TY  - JOUR
AU  - Đukanović, Ljubica
AU  - Lezaić, Višnja
AU  - Bukvić, Danica
AU  - Mirković, Duško
AU  - Marić, Ivko
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3247
AB  - Background: A previous study indicated that Balkan endemic nephropathy (BEN) patients in the early stage of the disease had significantly higher creatinine clearance (Ccr) than healthy persons. The aim of the study was to assess whether tubular creatinine secretion affects Ccr in early stages of BEN and to check the applicability of serum creatinine-based glomerular filtration rate (GFR) equations in these patients. Methods: The study involved 21 BEN patients with estimated GFR (eGFR) above 60 mL/min/1.73 m(2), excluding any conditions that could affect GFR or tubular creatinine secretion, and 15 healthy controls. In all participants Ccr with and without cimetidine and iohexol clearance (mGFR) were measured and eGFR calculated using Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) and Modification of Diet in Renal Disease Study (MDRD) equations. Glomerular hyperfiltration cutoff (GFR-HF) was calculated. Results: There was no significant difference between the groups in Ccr before and after cimetidine or for eGFR, but mGFR was significantly higher in BEN patients than in controls (122.02 +/- 28.03 mL/min/1.73 m(2) vs. 101.15 +/- 27.32 mL/min/1.73 m(2); p = 0.032). Cimetidine administration reduced Ccr by 10% in both groups. The ratio of Ccr to mGFR was significantly above one in seven BEN patients and five controls and their mGFR values were similar. Seven other patients and eight controls had this ratio equal to one, while values below one were recorded for seven more patients and two controls. mGFR of all these 14 patients was significantly higher than that of healthy controls (129.88 +/- 27.52 mL/min/1.73 m(2) vs. 107.43 +/- 19.51 mL/min/1.73 m(2); p = 0.009). Mean GFR-HF was significantly higher than mGFR in controls, but these two values were similar in BEN patients. eGFR underestimated mGFR in both BEN patients and controls. Conclusion: The ratio of Ccr to mGFR and mGFR to GFR-HF indicated that elevated mGFR in early stages of BEN could be explained by increased glomerular filtration, but tubular creatinine secretion augmented Ccr in a smaller proportion of patients, who did not differ from healthy subjects.
PB  - MDPI, Basel
T2  - Medicina-Lithuania
T1  - Increased Glomerular Filtration Rate in Early Stage of Balkan Endemic Nephropathy
VL  - 55
IS  - 5
DO  - 10.3390/medicina55050155
ER  - 

@article{
author = "Đukanović, Ljubica and Lezaić, Višnja and Bukvić, Danica and Mirković, Duško and Marić, Ivko",
year = "2019",
abstract = "Background: A previous study indicated that Balkan endemic nephropathy (BEN) patients in the early stage of the disease had significantly higher creatinine clearance (Ccr) than healthy persons. The aim of the study was to assess whether tubular creatinine secretion affects Ccr in early stages of BEN and to check the applicability of serum creatinine-based glomerular filtration rate (GFR) equations in these patients. Methods: The study involved 21 BEN patients with estimated GFR (eGFR) above 60 mL/min/1.73 m(2), excluding any conditions that could affect GFR or tubular creatinine secretion, and 15 healthy controls. In all participants Ccr with and without cimetidine and iohexol clearance (mGFR) were measured and eGFR calculated using Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) and Modification of Diet in Renal Disease Study (MDRD) equations. Glomerular hyperfiltration cutoff (GFR-HF) was calculated. Results: There was no significant difference between the groups in Ccr before and after cimetidine or for eGFR, but mGFR was significantly higher in BEN patients than in controls (122.02 +/- 28.03 mL/min/1.73 m(2) vs. 101.15 +/- 27.32 mL/min/1.73 m(2); p = 0.032). Cimetidine administration reduced Ccr by 10% in both groups. The ratio of Ccr to mGFR was significantly above one in seven BEN patients and five controls and their mGFR values were similar. Seven other patients and eight controls had this ratio equal to one, while values below one were recorded for seven more patients and two controls. mGFR of all these 14 patients was significantly higher than that of healthy controls (129.88 +/- 27.52 mL/min/1.73 m(2) vs. 107.43 +/- 19.51 mL/min/1.73 m(2); p = 0.009). Mean GFR-HF was significantly higher than mGFR in controls, but these two values were similar in BEN patients. eGFR underestimated mGFR in both BEN patients and controls. Conclusion: The ratio of Ccr to mGFR and mGFR to GFR-HF indicated that elevated mGFR in early stages of BEN could be explained by increased glomerular filtration, but tubular creatinine secretion augmented Ccr in a smaller proportion of patients, who did not differ from healthy subjects.",
publisher = "MDPI, Basel",
journal = "Medicina-Lithuania",
title = "Increased Glomerular Filtration Rate in Early Stage of Balkan Endemic Nephropathy",
volume = "55",
number = "5",
doi = "10.3390/medicina55050155"
}

Đukanović, L., Lezaić, V., Bukvić, D., Mirković, D.,& Marić, I.. (2019). Increased Glomerular Filtration Rate in Early Stage of Balkan Endemic Nephropathy. in Medicina-Lithuania
MDPI, Basel., 55(5).
https://doi.org/10.3390/medicina55050155

Đukanović L, Lezaić V, Bukvić D, Mirković D, Marić I. Increased Glomerular Filtration Rate in Early Stage of Balkan Endemic Nephropathy. in Medicina-Lithuania. 2019;55(5).
doi:10.3390/medicina55050155 .

Đukanović, Ljubica, Lezaić, Višnja, Bukvić, Danica, Mirković, Duško, Marić, Ivko, "Increased Glomerular Filtration Rate in Early Stage of Balkan Endemic Nephropathy" in Medicina-Lithuania, 55, no. 5 (2019),
https://doi.org/10.3390/medicina55050155 . .