TY  - JOUR
AU  - Subošić, Branko
AU  - Zdravković, Vera
AU  - Ješić, Maja
AU  - Munjas, Jelena
AU  - Kovačević, Smiljka
AU  - Guzonjić, Azra
AU  - Mitrović, Jadranka
AU  - Saso, Luciano
AU  - Đuričić, Ivana
AU  - Kotur-Stevuljević, Jelena
PY  - 2024
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5654
AB  - Obesity is multifactorial pathophysiological condition with an imbalance in biochemical, immunochemical, redox status and genetic parameters values. We aimed estimate connection between relative leukocyte telomere lengths (rLRL) - biomarker of cellular aging with metabolic and redox status biomarkers values in a group of obese and lean children. The study includes 110 obese and 42 lean children and adolescents, both genders. The results suggested that rLTL are significantly shorter in obese, compared to lean group (p<0,01). Negative correlation of rLTL with total oxidant status, TOS (Spearman's ρ = -0.365, p<0.001) as well as with C reactive protein (Spearman's ρ= -0,363, p<0.001) were observed. Principal component analysis (PCA) extracted three distinct factors (i.e. principal components) entitled as: prooxidant factor with 35% of total variability; antioxidant factor with 30% of total variability and lipid antioxidant - biological ageing factor with 12% of the total variability. The most important predictor of body mass index (BMI) >30kg/m2 according to logistic regression analysis was PCA derived antioxidant factor's score (OR: 1.66, 95th Cl: 1.05-2.6, p=0.029). PCA analysis confirmed oxidative stress importance in biological ageing caused by obesity and its multiple consequences related to prooxidants augmentation and antioxidants exhaustion and gave us clear signs of disturbed cellular homeostasis deepness, even before any overt disease occurrence.
PB  - Cambridge University Press
T2  - British Journal of Nutrition
T1  - Childhood obesity accelerates biological ageing: is oxidative stress a link?
DO  - 10.1017/S0007114524000898
ER  - 

@article{
author = "Subošić, Branko and Zdravković, Vera and Ješić, Maja and Munjas, Jelena and Kovačević, Smiljka and Guzonjić, Azra and Mitrović, Jadranka and Saso, Luciano and Đuričić, Ivana and Kotur-Stevuljević, Jelena",
year = "2024",
abstract = "Obesity is multifactorial pathophysiological condition with an imbalance in biochemical, immunochemical, redox status and genetic parameters values. We aimed estimate connection between relative leukocyte telomere lengths (rLRL) - biomarker of cellular aging with metabolic and redox status biomarkers values in a group of obese and lean children. The study includes 110 obese and 42 lean children and adolescents, both genders. The results suggested that rLTL are significantly shorter in obese, compared to lean group (p<0,01). Negative correlation of rLTL with total oxidant status, TOS (Spearman's ρ = -0.365, p<0.001) as well as with C reactive protein (Spearman's ρ= -0,363, p<0.001) were observed. Principal component analysis (PCA) extracted three distinct factors (i.e. principal components) entitled as: prooxidant factor with 35% of total variability; antioxidant factor with 30% of total variability and lipid antioxidant - biological ageing factor with 12% of the total variability. The most important predictor of body mass index (BMI) >30kg/m2 according to logistic regression analysis was PCA derived antioxidant factor's score (OR: 1.66, 95th Cl: 1.05-2.6, p=0.029). PCA analysis confirmed oxidative stress importance in biological ageing caused by obesity and its multiple consequences related to prooxidants augmentation and antioxidants exhaustion and gave us clear signs of disturbed cellular homeostasis deepness, even before any overt disease occurrence.",
publisher = "Cambridge University Press",
journal = "British Journal of Nutrition",
title = "Childhood obesity accelerates biological ageing: is oxidative stress a link?",
doi = "10.1017/S0007114524000898"
}

Subošić, B., Zdravković, V., Ješić, M., Munjas, J., Kovačević, S., Guzonjić, A., Mitrović, J., Saso, L., Đuričić, I.,& Kotur-Stevuljević, J.. (2024). Childhood obesity accelerates biological ageing: is oxidative stress a link?. in British Journal of Nutrition
Cambridge University Press..
https://doi.org/10.1017/S0007114524000898

Subošić B, Zdravković V, Ješić M, Munjas J, Kovačević S, Guzonjić A, Mitrović J, Saso L, Đuričić I, Kotur-Stevuljević J. Childhood obesity accelerates biological ageing: is oxidative stress a link?. in British Journal of Nutrition. 2024;.
doi:10.1017/S0007114524000898 .

Subošić, Branko, Zdravković, Vera, Ješić, Maja, Munjas, Jelena, Kovačević, Smiljka, Guzonjić, Azra, Mitrović, Jadranka, Saso, Luciano, Đuričić, Ivana, Kotur-Stevuljević, Jelena, "Childhood obesity accelerates biological ageing: is oxidative stress a link?" in British Journal of Nutrition (2024),
https://doi.org/10.1017/S0007114524000898 . .

TY  - CONF
AU  - Spasojević-Dimitrijeva, Brankica
AU  - Kotur-Stevuljević, Jelena
AU  - Đukić, Milan
AU  - Mitrović, Jadranka
AU  - Cvetković, Mirjana
AU  - Miloševski-Lomić, Gordana
AU  - Paripović, Dušan
AU  - Gojković, Ivan
AU  - Kostić, Mirjana
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3079
PB  - Springer, New York
C3  - Pediatric Nephrology
T1  - Acute kidney injury after gadolinium and iodinated-based contrast media exposure in children with normal renal function
VL  - 33
IS  - 10
SP  - 1840
EP  - 1841
DO  - 10.1007/s00467-018-4028-x
ER  - 

@conference{
author = "Spasojević-Dimitrijeva, Brankica and Kotur-Stevuljević, Jelena and Đukić, Milan and Mitrović, Jadranka and Cvetković, Mirjana and Miloševski-Lomić, Gordana and Paripović, Dušan and Gojković, Ivan and Kostić, Mirjana",
year = "2018",
publisher = "Springer, New York",
journal = "Pediatric Nephrology",
title = "Acute kidney injury after gadolinium and iodinated-based contrast media exposure in children with normal renal function",
volume = "33",
number = "10",
pages = "1840-1841",
doi = "10.1007/s00467-018-4028-x"
}

Spasojević-Dimitrijeva, B., Kotur-Stevuljević, J., Đukić, M., Mitrović, J., Cvetković, M., Miloševski-Lomić, G., Paripović, D., Gojković, I.,& Kostić, M.. (2018). Acute kidney injury after gadolinium and iodinated-based contrast media exposure in children with normal renal function. in Pediatric Nephrology
Springer, New York., 33(10), 1840-1841.
https://doi.org/10.1007/s00467-018-4028-x

Spasojević-Dimitrijeva B, Kotur-Stevuljević J, Đukić M, Mitrović J, Cvetković M, Miloševski-Lomić G, Paripović D, Gojković I, Kostić M. Acute kidney injury after gadolinium and iodinated-based contrast media exposure in children with normal renal function. in Pediatric Nephrology. 2018;33(10):1840-1841.
doi:10.1007/s00467-018-4028-x .

Spasojević-Dimitrijeva, Brankica, Kotur-Stevuljević, Jelena, Đukić, Milan, Mitrović, Jadranka, Cvetković, Mirjana, Miloševski-Lomić, Gordana, Paripović, Dušan, Gojković, Ivan, Kostić, Mirjana, "Acute kidney injury after gadolinium and iodinated-based contrast media exposure in children with normal renal function" in Pediatric Nephrology, 33, no. 10 (2018):1840-1841,
https://doi.org/10.1007/s00467-018-4028-x . .

TY  - JOUR
AU  - Spasojević-Dimitrijeva, Brankica
AU  - Kotur-Stevuljević, Jelena
AU  - Dukić, Milan
AU  - Paripović, Dušan
AU  - Miloševski-Lomić, Gordana
AU  - Spasojević-Kalimanovska, Vesna
AU  - Pavicević, Polina
AU  - Mitrović, Jadranka
AU  - Kostić, Mirjana
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2793
AB  - Background: New renal biomarkers such as neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) show promise in early diagnosis of contrast media induced acute kidney injury (CI-AKI). The purpose of our study was to compare the subclinical nephrotoxicity (a condition without changes in standard renal biomarkers) of gadolinium-based contrast media (Gd-DTPA, gadopentetate dimeglumine) and iodinated-based contrast media (iopromide) in pediatric patients with normal kidney function. Material/Methods: The first group (n=58) of patients included in the study were undergoing angiography with iopromide, and the second group (n=65) were undergoing magnetic resonance (MR) angiography/urography with Gd-DTPA administration. The concentrations of NGAL and KIM-1 were measured four times in the urine (pre-contrast, then at four hours, 24 hours, and 48 hours after contrast administration), and serum NGAL was measured at 0 (base-line), 24 hours, and 48 hours after contrast exposure. Results: After 24 hours, serum NGAL increase of >= 25% was noticed in 32.6% of the patients in the iopromide group and in 25.45% of the patients in the gadolinium group, with significantly higher average percent of this increase in first group (62.23% vs. 36.44%, p=0.002). In the Gd-DTPA group, we observed a statistically significant increase in urinary KIM-1 24 hours after the procedure. Normalized urinary KIM-1, 24 hours after contrast exposure, was a better predictive factor for CI-AKI than other biomarkers (AUC 0.757, cut off 214 pg/mg, sensitivity 83.3%, specificity 54.2%, p=0.035). Conclusions: In children with normal renal function, exposure to iodinated-based and gadolinium-based media might lead to subclinical nephrotoxicity, which could be detected using serum NGAL and urinary KIM-1.
PB  - Int Scientific Information, Inc, Melville
T2  - Medical Science Monitor
T1  - Serum Neutrophil Gelatinase-Associated Lipocalin and Urinary Kidney Injury Molecule-1 as Potential Biomarkers of Subclinical Nephrotoxicity After Gadolinium-Based and Iodinated-Based Contrast Media Exposure in Pediatric Patients with Normal Kidney Functio
VL  - 23
DO  - 10.12659/MSM.903255
ER  - 

@article{
author = "Spasojević-Dimitrijeva, Brankica and Kotur-Stevuljević, Jelena and Dukić, Milan and Paripović, Dušan and Miloševski-Lomić, Gordana and Spasojević-Kalimanovska, Vesna and Pavicević, Polina and Mitrović, Jadranka and Kostić, Mirjana",
year = "2017",
abstract = "Background: New renal biomarkers such as neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) show promise in early diagnosis of contrast media induced acute kidney injury (CI-AKI). The purpose of our study was to compare the subclinical nephrotoxicity (a condition without changes in standard renal biomarkers) of gadolinium-based contrast media (Gd-DTPA, gadopentetate dimeglumine) and iodinated-based contrast media (iopromide) in pediatric patients with normal kidney function. Material/Methods: The first group (n=58) of patients included in the study were undergoing angiography with iopromide, and the second group (n=65) were undergoing magnetic resonance (MR) angiography/urography with Gd-DTPA administration. The concentrations of NGAL and KIM-1 were measured four times in the urine (pre-contrast, then at four hours, 24 hours, and 48 hours after contrast administration), and serum NGAL was measured at 0 (base-line), 24 hours, and 48 hours after contrast exposure. Results: After 24 hours, serum NGAL increase of >= 25% was noticed in 32.6% of the patients in the iopromide group and in 25.45% of the patients in the gadolinium group, with significantly higher average percent of this increase in first group (62.23% vs. 36.44%, p=0.002). In the Gd-DTPA group, we observed a statistically significant increase in urinary KIM-1 24 hours after the procedure. Normalized urinary KIM-1, 24 hours after contrast exposure, was a better predictive factor for CI-AKI than other biomarkers (AUC 0.757, cut off 214 pg/mg, sensitivity 83.3%, specificity 54.2%, p=0.035). Conclusions: In children with normal renal function, exposure to iodinated-based and gadolinium-based media might lead to subclinical nephrotoxicity, which could be detected using serum NGAL and urinary KIM-1.",
publisher = "Int Scientific Information, Inc, Melville",
journal = "Medical Science Monitor",
title = "Serum Neutrophil Gelatinase-Associated Lipocalin and Urinary Kidney Injury Molecule-1 as Potential Biomarkers of Subclinical Nephrotoxicity After Gadolinium-Based and Iodinated-Based Contrast Media Exposure in Pediatric Patients with Normal Kidney Functio",
volume = "23",
doi = "10.12659/MSM.903255"
}

Spasojević-Dimitrijeva, B., Kotur-Stevuljević, J., Dukić, M., Paripović, D., Miloševski-Lomić, G., Spasojević-Kalimanovska, V., Pavicević, P., Mitrović, J.,& Kostić, M.. (2017). Serum Neutrophil Gelatinase-Associated Lipocalin and Urinary Kidney Injury Molecule-1 as Potential Biomarkers of Subclinical Nephrotoxicity After Gadolinium-Based and Iodinated-Based Contrast Media Exposure in Pediatric Patients with Normal Kidney Functio. in Medical Science Monitor
Int Scientific Information, Inc, Melville., 23.
https://doi.org/10.12659/MSM.903255

Spasojević-Dimitrijeva B, Kotur-Stevuljević J, Dukić M, Paripović D, Miloševski-Lomić G, Spasojević-Kalimanovska V, Pavicević P, Mitrović J, Kostić M. Serum Neutrophil Gelatinase-Associated Lipocalin and Urinary Kidney Injury Molecule-1 as Potential Biomarkers of Subclinical Nephrotoxicity After Gadolinium-Based and Iodinated-Based Contrast Media Exposure in Pediatric Patients with Normal Kidney Functio. in Medical Science Monitor. 2017;23.
doi:10.12659/MSM.903255 .

Spasojević-Dimitrijeva, Brankica, Kotur-Stevuljević, Jelena, Dukić, Milan, Paripović, Dušan, Miloševski-Lomić, Gordana, Spasojević-Kalimanovska, Vesna, Pavicević, Polina, Mitrović, Jadranka, Kostić, Mirjana, "Serum Neutrophil Gelatinase-Associated Lipocalin and Urinary Kidney Injury Molecule-1 as Potential Biomarkers of Subclinical Nephrotoxicity After Gadolinium-Based and Iodinated-Based Contrast Media Exposure in Pediatric Patients with Normal Kidney Functio" in Medical Science Monitor, 23 (2017),
https://doi.org/10.12659/MSM.903255 . .