TY  - JOUR
AU  - Ignjatović, Jelisaveta
AU  - Đuriš, Jelena
AU  - Cvijić, Sandra
AU  - Dobričić, Vladimir
AU  - Montepietra, Agnese
AU  - Lombardi, Chiara
AU  - Ibrić, Svetlana
AU  - Rossi, Alessandra
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3709
AB  - The aim of this study was to optimize the parameters of the complex melt-emulsification process coupled with the spray-drying, in order to maintain the balance between solid lipid microparticles (SLMs) powders aerodynamic performance and salbutamol sulfate release rate. Quality target product profile was identified and risk management and principal component analysis were used to guide formulation development. Obtained dry powders for inhalation (DPIs) were evaluated in terms of SLMs size distribution, morphology, true density, drug content, solid state characterization studies, in vitro aerosol performance and in vitro drug release. SLMs micrographs indicated spherical, porous particles. Selected powders showed satisfactory aerosol performance with a mean mass aerodynamic diameter of around 3 μm and acceptable fine particle fraction (FPF). Addition of trehalose positively affected SLMs aerodynamic properties. The results of in vitro dissolution testing indicated that salbutamol sulfate release from the tested SLMs formulations was modified, in comparison to the raw drug release. In conclusion, SLMs in a form of DPIs were successfully developed and numerous factors that affects SLMs properties were identified in this study. Further research is required for full understanding of each factor's influence on SLMs properties and optimization of DPIs with maximized FPFs.
PB  - Elsevier B.V.
T2  - European Journal of Pharmaceutical Sciences
T1  - Development of solid lipid microparticles by melt-emulsification/spray-drying processes as carriers for pulmonary drug delivery
VL  - 156
DO  - 10.1016/j.ejps.2020.105588
ER  - 

@article{
author = "Ignjatović, Jelisaveta and Đuriš, Jelena and Cvijić, Sandra and Dobričić, Vladimir and Montepietra, Agnese and Lombardi, Chiara and Ibrić, Svetlana and Rossi, Alessandra",
year = "2021",
abstract = "The aim of this study was to optimize the parameters of the complex melt-emulsification process coupled with the spray-drying, in order to maintain the balance between solid lipid microparticles (SLMs) powders aerodynamic performance and salbutamol sulfate release rate. Quality target product profile was identified and risk management and principal component analysis were used to guide formulation development. Obtained dry powders for inhalation (DPIs) were evaluated in terms of SLMs size distribution, morphology, true density, drug content, solid state characterization studies, in vitro aerosol performance and in vitro drug release. SLMs micrographs indicated spherical, porous particles. Selected powders showed satisfactory aerosol performance with a mean mass aerodynamic diameter of around 3 μm and acceptable fine particle fraction (FPF). Addition of trehalose positively affected SLMs aerodynamic properties. The results of in vitro dissolution testing indicated that salbutamol sulfate release from the tested SLMs formulations was modified, in comparison to the raw drug release. In conclusion, SLMs in a form of DPIs were successfully developed and numerous factors that affects SLMs properties were identified in this study. Further research is required for full understanding of each factor's influence on SLMs properties and optimization of DPIs with maximized FPFs.",
publisher = "Elsevier B.V.",
journal = "European Journal of Pharmaceutical Sciences",
title = "Development of solid lipid microparticles by melt-emulsification/spray-drying processes as carriers for pulmonary drug delivery",
volume = "156",
doi = "10.1016/j.ejps.2020.105588"
}

Ignjatović, J., Đuriš, J., Cvijić, S., Dobričić, V., Montepietra, A., Lombardi, C., Ibrić, S.,& Rossi, A.. (2021). Development of solid lipid microparticles by melt-emulsification/spray-drying processes as carriers for pulmonary drug delivery. in European Journal of Pharmaceutical Sciences
Elsevier B.V.., 156.
https://doi.org/10.1016/j.ejps.2020.105588

Ignjatović J, Đuriš J, Cvijić S, Dobričić V, Montepietra A, Lombardi C, Ibrić S, Rossi A. Development of solid lipid microparticles by melt-emulsification/spray-drying processes as carriers for pulmonary drug delivery. in European Journal of Pharmaceutical Sciences. 2021;156.
doi:10.1016/j.ejps.2020.105588 .

Ignjatović, Jelisaveta, Đuriš, Jelena, Cvijić, Sandra, Dobričić, Vladimir, Montepietra, Agnese, Lombardi, Chiara, Ibrić, Svetlana, Rossi, Alessandra, "Development of solid lipid microparticles by melt-emulsification/spray-drying processes as carriers for pulmonary drug delivery" in European Journal of Pharmaceutical Sciences, 156 (2021),
https://doi.org/10.1016/j.ejps.2020.105588 . .