TY  - JOUR
AU  - Petrović, Silvana
AU  - Dobrić, Silva
AU  - Bokonjić, Dubravko
AU  - Niketić, Marjan
AU  - Garcia-Pineres, A
AU  - Merfort, I
PY  - 2003
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/443
AB  - Oral administration of the chloroform extract from Tanacetum larvatum (Griseb. ex Pant.) Kanitz caused a dose-dependent anti-inflammatory effect in the carrageenan-induced rat paw oedema test. The obtained anti-inflammatory effect was 8.6, 32.8, 37.0 and 49.5% for the extract doses of 25, 50, 100 and 200 mg/kg, respectively, being statistically significant at a dose of 50 mg/kg. Indomethacin had a strong anti-inflammatory effect of 73.4% at a dose of 8 mg/kg, but large gastric lesions were detected. When the plant extract in the highest tested dose (200 mg/kg) was concomitantly given with indomethacin, the anti-inflammatory effect was slightly enhanced, but the gastric lesions were significantly reduced. The anti-inflammatory and anti-ulcer activity may be mainly due to the inhibition of DNA binding of the transcription factor NF-kappaB by components of the plant extract. This was proven in an electrophoretic mobility shift assay at a concentration of 50 mug/ml. Due to its anti-inflammatory as well as anti-ulcer effects, Tanacetum larvatum should especially be used combined with those drugs that are known both for their strong anti-inflammatory activities and the ulcerogenic side effects such as NSAIDs.
PB  - Elsevier Ireland Ltd, Clare
T2  - Journal of Ethnopharmacology
T1  - Evaluation of Tanacetum larvatum for an anti-inflammatory activity and for the protection against indomethacin-induced ulcerogenesis in rats
VL  - 87
IS  - 1
SP  - 109
EP  - 113
DO  - 10.1016/S0378-8741(03)00118-1
ER  - 

@article{
author = "Petrović, Silvana and Dobrić, Silva and Bokonjić, Dubravko and Niketić, Marjan and Garcia-Pineres, A and Merfort, I",
year = "2003",
abstract = "Oral administration of the chloroform extract from Tanacetum larvatum (Griseb. ex Pant.) Kanitz caused a dose-dependent anti-inflammatory effect in the carrageenan-induced rat paw oedema test. The obtained anti-inflammatory effect was 8.6, 32.8, 37.0 and 49.5% for the extract doses of 25, 50, 100 and 200 mg/kg, respectively, being statistically significant at a dose of 50 mg/kg. Indomethacin had a strong anti-inflammatory effect of 73.4% at a dose of 8 mg/kg, but large gastric lesions were detected. When the plant extract in the highest tested dose (200 mg/kg) was concomitantly given with indomethacin, the anti-inflammatory effect was slightly enhanced, but the gastric lesions were significantly reduced. The anti-inflammatory and anti-ulcer activity may be mainly due to the inhibition of DNA binding of the transcription factor NF-kappaB by components of the plant extract. This was proven in an electrophoretic mobility shift assay at a concentration of 50 mug/ml. Due to its anti-inflammatory as well as anti-ulcer effects, Tanacetum larvatum should especially be used combined with those drugs that are known both for their strong anti-inflammatory activities and the ulcerogenic side effects such as NSAIDs.",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Journal of Ethnopharmacology",
title = "Evaluation of Tanacetum larvatum for an anti-inflammatory activity and for the protection against indomethacin-induced ulcerogenesis in rats",
volume = "87",
number = "1",
pages = "109-113",
doi = "10.1016/S0378-8741(03)00118-1"
}

Petrović, S., Dobrić, S., Bokonjić, D., Niketić, M., Garcia-Pineres, A.,& Merfort, I.. (2003). Evaluation of Tanacetum larvatum for an anti-inflammatory activity and for the protection against indomethacin-induced ulcerogenesis in rats. in Journal of Ethnopharmacology
Elsevier Ireland Ltd, Clare., 87(1), 109-113.
https://doi.org/10.1016/S0378-8741(03)00118-1

Petrović S, Dobrić S, Bokonjić D, Niketić M, Garcia-Pineres A, Merfort I. Evaluation of Tanacetum larvatum for an anti-inflammatory activity and for the protection against indomethacin-induced ulcerogenesis in rats. in Journal of Ethnopharmacology. 2003;87(1):109-113.
doi:10.1016/S0378-8741(03)00118-1 .

Petrović, Silvana, Dobrić, Silva, Bokonjić, Dubravko, Niketić, Marjan, Garcia-Pineres, A, Merfort, I, "Evaluation of Tanacetum larvatum for an anti-inflammatory activity and for the protection against indomethacin-induced ulcerogenesis in rats" in Journal of Ethnopharmacology, 87, no. 1 (2003):109-113,
https://doi.org/10.1016/S0378-8741(03)00118-1 . .