.08 -> 161.07 and 272.08 -> 77.08. Developed method was fully validated and applied for identification and quantification of higenamine in different dietary supplements. According to the results, the most of investigated supplements were free of higenamine, and on the other hand, presence of higenamine was confirmed in some samples while it was not declared on the label.
PB  - Elsevier Science BV, Amsterdam
T2  - Journal of Pharmaceutical and Biomedical Analysis
T1  - Determination of higenamine in dietary supplements by UHPLC/MS/MS method
VL  - 146
SP  - 48
EP  - 52
DO  - 10.1016/j.jpba.2017.08.017
ER  - 

@article{
author = "Stajić, Ana and Anđelković, Marija and Dikić, Nenad and Rasić, J. and Vukašinović-Vesić, Milica and Ivanović, D. and Jančić-Stojanović, Biljana",
year = "2017",
abstract = "From 1st January 2017 higenamine was added on the WADA (World Anti-doping Agency) Prohibited list under S3 group beta-2 agonists as at all times banned substance for the athletes. The main origine of higenamine (or norcoclaurine) are different plants including Nandina domestica, Aconitum carmichaelii, Asarum heterotropioides, Galium divaricatum, Annona squamosa, Nelumbo nucifera etc. Higenamine main use is related to weight loss and it could be found (un)labeled in different dietary supplements. The objective of this study was development of sensitive and reliable UHPLC/MS/MS method for determination of higenamine in various dietary supplement samples. In order to obtain high method sensitivity, hydrophilic interaction liquid chromatography (HILIC) mode was applied. Separation was carried out on UHPLC Acquity BEH HILIC analytical column (2.1 mm x 100 mm, 1.7 mu m particle size). Mobile phase consisted of 0.1% formic acid in water and acetonitrile, respectively, was mixed in ratio of 30:70, v/v. Flow rate was set at 0.2 mL min(-1). Quercetin was used as an internal standard. ESI (+) source ionization mode using multi reaction monitoring (MRM) mode was utilized and three ion transitions of higenamine were followed 272.08 -> 107.01, 272.08 -> 161.07 and 272.08 -> 77.08. Developed method was fully validated and applied for identification and quantification of higenamine in different dietary supplements. According to the results, the most of investigated supplements were free of higenamine, and on the other hand, presence of higenamine was confirmed in some samples while it was not declared on the label.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Journal of Pharmaceutical and Biomedical Analysis",
title = "Determination of higenamine in dietary supplements by UHPLC/MS/MS method",
volume = "146",
pages = "48-52",
doi = "10.1016/j.jpba.2017.08.017"
}

Stajić, A., Anđelković, M., Dikić, N., Rasić, J., Vukašinović-Vesić, M., Ivanović, D.,& Jančić-Stojanović, B.. (2017). Determination of higenamine in dietary supplements by UHPLC/MS/MS method. in Journal of Pharmaceutical and Biomedical Analysis
Elsevier Science BV, Amsterdam., 146, 48-52.
https://doi.org/10.1016/j.jpba.2017.08.017

Stajić A, Anđelković M, Dikić N, Rasić J, Vukašinović-Vesić M, Ivanović D, Jančić-Stojanović B. Determination of higenamine in dietary supplements by UHPLC/MS/MS method. in Journal of Pharmaceutical and Biomedical Analysis. 2017;146:48-52.
doi:10.1016/j.jpba.2017.08.017 .

Stajić, Ana, Anđelković, Marija, Dikić, Nenad, Rasić, J., Vukašinović-Vesić, Milica, Ivanović, D., Jančić-Stojanović, Biljana, "Determination of higenamine in dietary supplements by UHPLC/MS/MS method" in Journal of Pharmaceutical and Biomedical Analysis, 146 (2017):48-52,
https://doi.org/10.1016/j.jpba.2017.08.017 . .

TY  - JOUR
AU  - Maksić, Jelena
AU  - Stajić, Ana
AU  - Knežević, Miroslav
AU  - Dacić-Krnjaja, Bojana
AU  - Jančić-Stojanović, Biljana
AU  - Medenica, Mirjana
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2860
AB  - Aim: The objective of the study was development of hydrophilic interaction liquid chromatography-ESI/MS/MS method for the determination of olopatadine in tear matrix. Materials & methods: Separation was performed on Acquity BEH amide column (2.1 x 100 mm, 1.7 mu m). The mobile phase was consisted of 0.1% formic acid in water and acetonitrile. Mianserin hydrochloride was implemented as an internal standard. The artificial tear fluid was used as matrix. The tear samples were collected using Schirmer test strips. For the optimization of ultra pressure liquid chromatography conditions, Box-Benhken design was utilized. Results: The optimal values of the ion source and collision cell parameters were found. Quantification was performed in multiple reaction monitoring mode. The optimized method was fully validated. Conclusion: The proposed method was utilized for monitoring of olopatadine in human tear.
PB  - Future Sci Ltd, London
T2  - Bioanalysis
T1  - Determination of olopatadine in human tears by hydrophilic interaction liquid chromatography-MS/MS method
VL  - 9
IS  - 24
SP  - 1943
EP  - 1954
DO  - 10.4155/bio-2017-0172
ER  - 

@article{
author = "Maksić, Jelena and Stajić, Ana and Knežević, Miroslav and Dacić-Krnjaja, Bojana and Jančić-Stojanović, Biljana and Medenica, Mirjana",
year = "2017",
abstract = "Aim: The objective of the study was development of hydrophilic interaction liquid chromatography-ESI/MS/MS method for the determination of olopatadine in tear matrix. Materials & methods: Separation was performed on Acquity BEH amide column (2.1 x 100 mm, 1.7 mu m). The mobile phase was consisted of 0.1% formic acid in water and acetonitrile. Mianserin hydrochloride was implemented as an internal standard. The artificial tear fluid was used as matrix. The tear samples were collected using Schirmer test strips. For the optimization of ultra pressure liquid chromatography conditions, Box-Benhken design was utilized. Results: The optimal values of the ion source and collision cell parameters were found. Quantification was performed in multiple reaction monitoring mode. The optimized method was fully validated. Conclusion: The proposed method was utilized for monitoring of olopatadine in human tear.",
publisher = "Future Sci Ltd, London",
journal = "Bioanalysis",
title = "Determination of olopatadine in human tears by hydrophilic interaction liquid chromatography-MS/MS method",
volume = "9",
number = "24",
pages = "1943-1954",
doi = "10.4155/bio-2017-0172"
}

Maksić, J., Stajić, A., Knežević, M., Dacić-Krnjaja, B., Jančić-Stojanović, B.,& Medenica, M.. (2017). Determination of olopatadine in human tears by hydrophilic interaction liquid chromatography-MS/MS method. in Bioanalysis
Future Sci Ltd, London., 9(24), 1943-1954.
https://doi.org/10.4155/bio-2017-0172

Maksić J, Stajić A, Knežević M, Dacić-Krnjaja B, Jančić-Stojanović B, Medenica M. Determination of olopatadine in human tears by hydrophilic interaction liquid chromatography-MS/MS method. in Bioanalysis. 2017;9(24):1943-1954.
doi:10.4155/bio-2017-0172 .

Maksić, Jelena, Stajić, Ana, Knežević, Miroslav, Dacić-Krnjaja, Bojana, Jančić-Stojanović, Biljana, Medenica, Mirjana, "Determination of olopatadine in human tears by hydrophilic interaction liquid chromatography-MS/MS method" in Bioanalysis, 9, no. 24 (2017):1943-1954,
https://doi.org/10.4155/bio-2017-0172 . .

TY  - JOUR
AU  - Tumpa, Anja
AU  - Miladinović, Tamara
AU  - Rakić, Tijana
AU  - Stajić, Ana
AU  - Jančić-Stojanović, Biljana
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2567
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3444
AB  - A liquid chromatography method is reported for the determination of diclofenac potassium and its impurities using Quality by Design criteria. Central composite design was used for the investigation of the influence of critical parameters on performance that included the methanol concentration in the mobile phase, the pH of the aqueous phase, and the potassium dihydrogen phosphate concentration in the aqueous phase. Mathematical models enabled theoretical examination of experimental space to achieve maximal separation in minimal analysis time. A Monte Carlo simulation was used to evaluate the risk of uncertainty in model predictions, to adjusting process parameters, and to identify design space. Fractional factorial design was employed for robustness testing and method was fully validated. Optimal conditions were a C18 150mmx4.6mm, 5 mu m particle size column; a methanol -68.3mmolL(-1) potassium dihydrogenphosphate (68.7:31.3, v/v) mobile phase at pH 3.0, a flow rate of 1mL min(-1), a column temperature of 25 degrees C, and ultraviolet detection at 254nm.
PB  - Taylor & Francis Inc, Philadelphia
T2  - Analytical Letters
T1  - Quality by Design Determination of Diclofenac Potassium and its Impurities by High-Performance Liquid Chromatography
VL  - 49
IS  - 4
SP  - 445
EP  - 457
DO  - 10.1080/00032719.2015.1075131
ER  - 

@article{
author = "Tumpa, Anja and Miladinović, Tamara and Rakić, Tijana and Stajić, Ana and Jančić-Stojanović, Biljana",
year = "2016",
abstract = "A liquid chromatography method is reported for the determination of diclofenac potassium and its impurities using Quality by Design criteria. Central composite design was used for the investigation of the influence of critical parameters on performance that included the methanol concentration in the mobile phase, the pH of the aqueous phase, and the potassium dihydrogen phosphate concentration in the aqueous phase. Mathematical models enabled theoretical examination of experimental space to achieve maximal separation in minimal analysis time. A Monte Carlo simulation was used to evaluate the risk of uncertainty in model predictions, to adjusting process parameters, and to identify design space. Fractional factorial design was employed for robustness testing and method was fully validated. Optimal conditions were a C18 150mmx4.6mm, 5 mu m particle size column; a methanol -68.3mmolL(-1) potassium dihydrogenphosphate (68.7:31.3, v/v) mobile phase at pH 3.0, a flow rate of 1mL min(-1), a column temperature of 25 degrees C, and ultraviolet detection at 254nm.",
publisher = "Taylor & Francis Inc, Philadelphia",
journal = "Analytical Letters",
title = "Quality by Design Determination of Diclofenac Potassium and its Impurities by High-Performance Liquid Chromatography",
volume = "49",
number = "4",
pages = "445-457",
doi = "10.1080/00032719.2015.1075131"
}

Tumpa, A., Miladinović, T., Rakić, T., Stajić, A.,& Jančić-Stojanović, B.. (2016). Quality by Design Determination of Diclofenac Potassium and its Impurities by High-Performance Liquid Chromatography. in Analytical Letters
Taylor & Francis Inc, Philadelphia., 49(4), 445-457.
https://doi.org/10.1080/00032719.2015.1075131

Tumpa A, Miladinović T, Rakić T, Stajić A, Jančić-Stojanović B. Quality by Design Determination of Diclofenac Potassium and its Impurities by High-Performance Liquid Chromatography. in Analytical Letters. 2016;49(4):445-457.
doi:10.1080/00032719.2015.1075131 .

Tumpa, Anja, Miladinović, Tamara, Rakić, Tijana, Stajić, Ana, Jančić-Stojanović, Biljana, "Quality by Design Determination of Diclofenac Potassium and its Impurities by High-Performance Liquid Chromatography" in Analytical Letters, 49, no. 4 (2016):445-457,
https://doi.org/10.1080/00032719.2015.1075131 . .

TY  - JOUR
AU  - Maksić, Jelena
AU  - Tumpa, Anja
AU  - Stajić, Ana
AU  - Jovanović, Marko
AU  - Rakić, Tijana
AU  - Jančić-Stojanović, Biljana
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2604
AB  - In this paper separation of granisetron and its two related substances in HILIC mode is presented. Separation was done on silica column derivatized with sulfoalkylbetaine groups (ZIC-HILIC). Firstly, retention mechanisms were assessed whereby retention factors of substances were followed in wide range of acetonitrile content (80-97%), at constant concentration of aqueous buffer (10 mM) as well as at constant pH value of 3.0. Further, in order to developed optimal HILIC method, Design of Experiments (DoE) methodology was applied. For optimization full factorial design 32 was employed. Influence of acetonitrile content and ammonium acetate concentration were investigated while pH of the water phase was kept at 3.3. Adequacy of obtained mathematical models was confirmed by ANOVA. Optimization goals (alpha > 1.15 and minimal run time) were accomplished with 94.7% of acetonitrile in mobile phase and 70 mM of ammonium acetate in water phase. Optimal point was in the middle of defined Design Space. In the next phase, robustness was experimetally tested by Rechtschaffen design. The investigated factors and their levels were: acetonitrile content (+/- 1%), ammonium acetate molarity in water phase (+/- 2 mM), pH value of water phase (+/- 0.2) and column temperature (+/- 4 degrees C). The validation scope included selectivity, linearity, accuracy and precision as well as determination of limit of detection (LOD) and limit of quantification (LOQ) for the related substances. Additionally, the validation acceptance criteria were met in all cases. Finally, the proposed method could be successfully utilized for estimation of granisetron HCl and its related substances in tablets and parenteral dosage forms, as well as for monitoring degradation under various stress conditions.
PB  - Elsevier Science BV, Amsterdam
T2  - Journal of Pharmaceutical and Biomedical Analysis
T1  - Hydrophilic interaction liquid chromatography in analysis of granisetron HCl and its related substances. Retention mechanisms and method development
VL  - 123
SP  - 93
EP  - 103
DO  - 10.1016/j.jpba.2016.02.010
ER  - 

@article{
author = "Maksić, Jelena and Tumpa, Anja and Stajić, Ana and Jovanović, Marko and Rakić, Tijana and Jančić-Stojanović, Biljana",
year = "2016",
abstract = "In this paper separation of granisetron and its two related substances in HILIC mode is presented. Separation was done on silica column derivatized with sulfoalkylbetaine groups (ZIC-HILIC). Firstly, retention mechanisms were assessed whereby retention factors of substances were followed in wide range of acetonitrile content (80-97%), at constant concentration of aqueous buffer (10 mM) as well as at constant pH value of 3.0. Further, in order to developed optimal HILIC method, Design of Experiments (DoE) methodology was applied. For optimization full factorial design 32 was employed. Influence of acetonitrile content and ammonium acetate concentration were investigated while pH of the water phase was kept at 3.3. Adequacy of obtained mathematical models was confirmed by ANOVA. Optimization goals (alpha > 1.15 and minimal run time) were accomplished with 94.7% of acetonitrile in mobile phase and 70 mM of ammonium acetate in water phase. Optimal point was in the middle of defined Design Space. In the next phase, robustness was experimetally tested by Rechtschaffen design. The investigated factors and their levels were: acetonitrile content (+/- 1%), ammonium acetate molarity in water phase (+/- 2 mM), pH value of water phase (+/- 0.2) and column temperature (+/- 4 degrees C). The validation scope included selectivity, linearity, accuracy and precision as well as determination of limit of detection (LOD) and limit of quantification (LOQ) for the related substances. Additionally, the validation acceptance criteria were met in all cases. Finally, the proposed method could be successfully utilized for estimation of granisetron HCl and its related substances in tablets and parenteral dosage forms, as well as for monitoring degradation under various stress conditions.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Journal of Pharmaceutical and Biomedical Analysis",
title = "Hydrophilic interaction liquid chromatography in analysis of granisetron HCl and its related substances. Retention mechanisms and method development",
volume = "123",
pages = "93-103",
doi = "10.1016/j.jpba.2016.02.010"
}

Maksić, J., Tumpa, A., Stajić, A., Jovanović, M., Rakić, T.,& Jančić-Stojanović, B.. (2016). Hydrophilic interaction liquid chromatography in analysis of granisetron HCl and its related substances. Retention mechanisms and method development. in Journal of Pharmaceutical and Biomedical Analysis
Elsevier Science BV, Amsterdam., 123, 93-103.
https://doi.org/10.1016/j.jpba.2016.02.010

Maksić J, Tumpa A, Stajić A, Jovanović M, Rakić T, Jančić-Stojanović B. Hydrophilic interaction liquid chromatography in analysis of granisetron HCl and its related substances. Retention mechanisms and method development. in Journal of Pharmaceutical and Biomedical Analysis. 2016;123:93-103.
doi:10.1016/j.jpba.2016.02.010 .

Maksić, Jelena, Tumpa, Anja, Stajić, Ana, Jovanović, Marko, Rakić, Tijana, Jančić-Stojanović, Biljana, "Hydrophilic interaction liquid chromatography in analysis of granisetron HCl and its related substances. Retention mechanisms and method development" in Journal of Pharmaceutical and Biomedical Analysis, 123 (2016):93-103,
https://doi.org/10.1016/j.jpba.2016.02.010 . .

TY  - JOUR
AU  - Tumpa, Anja
AU  - Miladinović, Tamara
AU  - Rakić, Tijana
AU  - Stajić, Ana
AU  - Jančić-Stojanović, Biljana
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2567
AB  - A liquid chromatography method is reported for the determination of diclofenac potassium and its impurities using Quality by Design criteria. Central composite design was used for the investigation of the influence of critical parameters on performance that included the methanol concentration in the mobile phase, the pH of the aqueous phase, and the potassium dihydrogen phosphate concentration in the aqueous phase. Mathematical models enabled theoretical examination of experimental space to achieve maximal separation in minimal analysis time. A Monte Carlo simulation was used to evaluate the risk of uncertainty in model predictions, to adjusting process parameters, and to identify design space. Fractional factorial design was employed for robustness testing and method was fully validated. Optimal conditions were a C18 150mmx4.6mm, 5 mu m particle size column; a methanol -68.3mmolL(-1) potassium dihydrogenphosphate (68.7:31.3, v/v) mobile phase at pH 3.0, a flow rate of 1mL min(-1), a column temperature of 25 degrees C, and ultraviolet detection at 254nm.
PB  - Taylor & Francis Inc, Philadelphia
T2  - Analytical Letters
T1  - Quality by Design Determination of Diclofenac Potassium and its Impurities by High-Performance Liquid Chromatography
VL  - 49
IS  - 4
SP  - 445
EP  - 457
DO  - 10.1080/00032719.2015.1075131
ER  - 

@article{
author = "Tumpa, Anja and Miladinović, Tamara and Rakić, Tijana and Stajić, Ana and Jančić-Stojanović, Biljana",
year = "2016",
abstract = "A liquid chromatography method is reported for the determination of diclofenac potassium and its impurities using Quality by Design criteria. Central composite design was used for the investigation of the influence of critical parameters on performance that included the methanol concentration in the mobile phase, the pH of the aqueous phase, and the potassium dihydrogen phosphate concentration in the aqueous phase. Mathematical models enabled theoretical examination of experimental space to achieve maximal separation in minimal analysis time. A Monte Carlo simulation was used to evaluate the risk of uncertainty in model predictions, to adjusting process parameters, and to identify design space. Fractional factorial design was employed for robustness testing and method was fully validated. Optimal conditions were a C18 150mmx4.6mm, 5 mu m particle size column; a methanol -68.3mmolL(-1) potassium dihydrogenphosphate (68.7:31.3, v/v) mobile phase at pH 3.0, a flow rate of 1mL min(-1), a column temperature of 25 degrees C, and ultraviolet detection at 254nm.",
publisher = "Taylor & Francis Inc, Philadelphia",
journal = "Analytical Letters",
title = "Quality by Design Determination of Diclofenac Potassium and its Impurities by High-Performance Liquid Chromatography",
volume = "49",
number = "4",
pages = "445-457",
doi = "10.1080/00032719.2015.1075131"
}

Tumpa, A., Miladinović, T., Rakić, T., Stajić, A.,& Jančić-Stojanović, B.. (2016). Quality by Design Determination of Diclofenac Potassium and its Impurities by High-Performance Liquid Chromatography. in Analytical Letters
Taylor & Francis Inc, Philadelphia., 49(4), 445-457.
https://doi.org/10.1080/00032719.2015.1075131

Tumpa A, Miladinović T, Rakić T, Stajić A, Jančić-Stojanović B. Quality by Design Determination of Diclofenac Potassium and its Impurities by High-Performance Liquid Chromatography. in Analytical Letters. 2016;49(4):445-457.
doi:10.1080/00032719.2015.1075131 .

Tumpa, Anja, Miladinović, Tamara, Rakić, Tijana, Stajić, Ana, Jančić-Stojanović, Biljana, "Quality by Design Determination of Diclofenac Potassium and its Impurities by High-Performance Liquid Chromatography" in Analytical Letters, 49, no. 4 (2016):445-457,
https://doi.org/10.1080/00032719.2015.1075131 . .

TY  - JOUR
AU  - Terzić, Jelena
AU  - Popović, Igor
AU  - Stajić, Ana
AU  - Tumpa, Anja
AU  - Jančić-Stojanović, Biljana
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2548
AB  - This paper deals with the development of hydrophilic interaction liquid chromatographic (HILIC) method for the analysis of bilastine and its degradation impurities following Analytical Quality by Design approach. It is the first time that the method for bilastine and its impurities is proposed. The main objective was to identify the conditions where an adequate separation in minimal analysis duration could be achieved within a robust region. Critical process parameters which have the most influence on method performance were defined as acetonitrile content in the mobile phase, pH of the aqueous phase and ammonium acetate concentration in the aqueous phase. Box-Behnken design was applied for establishing a relationship between critical process parameters and critical quality attributes. The defined mathematical models and Monte Carlo simulations were used to identify the design space. Fractional factorial design was applied for experimental robustness testing and the method is validated to verify the adequacy of selected optimal conditions: the analytical column Luna (R) HILIC (100 mm x 4.6 mm, 5 mu m particle size); mobile phase consisted of acetonitrile aqueous phase (50 mM ammonium acetate, pH adjusted to 5.3 with glacial acetic acid) (90.5:9.5, v/v); column temperature 30 degrees C, mobile phase flow rate 1 mL min(-1), wavelength of detection 275 nm.
PB  - Elsevier Science BV, Amsterdam
T2  - Journal of Pharmaceutical and Biomedical Analysis
T1  - Application of Analytical Quality by Design concept for bilastine and its degradation impurities determination by hydrophilic interaction liquid chromatographic method
VL  - 125
SP  - 385
EP  - 393
DO  - 10.1016/j.jpba.2016.04.022
ER  - 

@article{
author = "Terzić, Jelena and Popović, Igor and Stajić, Ana and Tumpa, Anja and Jančić-Stojanović, Biljana",
year = "2016",
abstract = "This paper deals with the development of hydrophilic interaction liquid chromatographic (HILIC) method for the analysis of bilastine and its degradation impurities following Analytical Quality by Design approach. It is the first time that the method for bilastine and its impurities is proposed. The main objective was to identify the conditions where an adequate separation in minimal analysis duration could be achieved within a robust region. Critical process parameters which have the most influence on method performance were defined as acetonitrile content in the mobile phase, pH of the aqueous phase and ammonium acetate concentration in the aqueous phase. Box-Behnken design was applied for establishing a relationship between critical process parameters and critical quality attributes. The defined mathematical models and Monte Carlo simulations were used to identify the design space. Fractional factorial design was applied for experimental robustness testing and the method is validated to verify the adequacy of selected optimal conditions: the analytical column Luna (R) HILIC (100 mm x 4.6 mm, 5 mu m particle size); mobile phase consisted of acetonitrile aqueous phase (50 mM ammonium acetate, pH adjusted to 5.3 with glacial acetic acid) (90.5:9.5, v/v); column temperature 30 degrees C, mobile phase flow rate 1 mL min(-1), wavelength of detection 275 nm.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Journal of Pharmaceutical and Biomedical Analysis",
title = "Application of Analytical Quality by Design concept for bilastine and its degradation impurities determination by hydrophilic interaction liquid chromatographic method",
volume = "125",
pages = "385-393",
doi = "10.1016/j.jpba.2016.04.022"
}

Terzić, J., Popović, I., Stajić, A., Tumpa, A.,& Jančić-Stojanović, B.. (2016). Application of Analytical Quality by Design concept for bilastine and its degradation impurities determination by hydrophilic interaction liquid chromatographic method. in Journal of Pharmaceutical and Biomedical Analysis
Elsevier Science BV, Amsterdam., 125, 385-393.
https://doi.org/10.1016/j.jpba.2016.04.022

Terzić J, Popović I, Stajić A, Tumpa A, Jančić-Stojanović B. Application of Analytical Quality by Design concept for bilastine and its degradation impurities determination by hydrophilic interaction liquid chromatographic method. in Journal of Pharmaceutical and Biomedical Analysis. 2016;125:385-393.
doi:10.1016/j.jpba.2016.04.022 .

Terzić, Jelena, Popović, Igor, Stajić, Ana, Tumpa, Anja, Jančić-Stojanović, Biljana, "Application of Analytical Quality by Design concept for bilastine and its degradation impurities determination by hydrophilic interaction liquid chromatographic method" in Journal of Pharmaceutical and Biomedical Analysis, 125 (2016):385-393,
https://doi.org/10.1016/j.jpba.2016.04.022 . .