TY  - JOUR
AU  - Đuričić, Ivana
AU  - Mazić, Sanja D.
AU  - Kotur-Stevuljević, Jelena
AU  - Đorđević, Vladimir
AU  - Šobajić, Slađana
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2144
AB  - Several dietary recommendations have been made for marine n-3 polyunsaturated fatty acid (PUPA) intake; however, the effectiveness of these fatty acids has not been thoroughly examined. The aim of this study was to investigate whether public-aimed dietary recommendations for long-chain n-3 PUPA from oily fish or fish oil supplements are efficient in optimizing their status in red blood cells (RBCs) and platelets of healthy middle-aged subjects with low customary fish consumption. In a randomized, cross-over trial conducted over an 8-week period and separated by a 6-month washout period, 33 participants received an oily fish (salmon), providing 274 mg eicosapentaenoic acid (EPA) + 671 mg docosahexaenoic acid (DHA) per day, or a commercial fish oil supplement, providing 396 mg EPA + 250 mg DHA per day. Blood samples were collected before and after each intervention period, and RBCs and platelets were used for analysis of fatty acids. After 8 weeks, there were significant increases in EPA and DHA content in RBCs and platelets with both salmon and fish oil capsules. The increase in EPA in both RBCs and platelets was higher with capsules, whereas the increase in DHA in both RBCs and platelets was higher with salmon. In spite of the quantitative and qualitative differences between n-3 fatty acid profiles in salmon and the fish oil supplement, the overall incorporation of these fatty acids into RBCs and platelets did not differ in our short-term study (P>.05). The sum of EPA + DHA significantly increased in both compartments following dietary recommendations for oily fish and fish oil supplements intake in middle-aged healthy subjects with low baseline long-chain n-3 PUPA status, although targeted values with optimal cardioprotective effect of more than 8% were not achieved.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Nutrition Research
T1  - Long-chain n-3 polyunsaturated fatty acid dietary recommendations are moderately efficient in optimizing their status in healthy middle-aged subjects with low fish consumption: a cross-over study
VL  - 34
IS  - 3
SP  - 210
EP  - 218
DO  - 10.1016/j.nutres.2013.12.008
ER  - 

@article{
author = "Đuričić, Ivana and Mazić, Sanja D. and Kotur-Stevuljević, Jelena and Đorđević, Vladimir and Šobajić, Slađana",
year = "2014",
abstract = "Several dietary recommendations have been made for marine n-3 polyunsaturated fatty acid (PUPA) intake; however, the effectiveness of these fatty acids has not been thoroughly examined. The aim of this study was to investigate whether public-aimed dietary recommendations for long-chain n-3 PUPA from oily fish or fish oil supplements are efficient in optimizing their status in red blood cells (RBCs) and platelets of healthy middle-aged subjects with low customary fish consumption. In a randomized, cross-over trial conducted over an 8-week period and separated by a 6-month washout period, 33 participants received an oily fish (salmon), providing 274 mg eicosapentaenoic acid (EPA) + 671 mg docosahexaenoic acid (DHA) per day, or a commercial fish oil supplement, providing 396 mg EPA + 250 mg DHA per day. Blood samples were collected before and after each intervention period, and RBCs and platelets were used for analysis of fatty acids. After 8 weeks, there were significant increases in EPA and DHA content in RBCs and platelets with both salmon and fish oil capsules. The increase in EPA in both RBCs and platelets was higher with capsules, whereas the increase in DHA in both RBCs and platelets was higher with salmon. In spite of the quantitative and qualitative differences between n-3 fatty acid profiles in salmon and the fish oil supplement, the overall incorporation of these fatty acids into RBCs and platelets did not differ in our short-term study (P>.05). The sum of EPA + DHA significantly increased in both compartments following dietary recommendations for oily fish and fish oil supplements intake in middle-aged healthy subjects with low baseline long-chain n-3 PUPA status, although targeted values with optimal cardioprotective effect of more than 8% were not achieved.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Nutrition Research",
title = "Long-chain n-3 polyunsaturated fatty acid dietary recommendations are moderately efficient in optimizing their status in healthy middle-aged subjects with low fish consumption: a cross-over study",
volume = "34",
number = "3",
pages = "210-218",
doi = "10.1016/j.nutres.2013.12.008"
}

Đuričić, I., Mazić, S. D., Kotur-Stevuljević, J., Đorđević, V.,& Šobajić, S.. (2014). Long-chain n-3 polyunsaturated fatty acid dietary recommendations are moderately efficient in optimizing their status in healthy middle-aged subjects with low fish consumption: a cross-over study. in Nutrition Research
Pergamon-Elsevier Science Ltd, Oxford., 34(3), 210-218.
https://doi.org/10.1016/j.nutres.2013.12.008

Đuričić I, Mazić SD, Kotur-Stevuljević J, Đorđević V, Šobajić S. Long-chain n-3 polyunsaturated fatty acid dietary recommendations are moderately efficient in optimizing their status in healthy middle-aged subjects with low fish consumption: a cross-over study. in Nutrition Research. 2014;34(3):210-218.
doi:10.1016/j.nutres.2013.12.008 .

Đuričić, Ivana, Mazić, Sanja D., Kotur-Stevuljević, Jelena, Đorđević, Vladimir, Šobajić, Slađana, "Long-chain n-3 polyunsaturated fatty acid dietary recommendations are moderately efficient in optimizing their status in healthy middle-aged subjects with low fish consumption: a cross-over study" in Nutrition Research, 34, no. 3 (2014):210-218,
https://doi.org/10.1016/j.nutres.2013.12.008 . .