@article{
author = "Ćirić, Ana and Milinković Budinčić, Jelena and Medarević, Đorđe and Dobričić, Vladimir and Rmandić, Milena and Barudžija, Tanja and Malenović, Anđelija and Petrović, Lidija and Đekić, Ljiljana",
year = "2022",
abstract = "Polyelectrolyte complexes (PECs) are attractive carriers with recognized potential to
enhance oral delivery of poorly soluble high-dosed low-molecular-weight drugs. The formulation
of solid oral dosage forms requires the drying of PECs, which may affect their physicochemical
and biopharmaceutical properties. The aim of this study was to investigate the effect of spray-
drying on the properties of ibuprofen-loaded chitosan/xanthan gum PECs and to assess the drug
release kinetics from such PECs filled into hard capsules in comparison with corresponding PECs
which are dried under ambient conditions. The yield, ibuprofen content, entrapment efficiency,
and residual moisture content of spray-dried PECs were lower than those of ambient-dried PECs.
Better flowability of spray-dried PECs was attributed to the almost spherical particle shape,
shown by scanning electron microscopy. DSC and PXRD analysis confirmed the amorphization
of ibuprofen during spray-drying. All the investigated PECs, obtained by drying under ambient
conditions as well as by spray-drying, had high rehydration capacity both in 0.1 M hydrochloric
acid (pH 1.2) and phosphate buffer pH 7.4. In vitro ibuprofen release from dried PECs was
controlled during 12 h with the release of approximately 30% of entrapped ibuprofen. Spray-dried
PECs provided better control of ibuprofen diffusion from the carrier compared to the ambient-
dried ones., Polielektrolitni kompleksi (PEK) su atraktivni nosači sa potencijalom poboljšanja peroralne isporuke slabo rastvorljivih visokodoziranih lekovitih supstanci niske molekulske mase. Formulisanje čvrstih oralnih farmaceutskih oblika na bazi PEK zahteva njihovo sušenje, što može uticati na fizičko-hemijska i biofarmaceutska svojstva kompleksa. Cilj ove studije bio je da se ispita efekat sušenja raspršivanjem na svojstva PEK hitozana i ksantan gume u koje je inkorporiran ibuprofen i da se proceni kinetika oslobađanja lekovite supstance iz takvih PEK napunjenih u tvrde kapsule u poređenju sa odgovarajućim PEK koji su sušeni pod ambijentalnim uslovima. Prinos, sadržaj ibuprofena, efikasnost inkorporiranja i sadržaj vlage PEK sušenih raspršivanjem bili su niži nego kod PEK sušenih pod ambijentalnim uslovima. Bolja protočnost PEK osušenih raspršivanjem je posledica skoro sfernog oblika čestica, što je pokazano skenirajućom elektronskom mikroskopijom. Rezultati DSC i PXRD analiza su potvrdili amorfizaciju ibuprofena tokom sušenja raspršivanjem. Ispitivani PEK osušeni pod različitim uslovima imali su visoku sposobnost rehidratacije u 0,1 M hlorovodoničnoj kiselini (pH 1,2) i fosfatnom puferu pH 7,4. In vitro oslobađanje ibuprofena iz osušenih PEK bilo je kontrolisano tokom 12 h uz oslobađanje približno 30% inkorporiranog ibuprofena. PEK sušeni raspršivanjem obezbedili su bolju kontrolu difuzije ibuprofena iz nosača u poređenju sa onima sušenim pod ambijentalnim uslovima.",
publisher = "Savez farmaceutskih udruženja Srbije",
journal = "Arhiv za farmaciju",
title = "Influence of spray-drying process on properties of chitosan/xanthan gum polyelectrolyte complexes as carriers for oral delivery of ibuprofen, Uticaj postupka sušenja raspršivanjem na svojstva polielektrolitnih kompleksa hitozana i ksantan gume kao nosača za peroralnu isporuku ibuprofena",
volume = "72",
number = "1",
pages = "36-60",
doi = "10.5937/arhfarm72-35133"
}
