TY  - JOUR
AU  - Milinković Budinčić, Jelena
AU  - Petrović, Lidija
AU  - Đekić, Ljiljana
AU  - Aleksić, Milijana
AU  - Fraj, Jadranka
AU  - Popović, Senka
AU  - Bučko, Sandra
AU  - Katona, Jaroslav
AU  - Spasojević, Ljiljana
AU  - Škrbić, Jelena
AU  - Malenović, Anđelija
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4021
AB  - Microencapsulation of bioactive substances is a common strategy for their protection and release rate control. The use of chitosan (Ch) is particularly promising due to its abundance, biocompatibility, and interaction with anionic surfactants to form complexes of different characteristics with relevance for use in microcapsule wall design. In this study, Ch/sodium dodecyl sulfate (SDS) microcapsules, without and with cross-linking agent (formaldehyde (FA) or glutaraldehyde (GA)), were obtained by the spray drying of vitamin E loaded oil-in-water emulsion. All of the microcapsules had good stability during the drying process. Depending on the composition, their product yield, moisture content, and encapsulation efficiency varied between 11–34%, 1.14–1.62%, and 94–126%, respectively. SEM and FTIR analysis results indicate that SDS as well as cross-linkers significantly affected the microcapsule wall properties. The profiles of in vitro vitamin E release from the investigated microcapsules fit with the Korsmeyer-Peppas model (r2 > 0.9). The chemical structure of the anionic surfactant was found to have a significant effect on the vitamin E release mechanism. Ch/SDS coacervates may build a microcapsule wall without toxic crosslinkers. This enabled the combined diffusion/swelling based release mechanism of the encapsulated lipophilic substance, which can be considered favorable for utilization in food and pharmaceutical products.
PB  - MDPI
T2  - Pharmaceuticals
T1  - Chitosan/Sodium Dodecyl Sulfate Complexes for Microencapsulation of Vitamin E and Its Release Profile— Understanding the Effect of Anionic Surfactant
VL  - 15
IS  - 1
DO  - 10.3390/ph15010054
ER  - 

@article{
author = "Milinković Budinčić, Jelena and Petrović, Lidija and Đekić, Ljiljana and Aleksić, Milijana and Fraj, Jadranka and Popović, Senka and Bučko, Sandra and Katona, Jaroslav and Spasojević, Ljiljana and Škrbić, Jelena and Malenović, Anđelija",
year = "2021",
abstract = "Microencapsulation of bioactive substances is a common strategy for their protection and release rate control. The use of chitosan (Ch) is particularly promising due to its abundance, biocompatibility, and interaction with anionic surfactants to form complexes of different characteristics with relevance for use in microcapsule wall design. In this study, Ch/sodium dodecyl sulfate (SDS) microcapsules, without and with cross-linking agent (formaldehyde (FA) or glutaraldehyde (GA)), were obtained by the spray drying of vitamin E loaded oil-in-water emulsion. All of the microcapsules had good stability during the drying process. Depending on the composition, their product yield, moisture content, and encapsulation efficiency varied between 11–34%, 1.14–1.62%, and 94–126%, respectively. SEM and FTIR analysis results indicate that SDS as well as cross-linkers significantly affected the microcapsule wall properties. The profiles of in vitro vitamin E release from the investigated microcapsules fit with the Korsmeyer-Peppas model (r2 > 0.9). The chemical structure of the anionic surfactant was found to have a significant effect on the vitamin E release mechanism. Ch/SDS coacervates may build a microcapsule wall without toxic crosslinkers. This enabled the combined diffusion/swelling based release mechanism of the encapsulated lipophilic substance, which can be considered favorable for utilization in food and pharmaceutical products.",
publisher = "MDPI",
journal = "Pharmaceuticals",
title = "Chitosan/Sodium Dodecyl Sulfate Complexes for Microencapsulation of Vitamin E and Its Release Profile— Understanding the Effect of Anionic Surfactant",
volume = "15",
number = "1",
doi = "10.3390/ph15010054"
}

Milinković Budinčić, J., Petrović, L., Đekić, L., Aleksić, M., Fraj, J., Popović, S., Bučko, S., Katona, J., Spasojević, L., Škrbić, J.,& Malenović, A.. (2021). Chitosan/Sodium Dodecyl Sulfate Complexes for Microencapsulation of Vitamin E and Its Release Profile— Understanding the Effect of Anionic Surfactant. in Pharmaceuticals
MDPI., 15(1).
https://doi.org/10.3390/ph15010054

Milinković Budinčić J, Petrović L, Đekić L, Aleksić M, Fraj J, Popović S, Bučko S, Katona J, Spasojević L, Škrbić J, Malenović A. Chitosan/Sodium Dodecyl Sulfate Complexes for Microencapsulation of Vitamin E and Its Release Profile— Understanding the Effect of Anionic Surfactant. in Pharmaceuticals. 2021;15(1).
doi:10.3390/ph15010054 .

Milinković Budinčić, Jelena, Petrović, Lidija, Đekić, Ljiljana, Aleksić, Milijana, Fraj, Jadranka, Popović, Senka, Bučko, Sandra, Katona, Jaroslav, Spasojević, Ljiljana, Škrbić, Jelena, Malenović, Anđelija, "Chitosan/Sodium Dodecyl Sulfate Complexes for Microencapsulation of Vitamin E and Its Release Profile— Understanding the Effect of Anionic Surfactant" in Pharmaceuticals, 15, no. 1 (2021),
https://doi.org/10.3390/ph15010054 . .

TY  - JOUR
AU  - Milinković Budinčić, Jelena
AU  - Petrović, Lidija
AU  - Đekić, Ljiljana
AU  - Fraj, Jadranka
AU  - Bučko, Sandra
AU  - Katona, Jaroslav
AU  - Spasojević, Ljiljana
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3774
AB  - Potential benefit of microencapsulation is its ability to deliver and protect incorporated ingredients such as vitamin E. Microcapsule wall properties can be changed by adding of coss-linking agents that are usually considered toxic for application. The microcapsules were prepared by a spray-drying technique using coacervation method, by depositing the coacervate formed in the mixture of chitosan and sodium lauryl ether sulfate to the oil/water interface. All obtained microcapsules suspensions had slightly lower mean diameter compared to the starting emulsion (6.85 ± 0.213 μm), which shows their good stability during the drying process. The choice and absence of cross-linking agents had influence on kinetics of vitamin E release. Encapsulation efficiency of microcapsules without cross-linking agent was 73.17 ± 0.64 %. This study avoided the use of aldehydes as cross-linking agents and found that chitosan/SLES complex can be used as wall material for the microencapsulation of hydrophobic active molecules in cosmetic industry.
PB  - Elsevier Ltd
T2  - Carbohydrate Polymers
T1  - Study of vitamin E microencapsulation and controlled release from chitosan/sodium lauryl ether sulfate microcapsules
VL  - 251
DO  - 10.1016/j.carbpol.2020.116988
ER  - 

@article{
author = "Milinković Budinčić, Jelena and Petrović, Lidija and Đekić, Ljiljana and Fraj, Jadranka and Bučko, Sandra and Katona, Jaroslav and Spasojević, Ljiljana",
year = "2021",
abstract = "Potential benefit of microencapsulation is its ability to deliver and protect incorporated ingredients such as vitamin E. Microcapsule wall properties can be changed by adding of coss-linking agents that are usually considered toxic for application. The microcapsules were prepared by a spray-drying technique using coacervation method, by depositing the coacervate formed in the mixture of chitosan and sodium lauryl ether sulfate to the oil/water interface. All obtained microcapsules suspensions had slightly lower mean diameter compared to the starting emulsion (6.85 ± 0.213 μm), which shows their good stability during the drying process. The choice and absence of cross-linking agents had influence on kinetics of vitamin E release. Encapsulation efficiency of microcapsules without cross-linking agent was 73.17 ± 0.64 %. This study avoided the use of aldehydes as cross-linking agents and found that chitosan/SLES complex can be used as wall material for the microencapsulation of hydrophobic active molecules in cosmetic industry.",
publisher = "Elsevier Ltd",
journal = "Carbohydrate Polymers",
title = "Study of vitamin E microencapsulation and controlled release from chitosan/sodium lauryl ether sulfate microcapsules",
volume = "251",
doi = "10.1016/j.carbpol.2020.116988"
}

Milinković Budinčić, J., Petrović, L., Đekić, L., Fraj, J., Bučko, S., Katona, J.,& Spasojević, L.. (2021). Study of vitamin E microencapsulation and controlled release from chitosan/sodium lauryl ether sulfate microcapsules. in Carbohydrate Polymers
Elsevier Ltd., 251.
https://doi.org/10.1016/j.carbpol.2020.116988

Milinković Budinčić J, Petrović L, Đekić L, Fraj J, Bučko S, Katona J, Spasojević L. Study of vitamin E microencapsulation and controlled release from chitosan/sodium lauryl ether sulfate microcapsules. in Carbohydrate Polymers. 2021;251.
doi:10.1016/j.carbpol.2020.116988 .

Milinković Budinčić, Jelena, Petrović, Lidija, Đekić, Ljiljana, Fraj, Jadranka, Bučko, Sandra, Katona, Jaroslav, Spasojević, Ljiljana, "Study of vitamin E microencapsulation and controlled release from chitosan/sodium lauryl ether sulfate microcapsules" in Carbohydrate Polymers, 251 (2021),
https://doi.org/10.1016/j.carbpol.2020.116988 . .

TY  - JOUR
AU  - Fraj, Jadranka
AU  - Petrović, Lidija
AU  - Đekić, Ljiljana
AU  - Milinković Budinčić, Jelena
AU  - Bučko, Sandra
AU  - Katona, Jaroslav
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3695
AB  - The objective of this study was to produce and characterize microcapsules for simultaneous encapsulation hydrophilic and lipophilic active substances. For this purpose, double emulsification process was employed, followed by complex coacervation in the system of two oppositely charged biopolymers, gelatin and sodium caseinate (NaCAS). Properties of the microcapsules wall have been regulated by cross-linking of the gelatin/NaCAS complex at the interface with genipin. Vitamins C and E were selected as model hydrophilic and lipophilic bioactive compounds for this study. Investigations of surface morphology, encapsulation efficiency (EE) and kinetic of vitamin C release have shown that genipin concentration as well as interaction in gelatin/NaCAS system make an influence on microcapsules properties. Genipin concentration of 2 mmol/g, was chosen as the optimal and the highest EE of the vitamins were obtained at proteins mass ratio of 2:1. The results of release kinetic determination of the vitamins showed that release mechanism is simple diffusion.
PB  - Elsevier Ltd
T2  - Journal of Food Engineering
T1  - Encapsulation and release of vitamin C in double W/O/W emulsions followed by complex coacervation in gelatin-sodium caseinate system
VL  - 292
DO  - 10.1016/j.jfoodeng.2020.110353
ER  - 

@article{
author = "Fraj, Jadranka and Petrović, Lidija and Đekić, Ljiljana and Milinković Budinčić, Jelena and Bučko, Sandra and Katona, Jaroslav",
year = "2021",
abstract = "The objective of this study was to produce and characterize microcapsules for simultaneous encapsulation hydrophilic and lipophilic active substances. For this purpose, double emulsification process was employed, followed by complex coacervation in the system of two oppositely charged biopolymers, gelatin and sodium caseinate (NaCAS). Properties of the microcapsules wall have been regulated by cross-linking of the gelatin/NaCAS complex at the interface with genipin. Vitamins C and E were selected as model hydrophilic and lipophilic bioactive compounds for this study. Investigations of surface morphology, encapsulation efficiency (EE) and kinetic of vitamin C release have shown that genipin concentration as well as interaction in gelatin/NaCAS system make an influence on microcapsules properties. Genipin concentration of 2 mmol/g, was chosen as the optimal and the highest EE of the vitamins were obtained at proteins mass ratio of 2:1. The results of release kinetic determination of the vitamins showed that release mechanism is simple diffusion.",
publisher = "Elsevier Ltd",
journal = "Journal of Food Engineering",
title = "Encapsulation and release of vitamin C in double W/O/W emulsions followed by complex coacervation in gelatin-sodium caseinate system",
volume = "292",
doi = "10.1016/j.jfoodeng.2020.110353"
}

Fraj, J., Petrović, L., Đekić, L., Milinković Budinčić, J., Bučko, S.,& Katona, J.. (2021). Encapsulation and release of vitamin C in double W/O/W emulsions followed by complex coacervation in gelatin-sodium caseinate system. in Journal of Food Engineering
Elsevier Ltd., 292.
https://doi.org/10.1016/j.jfoodeng.2020.110353

Fraj J, Petrović L, Đekić L, Milinković Budinčić J, Bučko S, Katona J. Encapsulation and release of vitamin C in double W/O/W emulsions followed by complex coacervation in gelatin-sodium caseinate system. in Journal of Food Engineering. 2021;292.
doi:10.1016/j.jfoodeng.2020.110353 .

Fraj, Jadranka, Petrović, Lidija, Đekić, Ljiljana, Milinković Budinčić, Jelena, Bučko, Sandra, Katona, Jaroslav, "Encapsulation and release of vitamin C in double W/O/W emulsions followed by complex coacervation in gelatin-sodium caseinate system" in Journal of Food Engineering, 292 (2021),
https://doi.org/10.1016/j.jfoodeng.2020.110353 . .