TY  - JOUR
AU  - Maksimović, Zoran
AU  - Dobrić, Silva
AU  - Kovačević, Nada
AU  - Milovanović, Z
PY  - 2004
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/502
AB  - Maydis stigma (corn silk) is a herbal drug reputed for the treatment of urinary ailments in various traditional medicine systems. To determine its influence on urinary volume and the excretion of sodium, potassium and chloride, 5% and 10% decoctions were administered daily to adult male Wistar rats for eight days. The concentration of electrolytes and urea in plasma, the influence of treatment on urinary pH value as well as creatinine clearance were also investigated. Daily oral administration of 5% decoction at the dose of 10 ml/kg led to a significant and acute diuresis in rats, reaching the peak value in the first 24 h of treatment. Over a similar period, application of 10% decoction did not affect urinary excretion of water, but significantly increased the pH value of excreted urine. A significant decrease in sodium and chloride plasma levels was observed in both treated groups. The creatinine clearance was markedly increased after the treatment with both extracts. Our findings indicate that the diuretic effect of 5% aqueous Maydis stigma extract is in accordance with the increase in glomerular filtration rate and inhibition of sodium and chloride tubular reabsorption, caused a by still unidentified intrinsic factor, but not the salt-loading effect.
PB  - Govi-Verlag  Pharmazeutischer Verlag Gmbh, Eschborn
T2  - Pharmazie
T1  - Diuretic activity of Maydis stigma extract in rats
VL  - 59
IS  - 12
SP  - 967
EP  - 971
UR  - https://hdl.handle.net/21.15107/rcub_farfar_502
ER  - 

@article{
author = "Maksimović, Zoran and Dobrić, Silva and Kovačević, Nada and Milovanović, Z",
year = "2004",
abstract = "Maydis stigma (corn silk) is a herbal drug reputed for the treatment of urinary ailments in various traditional medicine systems. To determine its influence on urinary volume and the excretion of sodium, potassium and chloride, 5% and 10% decoctions were administered daily to adult male Wistar rats for eight days. The concentration of electrolytes and urea in plasma, the influence of treatment on urinary pH value as well as creatinine clearance were also investigated. Daily oral administration of 5% decoction at the dose of 10 ml/kg led to a significant and acute diuresis in rats, reaching the peak value in the first 24 h of treatment. Over a similar period, application of 10% decoction did not affect urinary excretion of water, but significantly increased the pH value of excreted urine. A significant decrease in sodium and chloride plasma levels was observed in both treated groups. The creatinine clearance was markedly increased after the treatment with both extracts. Our findings indicate that the diuretic effect of 5% aqueous Maydis stigma extract is in accordance with the increase in glomerular filtration rate and inhibition of sodium and chloride tubular reabsorption, caused a by still unidentified intrinsic factor, but not the salt-loading effect.",
publisher = "Govi-Verlag  Pharmazeutischer Verlag Gmbh, Eschborn",
journal = "Pharmazie",
title = "Diuretic activity of Maydis stigma extract in rats",
volume = "59",
number = "12",
pages = "967-971",
url = "https://hdl.handle.net/21.15107/rcub_farfar_502"
}

Maksimović, Z., Dobrić, S., Kovačević, N.,& Milovanović, Z.. (2004). Diuretic activity of Maydis stigma extract in rats. in Pharmazie
Govi-Verlag  Pharmazeutischer Verlag Gmbh, Eschborn., 59(12), 967-971.
https://hdl.handle.net/21.15107/rcub_farfar_502

Maksimović Z, Dobrić S, Kovačević N, Milovanović Z. Diuretic activity of Maydis stigma extract in rats. in Pharmazie. 2004;59(12):967-971.
https://hdl.handle.net/21.15107/rcub_farfar_502 .

Maksimović, Zoran, Dobrić, Silva, Kovačević, Nada, Milovanović, Z, "Diuretic activity of Maydis stigma extract in rats" in Pharmazie, 59, no. 12 (2004):967-971,
https://hdl.handle.net/21.15107/rcub_farfar_502 .