TY  - JOUR
AU  - Ristovski-Kornić, Danijela
AU  - Stefanović, Aleksandra
AU  - Kotur-Stevuljević, Jelena
AU  - Zeljković, Aleksandra
AU  - Spasojević-Kalimanovska, Vesna
AU  - Vekić, Jelena
AU  - Miljković, Milica
AU  - Paripović, Dušan
AU  - Peco-Antić, Amira
AU  - Jelić-Ivanović, Zorana
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2956
AB  - Background: The aim of this study was to explore oxidative stress status, especially the enzyme myeloperoxidase in children with end-stage renal disease. Also, we investigated possible associations between the atherogenic index of plasma and these parameters. Methods: Lipid status parameters, oxidative stress status parameters, and myeloperoxidase concentration were measured in the sera of 20 children in the last stage of chronic renal disease (ESRD) and 35 healthy children of matching age and sex. The Atherogenic Index of Plasma (AIP) was calculated according to the appropriate equation. Results: We did not find any significant differences in myeloperoxidase concentrations between the investigated groups (p = 0.394). Oxidative stress parameters were, however, significantly higher in the patient group (p  lt  0.001), as well as the atherogenic index of plasma (p  lt  0.001). Myelo per oxidase concentration and advanced oxidation protein product (AOPP) concentration were independently associated with increased AIP in the patient group (p  lt  0.05). Conclusions: Changes in AIP in children with ERSD are associated with the oxidative stress status and myeloper oxidase concentration.
PB  - Društvo medicinskih biohemičara Srbije, Beograd i Versita
T2  - Journal of Medical Biochemistry
T1  - Association of Myeloperoxidase and the Atherogenic Index of Plasma in Children with End-Stage Renal Disease
VL  - 36
IS  - 1
SP  - 23
EP  - 31
DO  - 10.1515/jomb-2016-0027
ER  - 

@article{
author = "Ristovski-Kornić, Danijela and Stefanović, Aleksandra and Kotur-Stevuljević, Jelena and Zeljković, Aleksandra and Spasojević-Kalimanovska, Vesna and Vekić, Jelena and Miljković, Milica and Paripović, Dušan and Peco-Antić, Amira and Jelić-Ivanović, Zorana",
year = "2017",
abstract = "Background: The aim of this study was to explore oxidative stress status, especially the enzyme myeloperoxidase in children with end-stage renal disease. Also, we investigated possible associations between the atherogenic index of plasma and these parameters. Methods: Lipid status parameters, oxidative stress status parameters, and myeloperoxidase concentration were measured in the sera of 20 children in the last stage of chronic renal disease (ESRD) and 35 healthy children of matching age and sex. The Atherogenic Index of Plasma (AIP) was calculated according to the appropriate equation. Results: We did not find any significant differences in myeloperoxidase concentrations between the investigated groups (p = 0.394). Oxidative stress parameters were, however, significantly higher in the patient group (p  lt  0.001), as well as the atherogenic index of plasma (p  lt  0.001). Myelo per oxidase concentration and advanced oxidation protein product (AOPP) concentration were independently associated with increased AIP in the patient group (p  lt  0.05). Conclusions: Changes in AIP in children with ERSD are associated with the oxidative stress status and myeloper oxidase concentration.",
publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita",
journal = "Journal of Medical Biochemistry",
title = "Association of Myeloperoxidase and the Atherogenic Index of Plasma in Children with End-Stage Renal Disease",
volume = "36",
number = "1",
pages = "23-31",
doi = "10.1515/jomb-2016-0027"
}

Ristovski-Kornić, D., Stefanović, A., Kotur-Stevuljević, J., Zeljković, A., Spasojević-Kalimanovska, V., Vekić, J., Miljković, M., Paripović, D., Peco-Antić, A.,& Jelić-Ivanović, Z.. (2017). Association of Myeloperoxidase and the Atherogenic Index of Plasma in Children with End-Stage Renal Disease. in Journal of Medical Biochemistry
Društvo medicinskih biohemičara Srbije, Beograd i Versita., 36(1), 23-31.
https://doi.org/10.1515/jomb-2016-0027

Ristovski-Kornić D, Stefanović A, Kotur-Stevuljević J, Zeljković A, Spasojević-Kalimanovska V, Vekić J, Miljković M, Paripović D, Peco-Antić A, Jelić-Ivanović Z. Association of Myeloperoxidase and the Atherogenic Index of Plasma in Children with End-Stage Renal Disease. in Journal of Medical Biochemistry. 2017;36(1):23-31.
doi:10.1515/jomb-2016-0027 .

Ristovski-Kornić, Danijela, Stefanović, Aleksandra, Kotur-Stevuljević, Jelena, Zeljković, Aleksandra, Spasojević-Kalimanovska, Vesna, Vekić, Jelena, Miljković, Milica, Paripović, Dušan, Peco-Antić, Amira, Jelić-Ivanović, Zorana, "Association of Myeloperoxidase and the Atherogenic Index of Plasma in Children with End-Stage Renal Disease" in Journal of Medical Biochemistry, 36, no. 1 (2017):23-31,
https://doi.org/10.1515/jomb-2016-0027 . .

TY  - JOUR
AU  - Stefanović, Aleksandra
AU  - Ristovski-Kornić, Danijela
AU  - Kotur-Stevuljević, Jelena
AU  - Spasojević-Kalimanovska, Vesna
AU  - Vekić, Jelena
AU  - Miljković, Milica
AU  - Paripović, Dušan
AU  - Peco-Antić, Amira
AU  - Jelić-Ivanović, Zorana
AU  - Zeljković, Aleksandra
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2815
AB  - Background: Unfavorable lipid profile presents one of most important risk factor for cardiovascular disease in renal pathology. Myeloperoxidase (MPO) as enzyme which oxidizes lipoproteins and paraoxonase1 (PON1) as anti-oxidative enzyme have been involved in pathogenesis of cardiovascular disease. In the present study we sought to assess oxidative stress status, lipoprotein subclasses distribution as well as functionality of high density lipoprotein (HDL) trough MPO/PON1 ratio in children with chronic kidney disease (CKD) and children after renal transplantation. Methods: PON1 activity and oxidative stress parameters were measured spectrophotometrically, while MPO concentration was determined using immunoassay. Separation of lipoprotein subclasses was performed by vertical gradient gel electrophoresis in 19 children with different stage of CKD and 19 post-transplantation patients (PT). Results: CKD patients had increased MPO/PON1 ratio and higher prevalence of smaller HDL subclasses when compared to PT subjects. Also, there was a significant positive correlation between MPO level and MPO/PON1 ratio with relative proportion of smaller HDL subclasses. Conclusions: Children with CKD have impaired HDL distribution that is improved after kidney transplantation. Since that measurement of HDL distribution and functionality arenot routinely available, MPO/PON1 ratio may be useful marker that could provide necessary information.
PB  - Društvo medicinskih biohemičara Srbije, Beograd i Versita
T2  - Journal of Medical Biochemistry
T1  - Alterations of HDL Particles in Children with End-Stage Renal Disease
VL  - 36
IS  - 4
SP  - 358
EP  - 365
DO  - 10.1515/jomb-2017-0019
ER  - 

@article{
author = "Stefanović, Aleksandra and Ristovski-Kornić, Danijela and Kotur-Stevuljević, Jelena and Spasojević-Kalimanovska, Vesna and Vekić, Jelena and Miljković, Milica and Paripović, Dušan and Peco-Antić, Amira and Jelić-Ivanović, Zorana and Zeljković, Aleksandra",
year = "2017",
abstract = "Background: Unfavorable lipid profile presents one of most important risk factor for cardiovascular disease in renal pathology. Myeloperoxidase (MPO) as enzyme which oxidizes lipoproteins and paraoxonase1 (PON1) as anti-oxidative enzyme have been involved in pathogenesis of cardiovascular disease. In the present study we sought to assess oxidative stress status, lipoprotein subclasses distribution as well as functionality of high density lipoprotein (HDL) trough MPO/PON1 ratio in children with chronic kidney disease (CKD) and children after renal transplantation. Methods: PON1 activity and oxidative stress parameters were measured spectrophotometrically, while MPO concentration was determined using immunoassay. Separation of lipoprotein subclasses was performed by vertical gradient gel electrophoresis in 19 children with different stage of CKD and 19 post-transplantation patients (PT). Results: CKD patients had increased MPO/PON1 ratio and higher prevalence of smaller HDL subclasses when compared to PT subjects. Also, there was a significant positive correlation between MPO level and MPO/PON1 ratio with relative proportion of smaller HDL subclasses. Conclusions: Children with CKD have impaired HDL distribution that is improved after kidney transplantation. Since that measurement of HDL distribution and functionality arenot routinely available, MPO/PON1 ratio may be useful marker that could provide necessary information.",
publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita",
journal = "Journal of Medical Biochemistry",
title = "Alterations of HDL Particles in Children with End-Stage Renal Disease",
volume = "36",
number = "4",
pages = "358-365",
doi = "10.1515/jomb-2017-0019"
}

Stefanović, A., Ristovski-Kornić, D., Kotur-Stevuljević, J., Spasojević-Kalimanovska, V., Vekić, J., Miljković, M., Paripović, D., Peco-Antić, A., Jelić-Ivanović, Z.,& Zeljković, A.. (2017). Alterations of HDL Particles in Children with End-Stage Renal Disease. in Journal of Medical Biochemistry
Društvo medicinskih biohemičara Srbije, Beograd i Versita., 36(4), 358-365.
https://doi.org/10.1515/jomb-2017-0019

Stefanović A, Ristovski-Kornić D, Kotur-Stevuljević J, Spasojević-Kalimanovska V, Vekić J, Miljković M, Paripović D, Peco-Antić A, Jelić-Ivanović Z, Zeljković A. Alterations of HDL Particles in Children with End-Stage Renal Disease. in Journal of Medical Biochemistry. 2017;36(4):358-365.
doi:10.1515/jomb-2017-0019 .

Stefanović, Aleksandra, Ristovski-Kornić, Danijela, Kotur-Stevuljević, Jelena, Spasojević-Kalimanovska, Vesna, Vekić, Jelena, Miljković, Milica, Paripović, Dušan, Peco-Antić, Amira, Jelić-Ivanović, Zorana, Zeljković, Aleksandra, "Alterations of HDL Particles in Children with End-Stage Renal Disease" in Journal of Medical Biochemistry, 36, no. 4 (2017):358-365,
https://doi.org/10.1515/jomb-2017-0019 . .