TY  - JOUR
AU  - Perić, Aleksandar
AU  - Vezmar-Kovačević, Sandra
AU  - Barac, Aleksandra
AU  - Gacesa, Dejan
AU  - Perić, Aneta
AU  - Matković-Jozin, Svjetlana
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3352
AB  - Background: Aspirin-induced chronic rhinosinusitis (CRS) is a severe progressive persistent disease, usually associated with nasal polyps (NPs). Aim/objective: To compare effect of hypertonic (2.3% NaCl) sea water and isotonic 0.9% NaCl on symptoms and endoscopic findings in those patients in the period of 1 month after endoscopic sinus surgery (ESS). Material and methods: This prospective, randomized study included 30 patients with aspirin-induced CRS undergoing ESS. Patients were divided into two groups of 15 subjects and one of the two nasal irrigation solutions was administered in each group. Intensity of 5 symptoms (nasal obstruction, nasal discharge/postnasal drip, facial pain/pressure, headache and trouble sleeping) and endoscopic findings were assessed during the 1st, 7th, 14th, 21st and 28th days after the nasal packs removal. Results: We found significantly lower total symptom score (TSS) during the 7th (p= .009), 14th (p = .003), 21st (p  lt  .001) and the 28th day (p=.001), lower total endoscopic score (TES) on the 21st (p = .002) and 28th day (p = .001), lower nasal obstruction, facial pain/pressure, headache and trouble sleeping, and lower nasal mucosal edema, nasal secretion and nasal crusting in patients treated by hypertonic sea water. Conclusion and significance: Hypertonic sea water should be recommended douching solution in the early postoperative care of patients with aspirin-induced CRS.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Acta Oto-Laryngologica
T1  - Efficacy of hypertonic (2.3%) sea water in patients with aspirin-induced chronic rhinosinusitis following endoscopic sinus surgery
VL  - 139
IS  - 6
SP  - 529
EP  - 535
DO  - 10.1080/00016489.2019.1605454
ER  - 

@article{
author = "Perić, Aleksandar and Vezmar-Kovačević, Sandra and Barac, Aleksandra and Gacesa, Dejan and Perić, Aneta and Matković-Jozin, Svjetlana",
year = "2019",
abstract = "Background: Aspirin-induced chronic rhinosinusitis (CRS) is a severe progressive persistent disease, usually associated with nasal polyps (NPs). Aim/objective: To compare effect of hypertonic (2.3% NaCl) sea water and isotonic 0.9% NaCl on symptoms and endoscopic findings in those patients in the period of 1 month after endoscopic sinus surgery (ESS). Material and methods: This prospective, randomized study included 30 patients with aspirin-induced CRS undergoing ESS. Patients were divided into two groups of 15 subjects and one of the two nasal irrigation solutions was administered in each group. Intensity of 5 symptoms (nasal obstruction, nasal discharge/postnasal drip, facial pain/pressure, headache and trouble sleeping) and endoscopic findings were assessed during the 1st, 7th, 14th, 21st and 28th days after the nasal packs removal. Results: We found significantly lower total symptom score (TSS) during the 7th (p= .009), 14th (p = .003), 21st (p  lt  .001) and the 28th day (p=.001), lower total endoscopic score (TES) on the 21st (p = .002) and 28th day (p = .001), lower nasal obstruction, facial pain/pressure, headache and trouble sleeping, and lower nasal mucosal edema, nasal secretion and nasal crusting in patients treated by hypertonic sea water. Conclusion and significance: Hypertonic sea water should be recommended douching solution in the early postoperative care of patients with aspirin-induced CRS.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Acta Oto-Laryngologica",
title = "Efficacy of hypertonic (2.3%) sea water in patients with aspirin-induced chronic rhinosinusitis following endoscopic sinus surgery",
volume = "139",
number = "6",
pages = "529-535",
doi = "10.1080/00016489.2019.1605454"
}

Perić, A., Vezmar-Kovačević, S., Barac, A., Gacesa, D., Perić, A.,& Matković-Jozin, S.. (2019). Efficacy of hypertonic (2.3%) sea water in patients with aspirin-induced chronic rhinosinusitis following endoscopic sinus surgery. in Acta Oto-Laryngologica
Taylor & Francis Ltd, Abingdon., 139(6), 529-535.
https://doi.org/10.1080/00016489.2019.1605454

Perić A, Vezmar-Kovačević S, Barac A, Gacesa D, Perić A, Matković-Jozin S. Efficacy of hypertonic (2.3%) sea water in patients with aspirin-induced chronic rhinosinusitis following endoscopic sinus surgery. in Acta Oto-Laryngologica. 2019;139(6):529-535.
doi:10.1080/00016489.2019.1605454 .

Perić, Aleksandar, Vezmar-Kovačević, Sandra, Barac, Aleksandra, Gacesa, Dejan, Perić, Aneta, Matković-Jozin, Svjetlana, "Efficacy of hypertonic (2.3%) sea water in patients with aspirin-induced chronic rhinosinusitis following endoscopic sinus surgery" in Acta Oto-Laryngologica, 139, no. 6 (2019):529-535,
https://doi.org/10.1080/00016489.2019.1605454 . .