TY  - CHAP
AU  - Jokanović, Milan
AU  - Antonijević, Biljana
AU  - Vučinić, Slavica
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1582
PB  - John Wiley and Sons
T2  - Anticholinesterase Pesticides: Metabolism, Neurotoxicity, and Epidemiology
T1  - Epidemiological Studies of Anticholinesterase Pesticide Poisoning in Serbia
SP  - 481
EP  - 494
DO  - 10.1002/9780470640500.ch35
ER  - 

@inbook{
author = "Jokanović, Milan and Antonijević, Biljana and Vučinić, Slavica",
year = "2011",
publisher = "John Wiley and Sons",
journal = "Anticholinesterase Pesticides: Metabolism, Neurotoxicity, and Epidemiology",
booktitle = "Epidemiological Studies of Anticholinesterase Pesticide Poisoning in Serbia",
pages = "481-494",
doi = "10.1002/9780470640500.ch35"
}

Jokanović, M., Antonijević, B.,& Vučinić, S.. (2011). Epidemiological Studies of Anticholinesterase Pesticide Poisoning in Serbia. in Anticholinesterase Pesticides: Metabolism, Neurotoxicity, and Epidemiology
John Wiley and Sons., 481-494.
https://doi.org/10.1002/9780470640500.ch35

Jokanović M, Antonijević B, Vučinić S. Epidemiological Studies of Anticholinesterase Pesticide Poisoning in Serbia. in Anticholinesterase Pesticides: Metabolism, Neurotoxicity, and Epidemiology. 2011;:481-494.
doi:10.1002/9780470640500.ch35 .

Jokanović, Milan, Antonijević, Biljana, Vučinić, Slavica, "Epidemiological Studies of Anticholinesterase Pesticide Poisoning in Serbia" in Anticholinesterase Pesticides: Metabolism, Neurotoxicity, and Epidemiology (2011):481-494,
https://doi.org/10.1002/9780470640500.ch35 . .

TY  - JOUR
AU  - Stepanović-Petrović, Radica
AU  - Savić, Vladimir
AU  - Tomić, Maja
AU  - Tokić-Vujošević, Zorana
AU  - Simić, Milena
AU  - Stepanović, Jelena M.
AU  - Jokanović, Milan
AU  - Micov, Ana
PY  - 2010
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1337
AB  - Background/Aims: 5-Ketoximeisosorbide-2-mononitrate (50-IS-2-MN) was synthesized and its pharmacological and toxicological characteristics were examined and compared with its parent drug, isosorbide-5-mononitrate (IS-5-MN, CAS 16051-77-7), and its diastereoisomer 2-ketoximeisosorbide-5-mononitrate. Methods: Vasorelaxation was studied on phenylephrine-precontracted rat superior mesenteric artery rings in organ bath procedure. In some rings, the endothelium was mechanically removed. In vitro tolerance was induced by treating the precontracted rings with maximal concentrations of the parent drug and the ketoximes, and after washing out, the procedure was repeated for two times. Furthermore, rats were treated with a single oral dose (1000 mg/kg) of 50-IS-2-MN and 20-IS-5-MN. Results: After a phenylephrine-induced contraction, 50-IS-2-MN (10(-8)-10(-4) mol/l) caused a concentration-dependent relaxation of the rat superior mesenteric artery that was strongly potentiated after the removal of the vascular endothelium. In preparations with or without endothelium, 50-IS-2-MN was a more potent relaxant than either the parent compound or its isomer. The mechanism of the relaxant effect of 50-IS-2-MN involves the activated soluble guanylyl cyclase-cyclic GMP pathway. Hydralazine (10(-5) mol/l), a strong antioxidant, ameliorated tolerance to IS-5-MN, but did not affect the absence of tolerance to either ketoxime. The minimum lethal dose in rat for 50-IS-2-MN and 20-IS-5-MN was greater than 1000 mg/kg. Conclusion: These results suggest that the modification of the configuration at the ester carbon of IS-5-MN contributes to more potent and tolerance-devoid activity on the rat superior mesenteric artery.
PB  - ECV-Editio Cantor Verlag Medizin Naturwissenschaften, Aulendorf
T2  - Arzneimittelforschung - Drug Research
T1  - Comparison of vasorelaxant effect and tolerance profile of a novel isosorbide-5-mononitrate derivative with its stereoisomer and parent drug on rat mesenteric artery
VL  - 60
IS  - 4
SP  - 189
EP  - 197
DO  - 10.1055/s-0031-1296272
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1337
ER  - 

@article{
author = "Stepanović-Petrović, Radica and Savić, Vladimir and Tomić, Maja and Tokić-Vujošević, Zorana and Simić, Milena and Stepanović, Jelena M. and Jokanović, Milan and Micov, Ana",
year = "2010",
abstract = "Background/Aims: 5-Ketoximeisosorbide-2-mononitrate (50-IS-2-MN) was synthesized and its pharmacological and toxicological characteristics were examined and compared with its parent drug, isosorbide-5-mononitrate (IS-5-MN, CAS 16051-77-7), and its diastereoisomer 2-ketoximeisosorbide-5-mononitrate. Methods: Vasorelaxation was studied on phenylephrine-precontracted rat superior mesenteric artery rings in organ bath procedure. In some rings, the endothelium was mechanically removed. In vitro tolerance was induced by treating the precontracted rings with maximal concentrations of the parent drug and the ketoximes, and after washing out, the procedure was repeated for two times. Furthermore, rats were treated with a single oral dose (1000 mg/kg) of 50-IS-2-MN and 20-IS-5-MN. Results: After a phenylephrine-induced contraction, 50-IS-2-MN (10(-8)-10(-4) mol/l) caused a concentration-dependent relaxation of the rat superior mesenteric artery that was strongly potentiated after the removal of the vascular endothelium. In preparations with or without endothelium, 50-IS-2-MN was a more potent relaxant than either the parent compound or its isomer. The mechanism of the relaxant effect of 50-IS-2-MN involves the activated soluble guanylyl cyclase-cyclic GMP pathway. Hydralazine (10(-5) mol/l), a strong antioxidant, ameliorated tolerance to IS-5-MN, but did not affect the absence of tolerance to either ketoxime. The minimum lethal dose in rat for 50-IS-2-MN and 20-IS-5-MN was greater than 1000 mg/kg. Conclusion: These results suggest that the modification of the configuration at the ester carbon of IS-5-MN contributes to more potent and tolerance-devoid activity on the rat superior mesenteric artery.",
publisher = "ECV-Editio Cantor Verlag Medizin Naturwissenschaften, Aulendorf",
journal = "Arzneimittelforschung - Drug Research",
title = "Comparison of vasorelaxant effect and tolerance profile of a novel isosorbide-5-mononitrate derivative with its stereoisomer and parent drug on rat mesenteric artery",
volume = "60",
number = "4",
pages = "189-197",
doi = "10.1055/s-0031-1296272",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1337"
}

Stepanović-Petrović, R., Savić, V., Tomić, M., Tokić-Vujošević, Z., Simić, M., Stepanović, J. M., Jokanović, M.,& Micov, A.. (2010). Comparison of vasorelaxant effect and tolerance profile of a novel isosorbide-5-mononitrate derivative with its stereoisomer and parent drug on rat mesenteric artery. in Arzneimittelforschung - Drug Research
ECV-Editio Cantor Verlag Medizin Naturwissenschaften, Aulendorf., 60(4), 189-197.
https://doi.org/10.1055/s-0031-1296272
https://hdl.handle.net/21.15107/rcub_farfar_1337

Stepanović-Petrović R, Savić V, Tomić M, Tokić-Vujošević Z, Simić M, Stepanović JM, Jokanović M, Micov A. Comparison of vasorelaxant effect and tolerance profile of a novel isosorbide-5-mononitrate derivative with its stereoisomer and parent drug on rat mesenteric artery. in Arzneimittelforschung - Drug Research. 2010;60(4):189-197.
doi:10.1055/s-0031-1296272
https://hdl.handle.net/21.15107/rcub_farfar_1337 .

Stepanović-Petrović, Radica, Savić, Vladimir, Tomić, Maja, Tokić-Vujošević, Zorana, Simić, Milena, Stepanović, Jelena M., Jokanović, Milan, Micov, Ana, "Comparison of vasorelaxant effect and tolerance profile of a novel isosorbide-5-mononitrate derivative with its stereoisomer and parent drug on rat mesenteric artery" in Arzneimittelforschung - Drug Research, 60, no. 4 (2010):189-197,
https://doi.org/10.1055/s-0031-1296272 .,
https://hdl.handle.net/21.15107/rcub_farfar_1337 .

TY  - JOUR
AU  - Jokanović, Milan
AU  - Maksimović, Matej
AU  - Stepanović-Petrović, Radica
PY  - 1995
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/121
AB  - Phosphamidon (PSM) is an organophosphorus insecticide widely used in agriculture. This study was undertaken to examine the interaction of PSM with acetylcholinesterase (AChE) and neuropathy target esterase (NTE) of hen brain in vitro and in vivo. PSM was a potent inhibitor of AChE, with an I50 of 2.9μM and second-order rate constant (ka) of 1.2×104 M-1 min-1 at 37°C. PSM-inhibited AChE aged rapidly (t1/2=1.9h). Pyridinium oximes pralidoxime, trimedoxime, obidoxime and HI-6 were effective reactivators of PSM-inhibited AChE, providing up to 75% reactivation. PSM was one of the weakest inhibitors of NTE among organophosphorus compounds, with an I50 of 19 mM and ka of 1.8 M-1 min-1 at 37°C. Inhibited NTE did not reactivate spontaneously and KF-induced reactivation was not obtained even at the earliest tested moments, so it was not clear whether aging of PSM-inhibited NTE occurred very quickly or the KF molecule could not affect the stability of phosphoryl-NTE bond. From the ratio of kas for NTE and AChE (0.00015) it was predicted that delayed neuropathic effects of PSM in vivo would appear only at doses far above the acute LD50. The LD50 value of PSM p.o. for hens was 9 mg/kg. Hens were treated with a single oral dose of PSM, combined with standard antidotal treatment which included atropine, physostigmine, pralidoxime and anticonvulsant midazolam. Doses of 90 and 250 mg/kg caused up to 27% and 45% NTE inhibition 48h after poisoning, respectively. Clinical signs of neuropathy were not seen up to 25 days after treatment, which could be expected, since the proposed level (>70%) of NTE inhibition necessary for the occurrence of delayed neuropathy was not achieved. The results suggest that PSM, at doses tested, has no ability to cause delayed neuropathy in hens without showing signs of severe cholinergic intoxication.
PB  - Springer-Verlag
T2  - Archives of Toxicology
T1  - Interaction of phosphamidon with neuropathy target esterase and acetylcholinesterase of hen brain
VL  - 69
IS  - 6
SP  - 425
EP  - 428
DO  - 10.1007/s002040050195
ER  - 

@article{
author = "Jokanović, Milan and Maksimović, Matej and Stepanović-Petrović, Radica",
year = "1995",
abstract = "Phosphamidon (PSM) is an organophosphorus insecticide widely used in agriculture. This study was undertaken to examine the interaction of PSM with acetylcholinesterase (AChE) and neuropathy target esterase (NTE) of hen brain in vitro and in vivo. PSM was a potent inhibitor of AChE, with an I50 of 2.9μM and second-order rate constant (ka) of 1.2×104 M-1 min-1 at 37°C. PSM-inhibited AChE aged rapidly (t1/2=1.9h). Pyridinium oximes pralidoxime, trimedoxime, obidoxime and HI-6 were effective reactivators of PSM-inhibited AChE, providing up to 75% reactivation. PSM was one of the weakest inhibitors of NTE among organophosphorus compounds, with an I50 of 19 mM and ka of 1.8 M-1 min-1 at 37°C. Inhibited NTE did not reactivate spontaneously and KF-induced reactivation was not obtained even at the earliest tested moments, so it was not clear whether aging of PSM-inhibited NTE occurred very quickly or the KF molecule could not affect the stability of phosphoryl-NTE bond. From the ratio of kas for NTE and AChE (0.00015) it was predicted that delayed neuropathic effects of PSM in vivo would appear only at doses far above the acute LD50. The LD50 value of PSM p.o. for hens was 9 mg/kg. Hens were treated with a single oral dose of PSM, combined with standard antidotal treatment which included atropine, physostigmine, pralidoxime and anticonvulsant midazolam. Doses of 90 and 250 mg/kg caused up to 27% and 45% NTE inhibition 48h after poisoning, respectively. Clinical signs of neuropathy were not seen up to 25 days after treatment, which could be expected, since the proposed level (>70%) of NTE inhibition necessary for the occurrence of delayed neuropathy was not achieved. The results suggest that PSM, at doses tested, has no ability to cause delayed neuropathy in hens without showing signs of severe cholinergic intoxication.",
publisher = "Springer-Verlag",
journal = "Archives of Toxicology",
title = "Interaction of phosphamidon with neuropathy target esterase and acetylcholinesterase of hen brain",
volume = "69",
number = "6",
pages = "425-428",
doi = "10.1007/s002040050195"
}

Jokanović, M., Maksimović, M.,& Stepanović-Petrović, R.. (1995). Interaction of phosphamidon with neuropathy target esterase and acetylcholinesterase of hen brain. in Archives of Toxicology
Springer-Verlag., 69(6), 425-428.
https://doi.org/10.1007/s002040050195

Jokanović M, Maksimović M, Stepanović-Petrović R. Interaction of phosphamidon with neuropathy target esterase and acetylcholinesterase of hen brain. in Archives of Toxicology. 1995;69(6):425-428.
doi:10.1007/s002040050195 .

Jokanović, Milan, Maksimović, Matej, Stepanović-Petrović, Radica, "Interaction of phosphamidon with neuropathy target esterase and acetylcholinesterase of hen brain" in Archives of Toxicology, 69, no. 6 (1995):425-428,
https://doi.org/10.1007/s002040050195 . .