TY  - PAT
AU  - Ilić-Stojanović, Snežana
AU  - Nikolić, Vesna
AU  - Kundaković, Tatjana
AU  - Nikolić, Ljubiša
AU  - Savić-Gajić, Ivana
AU  - Savić, Ivan
AU  - Jocić, Emilija
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5114
AB  - Pronalazak se odnosi na novu primenu hidrogelova poli(N-izopropilakrilamid-ko-2-hidroksipropilmetakrilata), p(NIPAM-HPMet)-a i poli(N-izopropilakrilamida), p(NIPAM)-a, kao nosača za modifikovano oslobađanje elaginske kiseline i ekstrakta Alchemilla vulgaris L. sa visokim sadržajem elaginske kiseline. Analiza FTIR spektara homopolimera p(NIPAM)-a i kopolimera p(NIPAM-HPMet)-a sa uklopljenim standardom elaginske kiseline i ekstraktom Alchemilla vulgaris L., ukazuju na formiranje intermolekulskih vodoničnih veza između lanaca homopolimera, tj. kopolimera, s jedne strane i elaginske kiseline, s druge strane. Hidrogelovi p(NIPAM) i p(NIPAM-HPMet) su se pokazali kao pogodni nosači elaginske kiseline, jer omogućavaju njeno modifikovano oslobađanje.
PB  - Zavod za Intelektualnu svojinu, Republika Srbija
T2  - Гласник интелектуалне својине
T1  - Поступак примене термоосетљивих хидрогелова за модификовано ослобађање елагинске киселине
T1  - Postupak primene termoosetljivih hidrogelova za modifikovano oslobađanje elaginske kiseline
VL  - 2
SP  - 7
EP  - 7
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5114
ER  - 

@misc{
author = "Ilić-Stojanović, Snežana and Nikolić, Vesna and Kundaković, Tatjana and Nikolić, Ljubiša and Savić-Gajić, Ivana and Savić, Ivan and Jocić, Emilija",
year = "2018",
abstract = "Pronalazak se odnosi na novu primenu hidrogelova poli(N-izopropilakrilamid-ko-2-hidroksipropilmetakrilata), p(NIPAM-HPMet)-a i poli(N-izopropilakrilamida), p(NIPAM)-a, kao nosača za modifikovano oslobađanje elaginske kiseline i ekstrakta Alchemilla vulgaris L. sa visokim sadržajem elaginske kiseline. Analiza FTIR spektara homopolimera p(NIPAM)-a i kopolimera p(NIPAM-HPMet)-a sa uklopljenim standardom elaginske kiseline i ekstraktom Alchemilla vulgaris L., ukazuju na formiranje intermolekulskih vodoničnih veza između lanaca homopolimera, tj. kopolimera, s jedne strane i elaginske kiseline, s druge strane. Hidrogelovi p(NIPAM) i p(NIPAM-HPMet) su se pokazali kao pogodni nosači elaginske kiseline, jer omogućavaju njeno modifikovano oslobađanje.",
publisher = "Zavod za Intelektualnu svojinu, Republika Srbija",
journal = "Гласник интелектуалне својине",
title = "Поступак примене термоосетљивих хидрогелова за модификовано ослобађање елагинске киселине, Postupak primene termoosetljivih hidrogelova za modifikovano oslobađanje elaginske kiseline",
volume = "2",
pages = "7-7",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5114"
}

Ilić-Stojanović, S., Nikolić, V., Kundaković, T., Nikolić, L., Savić-Gajić, I., Savić, I.,& Jocić, E.. (2018). Поступак примене термоосетљивих хидрогелова за модификовано ослобађање елагинске киселине. in Гласник интелектуалне својине
Zavod za Intelektualnu svojinu, Republika Srbija., 2, 7-7.
https://hdl.handle.net/21.15107/rcub_farfar_5114

Ilić-Stojanović S, Nikolić V, Kundaković T, Nikolić L, Savić-Gajić I, Savić I, Jocić E. Поступак примене термоосетљивих хидрогелова за модификовано ослобађање елагинске киселине. in Гласник интелектуалне својине. 2018;2:7-7.
https://hdl.handle.net/21.15107/rcub_farfar_5114 .

Ilić-Stojanović, Snežana, Nikolić, Vesna, Kundaković, Tatjana, Nikolić, Ljubiša, Savić-Gajić, Ivana, Savić, Ivan, Jocić, Emilija, "Поступак примене термоосетљивих хидрогелова за модификовано ослобађање елагинске киселине" in Гласник интелектуалне својине, 2 (2018):7-7,
https://hdl.handle.net/21.15107/rcub_farfar_5114 .

TY  - JOUR
AU  - Ilić-Stojanović, Snežana
AU  - Nikolić, Vesna D.
AU  - Kundaković, Tatjana
AU  - Savić, Ivan
AU  - Savić-Gajić, Ivana
AU  - Jocić, Emilija
AU  - Nikolić, Ljubiša
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3421
AB  - Stimulus-sensitive hydrogels are used as carriers for modified release of pharmaceuticals. The synthesis of thermosensitive hydrogels poly(N-isopropylacrylamide), p(NIPAM), and poly(N-isopropylacrylamide-co-2-hydroxypropyl methacrylate), p(NIPAM-HPMet), is performed. The synthesized hydrogels are characterized using FTIR and scanning electron microscope methods and swelling properties, and applied for modified release of ellagic acid (EA). This work presents the selective extraction of EA, as a natural antioxidant, from the aerial parts of Alchemilla vulgaris L. EA and A. vulgaris extract are incorporated into p(NIPAM) and p(NIPAM-HPMet) hydrogels and characterized by FTIR method. The EA content in the extract by the UHPLC-DAD-HESI-MS/MS method is determined (0.64mgcm(-3)). The total flavonoids content in the A. vulgaris extract was determined by the spectrophotometric method. Antioxidant activity of the A. vulgaris extract and EA is examined using the 2,2-diphenyl-1-picrylhydrazyl assay. The p(NIPAM-HPMet) shows a better incorporation and release at 37 degrees C of EA standard and A. vulgaris extract (98.87 and 96.45% respectively), compared with p(NIPAM). [GRAPHICS]
PB  - Taylor & Francis As, Oslo
T2  - International Journal of Polymeric Materials and Polymeric Biomaterials
T1  - Thermosensitive hydrogels for modified release of ellagic acid obtained from Alchemilla vulgaris L. extract
VL  - 67
IS  - 9
SP  - 553
EP  - 563
DO  - 10.1080/00914037.2017.1354202
ER  - 

@article{
author = "Ilić-Stojanović, Snežana and Nikolić, Vesna D. and Kundaković, Tatjana and Savić, Ivan and Savić-Gajić, Ivana and Jocić, Emilija and Nikolić, Ljubiša",
year = "2018",
abstract = "Stimulus-sensitive hydrogels are used as carriers for modified release of pharmaceuticals. The synthesis of thermosensitive hydrogels poly(N-isopropylacrylamide), p(NIPAM), and poly(N-isopropylacrylamide-co-2-hydroxypropyl methacrylate), p(NIPAM-HPMet), is performed. The synthesized hydrogels are characterized using FTIR and scanning electron microscope methods and swelling properties, and applied for modified release of ellagic acid (EA). This work presents the selective extraction of EA, as a natural antioxidant, from the aerial parts of Alchemilla vulgaris L. EA and A. vulgaris extract are incorporated into p(NIPAM) and p(NIPAM-HPMet) hydrogels and characterized by FTIR method. The EA content in the extract by the UHPLC-DAD-HESI-MS/MS method is determined (0.64mgcm(-3)). The total flavonoids content in the A. vulgaris extract was determined by the spectrophotometric method. Antioxidant activity of the A. vulgaris extract and EA is examined using the 2,2-diphenyl-1-picrylhydrazyl assay. The p(NIPAM-HPMet) shows a better incorporation and release at 37 degrees C of EA standard and A. vulgaris extract (98.87 and 96.45% respectively), compared with p(NIPAM). [GRAPHICS]",
publisher = "Taylor & Francis As, Oslo",
journal = "International Journal of Polymeric Materials and Polymeric Biomaterials",
title = "Thermosensitive hydrogels for modified release of ellagic acid obtained from Alchemilla vulgaris L. extract",
volume = "67",
number = "9",
pages = "553-563",
doi = "10.1080/00914037.2017.1354202"
}

Ilić-Stojanović, S., Nikolić, V. D., Kundaković, T., Savić, I., Savić-Gajić, I., Jocić, E.,& Nikolić, L.. (2018). Thermosensitive hydrogels for modified release of ellagic acid obtained from Alchemilla vulgaris L. extract. in International Journal of Polymeric Materials and Polymeric Biomaterials
Taylor & Francis As, Oslo., 67(9), 553-563.
https://doi.org/10.1080/00914037.2017.1354202

Ilić-Stojanović S, Nikolić VD, Kundaković T, Savić I, Savić-Gajić I, Jocić E, Nikolić L. Thermosensitive hydrogels for modified release of ellagic acid obtained from Alchemilla vulgaris L. extract. in International Journal of Polymeric Materials and Polymeric Biomaterials. 2018;67(9):553-563.
doi:10.1080/00914037.2017.1354202 .

Ilić-Stojanović, Snežana, Nikolić, Vesna D., Kundaković, Tatjana, Savić, Ivan, Savić-Gajić, Ivana, Jocić, Emilija, Nikolić, Ljubiša, "Thermosensitive hydrogels for modified release of ellagic acid obtained from Alchemilla vulgaris L. extract" in International Journal of Polymeric Materials and Polymeric Biomaterials, 67, no. 9 (2018):553-563,
https://doi.org/10.1080/00914037.2017.1354202 . .

TY  - JOUR
AU  - Ilić-Stojanović, Snežana
AU  - Nikolić, Vesna D.
AU  - Kundaković, Tatjana
AU  - Savić, Ivan
AU  - Savić-Gajić, Ivana
AU  - Jocić, Emilija
AU  - Nikolić, Ljubiša
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3155
AB  - Stimulus-sensitive hydrogels are used as carriers for modified release of pharmaceuticals. The synthesis of thermosensitive hydrogels poly(N-isopropylacrylamide), p(NIPAM), and poly(N-isopropylacrylamide-co-2-hydroxypropyl methacrylate), p(NIPAM-HPMet), is performed. The synthesized hydrogels are characterized using FTIR and scanning electron microscope methods and swelling properties, and applied for modified release of ellagic acid (EA). This work presents the selective extraction of EA, as a natural antioxidant, from the aerial parts of Alchemilla vulgaris L. EA and A. vulgaris extract are incorporated into p(NIPAM) and p(NIPAM-HPMet) hydrogels and characterized by FTIR method. The EA content in the extract by the UHPLC-DAD-HESI-MS/MS method is determined (0.64mgcm(-3)). The total flavonoids content in the A. vulgaris extract was determined by the spectrophotometric method. Antioxidant activity of the A. vulgaris extract and EA is examined using the 2,2-diphenyl-1-picrylhydrazyl assay. The p(NIPAM-HPMet) shows a better incorporation and release at 37 degrees C of EA standard and A. vulgaris extract (98.87 and 96.45% respectively), compared with p(NIPAM). [GRAPHICS]
PB  - Taylor & Francis As, Oslo
T2  - International Journal of Polymeric Materials and Polymeric Biomaterials
T1  - Thermosensitive hydrogels for modified release of ellagic acid obtained from Alchemilla vulgaris L. extract
VL  - 67
IS  - 9
SP  - 553
EP  - 563
DO  - 10.1080/00914037.2017.1354202
ER  - 

@article{
author = "Ilić-Stojanović, Snežana and Nikolić, Vesna D. and Kundaković, Tatjana and Savić, Ivan and Savić-Gajić, Ivana and Jocić, Emilija and Nikolić, Ljubiša",
year = "2018",
abstract = "Stimulus-sensitive hydrogels are used as carriers for modified release of pharmaceuticals. The synthesis of thermosensitive hydrogels poly(N-isopropylacrylamide), p(NIPAM), and poly(N-isopropylacrylamide-co-2-hydroxypropyl methacrylate), p(NIPAM-HPMet), is performed. The synthesized hydrogels are characterized using FTIR and scanning electron microscope methods and swelling properties, and applied for modified release of ellagic acid (EA). This work presents the selective extraction of EA, as a natural antioxidant, from the aerial parts of Alchemilla vulgaris L. EA and A. vulgaris extract are incorporated into p(NIPAM) and p(NIPAM-HPMet) hydrogels and characterized by FTIR method. The EA content in the extract by the UHPLC-DAD-HESI-MS/MS method is determined (0.64mgcm(-3)). The total flavonoids content in the A. vulgaris extract was determined by the spectrophotometric method. Antioxidant activity of the A. vulgaris extract and EA is examined using the 2,2-diphenyl-1-picrylhydrazyl assay. The p(NIPAM-HPMet) shows a better incorporation and release at 37 degrees C of EA standard and A. vulgaris extract (98.87 and 96.45% respectively), compared with p(NIPAM). [GRAPHICS]",
publisher = "Taylor & Francis As, Oslo",
journal = "International Journal of Polymeric Materials and Polymeric Biomaterials",
title = "Thermosensitive hydrogels for modified release of ellagic acid obtained from Alchemilla vulgaris L. extract",
volume = "67",
number = "9",
pages = "553-563",
doi = "10.1080/00914037.2017.1354202"
}

Ilić-Stojanović, S., Nikolić, V. D., Kundaković, T., Savić, I., Savić-Gajić, I., Jocić, E.,& Nikolić, L.. (2018). Thermosensitive hydrogels for modified release of ellagic acid obtained from Alchemilla vulgaris L. extract. in International Journal of Polymeric Materials and Polymeric Biomaterials
Taylor & Francis As, Oslo., 67(9), 553-563.
https://doi.org/10.1080/00914037.2017.1354202

Ilić-Stojanović S, Nikolić VD, Kundaković T, Savić I, Savić-Gajić I, Jocić E, Nikolić L. Thermosensitive hydrogels for modified release of ellagic acid obtained from Alchemilla vulgaris L. extract. in International Journal of Polymeric Materials and Polymeric Biomaterials. 2018;67(9):553-563.
doi:10.1080/00914037.2017.1354202 .

Ilić-Stojanović, Snežana, Nikolić, Vesna D., Kundaković, Tatjana, Savić, Ivan, Savić-Gajić, Ivana, Jocić, Emilija, Nikolić, Ljubiša, "Thermosensitive hydrogels for modified release of ellagic acid obtained from Alchemilla vulgaris L. extract" in International Journal of Polymeric Materials and Polymeric Biomaterials, 67, no. 9 (2018):553-563,
https://doi.org/10.1080/00914037.2017.1354202 . .