TY  - JOUR
AU  - Đukić-Ćosić, Danijela
AU  - Antonijević, Evica
AU  - Mandinić, Zoran
AU  - Ćurčić, Marijana
AU  - Ćupić-Miladinović, Dejana
AU  - Antonijević, Biljana
AU  - Matović, Vesna
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3274
AB  - Background/Aim. Fluoride has beneficial effect on dental caries prevention and enables high hardness of enamel. However, fluoride intake above optimal levels can have adverse effects on teeth and bones, especially in young children during the period of intense growth and teeth development. The aim of this study was to assess fluoride intake from water and toothpaste among 3-year-old children in Belgrade, Serbia, in the municipalities of Vračar and Novi Beograd. Methods. A questionnaire for the parents (n = 40) was used to provide information on the water consumption (tap and/or bottled water) and the brand of toothpaste used by children as well as the frequency of tooth brushing and the amount of toothpaste during brushing. Fluoride concentrations in water and toothpaste samples were determined electrochemically by using fluoride-selective electrode. Fluoride intake was estimated through a mathematical model commonly used by the U.S. Environmental Protection Agency. Results. The obtained results indicate no significant difference in daily fluoride intake through drinking water and toothpaste in 3-year-old children in Vračar (n = 19) compared to Novi Beograd (n = 21) (p > 0.05). However, all estimated fluoride levels (0.089-0.625 mg/day) are significantly lower than the optimal daily intake level for caries protection (0.7 mg/day for children up to 4 years, FNB-USA National Institute of Medicine) and two to six times lower than tolerable upper fluoride level for the children of same age (1.3 mg/day, FNB-USA National Institute of Medicine). Furthermore, calculated daily fluoride intake per kilogram body weight confirm very low fluoride intake by water and toothpaste in children of investigated municipalities in Belgrade, being significantly below the recommended an adequate intake (0.05 mg/kg/day, EFSA). Conclusion. This preliminary study has shown that daily fluoride intake in 3-year-olds is lower than tolerable upper fluoride level, even not sufficient for the prevention of dental caries.
AB  - Uvod/Cilj. Fluoridi imaju pozitivan efekat na prevenciju karijesa zuba kao i povećanje čvrstine zubnog emajla. Međutim, njihov unos iznad optimalnog može imati štetne efekte na zube i kosti, posebno kod male dece tokom intenzivnog rasta i razvoja zuba. Cilj ovog rada bio je da se proceni unos fluorida putem vode za piće i paste za zube kod dece uzrasta od tri godine u Beogradu, na teritoriji dve opštine, Vračar i Novi Beograd. Metode. Anketnim upitnicima (n = 40) za roditelje dobijeni su podaci o vrsti vode koju deca piju (česmenska i/ili flaširana), proizvodima koje koriste za čišćenje i negu zuba, učestalosti pranja zuba kao i količini paste za zube koja se koristi po jednom pranju. Sadržaj fluorida u vodi za piće i pastama za zube određen je elektrohemijski sa fluoridnom jonselektivnom elektrodom. Unos fluorida procenjen je korišćenjem matematičkog modela datog od strane Američke agencije za zaštitu životne sredine. Rezultati. Dobijeni rezultati pokazuju da nema statistički značajne razlike u dnevnom unosu fluorida putem vode za piće i paste za zube između dece uzrasta od tri godine na Vračaru i Novom Beogradu (p > 0,05). Međutim, sve procenjene vrednosti unosa fluorida (0,089-0,625 mg/dan) značajno su niže od optimalnog dnevnog unosa za prevenciju karijesa (0,7 mg/dan za decu uzrasta do 4 godine, FNB-Nacionalnog instituta medicine, SAD) i dva do šest puta niže od tolerišućeg gornjeg nivoa unosa fluorida za decu istog uzrasta (1,3 mg/dan, FNBNacionalnog instituta medicine, SAD). Štaviše, izračunati dnevni unosi fluorida izraženi po kilogramu telesne mase potvrđuju veoma nizak unos fluorida kod dece ispitivanih opština u Beogradu, čak značajno niže od preporučenog optimalnog unosa (0,05 mg/kg/dan, EFSA). Zaključak. Ovim preliminarnim istraživanjem pokazano je da je dnevni unos fluorida kod trogodišnjaka u Beogradu značajno niži od tolerišućeg gornjeg nivoa unosa fluorida, čak niži od optimalnog unosa za prevenciju karijesa.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Assessment of fluoride intake from drinking water and toothpaste in 3-year-olds: Preliminary results in Belgrade, Republic of Serbia
T1  - Procena unosa fluorida putem vode za piće i paste za zube kod dece uzrasta od tri godine - preliminarni rezultati u Beogradu, Republika Srbija
VL  - 76
IS  - 6
SP  - 607
EP  - 614
DO  - 10.2298/VSP170721136D
ER  - 

@article{
author = "Đukić-Ćosić, Danijela and Antonijević, Evica and Mandinić, Zoran and Ćurčić, Marijana and Ćupić-Miladinović, Dejana and Antonijević, Biljana and Matović, Vesna",
year = "2019",
abstract = "Background/Aim. Fluoride has beneficial effect on dental caries prevention and enables high hardness of enamel. However, fluoride intake above optimal levels can have adverse effects on teeth and bones, especially in young children during the period of intense growth and teeth development. The aim of this study was to assess fluoride intake from water and toothpaste among 3-year-old children in Belgrade, Serbia, in the municipalities of Vračar and Novi Beograd. Methods. A questionnaire for the parents (n = 40) was used to provide information on the water consumption (tap and/or bottled water) and the brand of toothpaste used by children as well as the frequency of tooth brushing and the amount of toothpaste during brushing. Fluoride concentrations in water and toothpaste samples were determined electrochemically by using fluoride-selective electrode. Fluoride intake was estimated through a mathematical model commonly used by the U.S. Environmental Protection Agency. Results. The obtained results indicate no significant difference in daily fluoride intake through drinking water and toothpaste in 3-year-old children in Vračar (n = 19) compared to Novi Beograd (n = 21) (p > 0.05). However, all estimated fluoride levels (0.089-0.625 mg/day) are significantly lower than the optimal daily intake level for caries protection (0.7 mg/day for children up to 4 years, FNB-USA National Institute of Medicine) and two to six times lower than tolerable upper fluoride level for the children of same age (1.3 mg/day, FNB-USA National Institute of Medicine). Furthermore, calculated daily fluoride intake per kilogram body weight confirm very low fluoride intake by water and toothpaste in children of investigated municipalities in Belgrade, being significantly below the recommended an adequate intake (0.05 mg/kg/day, EFSA). Conclusion. This preliminary study has shown that daily fluoride intake in 3-year-olds is lower than tolerable upper fluoride level, even not sufficient for the prevention of dental caries., Uvod/Cilj. Fluoridi imaju pozitivan efekat na prevenciju karijesa zuba kao i povećanje čvrstine zubnog emajla. Međutim, njihov unos iznad optimalnog može imati štetne efekte na zube i kosti, posebno kod male dece tokom intenzivnog rasta i razvoja zuba. Cilj ovog rada bio je da se proceni unos fluorida putem vode za piće i paste za zube kod dece uzrasta od tri godine u Beogradu, na teritoriji dve opštine, Vračar i Novi Beograd. Metode. Anketnim upitnicima (n = 40) za roditelje dobijeni su podaci o vrsti vode koju deca piju (česmenska i/ili flaširana), proizvodima koje koriste za čišćenje i negu zuba, učestalosti pranja zuba kao i količini paste za zube koja se koristi po jednom pranju. Sadržaj fluorida u vodi za piće i pastama za zube određen je elektrohemijski sa fluoridnom jonselektivnom elektrodom. Unos fluorida procenjen je korišćenjem matematičkog modela datog od strane Američke agencije za zaštitu životne sredine. Rezultati. Dobijeni rezultati pokazuju da nema statistički značajne razlike u dnevnom unosu fluorida putem vode za piće i paste za zube između dece uzrasta od tri godine na Vračaru i Novom Beogradu (p > 0,05). Međutim, sve procenjene vrednosti unosa fluorida (0,089-0,625 mg/dan) značajno su niže od optimalnog dnevnog unosa za prevenciju karijesa (0,7 mg/dan za decu uzrasta do 4 godine, FNB-Nacionalnog instituta medicine, SAD) i dva do šest puta niže od tolerišućeg gornjeg nivoa unosa fluorida za decu istog uzrasta (1,3 mg/dan, FNBNacionalnog instituta medicine, SAD). Štaviše, izračunati dnevni unosi fluorida izraženi po kilogramu telesne mase potvrđuju veoma nizak unos fluorida kod dece ispitivanih opština u Beogradu, čak značajno niže od preporučenog optimalnog unosa (0,05 mg/kg/dan, EFSA). Zaključak. Ovim preliminarnim istraživanjem pokazano je da je dnevni unos fluorida kod trogodišnjaka u Beogradu značajno niži od tolerišućeg gornjeg nivoa unosa fluorida, čak niži od optimalnog unosa za prevenciju karijesa.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Assessment of fluoride intake from drinking water and toothpaste in 3-year-olds: Preliminary results in Belgrade, Republic of Serbia, Procena unosa fluorida putem vode za piće i paste za zube kod dece uzrasta od tri godine - preliminarni rezultati u Beogradu, Republika Srbija",
volume = "76",
number = "6",
pages = "607-614",
doi = "10.2298/VSP170721136D"
}

Đukić-Ćosić, D., Antonijević, E., Mandinić, Z., Ćurčić, M., Ćupić-Miladinović, D., Antonijević, B.,& Matović, V.. (2019). Assessment of fluoride intake from drinking water and toothpaste in 3-year-olds: Preliminary results in Belgrade, Republic of Serbia. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 76(6), 607-614.
https://doi.org/10.2298/VSP170721136D

Đukić-Ćosić D, Antonijević E, Mandinić Z, Ćurčić M, Ćupić-Miladinović D, Antonijević B, Matović V. Assessment of fluoride intake from drinking water and toothpaste in 3-year-olds: Preliminary results in Belgrade, Republic of Serbia. in Vojnosanitetski pregled. 2019;76(6):607-614.
doi:10.2298/VSP170721136D .

Đukić-Ćosić, Danijela, Antonijević, Evica, Mandinić, Zoran, Ćurčić, Marijana, Ćupić-Miladinović, Dejana, Antonijević, Biljana, Matović, Vesna, "Assessment of fluoride intake from drinking water and toothpaste in 3-year-olds: Preliminary results in Belgrade, Republic of Serbia" in Vojnosanitetski pregled, 76, no. 6 (2019):607-614,
https://doi.org/10.2298/VSP170721136D . .

TY  - CONF
AU  - Čupić-Miladinović, Dejana
AU  - Borozan, Sunčica
AU  - Peković, S.
AU  - Dacić, S.
AU  - Đukić-Ćosić, Danijela
AU  - Ćupić, Vitomir
AU  - Ivanović, S.
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3128
PB  - Elsevier Ireland Ltd, Clare
C3  - Toxicology Letters
T1  - The effect of thiamine on oxidative stress and apoptosis in the liver of Japanese quails treated with chlorpyrifos
VL  - 295
IS  - Supplement 1
SP  - S264
EP  - S264
DO  - 10.1016/j.toxlet.2018.06.1062
ER  - 

@conference{
author = "Čupić-Miladinović, Dejana and Borozan, Sunčica and Peković, S. and Dacić, S. and Đukić-Ćosić, Danijela and Ćupić, Vitomir and Ivanović, S.",
year = "2018",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Toxicology Letters",
title = "The effect of thiamine on oxidative stress and apoptosis in the liver of Japanese quails treated with chlorpyrifos",
volume = "295",
number = "Supplement 1",
pages = "S264-S264",
doi = "10.1016/j.toxlet.2018.06.1062"
}

Čupić-Miladinović, D., Borozan, S., Peković, S., Dacić, S., Đukić-Ćosić, D., Ćupić, V.,& Ivanović, S.. (2018). The effect of thiamine on oxidative stress and apoptosis in the liver of Japanese quails treated with chlorpyrifos. in Toxicology Letters
Elsevier Ireland Ltd, Clare., 295(Supplement 1), S264-S264.
https://doi.org/10.1016/j.toxlet.2018.06.1062

Čupić-Miladinović D, Borozan S, Peković S, Dacić S, Đukić-Ćosić D, Ćupić V, Ivanović S. The effect of thiamine on oxidative stress and apoptosis in the liver of Japanese quails treated with chlorpyrifos. in Toxicology Letters. 2018;295(Supplement 1):S264-S264.
doi:10.1016/j.toxlet.2018.06.1062 .

Čupić-Miladinović, Dejana, Borozan, Sunčica, Peković, S., Dacić, S., Đukić-Ćosić, Danijela, Ćupić, Vitomir, Ivanović, S., "The effect of thiamine on oxidative stress and apoptosis in the liver of Japanese quails treated with chlorpyrifos" in Toxicology Letters, 295, no. Supplement 1 (2018):S264-S264,
https://doi.org/10.1016/j.toxlet.2018.06.1062 . .

TY  - JOUR
AU  - Antonijević, Evica
AU  - Musilek, Kamil
AU  - Kuca, Kamil
AU  - Đukić-Ćosić, Danijela
AU  - Ćurčić, Marijana
AU  - Čupić-Miladinović, Dejana
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3055
AB  - Inhibition of acethylcholinesterase (AChE) as a key molecular event induced by organophosphate (OP) pesticides and nerve agents presents a human health concern. In efficacy testing of experimental oximes, potential antidotes in OP poisoning, reactivation of OP-inhibited AChE is used as specific endpoint. However, according to our best knowledge, so far oximes have not been quantitatively evaluated by comprehensive benchmark dose (BMD) approach, that would improve both identification and quantification of the effect and allow more rigorous comparison of efficacies. Thus, we have examined in vivo dose-response relationship for two promising experimental oximes, K203 and K027, concerning reactivation of erythrocyte AChE inhibited by dichlorvos (DDVP). Groups of Wistar rats were treated with six different doses of oximes (i.m) immediately after DDVP challenge (s.c) and AChE was measured 60 min later. Dose-response modeling was done by PROAST software 65.5 (RIVM, The Nederlands). BMD-covariate method resulted in four-parameter model from both exponential and Hill model families as the best estimate of relationship between AChE activity and oxime dose, with potency parameter being oxime-dependent. Oxime K027 was shown to be 1.929-fold more potent considering that 58% increase in AChE activity was achived with the dose BMD58-K027 = 52 mu mol/kg in contrast to BMD58-K203 = 100 mu mol/kg.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Food and Chemical Toxicology
T1  - Dose-response modeling of reactivating potency of oximes K027 and K203 against a direct acetylcholinesterase inhibitor in rat erythrocytes
VL  - 121
SP  - 224
EP  - 230
DO  - 10.1016/j.fct.2018.08.065
ER  - 

@article{
author = "Antonijević, Evica and Musilek, Kamil and Kuca, Kamil and Đukić-Ćosić, Danijela and Ćurčić, Marijana and Čupić-Miladinović, Dejana and Bulat, Zorica and Antonijević, Biljana",
year = "2018",
abstract = "Inhibition of acethylcholinesterase (AChE) as a key molecular event induced by organophosphate (OP) pesticides and nerve agents presents a human health concern. In efficacy testing of experimental oximes, potential antidotes in OP poisoning, reactivation of OP-inhibited AChE is used as specific endpoint. However, according to our best knowledge, so far oximes have not been quantitatively evaluated by comprehensive benchmark dose (BMD) approach, that would improve both identification and quantification of the effect and allow more rigorous comparison of efficacies. Thus, we have examined in vivo dose-response relationship for two promising experimental oximes, K203 and K027, concerning reactivation of erythrocyte AChE inhibited by dichlorvos (DDVP). Groups of Wistar rats were treated with six different doses of oximes (i.m) immediately after DDVP challenge (s.c) and AChE was measured 60 min later. Dose-response modeling was done by PROAST software 65.5 (RIVM, The Nederlands). BMD-covariate method resulted in four-parameter model from both exponential and Hill model families as the best estimate of relationship between AChE activity and oxime dose, with potency parameter being oxime-dependent. Oxime K027 was shown to be 1.929-fold more potent considering that 58% increase in AChE activity was achived with the dose BMD58-K027 = 52 mu mol/kg in contrast to BMD58-K203 = 100 mu mol/kg.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Food and Chemical Toxicology",
title = "Dose-response modeling of reactivating potency of oximes K027 and K203 against a direct acetylcholinesterase inhibitor in rat erythrocytes",
volume = "121",
pages = "224-230",
doi = "10.1016/j.fct.2018.08.065"
}

Antonijević, E., Musilek, K., Kuca, K., Đukić-Ćosić, D., Ćurčić, M., Čupić-Miladinović, D., Bulat, Z.,& Antonijević, B.. (2018). Dose-response modeling of reactivating potency of oximes K027 and K203 against a direct acetylcholinesterase inhibitor in rat erythrocytes. in Food and Chemical Toxicology
Pergamon-Elsevier Science Ltd, Oxford., 121, 224-230.
https://doi.org/10.1016/j.fct.2018.08.065

Antonijević E, Musilek K, Kuca K, Đukić-Ćosić D, Ćurčić M, Čupić-Miladinović D, Bulat Z, Antonijević B. Dose-response modeling of reactivating potency of oximes K027 and K203 against a direct acetylcholinesterase inhibitor in rat erythrocytes. in Food and Chemical Toxicology. 2018;121:224-230.
doi:10.1016/j.fct.2018.08.065 .

Antonijević, Evica, Musilek, Kamil, Kuca, Kamil, Đukić-Ćosić, Danijela, Ćurčić, Marijana, Čupić-Miladinović, Dejana, Bulat, Zorica, Antonijević, Biljana, "Dose-response modeling of reactivating potency of oximes K027 and K203 against a direct acetylcholinesterase inhibitor in rat erythrocytes" in Food and Chemical Toxicology, 121 (2018):224-230,
https://doi.org/10.1016/j.fct.2018.08.065 . .

TY  - JOUR
AU  - Radaković, Milena
AU  - Borozan, Sunčica
AU  - Đelić, Ninoslav
AU  - Ivanović, Sasa
AU  - Čupić-Miladinović, Dejana
AU  - Ristanić, Marko
AU  - Potparević, Biljana
AU  - Stanimirović, Zoran
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3064
AB  - This study is aimed at analysing biochemical and genetic endpoints of toxic effects after administration of adrenaline. For this purpose, the study was carried out on Wistar rats and three doses of adrenaline were used: 0.75 mg/kg, 1.5 mg/kg, and 3 mg/kg body weight. To achieve these aims, we investigated the effects of adrenaline on catalase (CAT), Cu, Zn-superoxide dismutase (SOD), malondialdehyde (MDA), nitrite (NO2-), carbonyl groups (PCC), and nitrotyrosine (3-NT). Total activity of lactate dehydrogenase (LDH), its relative distribution (LDH1-LDH5) activity, level of acute phase proteins (APPs), and genotoxic effect were also evaluated. The obtained results revealed that all doses of adrenaline induced a significant rise in CAT activity, MDA level, PCC, NO2-, and 3-NT and a significant decrease in SOD activity compared to control. Adrenaline exerted an increase in total activity of LDH, LDH1, and LDH2 isoenzymes. Further study showed that adrenaline significantly decreased serum albumin level and albumin-globulin ratio, while the level of APPs (alpha(1) -acid glycoprotein and haptoglobulin) is increased. The micronucleus test revealed a genotoxic effect of adrenaline at higher concentrations (1.5 mg/kg and 3 mg/kg body weight) compared to untreated rats. It can be concluded that adrenaline exerts oxidative and nitrative stress in rats, increased damage to lipids and proteins, and damage of cardiomyocytes and cytogenetic damage. Obtained results may contribute to better understanding of the toxicity of adrenaline with aims to preventing its harmful effects.
PB  - Hindawi Ltd, London
T2  - Oxidative Medicine and Cellular Longevity
T1  - Nitroso-Oxidative Stress, Acute Phase Response, and Cytogenetic Damage in Wistar Rats Treated with Adrenaline
DO  - 10.1155/2018/1805354
ER  - 

@article{
author = "Radaković, Milena and Borozan, Sunčica and Đelić, Ninoslav and Ivanović, Sasa and Čupić-Miladinović, Dejana and Ristanić, Marko and Potparević, Biljana and Stanimirović, Zoran",
year = "2018",
abstract = "This study is aimed at analysing biochemical and genetic endpoints of toxic effects after administration of adrenaline. For this purpose, the study was carried out on Wistar rats and three doses of adrenaline were used: 0.75 mg/kg, 1.5 mg/kg, and 3 mg/kg body weight. To achieve these aims, we investigated the effects of adrenaline on catalase (CAT), Cu, Zn-superoxide dismutase (SOD), malondialdehyde (MDA), nitrite (NO2-), carbonyl groups (PCC), and nitrotyrosine (3-NT). Total activity of lactate dehydrogenase (LDH), its relative distribution (LDH1-LDH5) activity, level of acute phase proteins (APPs), and genotoxic effect were also evaluated. The obtained results revealed that all doses of adrenaline induced a significant rise in CAT activity, MDA level, PCC, NO2-, and 3-NT and a significant decrease in SOD activity compared to control. Adrenaline exerted an increase in total activity of LDH, LDH1, and LDH2 isoenzymes. Further study showed that adrenaline significantly decreased serum albumin level and albumin-globulin ratio, while the level of APPs (alpha(1) -acid glycoprotein and haptoglobulin) is increased. The micronucleus test revealed a genotoxic effect of adrenaline at higher concentrations (1.5 mg/kg and 3 mg/kg body weight) compared to untreated rats. It can be concluded that adrenaline exerts oxidative and nitrative stress in rats, increased damage to lipids and proteins, and damage of cardiomyocytes and cytogenetic damage. Obtained results may contribute to better understanding of the toxicity of adrenaline with aims to preventing its harmful effects.",
publisher = "Hindawi Ltd, London",
journal = "Oxidative Medicine and Cellular Longevity",
title = "Nitroso-Oxidative Stress, Acute Phase Response, and Cytogenetic Damage in Wistar Rats Treated with Adrenaline",
doi = "10.1155/2018/1805354"
}

Radaković, M., Borozan, S., Đelić, N., Ivanović, S., Čupić-Miladinović, D., Ristanić, M., Potparević, B.,& Stanimirović, Z.. (2018). Nitroso-Oxidative Stress, Acute Phase Response, and Cytogenetic Damage in Wistar Rats Treated with Adrenaline. in Oxidative Medicine and Cellular Longevity
Hindawi Ltd, London..
https://doi.org/10.1155/2018/1805354

Radaković M, Borozan S, Đelić N, Ivanović S, Čupić-Miladinović D, Ristanić M, Potparević B, Stanimirović Z. Nitroso-Oxidative Stress, Acute Phase Response, and Cytogenetic Damage in Wistar Rats Treated with Adrenaline. in Oxidative Medicine and Cellular Longevity. 2018;.
doi:10.1155/2018/1805354 .

Radaković, Milena, Borozan, Sunčica, Đelić, Ninoslav, Ivanović, Sasa, Čupić-Miladinović, Dejana, Ristanić, Marko, Potparević, Biljana, Stanimirović, Zoran, "Nitroso-Oxidative Stress, Acute Phase Response, and Cytogenetic Damage in Wistar Rats Treated with Adrenaline" in Oxidative Medicine and Cellular Longevity (2018),
https://doi.org/10.1155/2018/1805354 . .

TY  - JOUR
AU  - Jović, Slavoljub
AU  - Ćupić, Vitomir
AU  - Ristić, Gordana
AU  - Vakanjac, Slobodanka
AU  - Dimitrijević, Blagoje
AU  - Čupić-Miladinović, Dejana
AU  - Živković, Lada
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2776
AB  - The objective of this work was to investigate the influence of the day of farrowing induction on the number of newborn piglets (live born and dead born), body mass and mortality of neonatal pigs in litter by the tenth day of age. For the investigation purpose, there were chosen 167 pregnant animals, 34 gilts and 133 sows, divided into 3 groups each, according to the day of pregnancy when prostaglandin analogue, dinoprost-tromethamine, was applied (from 112th to 114th day). Fastest-induced parturition was in gilts which were administered dinoprost on the 113th day of pregnancy, (34,30 ± 6,23) h after application, that is, in sows which were administered prostaglandin on the 114th day of pregnancy, (29,57 ± 4,14) h after application of dinoprost. Most gilts (75 %) and sows (90,91%) started farrowing 24-36 h after dinoprost application, when it was given on the 113th day of pregnancy. During daily twelve-hour working time (7-19 h), 67,07% out of all the treated animals started farrowing. When farrowing was induced on the 112th day of pregnancy, 17 sows (12,78%) needed obstetric assistance for dystocia, while 47 (35,34 %) sows had troublesome farrowing. Along with the delayed induction, body mass of newborn pigs increased, and the largest recorded weight was 1,27 kg in sows, that is 1,38 kg in gilts, which were given dinoprost on the 114th day of pregnancy, with the lowest number of live born pigs of body mass less than 1 kg (23,76%). In this experiment there was determined the connection between the body mass and vitality of newborn piglets, so the lowest mortality rate of the pigs by the 10th day of age was noticed in sows and gilts which were given dinoprost on the 114th day of pregnancy (11,05%), in regard to the pigs born of sows and gilts which were given dinoprost on the 112th day of pregnancy (15,39 %).
AB  - Cilj ovog rada bio je da se ispita uticaj izbora dana indukcije prašenja na broj novorođene prasadi (živo i mrtvorođene), telesnu masu i mortalitet neonatalne prasadi u leglu do 10. dana starosti. Za ispitivanje je izabrano 167 gravidnih životinja, 34 nazimica i 133 krmača, podeljenih u po 3 grupe, prema danu graviditeta kada je aplikovan analog prostaglandina, dinoprost-trometamin (od 112­114. dana). Najbrže je indukovan partus kod nazimica kojima je aplikovan dinoprost 113. dana graviditeta (34,30 ± 6,23) h nakon aplikacije, odnosno kod krmača kojima je aplikovan prostaglandin 114. dana graviditeta (29,57 ± 4,14) h nakon aplikacije dinoprosta. Najviše nazimica (75 %) i krmača (90,91%) započelo je prašenje 24-36 h nakon aplikacije dinoprosta, kada je on aplikovan 113. dana graviditeta. U toku dnevnog dvanaestočasovnog radnog vremena (7-19 h) započelo je prašenje 67,07% od ukupno tretiranih životinja. Kada je indukovano prašenje na 112 dan graviditeta 17 krmača (12,78%) zahtevalo je akušersku pomoć zbog distocije, dok je od ukupnog broja krmača 47 (35,34 %) bilo sa problematičnim prašenjem. Sa odlaganjem indukcije rasla je telesna masa novorođene prasadi, pri čemu je najveća zabeležena iznosila 1,27 kg kod krmača, odnosno 1,38 kg kod nazimica, kojima je dinoprost aplikovan 114. dana graviditeta, sa najmanje živorođene prasadi telesne mase ispod 1 kg (23,76%). U ogledu je utvrđena povezanost telesne mase sa vitalnošću novorođene prasadi, tako da je najmanja stopa smrtnosti prasadi do 10. dana života, zabeležena kod krmača i nazimica kojima je dinoprost aplikovan 114. dana graviditeta (11,05%), u odnosu na prasad rođenu kod krmača i nazimica kojima je dinoprost aplikovan 112. dana graviditeta (15,39%).
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Veterinarski glasnik
T1  - The influence of the induction of farrowing on live birth, body mass, appearance of dystocia, mortality and surviving of neonatal pigs in litter during the first ten days
T1  - Vlijanie indukcii oporosa na živoroždenie, massu tela, vozniknovenie distocii, smertnost' i vyživanie novoroždennyh porosjat v pervye desjat' dnej
T1  - Uticaj indukcije prašenja na živorođenost, telesnu masu, pojavu distocije, mortalitet i preživljavanje neonatalne prasadi u leglu u prvih deset dana
VL  - 70
IS  - 1-2
SP  - 13
EP  - 29
DO  - 10.2298/VETGL1602013J
ER  - 

@article{
author = "Jović, Slavoljub and Ćupić, Vitomir and Ristić, Gordana and Vakanjac, Slobodanka and Dimitrijević, Blagoje and Čupić-Miladinović, Dejana and Živković, Lada",
year = "2016",
abstract = "The objective of this work was to investigate the influence of the day of farrowing induction on the number of newborn piglets (live born and dead born), body mass and mortality of neonatal pigs in litter by the tenth day of age. For the investigation purpose, there were chosen 167 pregnant animals, 34 gilts and 133 sows, divided into 3 groups each, according to the day of pregnancy when prostaglandin analogue, dinoprost-tromethamine, was applied (from 112th to 114th day). Fastest-induced parturition was in gilts which were administered dinoprost on the 113th day of pregnancy, (34,30 ± 6,23) h after application, that is, in sows which were administered prostaglandin on the 114th day of pregnancy, (29,57 ± 4,14) h after application of dinoprost. Most gilts (75 %) and sows (90,91%) started farrowing 24-36 h after dinoprost application, when it was given on the 113th day of pregnancy. During daily twelve-hour working time (7-19 h), 67,07% out of all the treated animals started farrowing. When farrowing was induced on the 112th day of pregnancy, 17 sows (12,78%) needed obstetric assistance for dystocia, while 47 (35,34 %) sows had troublesome farrowing. Along with the delayed induction, body mass of newborn pigs increased, and the largest recorded weight was 1,27 kg in sows, that is 1,38 kg in gilts, which were given dinoprost on the 114th day of pregnancy, with the lowest number of live born pigs of body mass less than 1 kg (23,76%). In this experiment there was determined the connection between the body mass and vitality of newborn piglets, so the lowest mortality rate of the pigs by the 10th day of age was noticed in sows and gilts which were given dinoprost on the 114th day of pregnancy (11,05%), in regard to the pigs born of sows and gilts which were given dinoprost on the 112th day of pregnancy (15,39 %)., Cilj ovog rada bio je da se ispita uticaj izbora dana indukcije prašenja na broj novorođene prasadi (živo i mrtvorođene), telesnu masu i mortalitet neonatalne prasadi u leglu do 10. dana starosti. Za ispitivanje je izabrano 167 gravidnih životinja, 34 nazimica i 133 krmača, podeljenih u po 3 grupe, prema danu graviditeta kada je aplikovan analog prostaglandina, dinoprost-trometamin (od 112­114. dana). Najbrže je indukovan partus kod nazimica kojima je aplikovan dinoprost 113. dana graviditeta (34,30 ± 6,23) h nakon aplikacije, odnosno kod krmača kojima je aplikovan prostaglandin 114. dana graviditeta (29,57 ± 4,14) h nakon aplikacije dinoprosta. Najviše nazimica (75 %) i krmača (90,91%) započelo je prašenje 24-36 h nakon aplikacije dinoprosta, kada je on aplikovan 113. dana graviditeta. U toku dnevnog dvanaestočasovnog radnog vremena (7-19 h) započelo je prašenje 67,07% od ukupno tretiranih životinja. Kada je indukovano prašenje na 112 dan graviditeta 17 krmača (12,78%) zahtevalo je akušersku pomoć zbog distocije, dok je od ukupnog broja krmača 47 (35,34 %) bilo sa problematičnim prašenjem. Sa odlaganjem indukcije rasla je telesna masa novorođene prasadi, pri čemu je najveća zabeležena iznosila 1,27 kg kod krmača, odnosno 1,38 kg kod nazimica, kojima je dinoprost aplikovan 114. dana graviditeta, sa najmanje živorođene prasadi telesne mase ispod 1 kg (23,76%). U ogledu je utvrđena povezanost telesne mase sa vitalnošću novorođene prasadi, tako da je najmanja stopa smrtnosti prasadi do 10. dana života, zabeležena kod krmača i nazimica kojima je dinoprost aplikovan 114. dana graviditeta (11,05%), u odnosu na prasad rođenu kod krmača i nazimica kojima je dinoprost aplikovan 112. dana graviditeta (15,39%).",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Veterinarski glasnik",
title = "The influence of the induction of farrowing on live birth, body mass, appearance of dystocia, mortality and surviving of neonatal pigs in litter during the first ten days, Vlijanie indukcii oporosa na živoroždenie, massu tela, vozniknovenie distocii, smertnost' i vyživanie novoroždennyh porosjat v pervye desjat' dnej, Uticaj indukcije prašenja na živorođenost, telesnu masu, pojavu distocije, mortalitet i preživljavanje neonatalne prasadi u leglu u prvih deset dana",
volume = "70",
number = "1-2",
pages = "13-29",
doi = "10.2298/VETGL1602013J"
}

Jović, S., Ćupić, V., Ristić, G., Vakanjac, S., Dimitrijević, B., Čupić-Miladinović, D.,& Živković, L.. (2016). The influence of the induction of farrowing on live birth, body mass, appearance of dystocia, mortality and surviving of neonatal pigs in litter during the first ten days. in Veterinarski glasnik
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 70(1-2), 13-29.
https://doi.org/10.2298/VETGL1602013J

Jović S, Ćupić V, Ristić G, Vakanjac S, Dimitrijević B, Čupić-Miladinović D, Živković L. The influence of the induction of farrowing on live birth, body mass, appearance of dystocia, mortality and surviving of neonatal pigs in litter during the first ten days. in Veterinarski glasnik. 2016;70(1-2):13-29.
doi:10.2298/VETGL1602013J .

Jović, Slavoljub, Ćupić, Vitomir, Ristić, Gordana, Vakanjac, Slobodanka, Dimitrijević, Blagoje, Čupić-Miladinović, Dejana, Živković, Lada, "The influence of the induction of farrowing on live birth, body mass, appearance of dystocia, mortality and surviving of neonatal pigs in litter during the first ten days" in Veterinarski glasnik, 70, no. 1-2 (2016):13-29,
https://doi.org/10.2298/VETGL1602013J . .

TY  - CONF
AU  - Čupić-Miladinović, Dejana
AU  - Borozan, Sunčica
AU  - Popović, Z.
AU  - Ćupić, Vitomir
AU  - Velev, R.
AU  - Antonijević, Biljana
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2367
PB  - Elsevier Ireland Ltd, Clare
C3  - Toxicology Letters
T1  - The influence of chlorpyrifos on the activity of butyryilcholinesterase and catalase, as well as concentration of malondialdehyde in plasma of Japanese quail
VL  - 238
IS  - 2, Supplement
SP  - S111
EP  - S111
DO  - 10.1016/j.toxlet.2015.08.360
ER  - 

@conference{
author = "Čupić-Miladinović, Dejana and Borozan, Sunčica and Popović, Z. and Ćupić, Vitomir and Velev, R. and Antonijević, Biljana",
year = "2015",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Toxicology Letters",
title = "The influence of chlorpyrifos on the activity of butyryilcholinesterase and catalase, as well as concentration of malondialdehyde in plasma of Japanese quail",
volume = "238",
number = "2, Supplement",
pages = "S111-S111",
doi = "10.1016/j.toxlet.2015.08.360"
}

Čupić-Miladinović, D., Borozan, S., Popović, Z., Ćupić, V., Velev, R.,& Antonijević, B.. (2015). The influence of chlorpyrifos on the activity of butyryilcholinesterase and catalase, as well as concentration of malondialdehyde in plasma of Japanese quail. in Toxicology Letters
Elsevier Ireland Ltd, Clare., 238(2, Supplement), S111-S111.
https://doi.org/10.1016/j.toxlet.2015.08.360

Čupić-Miladinović D, Borozan S, Popović Z, Ćupić V, Velev R, Antonijević B. The influence of chlorpyrifos on the activity of butyryilcholinesterase and catalase, as well as concentration of malondialdehyde in plasma of Japanese quail. in Toxicology Letters. 2015;238(2, Supplement):S111-S111.
doi:10.1016/j.toxlet.2015.08.360 .

Čupić-Miladinović, Dejana, Borozan, Sunčica, Popović, Z., Ćupić, Vitomir, Velev, R., Antonijević, Biljana, "The influence of chlorpyrifos on the activity of butyryilcholinesterase and catalase, as well as concentration of malondialdehyde in plasma of Japanese quail" in Toxicology Letters, 238, no. 2, Supplement (2015):S111-S111,
https://doi.org/10.1016/j.toxlet.2015.08.360 . .

TY  - JOUR
AU  - Filipić, Brankica
AU  - Golić, Nataša
AU  - Jovčić, Branko
AU  - Ćupić-Miladinović, Dejana
AU  - Soković, Svetlana
AU  - Popović, Dušanka
AU  - Kojić, Milan
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2483
AB  - Lactic acid bacteria (LAB) are widely used in the food industry, especially in the pro­duction of fermented dairy products and meat. The most studied species among LAB is Lactococcus lactis. L. lactis strains are of great importance in the production of fermented dairy products such as yogurt, butter, fresh cheese and some kind of semi-hard cheese. Although L. lactis acquired the 'Generally Regarded As Safe' (GRAS) status, many investigations indicated that lactococci may act as reservoirs of antibiotic resistance genes, which could be transferred to other bacterial species in human gastrointestinal tract includ­ing pathogens. The genome analysis of L. lactis indicated the presence of at least 40 putative drug transporter genes, and only four multidrug resistance (MDR) transporters are functional­ly characterized: LmrA, LmrP, LmrCD i CmbT. LmrA is the first described MDR transport­er in prokaryotes. LmrCD is responsible for resistance to cholate, which is an integral part of human bile and LmrCD is important for intestinal survival of lactococci that are used as probiotics. Secondary multidrug transporter LmrP confers resistance to lincosamides, mac­rolides, streptogramins and tetracyclines. CmbT protein has an effect on the host cell re­sistance to lincomycin, sulfadiazine, streptomycin, rifampicin, puromycin and sulfametox­azole. Since the food chain is an important way of transmitting resistance genes in human and animal population, it is of great importance to study the mechanisms of resistance in lactococci and other LAB, intended for the food industry.
AB  - Bakterije mlečne kiseline (BMK) imaju veliku primenu u prehrambenoj industriji, posebno u proizvodnji fermentisanih mlečnih proizvoda i mesa. Najviše izučavana vrsta u okviru BMK je Lactococcus lactis. Sojevi koji pripadaju vrsti L. lactis su od izuzetnog značaja u proizvodnji fermentisanih mlečnih proizvoda poput kiselog mleka, maslaca, svežih sireva i nekih vrsta polutvrdih sireva. Iako se generalno laktokoke smatraju bezbednim mikroorganizmima, istraživanja ukazuju da mogu biti rezervoari gena za rezistenciju na antibiotike, koji se horizontalnim transferom mogu preneti na druge bakterijske vrste, uključujući i patogene. Pokazano je da se u membrani bakterija vrste L. lactis nalaze efluksne pumpe koje obezbeđuju rezistenciju na strukturno različite supstrate (eng. multidrug resistance transporters-MDR). Analizom genoma L. lactis detektovano je prisustvo 40 potencijalnih gena koji kodiraju MDR transportere, od čega su do danas svega četiri funkcionalno okarakterisana: LmrA, LmrP, LmrCD i CmbT. LmrA je prvi uopšte opisan primarni transporter kod prokariota. LmrCD obezbeđuje rezistenciju na holat koji ulazi u sastav žuči, što je značajno za preživljavanje laktokoka koje se primenjuju kao probiotici u digestivnom traktu ljudi i životinja. LmrP je sekundarni transporter i obezbeđuje rezistenciju na neke linkozamide, makrolide, streptogramine I tetracikline. CmbT je poslednji okarakterisan MDR transporter kod L. lactis i doprinosi rezistenciji na linkomicin, sulfonamidne antibiotike, sulfametoksazol i sulfadiazin, aminoglikozidni antibiotik streptomicin, aminonukleozidni antibiotik puromicin i semisintetski antibiotik rifampicin. Kako lanac hrane predstavlja važan put prenosa gena za rezistenciju u okviru ljudske i životinjske populacije, neophodno je intenzivno izučavanje mehanizama rezistencije kod laktokoka i drugih BMK namenjenih za upotrebu u prehrambenoj industriji.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Veterinarski glasnik
T1  - Resistance to antibiotics in lacid acid bacteria: Strain Lactococcus
T1  - Rezistencija na antibiotike kod bakterija mlečne kiseline - rod Lactococcus
VL  - 69
IS  - 3-4
SP  - 271
EP  - 281
DO  - 10.2298/VETGL1504271F
ER  - 

@article{
author = "Filipić, Brankica and Golić, Nataša and Jovčić, Branko and Ćupić-Miladinović, Dejana and Soković, Svetlana and Popović, Dušanka and Kojić, Milan",
year = "2015",
abstract = "Lactic acid bacteria (LAB) are widely used in the food industry, especially in the pro­duction of fermented dairy products and meat. The most studied species among LAB is Lactococcus lactis. L. lactis strains are of great importance in the production of fermented dairy products such as yogurt, butter, fresh cheese and some kind of semi-hard cheese. Although L. lactis acquired the 'Generally Regarded As Safe' (GRAS) status, many investigations indicated that lactococci may act as reservoirs of antibiotic resistance genes, which could be transferred to other bacterial species in human gastrointestinal tract includ­ing pathogens. The genome analysis of L. lactis indicated the presence of at least 40 putative drug transporter genes, and only four multidrug resistance (MDR) transporters are functional­ly characterized: LmrA, LmrP, LmrCD i CmbT. LmrA is the first described MDR transport­er in prokaryotes. LmrCD is responsible for resistance to cholate, which is an integral part of human bile and LmrCD is important for intestinal survival of lactococci that are used as probiotics. Secondary multidrug transporter LmrP confers resistance to lincosamides, mac­rolides, streptogramins and tetracyclines. CmbT protein has an effect on the host cell re­sistance to lincomycin, sulfadiazine, streptomycin, rifampicin, puromycin and sulfametox­azole. Since the food chain is an important way of transmitting resistance genes in human and animal population, it is of great importance to study the mechanisms of resistance in lactococci and other LAB, intended for the food industry., Bakterije mlečne kiseline (BMK) imaju veliku primenu u prehrambenoj industriji, posebno u proizvodnji fermentisanih mlečnih proizvoda i mesa. Najviše izučavana vrsta u okviru BMK je Lactococcus lactis. Sojevi koji pripadaju vrsti L. lactis su od izuzetnog značaja u proizvodnji fermentisanih mlečnih proizvoda poput kiselog mleka, maslaca, svežih sireva i nekih vrsta polutvrdih sireva. Iako se generalno laktokoke smatraju bezbednim mikroorganizmima, istraživanja ukazuju da mogu biti rezervoari gena za rezistenciju na antibiotike, koji se horizontalnim transferom mogu preneti na druge bakterijske vrste, uključujući i patogene. Pokazano je da se u membrani bakterija vrste L. lactis nalaze efluksne pumpe koje obezbeđuju rezistenciju na strukturno različite supstrate (eng. multidrug resistance transporters-MDR). Analizom genoma L. lactis detektovano je prisustvo 40 potencijalnih gena koji kodiraju MDR transportere, od čega su do danas svega četiri funkcionalno okarakterisana: LmrA, LmrP, LmrCD i CmbT. LmrA je prvi uopšte opisan primarni transporter kod prokariota. LmrCD obezbeđuje rezistenciju na holat koji ulazi u sastav žuči, što je značajno za preživljavanje laktokoka koje se primenjuju kao probiotici u digestivnom traktu ljudi i životinja. LmrP je sekundarni transporter i obezbeđuje rezistenciju na neke linkozamide, makrolide, streptogramine I tetracikline. CmbT je poslednji okarakterisan MDR transporter kod L. lactis i doprinosi rezistenciji na linkomicin, sulfonamidne antibiotike, sulfametoksazol i sulfadiazin, aminoglikozidni antibiotik streptomicin, aminonukleozidni antibiotik puromicin i semisintetski antibiotik rifampicin. Kako lanac hrane predstavlja važan put prenosa gena za rezistenciju u okviru ljudske i životinjske populacije, neophodno je intenzivno izučavanje mehanizama rezistencije kod laktokoka i drugih BMK namenjenih za upotrebu u prehrambenoj industriji.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Veterinarski glasnik",
title = "Resistance to antibiotics in lacid acid bacteria: Strain Lactococcus, Rezistencija na antibiotike kod bakterija mlečne kiseline - rod Lactococcus",
volume = "69",
number = "3-4",
pages = "271-281",
doi = "10.2298/VETGL1504271F"
}

Filipić, B., Golić, N., Jovčić, B., Ćupić-Miladinović, D., Soković, S., Popović, D.,& Kojić, M.. (2015). Resistance to antibiotics in lacid acid bacteria: Strain Lactococcus. in Veterinarski glasnik
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 69(3-4), 271-281.
https://doi.org/10.2298/VETGL1504271F

Filipić B, Golić N, Jovčić B, Ćupić-Miladinović D, Soković S, Popović D, Kojić M. Resistance to antibiotics in lacid acid bacteria: Strain Lactococcus. in Veterinarski glasnik. 2015;69(3-4):271-281.
doi:10.2298/VETGL1504271F .

Filipić, Brankica, Golić, Nataša, Jovčić, Branko, Ćupić-Miladinović, Dejana, Soković, Svetlana, Popović, Dušanka, Kojić, Milan, "Resistance to antibiotics in lacid acid bacteria: Strain Lactococcus" in Veterinarski glasnik, 69, no. 3-4 (2015):271-281,
https://doi.org/10.2298/VETGL1504271F . .