TY  - JOUR
AU  - Nikolić, Vesna D.
AU  - Stanković, Mihajlo
AU  - Nikolić, Ljubiša
AU  - Nikolić, Goran
AU  - Ilić-Stojanović, Snežana
AU  - Popsavin, Mirjana
AU  - Zlatković, Sasa
AU  - Kundaković, Tatjana
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1992
AB  - Molecular inclusion complexes of usnic acid (UA) with beta-cyclodextrin (beta-CD) and 2-hydroxypropyl beta-cyclodextrin (HP beta-CD) were prepared by the co-precipitation method in the solid state in the molar ratio of 1:1. Structural complexes characterization was based on different methods, FTIR, H-1 NMR, XRD and DSC. Parallel to the complex by the above methods, corresponding physical mixtures of UA with cyclodextrins and complexing agents (beta-CD, HP beta-CD and UA) were analyzed. The results of DSC analysis showed that, at around 200 A degrees C, the endothermal peak in the complexes with cyclodextrins originating from the UA melting has disappeared. Complex diffractogram patterns do not contain peaks characteristic for the pure UA. They are more appropriate to cyclodextrin diffractogram. This fact points to the molecular encapsulation of UA in the cyclodextrin cavity. Chemical shifts in H-1 NMR spectra after the inclusion of UA into the cyclodextrin cavity, especially H-3 protons (0.0012 and 0.0102 ppm in the beta-CD and HP beta-CD, respectively) and H-5 and H-6 (0.0134 ppm) and hydrogen from CH3 (0.0073 ppm) HP beta-CD also points to the formation of molecular inclusion complexes. The improved solubility of UA in water was achieved by molecular incapsulation. In the complex with beta-CD the solubility is 0.3 mg/cm(3), with HP beta-CD 4.2 mg/cm(3) while the uncomplexed UA solubility is 0.06 mg/cm(3). The microbial activity of UA and both complexes was tested against eight bacteria and two fungi and during the test no reduced activity of UA in the complexes was observed.
PB  - Springer, Dordrecht
T2  - Journal of Inclusion Phenomena and Macrocyclic Chemistry
T1  - Inclusion complexes with cyclodextrin and usnic acid
VL  - 76
IS  - 1-2
SP  - 173
EP  - 182
DO  - 10.1007/s10847-012-0187-8
ER  - 

@article{
author = "Nikolić, Vesna D. and Stanković, Mihajlo and Nikolić, Ljubiša and Nikolić, Goran and Ilić-Stojanović, Snežana and Popsavin, Mirjana and Zlatković, Sasa and Kundaković, Tatjana",
year = "2013",
abstract = "Molecular inclusion complexes of usnic acid (UA) with beta-cyclodextrin (beta-CD) and 2-hydroxypropyl beta-cyclodextrin (HP beta-CD) were prepared by the co-precipitation method in the solid state in the molar ratio of 1:1. Structural complexes characterization was based on different methods, FTIR, H-1 NMR, XRD and DSC. Parallel to the complex by the above methods, corresponding physical mixtures of UA with cyclodextrins and complexing agents (beta-CD, HP beta-CD and UA) were analyzed. The results of DSC analysis showed that, at around 200 A degrees C, the endothermal peak in the complexes with cyclodextrins originating from the UA melting has disappeared. Complex diffractogram patterns do not contain peaks characteristic for the pure UA. They are more appropriate to cyclodextrin diffractogram. This fact points to the molecular encapsulation of UA in the cyclodextrin cavity. Chemical shifts in H-1 NMR spectra after the inclusion of UA into the cyclodextrin cavity, especially H-3 protons (0.0012 and 0.0102 ppm in the beta-CD and HP beta-CD, respectively) and H-5 and H-6 (0.0134 ppm) and hydrogen from CH3 (0.0073 ppm) HP beta-CD also points to the formation of molecular inclusion complexes. The improved solubility of UA in water was achieved by molecular incapsulation. In the complex with beta-CD the solubility is 0.3 mg/cm(3), with HP beta-CD 4.2 mg/cm(3) while the uncomplexed UA solubility is 0.06 mg/cm(3). The microbial activity of UA and both complexes was tested against eight bacteria and two fungi and during the test no reduced activity of UA in the complexes was observed.",
publisher = "Springer, Dordrecht",
journal = "Journal of Inclusion Phenomena and Macrocyclic Chemistry",
title = "Inclusion complexes with cyclodextrin and usnic acid",
volume = "76",
number = "1-2",
pages = "173-182",
doi = "10.1007/s10847-012-0187-8"
}

Nikolić, V. D., Stanković, M., Nikolić, L., Nikolić, G., Ilić-Stojanović, S., Popsavin, M., Zlatković, S.,& Kundaković, T.. (2013). Inclusion complexes with cyclodextrin and usnic acid. in Journal of Inclusion Phenomena and Macrocyclic Chemistry
Springer, Dordrecht., 76(1-2), 173-182.
https://doi.org/10.1007/s10847-012-0187-8

Nikolić VD, Stanković M, Nikolić L, Nikolić G, Ilić-Stojanović S, Popsavin M, Zlatković S, Kundaković T. Inclusion complexes with cyclodextrin and usnic acid. in Journal of Inclusion Phenomena and Macrocyclic Chemistry. 2013;76(1-2):173-182.
doi:10.1007/s10847-012-0187-8 .

Nikolić, Vesna D., Stanković, Mihajlo, Nikolić, Ljubiša, Nikolić, Goran, Ilić-Stojanović, Snežana, Popsavin, Mirjana, Zlatković, Sasa, Kundaković, Tatjana, "Inclusion complexes with cyclodextrin and usnic acid" in Journal of Inclusion Phenomena and Macrocyclic Chemistry, 76, no. 1-2 (2013):173-182,
https://doi.org/10.1007/s10847-012-0187-8 . .

TY  - JOUR
AU  - Kundaković, Tatjana
AU  - Milenković, Marina
AU  - Zlatković, Sasa
AU  - Nikolić, Vesna D.
AU  - Nikolić, Goran
AU  - Binić, Ivana
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1706
AB  - Background: Venous ulcers (ulcus cruris venosum) are a common chronic disease that requires continuing treatment and significantly influences a patient's way of life. The therapeutic effects of the ointment Herbadermal on epithelialization and microbial flora of venous ulcers in 25 patients (10 men and 15 women) were tested over a 7-week period. The major components of the ointment are extracts of garlic, St. John's wort, and calendula. Material and Methods: The patients were over 18 years of age, with ulceration of the lower leg no longer than 2 months or recurrent ulceration during the last 6 months. The involved patients did not use any other phytomedicines or supportive therapies. Parameters were evaluated before the treatment and every 2 weeks during the period of 7 weeks. The total treatment response was evaluated on the basis of epithelialization, granulation, fibrin deposits, exudation, and edema. Results: The percentage of epithelialization was 99.1% after 7 weeks, without significant effects on the microbial flora. Conclusion: This combination of extracts can be recommended as topical treatment for wound healing because of its epithelizing, anti-erythematous, and anti-edematous properties.
PB  - Karger, Basel
T2  - Forschende Komplementarmedizin
T1  - Treatment of Venous Ulcers with the Herbal-Based Ointment Herbadermal (R): A Prospective Non-Randomized Pilot Study
VL  - 19
IS  - 1
SP  - 26
EP  - 30
DO  - 10.1159/000335786
ER  - 

@article{
author = "Kundaković, Tatjana and Milenković, Marina and Zlatković, Sasa and Nikolić, Vesna D. and Nikolić, Goran and Binić, Ivana",
year = "2012",
abstract = "Background: Venous ulcers (ulcus cruris venosum) are a common chronic disease that requires continuing treatment and significantly influences a patient's way of life. The therapeutic effects of the ointment Herbadermal on epithelialization and microbial flora of venous ulcers in 25 patients (10 men and 15 women) were tested over a 7-week period. The major components of the ointment are extracts of garlic, St. John's wort, and calendula. Material and Methods: The patients were over 18 years of age, with ulceration of the lower leg no longer than 2 months or recurrent ulceration during the last 6 months. The involved patients did not use any other phytomedicines or supportive therapies. Parameters were evaluated before the treatment and every 2 weeks during the period of 7 weeks. The total treatment response was evaluated on the basis of epithelialization, granulation, fibrin deposits, exudation, and edema. Results: The percentage of epithelialization was 99.1% after 7 weeks, without significant effects on the microbial flora. Conclusion: This combination of extracts can be recommended as topical treatment for wound healing because of its epithelizing, anti-erythematous, and anti-edematous properties.",
publisher = "Karger, Basel",
journal = "Forschende Komplementarmedizin",
title = "Treatment of Venous Ulcers with the Herbal-Based Ointment Herbadermal (R): A Prospective Non-Randomized Pilot Study",
volume = "19",
number = "1",
pages = "26-30",
doi = "10.1159/000335786"
}

Kundaković, T., Milenković, M., Zlatković, S., Nikolić, V. D., Nikolić, G.,& Binić, I.. (2012). Treatment of Venous Ulcers with the Herbal-Based Ointment Herbadermal (R): A Prospective Non-Randomized Pilot Study. in Forschende Komplementarmedizin
Karger, Basel., 19(1), 26-30.
https://doi.org/10.1159/000335786

Kundaković T, Milenković M, Zlatković S, Nikolić VD, Nikolić G, Binić I. Treatment of Venous Ulcers with the Herbal-Based Ointment Herbadermal (R): A Prospective Non-Randomized Pilot Study. in Forschende Komplementarmedizin. 2012;19(1):26-30.
doi:10.1159/000335786 .

Kundaković, Tatjana, Milenković, Marina, Zlatković, Sasa, Nikolić, Vesna D., Nikolić, Goran, Binić, Ivana, "Treatment of Venous Ulcers with the Herbal-Based Ointment Herbadermal (R): A Prospective Non-Randomized Pilot Study" in Forschende Komplementarmedizin, 19, no. 1 (2012):26-30,
https://doi.org/10.1159/000335786 . .

TY  - JOUR
AU  - Kundaković, Tatjana
AU  - Milenković, Marina
AU  - Zlatković, Sasa
AU  - Kovačević, Nada
AU  - Nikolić, Goran
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1478
AB  - The composition of the essential oil obtained by hydrodistillation from the aerial parts of Satureja kitaibelii from Rtanj mountain (Serbia), collected during three years, was studied. Thirty-nine components were identified in each sample of S. kitaibelii essential oil, representing about 87% of the oils. p-Cymene was the most dominant compound in all three oils (27.9%, 14.7% and 24.4%, respectively). The simple formulation of a lozenge with 0.2% of S. kitaibelii essential oil was prepared and the antimicrobial activity of the essential oil and the lozenge with essential oil was tested using a broth microdilution assay. Both essential oil and lozenge possessed strong antimicrobial activity with MIC values of 0.10-25 mu g/mL, and 0.97-15.6 mg/mL, respectively.
PB  - Natural Products Inc, Westerville
T2  - Natural Product Communications
T1  - Composition of Satureja kitaibelii Essential Oil and its Antimicrobial Activity
VL  - 6
IS  - 9
SP  - 1353
EP  - 1356
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1478
ER  - 

@article{
author = "Kundaković, Tatjana and Milenković, Marina and Zlatković, Sasa and Kovačević, Nada and Nikolić, Goran",
year = "2011",
abstract = "The composition of the essential oil obtained by hydrodistillation from the aerial parts of Satureja kitaibelii from Rtanj mountain (Serbia), collected during three years, was studied. Thirty-nine components were identified in each sample of S. kitaibelii essential oil, representing about 87% of the oils. p-Cymene was the most dominant compound in all three oils (27.9%, 14.7% and 24.4%, respectively). The simple formulation of a lozenge with 0.2% of S. kitaibelii essential oil was prepared and the antimicrobial activity of the essential oil and the lozenge with essential oil was tested using a broth microdilution assay. Both essential oil and lozenge possessed strong antimicrobial activity with MIC values of 0.10-25 mu g/mL, and 0.97-15.6 mg/mL, respectively.",
publisher = "Natural Products Inc, Westerville",
journal = "Natural Product Communications",
title = "Composition of Satureja kitaibelii Essential Oil and its Antimicrobial Activity",
volume = "6",
number = "9",
pages = "1353-1356",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1478"
}

Kundaković, T., Milenković, M., Zlatković, S., Kovačević, N.,& Nikolić, G.. (2011). Composition of Satureja kitaibelii Essential Oil and its Antimicrobial Activity. in Natural Product Communications
Natural Products Inc, Westerville., 6(9), 1353-1356.
https://hdl.handle.net/21.15107/rcub_farfar_1478

Kundaković T, Milenković M, Zlatković S, Kovačević N, Nikolić G. Composition of Satureja kitaibelii Essential Oil and its Antimicrobial Activity. in Natural Product Communications. 2011;6(9):1353-1356.
https://hdl.handle.net/21.15107/rcub_farfar_1478 .

Kundaković, Tatjana, Milenković, Marina, Zlatković, Sasa, Kovačević, Nada, Nikolić, Goran, "Composition of Satureja kitaibelii Essential Oil and its Antimicrobial Activity" in Natural Product Communications, 6, no. 9 (2011):1353-1356,
https://hdl.handle.net/21.15107/rcub_farfar_1478 .