TY  - JOUR
AU  - Đorđević, Sofija
AU  - Petrović, Silvana
AU  - Dobrić, Silva
AU  - Milenković, Marina
AU  - Božić, Dragana
AU  - Žižić, Slavica
AU  - Kukić, Jelena
PY  - 2007
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/946
AB  - The root of Carlina acanthifolia All. (Asteraceae) has been traditionally used in the treatment of various disorders including stomach and skin diseases. We studied antimicrobial, anti-inflammatory, anti-ulcer and antioxidant activities of Carlina acanthifolia root essential oil, in order to validate some of the ethnopharmacological claims. Antimicrobial activity was tested on 15 bacteria and three strains of fungi using the agar diffusion and broth microdilution methods. In assessing anti-inflammatory activity the carrageenan-induced rat paw oedema test was used, while ethanol-induced stress gastric ulcer test in rats was used in testing anti-ulcer activity. Antioxidant properties were evaluated trough the effect of the essential oil on lipid peroxidation (TBA assay) and its capability of quenching 2,2-diphenyl-1-picrylhydrazyl (DPPH) and OH radicals. The oil expressed significant antimicrobial activity, being the most active against Gram (+) bacteria: Streptococcus pyogenes, Enterococcus faecalis, Bacillus subtilis and against Candida albicans. In all applied concentrations, Carlina acanthifolia root essential oil reduced carrageenan-induced rat paw oedema in dose-dependent manner, achieving high degree of anti-inflammatory activity. The effect was comparable with that of indomethacin used as a reference drug. In the ethanol-induced stress gastric ulcer test in rats, it was shown that the tested essential oil produced significant dose-dependent gastroprotective activity. The results also pointed out substantial and dose-dependent antioxidant activity of the investigated essential oil, with carlina oxide as the main antioxidant component.
PB  - Elsevier Ireland Ltd, Clare
T2  - Journal of Ethnopharmacology
T1  - Antimicrobial, anti-inflammatory, anti-ulcer and antioxidant activities of Carlina acanthifolia root essential oil
VL  - 109
IS  - 3
SP  - 458
EP  - 463
DO  - 10.1016/j.jep.2006.08.021
ER  - 

@article{
author = "Đorđević, Sofija and Petrović, Silvana and Dobrić, Silva and Milenković, Marina and Božić, Dragana and Žižić, Slavica and Kukić, Jelena",
year = "2007",
abstract = "The root of Carlina acanthifolia All. (Asteraceae) has been traditionally used in the treatment of various disorders including stomach and skin diseases. We studied antimicrobial, anti-inflammatory, anti-ulcer and antioxidant activities of Carlina acanthifolia root essential oil, in order to validate some of the ethnopharmacological claims. Antimicrobial activity was tested on 15 bacteria and three strains of fungi using the agar diffusion and broth microdilution methods. In assessing anti-inflammatory activity the carrageenan-induced rat paw oedema test was used, while ethanol-induced stress gastric ulcer test in rats was used in testing anti-ulcer activity. Antioxidant properties were evaluated trough the effect of the essential oil on lipid peroxidation (TBA assay) and its capability of quenching 2,2-diphenyl-1-picrylhydrazyl (DPPH) and OH radicals. The oil expressed significant antimicrobial activity, being the most active against Gram (+) bacteria: Streptococcus pyogenes, Enterococcus faecalis, Bacillus subtilis and against Candida albicans. In all applied concentrations, Carlina acanthifolia root essential oil reduced carrageenan-induced rat paw oedema in dose-dependent manner, achieving high degree of anti-inflammatory activity. The effect was comparable with that of indomethacin used as a reference drug. In the ethanol-induced stress gastric ulcer test in rats, it was shown that the tested essential oil produced significant dose-dependent gastroprotective activity. The results also pointed out substantial and dose-dependent antioxidant activity of the investigated essential oil, with carlina oxide as the main antioxidant component.",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Journal of Ethnopharmacology",
title = "Antimicrobial, anti-inflammatory, anti-ulcer and antioxidant activities of Carlina acanthifolia root essential oil",
volume = "109",
number = "3",
pages = "458-463",
doi = "10.1016/j.jep.2006.08.021"
}

Đorđević, S., Petrović, S., Dobrić, S., Milenković, M., Božić, D., Žižić, S.,& Kukić, J.. (2007). Antimicrobial, anti-inflammatory, anti-ulcer and antioxidant activities of Carlina acanthifolia root essential oil. in Journal of Ethnopharmacology
Elsevier Ireland Ltd, Clare., 109(3), 458-463.
https://doi.org/10.1016/j.jep.2006.08.021

Đorđević S, Petrović S, Dobrić S, Milenković M, Božić D, Žižić S, Kukić J. Antimicrobial, anti-inflammatory, anti-ulcer and antioxidant activities of Carlina acanthifolia root essential oil. in Journal of Ethnopharmacology. 2007;109(3):458-463.
doi:10.1016/j.jep.2006.08.021 .

Đorđević, Sofija, Petrović, Silvana, Dobrić, Silva, Milenković, Marina, Božić, Dragana, Žižić, Slavica, Kukić, Jelena, "Antimicrobial, anti-inflammatory, anti-ulcer and antioxidant activities of Carlina acanthifolia root essential oil" in Journal of Ethnopharmacology, 109, no. 3 (2007):458-463,
https://doi.org/10.1016/j.jep.2006.08.021 . .

TY  - JOUR
AU  - Đorđević, Sofija
AU  - Milenković, Marina
AU  - Petrović, Silvana
AU  - Antić-Stanković, Jelena
AU  - Žižić, Slavica
PY  - 2005
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/633
AB  - Intrahospital infections are great clinico-therapeutical problem because they are caused by strains of bacteria which are multiresistant. For the purpose of finding new natural raw materials with antimicrobial activity, in this study we tested antibacterial activity of essential oil from Carlina acaulis subsp. caulescens root on clinical isolates of bacteria which are the most common etiological agents of intrahospital infections. Investigation of antibacterial activity of 4% essential oil solution in absolute ethanol was performed by agar dilution technique and broth microdilution technique on different strains of bacteria: Streptococcus pyogenes, Escherichia colt, Klebsiella pneumoniue. Pseudomonas aeruginosa, Slaphylococcus aurews and Acinetobacter spp., isolated from wound swabs and urine of hospitalised patients. Tested solution of essential oil showed high antibacterial activity against Streptococcus pyogenes, medium against Acinetobacler spp., Staphylococcus aureus and Pseudomonas aeruginosa, and moderate against Escherichia coli and Klebsiella pneumoniae.
AB  - Intrahospitalne infekcije predstavljaju veliki kliničko-terapijski problem, jer su izazvane sojevima bakterija koji pokazuju izrazitu rezistenciju na veći broj antibiotika sa različitim mehanizmima delovanja (multirezistentni sojevi). U cilju iznalaženja potencijalno novih prirodnih sirovina sa antimikrobnim dejstvom, u radu je ispitivano antibakterijsko delovanje etarskog ulja izolovanog iz korena vilinog sita, Carlina acaulis subsp. caulescens, na kliničke izolate bakterija koje poslednjih godina često dovode do intrahospitalnih infekcija. Ispitivanje antibakterijskog delovanja 4% rastvora etarskog ulja u apsolutnom etanolu izvršeno je agar-difuzionom i bujon-dilucionom metodom na različite sojeve bakterija: Streptococcus pyogenes, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Staphylococcus aureus i Acinetobacter spp., koji su izolovani iz briseva rana i urina hospitalizovanih bolesnika. Ispitivani rastvor etarskog ulja ispoljio je visoku antibakterijsku aktivnost prema Streptococcus pyogenes, znatnu na Acinetohacter spp., Staphvlococcus aureus i Pseudomonas aeruginosa, a umerenu na Escherichia coli i Klebsiella pneumoniae.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - Antimicrobial activity of essential oil from root of Carlina acaulis subsp. caulescens on clinical isolates of bacteria
T1  - Antimikrobna aktivnost etarskog ulja korena Carlina acaulis subsp. caulescens na kliničke izolate bakterija
VL  - 55
IS  - 5-6
SP  - 505
EP  - 512
UR  - https://hdl.handle.net/21.15107/rcub_farfar_633
ER  - 

@article{
author = "Đorđević, Sofija and Milenković, Marina and Petrović, Silvana and Antić-Stanković, Jelena and Žižić, Slavica",
year = "2005",
abstract = "Intrahospital infections are great clinico-therapeutical problem because they are caused by strains of bacteria which are multiresistant. For the purpose of finding new natural raw materials with antimicrobial activity, in this study we tested antibacterial activity of essential oil from Carlina acaulis subsp. caulescens root on clinical isolates of bacteria which are the most common etiological agents of intrahospital infections. Investigation of antibacterial activity of 4% essential oil solution in absolute ethanol was performed by agar dilution technique and broth microdilution technique on different strains of bacteria: Streptococcus pyogenes, Escherichia colt, Klebsiella pneumoniue. Pseudomonas aeruginosa, Slaphylococcus aurews and Acinetobacter spp., isolated from wound swabs and urine of hospitalised patients. Tested solution of essential oil showed high antibacterial activity against Streptococcus pyogenes, medium against Acinetobacler spp., Staphylococcus aureus and Pseudomonas aeruginosa, and moderate against Escherichia coli and Klebsiella pneumoniae., Intrahospitalne infekcije predstavljaju veliki kliničko-terapijski problem, jer su izazvane sojevima bakterija koji pokazuju izrazitu rezistenciju na veći broj antibiotika sa različitim mehanizmima delovanja (multirezistentni sojevi). U cilju iznalaženja potencijalno novih prirodnih sirovina sa antimikrobnim dejstvom, u radu je ispitivano antibakterijsko delovanje etarskog ulja izolovanog iz korena vilinog sita, Carlina acaulis subsp. caulescens, na kliničke izolate bakterija koje poslednjih godina često dovode do intrahospitalnih infekcija. Ispitivanje antibakterijskog delovanja 4% rastvora etarskog ulja u apsolutnom etanolu izvršeno je agar-difuzionom i bujon-dilucionom metodom na različite sojeve bakterija: Streptococcus pyogenes, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Staphylococcus aureus i Acinetobacter spp., koji su izolovani iz briseva rana i urina hospitalizovanih bolesnika. Ispitivani rastvor etarskog ulja ispoljio je visoku antibakterijsku aktivnost prema Streptococcus pyogenes, znatnu na Acinetohacter spp., Staphvlococcus aureus i Pseudomonas aeruginosa, a umerenu na Escherichia coli i Klebsiella pneumoniae.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Antimicrobial activity of essential oil from root of Carlina acaulis subsp. caulescens on clinical isolates of bacteria, Antimikrobna aktivnost etarskog ulja korena Carlina acaulis subsp. caulescens na kliničke izolate bakterija",
volume = "55",
number = "5-6",
pages = "505-512",
url = "https://hdl.handle.net/21.15107/rcub_farfar_633"
}

Đorđević, S., Milenković, M., Petrović, S., Antić-Stanković, J.,& Žižić, S.. (2005). Antimicrobial activity of essential oil from root of Carlina acaulis subsp. caulescens on clinical isolates of bacteria. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 55(5-6), 505-512.
https://hdl.handle.net/21.15107/rcub_farfar_633

Đorđević S, Milenković M, Petrović S, Antić-Stanković J, Žižić S. Antimicrobial activity of essential oil from root of Carlina acaulis subsp. caulescens on clinical isolates of bacteria. in Arhiv za farmaciju. 2005;55(5-6):505-512.
https://hdl.handle.net/21.15107/rcub_farfar_633 .

Đorđević, Sofija, Milenković, Marina, Petrović, Silvana, Antić-Stanković, Jelena, Žižić, Slavica, "Antimicrobial activity of essential oil from root of Carlina acaulis subsp. caulescens on clinical isolates of bacteria" in Arhiv za farmaciju, 55, no. 5-6 (2005):505-512,
https://hdl.handle.net/21.15107/rcub_farfar_633 .