TY  - JOUR
AU  - Aleksić, Ivana
AU  - German Ilić, Ilija
AU  - Cvijić, Sandra
AU  - Parojčić, Jelena
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3652
AB  - Liquisolid technology, as a promising approach for bioavailability enhancement, has received increasing attention in recent years. However, literature reports addressing the challenges for its industrial application, particularly those related to compaction behavior of liquisolid systems, are scarce. The aim of this study was to investigate the influence of process parameters and formulation variables on the flowability, wetting, and compaction properties of the liquisolid systems prepared in a fluid bed processor. The experiments with microcrystalline cellulose, as a carrier, were performed according to 23 full factorial design. The effects of liquid content, spray air pressure, and liquid feed rate on the properties of liquisolid systems were investigated. Liquisolid admixtures with microcrystalline cellulose were compared with those prepared with novel carriers, Fujicalin® and Neusilin® US2. “Out-die” Heckel, modified Walker, and Kuentz-Leuenberger models were used to analyze the compressibility of liquisolid admixtures. The results obtained showed that an increase in liquid content (in the range of 10 to 15%) led to a decrease in flowability of liquisolid admixtures with microcrystalline cellulose, as well as more pronounced influence of spraying conditions. On the other hand, higher liquid content led to higher compressibility. Fujicalin® and Neusilin® US2 liquisolid admixtures were found to have superior flowability and compressibility in comparison with those with microcrystalline cellulose, despite the considerably higher liquid load (50–55% liquid content in Neusilin® US2 compacts). Acceptable compactibility of the investigated liquisolid systems was observed. The fluid bed processor was shown to be suitable equipment for production of liquisolid systems, but with careful adjustment of process parameters.
PB  - Springer
T2  - AAPS PharmSciTech
T1  - An Investigation into the Influence of Process Parameters and Formulation Variables on Compaction Properties of Liquisolid Systems
VL  - 21
IS  - 7
DO  - 10.1208/s12249-020-01781-2
ER  - 

@article{
author = "Aleksić, Ivana and German Ilić, Ilija and Cvijić, Sandra and Parojčić, Jelena",
year = "2020",
abstract = "Liquisolid technology, as a promising approach for bioavailability enhancement, has received increasing attention in recent years. However, literature reports addressing the challenges for its industrial application, particularly those related to compaction behavior of liquisolid systems, are scarce. The aim of this study was to investigate the influence of process parameters and formulation variables on the flowability, wetting, and compaction properties of the liquisolid systems prepared in a fluid bed processor. The experiments with microcrystalline cellulose, as a carrier, were performed according to 23 full factorial design. The effects of liquid content, spray air pressure, and liquid feed rate on the properties of liquisolid systems were investigated. Liquisolid admixtures with microcrystalline cellulose were compared with those prepared with novel carriers, Fujicalin® and Neusilin® US2. “Out-die” Heckel, modified Walker, and Kuentz-Leuenberger models were used to analyze the compressibility of liquisolid admixtures. The results obtained showed that an increase in liquid content (in the range of 10 to 15%) led to a decrease in flowability of liquisolid admixtures with microcrystalline cellulose, as well as more pronounced influence of spraying conditions. On the other hand, higher liquid content led to higher compressibility. Fujicalin® and Neusilin® US2 liquisolid admixtures were found to have superior flowability and compressibility in comparison with those with microcrystalline cellulose, despite the considerably higher liquid load (50–55% liquid content in Neusilin® US2 compacts). Acceptable compactibility of the investigated liquisolid systems was observed. The fluid bed processor was shown to be suitable equipment for production of liquisolid systems, but with careful adjustment of process parameters.",
publisher = "Springer",
journal = "AAPS PharmSciTech",
title = "An Investigation into the Influence of Process Parameters and Formulation Variables on Compaction Properties of Liquisolid Systems",
volume = "21",
number = "7",
doi = "10.1208/s12249-020-01781-2"
}

Aleksić, I., German Ilić, I., Cvijić, S.,& Parojčić, J.. (2020). An Investigation into the Influence of Process Parameters and Formulation Variables on Compaction Properties of Liquisolid Systems. in AAPS PharmSciTech
Springer., 21(7).
https://doi.org/10.1208/s12249-020-01781-2

Aleksić I, German Ilić I, Cvijić S, Parojčić J. An Investigation into the Influence of Process Parameters and Formulation Variables on Compaction Properties of Liquisolid Systems. in AAPS PharmSciTech. 2020;21(7).
doi:10.1208/s12249-020-01781-2 .

Aleksić, Ivana, German Ilić, Ilija, Cvijić, Sandra, Parojčić, Jelena, "An Investigation into the Influence of Process Parameters and Formulation Variables on Compaction Properties of Liquisolid Systems" in AAPS PharmSciTech, 21, no. 7 (2020),
https://doi.org/10.1208/s12249-020-01781-2 . .

TY  - JOUR
AU  - Aleksić, Ivana
AU  - Đuriš, Jelena
AU  - Ilić, Ilija
AU  - Ibrić, Svetlana
AU  - Parojčić, Jelena
AU  - Srcić, Stanko
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2225
AB  - Fluidized bed melt granulation has recently been recognized as a promising technique with numerous advantages over conventional granulation techniques. The aim of this study was to evaluate the possibility of using response surface methodology and artificial neural networks for optimizing in situ fluidized bed melt granulation and to compare them with regard to modeling ability and predictability. The experiments were organized in line with the Box-Behnken design. The influence of binder content, binder particle size, and granulation time on granule properties was evaluated. In addition to the response surface analysis, a multilayer perceptron neural network was applied for data modeling. It was found that in situ fluidized bed melt granulation can be used for production of spherical granules with good flowability. Binder particle size had the most pronounced influence on granule size and shape, suggesting the importance of this parameter in achieving desired granule properties. It was found that binder content can be a critical factor for the width of granule size distribution and yield when immersion and layering is the dominant agglomeration mechanism. The results obtained indicate that both in silico techniques can be useful tools in defining the design space and optimization of in situ fluidized bed melt granulation.
PB  - Elsevier Science BV, Amsterdam
T2  - International Journal of Pharmaceutics
T1  - In silico modeling of in situ fluidized bed melt granulation
VL  - 466
IS  - 1-2
SP  - 21
EP  - 30
DO  - 10.1016/j.ijpharm.2014.02.045
ER  - 

@article{
author = "Aleksić, Ivana and Đuriš, Jelena and Ilić, Ilija and Ibrić, Svetlana and Parojčić, Jelena and Srcić, Stanko",
year = "2014",
abstract = "Fluidized bed melt granulation has recently been recognized as a promising technique with numerous advantages over conventional granulation techniques. The aim of this study was to evaluate the possibility of using response surface methodology and artificial neural networks for optimizing in situ fluidized bed melt granulation and to compare them with regard to modeling ability and predictability. The experiments were organized in line with the Box-Behnken design. The influence of binder content, binder particle size, and granulation time on granule properties was evaluated. In addition to the response surface analysis, a multilayer perceptron neural network was applied for data modeling. It was found that in situ fluidized bed melt granulation can be used for production of spherical granules with good flowability. Binder particle size had the most pronounced influence on granule size and shape, suggesting the importance of this parameter in achieving desired granule properties. It was found that binder content can be a critical factor for the width of granule size distribution and yield when immersion and layering is the dominant agglomeration mechanism. The results obtained indicate that both in silico techniques can be useful tools in defining the design space and optimization of in situ fluidized bed melt granulation.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "International Journal of Pharmaceutics",
title = "In silico modeling of in situ fluidized bed melt granulation",
volume = "466",
number = "1-2",
pages = "21-30",
doi = "10.1016/j.ijpharm.2014.02.045"
}

Aleksić, I., Đuriš, J., Ilić, I., Ibrić, S., Parojčić, J.,& Srcić, S.. (2014). In silico modeling of in situ fluidized bed melt granulation. in International Journal of Pharmaceutics
Elsevier Science BV, Amsterdam., 466(1-2), 21-30.
https://doi.org/10.1016/j.ijpharm.2014.02.045

Aleksić I, Đuriš J, Ilić I, Ibrić S, Parojčić J, Srcić S. In silico modeling of in situ fluidized bed melt granulation. in International Journal of Pharmaceutics. 2014;466(1-2):21-30.
doi:10.1016/j.ijpharm.2014.02.045 .

Aleksić, Ivana, Đuriš, Jelena, Ilić, Ilija, Ibrić, Svetlana, Parojčić, Jelena, Srcić, Stanko, "In silico modeling of in situ fluidized bed melt granulation" in International Journal of Pharmaceutics, 466, no. 1-2 (2014):21-30,
https://doi.org/10.1016/j.ijpharm.2014.02.045 . .

TY  - JOUR
AU  - Mašić, Ivana
AU  - Ilić, Ilija
AU  - Dreu, Rok
AU  - Ibrić, Svetlana
AU  - Parojčić, Jelena
AU  - Srcić, Stanko
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2179
AB  - Objective: The aim of this study was to investigate the influence of process parameters, binder content and binder addition method on characteristics of the granules obtained by melt granulation (MG) in fluidized bed. Methods: Spray-on experiments were performed according to 2 3 full factorial design. The effect of binder content, molten binder feed rate, and spray air pressure on granule size and size distribution, granule shape, Flowability and drug release rate was investigated. In the in situ experiments, the influence of binder particle size and binder content was evaluated. Solid-state characterization was performed by means of differential scanning calorimetry, X-ray powder diffraction and Fourier transform infrared spectroscopy. Results: Size of the granules obtained by spray-on procedure was significantly influenced by binder content and spray air pressure, while the width of particle size distribution was mainly affected by binder feed rate. Spray air pressure showed the most significant influence on granule shape. It was shown that smooth and spherical particles with good flow properties may be obtained by both procedures, spray-on and in situ MG. The results obtained indicated the influence of agglomeration mechanism on granule sphericity, with higher degree of granule sphericity observed when immersion and layering was the dominant mechanism. Paracetamol release from granulates was very rapid, but after compression of the granules into tablets, drug release was considerably slower. Solid-state analysis confirmed that the physical form of the granulate components remained unaffected after the MG process. Conclusion: The results presented indicate that MG in fluidized bed could be a good alternative to conventional granulation techniques.
PB  - Informa Healthcare, London
T2  - Drug Development and Industrial Pharmacy
T1  - Melt granulation in fluidized bed: a comparative study of spray-on versus in situ procedure
VL  - 40
IS  - 1
SP  - 23
EP  - 32
DO  - 10.3109/03639045.2012.744415
ER  - 

@article{
author = "Mašić, Ivana and Ilić, Ilija and Dreu, Rok and Ibrić, Svetlana and Parojčić, Jelena and Srcić, Stanko",
year = "2014",
abstract = "Objective: The aim of this study was to investigate the influence of process parameters, binder content and binder addition method on characteristics of the granules obtained by melt granulation (MG) in fluidized bed. Methods: Spray-on experiments were performed according to 2 3 full factorial design. The effect of binder content, molten binder feed rate, and spray air pressure on granule size and size distribution, granule shape, Flowability and drug release rate was investigated. In the in situ experiments, the influence of binder particle size and binder content was evaluated. Solid-state characterization was performed by means of differential scanning calorimetry, X-ray powder diffraction and Fourier transform infrared spectroscopy. Results: Size of the granules obtained by spray-on procedure was significantly influenced by binder content and spray air pressure, while the width of particle size distribution was mainly affected by binder feed rate. Spray air pressure showed the most significant influence on granule shape. It was shown that smooth and spherical particles with good flow properties may be obtained by both procedures, spray-on and in situ MG. The results obtained indicated the influence of agglomeration mechanism on granule sphericity, with higher degree of granule sphericity observed when immersion and layering was the dominant mechanism. Paracetamol release from granulates was very rapid, but after compression of the granules into tablets, drug release was considerably slower. Solid-state analysis confirmed that the physical form of the granulate components remained unaffected after the MG process. Conclusion: The results presented indicate that MG in fluidized bed could be a good alternative to conventional granulation techniques.",
publisher = "Informa Healthcare, London",
journal = "Drug Development and Industrial Pharmacy",
title = "Melt granulation in fluidized bed: a comparative study of spray-on versus in situ procedure",
volume = "40",
number = "1",
pages = "23-32",
doi = "10.3109/03639045.2012.744415"
}

Mašić, I., Ilić, I., Dreu, R., Ibrić, S., Parojčić, J.,& Srcić, S.. (2014). Melt granulation in fluidized bed: a comparative study of spray-on versus in situ procedure. in Drug Development and Industrial Pharmacy
Informa Healthcare, London., 40(1), 23-32.
https://doi.org/10.3109/03639045.2012.744415

Mašić I, Ilić I, Dreu R, Ibrić S, Parojčić J, Srcić S. Melt granulation in fluidized bed: a comparative study of spray-on versus in situ procedure. in Drug Development and Industrial Pharmacy. 2014;40(1):23-32.
doi:10.3109/03639045.2012.744415 .

Mašić, Ivana, Ilić, Ilija, Dreu, Rok, Ibrić, Svetlana, Parojčić, Jelena, Srcić, Stanko, "Melt granulation in fluidized bed: a comparative study of spray-on versus in situ procedure" in Drug Development and Industrial Pharmacy, 40, no. 1 (2014):23-32,
https://doi.org/10.3109/03639045.2012.744415 . .

TY  - JOUR
AU  - Mašić, Ivana
AU  - Ilić, Ilija
AU  - Dreu, Rok
AU  - Ibrić, Svetlana
AU  - Parojčić, Jelena
AU  - Đurić, Zorica
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1697
AB  - The aim of this study was to investigate the influence of binder content, binder particle size, granulation time and inlet air flow rate on granule size and size distribution, granule shape and flowability, as well as on drug release rate. Hydrophilic (polyetilenglycol 2000) and hydrophobic meltable binder (glyceryl palmitostearate) were used for in situ fluidized hot melt granulation. Granule size was mainly influenced by binder particle size. Binder content was shown to be important for narrow size distribution and good flow properties. The results obtained indicate that conventional fluid bed granulator may be suitable for production of highly spherical agglomerates, particularly when immersion and layering is dominant agglomeration mechanism. Granule shape was affected by interplay of binder content, binder particle size and granulation time. Solid state analysis confirmed unaltered physical state of the granulate components and the absence of interactions between the active and excipients. Besides the nature and amount of binder, the mechanism of agglomerate formation seems to have an impact on drug dissolution rate. The results of the present study indicate that fluidized hot melt granulation is a promising powder agglomeration technique for spherical granules production.
PB  - Elsevier Science BV, Amsterdam
T2  - International Journal of Pharmaceutics
T1  - An investigation into the effect of formulation variables and process parameters on characteristics of granules obtained by in situ fluidized hot melt granulation
VL  - 423
IS  - 2
SP  - 202
EP  - 212
DO  - 10.1016/j.ijpharm.2011.12.013
ER  - 

@article{
author = "Mašić, Ivana and Ilić, Ilija and Dreu, Rok and Ibrić, Svetlana and Parojčić, Jelena and Đurić, Zorica",
year = "2012",
abstract = "The aim of this study was to investigate the influence of binder content, binder particle size, granulation time and inlet air flow rate on granule size and size distribution, granule shape and flowability, as well as on drug release rate. Hydrophilic (polyetilenglycol 2000) and hydrophobic meltable binder (glyceryl palmitostearate) were used for in situ fluidized hot melt granulation. Granule size was mainly influenced by binder particle size. Binder content was shown to be important for narrow size distribution and good flow properties. The results obtained indicate that conventional fluid bed granulator may be suitable for production of highly spherical agglomerates, particularly when immersion and layering is dominant agglomeration mechanism. Granule shape was affected by interplay of binder content, binder particle size and granulation time. Solid state analysis confirmed unaltered physical state of the granulate components and the absence of interactions between the active and excipients. Besides the nature and amount of binder, the mechanism of agglomerate formation seems to have an impact on drug dissolution rate. The results of the present study indicate that fluidized hot melt granulation is a promising powder agglomeration technique for spherical granules production.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "International Journal of Pharmaceutics",
title = "An investigation into the effect of formulation variables and process parameters on characteristics of granules obtained by in situ fluidized hot melt granulation",
volume = "423",
number = "2",
pages = "202-212",
doi = "10.1016/j.ijpharm.2011.12.013"
}

Mašić, I., Ilić, I., Dreu, R., Ibrić, S., Parojčić, J.,& Đurić, Z.. (2012). An investigation into the effect of formulation variables and process parameters on characteristics of granules obtained by in situ fluidized hot melt granulation. in International Journal of Pharmaceutics
Elsevier Science BV, Amsterdam., 423(2), 202-212.
https://doi.org/10.1016/j.ijpharm.2011.12.013

Mašić I, Ilić I, Dreu R, Ibrić S, Parojčić J, Đurić Z. An investigation into the effect of formulation variables and process parameters on characteristics of granules obtained by in situ fluidized hot melt granulation. in International Journal of Pharmaceutics. 2012;423(2):202-212.
doi:10.1016/j.ijpharm.2011.12.013 .

Mašić, Ivana, Ilić, Ilija, Dreu, Rok, Ibrić, Svetlana, Parojčić, Jelena, Đurić, Zorica, "An investigation into the effect of formulation variables and process parameters on characteristics of granules obtained by in situ fluidized hot melt granulation" in International Journal of Pharmaceutics, 423, no. 2 (2012):202-212,
https://doi.org/10.1016/j.ijpharm.2011.12.013 . .

TY  - CONF
AU  - Mašić, Ivana
AU  - Ilić, Ilija
AU  - Parojčić, Jelena
AU  - Đurić, Zorica
AU  - Srcić, S.
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1463
PB  - Elsevier Science BV, Amsterdam
C3  - European Journal of Pharmaceutical Sciences
T1  - Fludized hot melt granulation: in situ vs. Spray-on procedure
VL  - 44
IS  - Supplement 1
SP  - 85
EP  - 86
DO  - 10.1016/j.ejps.2011.08.002
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1463
ER  - 

@conference{
author = "Mašić, Ivana and Ilić, Ilija and Parojčić, Jelena and Đurić, Zorica and Srcić, S.",
year = "2011",
publisher = "Elsevier Science BV, Amsterdam",
journal = "European Journal of Pharmaceutical Sciences",
title = "Fludized hot melt granulation: in situ vs. Spray-on procedure",
volume = "44",
number = "Supplement 1",
pages = "85-86",
doi = "10.1016/j.ejps.2011.08.002",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1463"
}

Mašić, I., Ilić, I., Parojčić, J., Đurić, Z.,& Srcić, S.. (2011). Fludized hot melt granulation: in situ vs. Spray-on procedure. in European Journal of Pharmaceutical Sciences
Elsevier Science BV, Amsterdam., 44(Supplement 1), 85-86.
https://doi.org/10.1016/j.ejps.2011.08.002
https://hdl.handle.net/21.15107/rcub_farfar_1463

Mašić I, Ilić I, Parojčić J, Đurić Z, Srcić S. Fludized hot melt granulation: in situ vs. Spray-on procedure. in European Journal of Pharmaceutical Sciences. 2011;44(Supplement 1):85-86.
doi:10.1016/j.ejps.2011.08.002
https://hdl.handle.net/21.15107/rcub_farfar_1463 .

Mašić, Ivana, Ilić, Ilija, Parojčić, Jelena, Đurić, Zorica, Srcić, S., "Fludized hot melt granulation: in situ vs. Spray-on procedure" in European Journal of Pharmaceutical Sciences, 44, no. Supplement 1 (2011):85-86,
https://doi.org/10.1016/j.ejps.2011.08.002 .,
https://hdl.handle.net/21.15107/rcub_farfar_1463 .