TY  - JOUR
AU  - Janićijević, Jelena
AU  - Krajišnik, Danina
AU  - Čalija, Bojan
AU  - Nedić-Vasiljević, Bojana
AU  - Dobričić, Vladimir
AU  - Daković, Aleksandra
AU  - Antonijević, Milan D.
AU  - Milić, Jela
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2360
AB  - Diatomite makes a promising candidate for a drug carrier because of its high porosity, large surface area, modifiable surface chemistry and biocompatibility. Herein, refined diatomite from Kolubara coal basin, which complied with the pharmacopoeial requirements for heavy metals content and microbiological quality, was used as a starting material. Inorganic modification of the starting material was performed through a simple, one-step procedure. Significant increase in adsorbent loading with diclofenac sodium (DS) was achieved after the modification process (similar to 373 mg/g) which enabled the preparation of comprimates containing therapeutic dose of the adsorbed drug. Adsorption of DS onto modified diatomite resulted in the alteration of the drug's XRD pattern and FTIR spectrum. In vitro drug release studies in phosphate buffer pH 7.5 demonstrated prolonged DS release over 8 h from comprimates containing DS adsorbed on modified diatomite (up to 37% after 8 h) and those containing physical mixture of the same composition (up to 45% after 8 h). The results of in vivo toxicity testing on mice pointed on potential safety of both unmodified (starting) and modified diatomite. All these findings favor the application of diatomite as a potential functional drug carrier.
PB  - Elsevier Science BV, Amsterdam
T2  - International Journal of Pharmaceutics
T1  - Modified local diatomite as potential functional drug carrier-A model study for diclofenac sodium
VL  - 496
IS  - 2
SP  - 466
EP  - 474
DO  - 10.1016/j.ijpharm.2015.10.047
ER  - 

@article{
author = "Janićijević, Jelena and Krajišnik, Danina and Čalija, Bojan and Nedić-Vasiljević, Bojana and Dobričić, Vladimir and Daković, Aleksandra and Antonijević, Milan D. and Milić, Jela",
year = "2015",
abstract = "Diatomite makes a promising candidate for a drug carrier because of its high porosity, large surface area, modifiable surface chemistry and biocompatibility. Herein, refined diatomite from Kolubara coal basin, which complied with the pharmacopoeial requirements for heavy metals content and microbiological quality, was used as a starting material. Inorganic modification of the starting material was performed through a simple, one-step procedure. Significant increase in adsorbent loading with diclofenac sodium (DS) was achieved after the modification process (similar to 373 mg/g) which enabled the preparation of comprimates containing therapeutic dose of the adsorbed drug. Adsorption of DS onto modified diatomite resulted in the alteration of the drug's XRD pattern and FTIR spectrum. In vitro drug release studies in phosphate buffer pH 7.5 demonstrated prolonged DS release over 8 h from comprimates containing DS adsorbed on modified diatomite (up to 37% after 8 h) and those containing physical mixture of the same composition (up to 45% after 8 h). The results of in vivo toxicity testing on mice pointed on potential safety of both unmodified (starting) and modified diatomite. All these findings favor the application of diatomite as a potential functional drug carrier.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "International Journal of Pharmaceutics",
title = "Modified local diatomite as potential functional drug carrier-A model study for diclofenac sodium",
volume = "496",
number = "2",
pages = "466-474",
doi = "10.1016/j.ijpharm.2015.10.047"
}

Janićijević, J., Krajišnik, D., Čalija, B., Nedić-Vasiljević, B., Dobričić, V., Daković, A., Antonijević, M. D.,& Milić, J.. (2015). Modified local diatomite as potential functional drug carrier-A model study for diclofenac sodium. in International Journal of Pharmaceutics
Elsevier Science BV, Amsterdam., 496(2), 466-474.
https://doi.org/10.1016/j.ijpharm.2015.10.047

Janićijević J, Krajišnik D, Čalija B, Nedić-Vasiljević B, Dobričić V, Daković A, Antonijević MD, Milić J. Modified local diatomite as potential functional drug carrier-A model study for diclofenac sodium. in International Journal of Pharmaceutics. 2015;496(2):466-474.
doi:10.1016/j.ijpharm.2015.10.047 .

Janićijević, Jelena, Krajišnik, Danina, Čalija, Bojan, Nedić-Vasiljević, Bojana, Dobričić, Vladimir, Daković, Aleksandra, Antonijević, Milan D., Milić, Jela, "Modified local diatomite as potential functional drug carrier-A model study for diclofenac sodium" in International Journal of Pharmaceutics, 496, no. 2 (2015):466-474,
https://doi.org/10.1016/j.ijpharm.2015.10.047 . .

TY  - JOUR
AU  - Đorđević-Filijović, Nataša
AU  - Antonijević, Milan D.
AU  - Pavlović, Aleksandar
AU  - Vucković, Ivan M.
AU  - Nikolić, Katarina
AU  - Agbaba, Danica
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2415
AB  - Stress stability testing represents an important part of the drug development process. It is used as an important tool for the identification of degradation products and degradation pathways, as well as for the assessment of changes in physical form of drug molecules. The impact of excipients on the stability of olanzapine confirms that levels of impurities and degradants are limiting parameters and are therefore used for stability evaluation. The major degradation product of olanzapine was identified as 2-methyl-5,10-dihydro-4H-thieno[2,3-b][1,5] benzodiazepine-4-one (III). The structure of III was determined by using LC-MS, IR and NMR. Compatibility and stress stability results demonstrated that tablet formulations of olanzapine are sensitive to temperature and moisture. In samples protected from moisture, the increase in concentration of III was shown to be highly temperature dependent and the degradation followed zero-order kinetics. In addition, studies of olanzapine with excipients and in formulated tablets revealed polymorphic phase changes in some samples, influenced by a combination of stress temperature and humidity conditions. Polymorphic transitions were monitored using x-ray powder diffraction (XRPD) analysis and exhibited no correlation between the phase change (appearance of a new polymorph) and the degradation process.
PB  - Informa Healthcare, London
T2  - Drug Development and Industrial Pharmacy
T1  - The stress stability of olanzapine: studies of interactions with excipients in solid state pharmaceutical formulations
VL  - 41
IS  - 3
SP  - 502
EP  - 514
DO  - 10.3109/03639045.2014.884114
ER  - 

@article{
author = "Đorđević-Filijović, Nataša and Antonijević, Milan D. and Pavlović, Aleksandar and Vucković, Ivan M. and Nikolić, Katarina and Agbaba, Danica",
year = "2015",
abstract = "Stress stability testing represents an important part of the drug development process. It is used as an important tool for the identification of degradation products and degradation pathways, as well as for the assessment of changes in physical form of drug molecules. The impact of excipients on the stability of olanzapine confirms that levels of impurities and degradants are limiting parameters and are therefore used for stability evaluation. The major degradation product of olanzapine was identified as 2-methyl-5,10-dihydro-4H-thieno[2,3-b][1,5] benzodiazepine-4-one (III). The structure of III was determined by using LC-MS, IR and NMR. Compatibility and stress stability results demonstrated that tablet formulations of olanzapine are sensitive to temperature and moisture. In samples protected from moisture, the increase in concentration of III was shown to be highly temperature dependent and the degradation followed zero-order kinetics. In addition, studies of olanzapine with excipients and in formulated tablets revealed polymorphic phase changes in some samples, influenced by a combination of stress temperature and humidity conditions. Polymorphic transitions were monitored using x-ray powder diffraction (XRPD) analysis and exhibited no correlation between the phase change (appearance of a new polymorph) and the degradation process.",
publisher = "Informa Healthcare, London",
journal = "Drug Development and Industrial Pharmacy",
title = "The stress stability of olanzapine: studies of interactions with excipients in solid state pharmaceutical formulations",
volume = "41",
number = "3",
pages = "502-514",
doi = "10.3109/03639045.2014.884114"
}

Đorđević-Filijović, N., Antonijević, M. D., Pavlović, A., Vucković, I. M., Nikolić, K.,& Agbaba, D.. (2015). The stress stability of olanzapine: studies of interactions with excipients in solid state pharmaceutical formulations. in Drug Development and Industrial Pharmacy
Informa Healthcare, London., 41(3), 502-514.
https://doi.org/10.3109/03639045.2014.884114

Đorđević-Filijović N, Antonijević MD, Pavlović A, Vucković IM, Nikolić K, Agbaba D. The stress stability of olanzapine: studies of interactions with excipients in solid state pharmaceutical formulations. in Drug Development and Industrial Pharmacy. 2015;41(3):502-514.
doi:10.3109/03639045.2014.884114 .

Đorđević-Filijović, Nataša, Antonijević, Milan D., Pavlović, Aleksandar, Vucković, Ivan M., Nikolić, Katarina, Agbaba, Danica, "The stress stability of olanzapine: studies of interactions with excipients in solid state pharmaceutical formulations" in Drug Development and Industrial Pharmacy, 41, no. 3 (2015):502-514,
https://doi.org/10.3109/03639045.2014.884114 . .