TY  - JOUR
AU  - Savić, Ivan
AU  - Nikolić, Vesna D.
AU  - Savić-Gajić, Ivana
AU  - Nikolić, Ljubiša
AU  - Ibrić, Svetlana
AU  - Gajić, Dragoljub G.
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2471
AB  - The process of amygdalin extraction from plum seeds was optimized using central composite design (CCD) and multilayer perceptron (MLP). The effect of time, ethanol concentration, solid-to-liquid ratio, and temperature on the amygdalin content in the extracts was estimated using both mathematical models. The MLP 4-3-1 with exponential function in hidden layer and linear function in output layer was used for describing the extraction process. MLP model was more superior compared with CCD model due to better prediction ability. According to MLP model, the suggested optimal conditions are: time of 120 min, 100% (v/v) ethanol, solid-to liquid ratio of 1:25 (m/v) and temperature of 34.4 degrees C. The predicted value of amygdalin content in the dried extract (25.42 g per 100 g) at these conditions was experimentally confirmed (25.30 g per 100 g of dried extract). Amygdalin (>90%) was isolated from the complex extraction mixture and structurally characterized by FT-IR, UV, and MS methods.
PB  - Frontiers Media Sa, Lausanne
T2  - Frontiers in Plant Science
T1  - Optimization of technological procedure for amygdalin isolation from plum seeds (Pruni domesticae semen)
VL  - 6
DO  - 10.3389/fpls.2015.00276
ER  - 

@article{
author = "Savić, Ivan and Nikolić, Vesna D. and Savić-Gajić, Ivana and Nikolić, Ljubiša and Ibrić, Svetlana and Gajić, Dragoljub G.",
year = "2015",
abstract = "The process of amygdalin extraction from plum seeds was optimized using central composite design (CCD) and multilayer perceptron (MLP). The effect of time, ethanol concentration, solid-to-liquid ratio, and temperature on the amygdalin content in the extracts was estimated using both mathematical models. The MLP 4-3-1 with exponential function in hidden layer and linear function in output layer was used for describing the extraction process. MLP model was more superior compared with CCD model due to better prediction ability. According to MLP model, the suggested optimal conditions are: time of 120 min, 100% (v/v) ethanol, solid-to liquid ratio of 1:25 (m/v) and temperature of 34.4 degrees C. The predicted value of amygdalin content in the dried extract (25.42 g per 100 g) at these conditions was experimentally confirmed (25.30 g per 100 g of dried extract). Amygdalin (>90%) was isolated from the complex extraction mixture and structurally characterized by FT-IR, UV, and MS methods.",
publisher = "Frontiers Media Sa, Lausanne",
journal = "Frontiers in Plant Science",
title = "Optimization of technological procedure for amygdalin isolation from plum seeds (Pruni domesticae semen)",
volume = "6",
doi = "10.3389/fpls.2015.00276"
}

Savić, I., Nikolić, V. D., Savić-Gajić, I., Nikolić, L., Ibrić, S.,& Gajić, D. G.. (2015). Optimization of technological procedure for amygdalin isolation from plum seeds (Pruni domesticae semen). in Frontiers in Plant Science
Frontiers Media Sa, Lausanne., 6.
https://doi.org/10.3389/fpls.2015.00276

Savić I, Nikolić VD, Savić-Gajić I, Nikolić L, Ibrić S, Gajić DG. Optimization of technological procedure for amygdalin isolation from plum seeds (Pruni domesticae semen). in Frontiers in Plant Science. 2015;6.
doi:10.3389/fpls.2015.00276 .

Savić, Ivan, Nikolić, Vesna D., Savić-Gajić, Ivana, Nikolić, Ljubiša, Ibrić, Svetlana, Gajić, Dragoljub G., "Optimization of technological procedure for amygdalin isolation from plum seeds (Pruni domesticae semen)" in Frontiers in Plant Science, 6 (2015),
https://doi.org/10.3389/fpls.2015.00276 . .