TY  - JOUR
AU  - Tabrizian, Kaveh
AU  - Miri, Fatemeh
AU  - Haseli, Shiva
AU  - Shahraki, Jafar
AU  - Belaran, Maryam
AU  - Rezaee, Ramin
AU  - Buha, Aleksandra
AU  - Tsatsakis, Aristidis
AU  - Arsene, Andreea Letiția
AU  - Șerban, Dragoș
AU  - Velescu, Bruno Ștefan
AU  - Hashemzaei, Mahmoud
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4315
AB  - There is controversy on the effect of statins on cognitive functions such as spatial memory. In the present study, effect of ten- day oral gavage of rosuvastatin (Ros, 20 mg/kg) on spatial learning and spatial memory retention impaired by H-89, was investigated in male rats. This study was comprised of two sets of experiments each including the following 3 groups (n = 8): Control group treated with DMSO; H-89 group received bilateral intra-hippocampal H-89 (10 μM/side, in DMSO) and Ros- H-89 group orally treated with Ros (20 mg/kg) and H-89 (similar to the H-89 group). For spatial learning (acquisition phase) assessment, from day 7 of Ros gavage, rats were trained in the Morris water maze (MWM) for four days (one block of 4 stages each day) and received daily H-89, 30 min after Ros gavage. On day 11, the probe test was performed. Also, to assess spatial memory retention, from day 7 to 10 of Ros gavage, rats were trained in MWM but received H-89 on day 10 only. On day 12, the probe test was performed. Besides, CREB and p-CREB protein expression was assessed in hippocampal samples and oxidative stress status was assessed in serum samples. We observed that H-89 led to a clear impairment of the spatial learning and spatial memory recall, increased levels of lipid peroxidation and downregulated CREB and p-CREB proteins, compared to the control group. However, Ros prevented H-89-induced deleterious consequences which might be probably in part due to its ameliorative effects on lipid peroxidation index and CREB and p-CREB expression.
PB  - Societatea de Științe Farmaceutice din România
T2  - Farmacia
T1  - Behavioural and molecular study of the effects of rosuvastatin on acquisition and retention of spatial memory impaired by H-89 in rats
VL  - 70
IS  - 5
SP  - 904
EP  - 911
DO  - 10.31925/farmacia.2022.5.16
ER  - 

@article{
author = "Tabrizian, Kaveh and Miri, Fatemeh and Haseli, Shiva and Shahraki, Jafar and Belaran, Maryam and Rezaee, Ramin and Buha, Aleksandra and Tsatsakis, Aristidis and Arsene, Andreea Letiția and Șerban, Dragoș and Velescu, Bruno Ștefan and Hashemzaei, Mahmoud",
year = "2022",
abstract = "There is controversy on the effect of statins on cognitive functions such as spatial memory. In the present study, effect of ten- day oral gavage of rosuvastatin (Ros, 20 mg/kg) on spatial learning and spatial memory retention impaired by H-89, was investigated in male rats. This study was comprised of two sets of experiments each including the following 3 groups (n = 8): Control group treated with DMSO; H-89 group received bilateral intra-hippocampal H-89 (10 μM/side, in DMSO) and Ros- H-89 group orally treated with Ros (20 mg/kg) and H-89 (similar to the H-89 group). For spatial learning (acquisition phase) assessment, from day 7 of Ros gavage, rats were trained in the Morris water maze (MWM) for four days (one block of 4 stages each day) and received daily H-89, 30 min after Ros gavage. On day 11, the probe test was performed. Also, to assess spatial memory retention, from day 7 to 10 of Ros gavage, rats were trained in MWM but received H-89 on day 10 only. On day 12, the probe test was performed. Besides, CREB and p-CREB protein expression was assessed in hippocampal samples and oxidative stress status was assessed in serum samples. We observed that H-89 led to a clear impairment of the spatial learning and spatial memory recall, increased levels of lipid peroxidation and downregulated CREB and p-CREB proteins, compared to the control group. However, Ros prevented H-89-induced deleterious consequences which might be probably in part due to its ameliorative effects on lipid peroxidation index and CREB and p-CREB expression.",
publisher = "Societatea de Științe Farmaceutice din România",
journal = "Farmacia",
title = "Behavioural and molecular study of the effects of rosuvastatin on acquisition and retention of spatial memory impaired by H-89 in rats",
volume = "70",
number = "5",
pages = "904-911",
doi = "10.31925/farmacia.2022.5.16"
}

Tabrizian, K., Miri, F., Haseli, S., Shahraki, J., Belaran, M., Rezaee, R., Buha, A., Tsatsakis, A., Arsene, A. L., Șerban, D., Velescu, B. Ș.,& Hashemzaei, M.. (2022). Behavioural and molecular study of the effects of rosuvastatin on acquisition and retention of spatial memory impaired by H-89 in rats. in Farmacia
Societatea de Științe Farmaceutice din România., 70(5), 904-911.
https://doi.org/10.31925/farmacia.2022.5.16

Tabrizian K, Miri F, Haseli S, Shahraki J, Belaran M, Rezaee R, Buha A, Tsatsakis A, Arsene AL, Șerban D, Velescu BȘ, Hashemzaei M. Behavioural and molecular study of the effects of rosuvastatin on acquisition and retention of spatial memory impaired by H-89 in rats. in Farmacia. 2022;70(5):904-911.
doi:10.31925/farmacia.2022.5.16 .

Tabrizian, Kaveh, Miri, Fatemeh, Haseli, Shiva, Shahraki, Jafar, Belaran, Maryam, Rezaee, Ramin, Buha, Aleksandra, Tsatsakis, Aristidis, Arsene, Andreea Letiția, Șerban, Dragoș, Velescu, Bruno Ștefan, Hashemzaei, Mahmoud, "Behavioural and molecular study of the effects of rosuvastatin on acquisition and retention of spatial memory impaired by H-89 in rats" in Farmacia, 70, no. 5 (2022):904-911,
https://doi.org/10.31925/farmacia.2022.5.16 . .