TY  - PAT
AU  - Kundaković, Tatjana
AU  - Nikolić, Vesna
AU  - Savić-Gajić, Ivana
AU  - Savić, Ivan
AU  - Savić, Saša
AU  - Ilić-Stojanović, Snežana
AU  - Nikolić, Ljubiša
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5111
AB  - Pronalazak se odnosi na nov postupak ekstrakcije elaginske kiseline iz herbe biljne vrste gospin plašt (Alchemilla vulgaris L.). Postupak ekstrakcije pokazuje neočekivanu selektivnost za elaginsku kiselinu, dok je sadržaj drugih jedinjenja ispod granica detekcije. Ispitivanja ekstrakta A. vulgaris pokazuju zadovoljavajuću antioksidativnu aktivnost, a određen je i sadržaj ukupnih flavonoida. Dobijeni ekstrakt herbe A. vulgaris može biti primenjen kao prirodni aditiv u prehrambenoj, kozmetičkoj i farmaceutskoj industriji, jer ima jak antioksidativni i zaštitni efekat.
PB  - Завод за интелектуалну својину, Република Србија
T2  - Гласник интелектуалне својине
T1  - Поступак екстракције елагинске киселине из госпиног плашта (Alchemilla vulgaris L.) РС-П-2017/0289.
T1  - Procedure for extraction of ellagic acid from lady`s mantles (Alchemilla vulgaris L.) RS-P-2017/0289.
IS  - 5
SP  - 23
EP  - 23
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5111
ER  - 

@misc{
author = "Kundaković, Tatjana and Nikolić, Vesna and Savić-Gajić, Ivana and Savić, Ivan and Savić, Saša and Ilić-Stojanović, Snežana and Nikolić, Ljubiša",
year = "2019",
abstract = "Pronalazak se odnosi na nov postupak ekstrakcije elaginske kiseline iz herbe biljne vrste gospin plašt (Alchemilla vulgaris L.). Postupak ekstrakcije pokazuje neočekivanu selektivnost za elaginsku kiselinu, dok je sadržaj drugih jedinjenja ispod granica detekcije. Ispitivanja ekstrakta A. vulgaris pokazuju zadovoljavajuću antioksidativnu aktivnost, a određen je i sadržaj ukupnih flavonoida. Dobijeni ekstrakt herbe A. vulgaris može biti primenjen kao prirodni aditiv u prehrambenoj, kozmetičkoj i farmaceutskoj industriji, jer ima jak antioksidativni i zaštitni efekat.",
publisher = "Завод за интелектуалну својину, Република Србија",
journal = "Гласник интелектуалне својине",
title = "Поступак екстракције елагинске киселине из госпиног плашта (Alchemilla vulgaris L.) РС-П-2017/0289., Procedure for extraction of ellagic acid from lady`s mantles (Alchemilla vulgaris L.) RS-P-2017/0289.",
number = "5",
pages = "23-23",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5111"
}

Kundaković, T., Nikolić, V., Savić-Gajić, I., Savić, I., Savić, S., Ilić-Stojanović, S.,& Nikolić, L.. (2019). Поступак екстракције елагинске киселине из госпиног плашта (Alchemilla vulgaris L.) РС-П-2017/0289.. in Гласник интелектуалне својине
Завод за интелектуалну својину, Република Србија.(5), 23-23.
https://hdl.handle.net/21.15107/rcub_farfar_5111

Kundaković T, Nikolić V, Savić-Gajić I, Savić I, Savić S, Ilić-Stojanović S, Nikolić L. Поступак екстракције елагинске киселине из госпиног плашта (Alchemilla vulgaris L.) РС-П-2017/0289.. in Гласник интелектуалне својине. 2019;(5):23-23.
https://hdl.handle.net/21.15107/rcub_farfar_5111 .

Kundaković, Tatjana, Nikolić, Vesna, Savić-Gajić, Ivana, Savić, Ivan, Savić, Saša, Ilić-Stojanović, Snežana, Nikolić, Ljubiša, "Поступак екстракције елагинске киселине из госпиног плашта (Alchemilla vulgaris L.) РС-П-2017/0289." in Гласник интелектуалне својине, no. 5 (2019):23-23,
https://hdl.handle.net/21.15107/rcub_farfar_5111 .

TY  - JOUR
AU  - Vladimirov, Marijana S.
AU  - Nikolić, Vesna D.
AU  - Stanojević, Ljiljana P.
AU  - Stanojević, Jelena S.
AU  - Nikolić, Ljubiša
AU  - Danilović, Bojana R.
AU  - Marinković, Valentina
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3374
AB  - The essential oil from birch (Betula pendula Roth.) buds was obtained by Clevenger-type hydrodistillation. Its qualitative and quantitative composition was determined by gas chromatography in combination with mass spectrometry (GC/MS) and flame ionization detection (GC/FID), respectively. Twenty-seven compounds, mainly sesquiterpene hydrocarbons (78.7%) and oxygenated sesquiterpenes (14.8%), were identified comprising 93.5% of total identified components in the essential oil. The most abundant compounds were germacrene D (21.7%) and -cadinene (17.0%). Antimicrobial activity of isolated essential oil against Gram-positive and Gram-negative bacteria as well as fungus Candida albicans was determined using the disc-diffusion method. The isolated essential oil has shown antimicrobial activity against the following microorganisms: Proteus vulgaris, Bacillus luteus and Klebsiella pneumoniae. Antioxidative activity of the essential oil was determined using the DPPH assay, after adding DPPH radical and after 20min, 30min and 60min incubation with radical. Essential oil showed antioxidant activity.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Journal of Essential Oil Bearing Plants
T1  - Chemical Composition, Antimicrobial andAntioxidant Activity of Birch (Betula pendula Roth.) Buds Essential Oil
VL  - 22
IS  - 1
SP  - 120
EP  - 130
DO  - 10.1080/0972060X.2019.1602084
ER  - 

@article{
author = "Vladimirov, Marijana S. and Nikolić, Vesna D. and Stanojević, Ljiljana P. and Stanojević, Jelena S. and Nikolić, Ljubiša and Danilović, Bojana R. and Marinković, Valentina",
year = "2019",
abstract = "The essential oil from birch (Betula pendula Roth.) buds was obtained by Clevenger-type hydrodistillation. Its qualitative and quantitative composition was determined by gas chromatography in combination with mass spectrometry (GC/MS) and flame ionization detection (GC/FID), respectively. Twenty-seven compounds, mainly sesquiterpene hydrocarbons (78.7%) and oxygenated sesquiterpenes (14.8%), were identified comprising 93.5% of total identified components in the essential oil. The most abundant compounds were germacrene D (21.7%) and -cadinene (17.0%). Antimicrobial activity of isolated essential oil against Gram-positive and Gram-negative bacteria as well as fungus Candida albicans was determined using the disc-diffusion method. The isolated essential oil has shown antimicrobial activity against the following microorganisms: Proteus vulgaris, Bacillus luteus and Klebsiella pneumoniae. Antioxidative activity of the essential oil was determined using the DPPH assay, after adding DPPH radical and after 20min, 30min and 60min incubation with radical. Essential oil showed antioxidant activity.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Journal of Essential Oil Bearing Plants",
title = "Chemical Composition, Antimicrobial andAntioxidant Activity of Birch (Betula pendula Roth.) Buds Essential Oil",
volume = "22",
number = "1",
pages = "120-130",
doi = "10.1080/0972060X.2019.1602084"
}

Vladimirov, M. S., Nikolić, V. D., Stanojević, L. P., Stanojević, J. S., Nikolić, L., Danilović, B. R.,& Marinković, V.. (2019). Chemical Composition, Antimicrobial andAntioxidant Activity of Birch (Betula pendula Roth.) Buds Essential Oil. in Journal of Essential Oil Bearing Plants
Taylor & Francis Ltd, Abingdon., 22(1), 120-130.
https://doi.org/10.1080/0972060X.2019.1602084

Vladimirov MS, Nikolić VD, Stanojević LP, Stanojević JS, Nikolić L, Danilović BR, Marinković V. Chemical Composition, Antimicrobial andAntioxidant Activity of Birch (Betula pendula Roth.) Buds Essential Oil. in Journal of Essential Oil Bearing Plants. 2019;22(1):120-130.
doi:10.1080/0972060X.2019.1602084 .

Vladimirov, Marijana S., Nikolić, Vesna D., Stanojević, Ljiljana P., Stanojević, Jelena S., Nikolić, Ljubiša, Danilović, Bojana R., Marinković, Valentina, "Chemical Composition, Antimicrobial andAntioxidant Activity of Birch (Betula pendula Roth.) Buds Essential Oil" in Journal of Essential Oil Bearing Plants, 22, no. 1 (2019):120-130,
https://doi.org/10.1080/0972060X.2019.1602084 . .

TY  - PAT
AU  - Ilić-Stojanović, Snežana
AU  - Nikolić, Vesna
AU  - Kundaković, Tatjana
AU  - Nikolić, Ljubiša
AU  - Savić-Gajić, Ivana
AU  - Savić, Ivan
AU  - Jocić, Emilija
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5114
AB  - Pronalazak se odnosi na novu primenu hidrogelova poli(N-izopropilakrilamid-ko-2-hidroksipropilmetakrilata), p(NIPAM-HPMet)-a i poli(N-izopropilakrilamida), p(NIPAM)-a, kao nosača za modifikovano oslobađanje elaginske kiseline i ekstrakta Alchemilla vulgaris L. sa visokim sadržajem elaginske kiseline. Analiza FTIR spektara homopolimera p(NIPAM)-a i kopolimera p(NIPAM-HPMet)-a sa uklopljenim standardom elaginske kiseline i ekstraktom Alchemilla vulgaris L., ukazuju na formiranje intermolekulskih vodoničnih veza između lanaca homopolimera, tj. kopolimera, s jedne strane i elaginske kiseline, s druge strane. Hidrogelovi p(NIPAM) i p(NIPAM-HPMet) su se pokazali kao pogodni nosači elaginske kiseline, jer omogućavaju njeno modifikovano oslobađanje.
PB  - Zavod za Intelektualnu svojinu, Republika Srbija
T2  - Гласник интелектуалне својине
T1  - Поступак примене термоосетљивих хидрогелова за модификовано ослобађање елагинске киселине
T1  - Postupak primene termoosetljivih hidrogelova za modifikovano oslobađanje elaginske kiseline
VL  - 2
SP  - 7
EP  - 7
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5114
ER  - 

@misc{
author = "Ilić-Stojanović, Snežana and Nikolić, Vesna and Kundaković, Tatjana and Nikolić, Ljubiša and Savić-Gajić, Ivana and Savić, Ivan and Jocić, Emilija",
year = "2018",
abstract = "Pronalazak se odnosi na novu primenu hidrogelova poli(N-izopropilakrilamid-ko-2-hidroksipropilmetakrilata), p(NIPAM-HPMet)-a i poli(N-izopropilakrilamida), p(NIPAM)-a, kao nosača za modifikovano oslobađanje elaginske kiseline i ekstrakta Alchemilla vulgaris L. sa visokim sadržajem elaginske kiseline. Analiza FTIR spektara homopolimera p(NIPAM)-a i kopolimera p(NIPAM-HPMet)-a sa uklopljenim standardom elaginske kiseline i ekstraktom Alchemilla vulgaris L., ukazuju na formiranje intermolekulskih vodoničnih veza između lanaca homopolimera, tj. kopolimera, s jedne strane i elaginske kiseline, s druge strane. Hidrogelovi p(NIPAM) i p(NIPAM-HPMet) su se pokazali kao pogodni nosači elaginske kiseline, jer omogućavaju njeno modifikovano oslobađanje.",
publisher = "Zavod za Intelektualnu svojinu, Republika Srbija",
journal = "Гласник интелектуалне својине",
title = "Поступак примене термоосетљивих хидрогелова за модификовано ослобађање елагинске киселине, Postupak primene termoosetljivih hidrogelova za modifikovano oslobađanje elaginske kiseline",
volume = "2",
pages = "7-7",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5114"
}

Ilić-Stojanović, S., Nikolić, V., Kundaković, T., Nikolić, L., Savić-Gajić, I., Savić, I.,& Jocić, E.. (2018). Поступак примене термоосетљивих хидрогелова за модификовано ослобађање елагинске киселине. in Гласник интелектуалне својине
Zavod za Intelektualnu svojinu, Republika Srbija., 2, 7-7.
https://hdl.handle.net/21.15107/rcub_farfar_5114

Ilić-Stojanović S, Nikolić V, Kundaković T, Nikolić L, Savić-Gajić I, Savić I, Jocić E. Поступак примене термоосетљивих хидрогелова за модификовано ослобађање елагинске киселине. in Гласник интелектуалне својине. 2018;2:7-7.
https://hdl.handle.net/21.15107/rcub_farfar_5114 .

Ilić-Stojanović, Snežana, Nikolić, Vesna, Kundaković, Tatjana, Nikolić, Ljubiša, Savić-Gajić, Ivana, Savić, Ivan, Jocić, Emilija, "Поступак примене термоосетљивих хидрогелова за модификовано ослобађање елагинске киселине" in Гласник интелектуалне својине, 2 (2018):7-7,
https://hdl.handle.net/21.15107/rcub_farfar_5114 .

TY  - JOUR
AU  - Ilić-Stojanović, Snežana
AU  - Nikolić, Vesna D.
AU  - Kundaković, Tatjana
AU  - Savić, Ivan
AU  - Savić-Gajić, Ivana
AU  - Jocić, Emilija
AU  - Nikolić, Ljubiša
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3421
AB  - Stimulus-sensitive hydrogels are used as carriers for modified release of pharmaceuticals. The synthesis of thermosensitive hydrogels poly(N-isopropylacrylamide), p(NIPAM), and poly(N-isopropylacrylamide-co-2-hydroxypropyl methacrylate), p(NIPAM-HPMet), is performed. The synthesized hydrogels are characterized using FTIR and scanning electron microscope methods and swelling properties, and applied for modified release of ellagic acid (EA). This work presents the selective extraction of EA, as a natural antioxidant, from the aerial parts of Alchemilla vulgaris L. EA and A. vulgaris extract are incorporated into p(NIPAM) and p(NIPAM-HPMet) hydrogels and characterized by FTIR method. The EA content in the extract by the UHPLC-DAD-HESI-MS/MS method is determined (0.64mgcm(-3)). The total flavonoids content in the A. vulgaris extract was determined by the spectrophotometric method. Antioxidant activity of the A. vulgaris extract and EA is examined using the 2,2-diphenyl-1-picrylhydrazyl assay. The p(NIPAM-HPMet) shows a better incorporation and release at 37 degrees C of EA standard and A. vulgaris extract (98.87 and 96.45% respectively), compared with p(NIPAM). [GRAPHICS]
PB  - Taylor & Francis As, Oslo
T2  - International Journal of Polymeric Materials and Polymeric Biomaterials
T1  - Thermosensitive hydrogels for modified release of ellagic acid obtained from Alchemilla vulgaris L. extract
VL  - 67
IS  - 9
SP  - 553
EP  - 563
DO  - 10.1080/00914037.2017.1354202
ER  - 

@article{
author = "Ilić-Stojanović, Snežana and Nikolić, Vesna D. and Kundaković, Tatjana and Savić, Ivan and Savić-Gajić, Ivana and Jocić, Emilija and Nikolić, Ljubiša",
year = "2018",
abstract = "Stimulus-sensitive hydrogels are used as carriers for modified release of pharmaceuticals. The synthesis of thermosensitive hydrogels poly(N-isopropylacrylamide), p(NIPAM), and poly(N-isopropylacrylamide-co-2-hydroxypropyl methacrylate), p(NIPAM-HPMet), is performed. The synthesized hydrogels are characterized using FTIR and scanning electron microscope methods and swelling properties, and applied for modified release of ellagic acid (EA). This work presents the selective extraction of EA, as a natural antioxidant, from the aerial parts of Alchemilla vulgaris L. EA and A. vulgaris extract are incorporated into p(NIPAM) and p(NIPAM-HPMet) hydrogels and characterized by FTIR method. The EA content in the extract by the UHPLC-DAD-HESI-MS/MS method is determined (0.64mgcm(-3)). The total flavonoids content in the A. vulgaris extract was determined by the spectrophotometric method. Antioxidant activity of the A. vulgaris extract and EA is examined using the 2,2-diphenyl-1-picrylhydrazyl assay. The p(NIPAM-HPMet) shows a better incorporation and release at 37 degrees C of EA standard and A. vulgaris extract (98.87 and 96.45% respectively), compared with p(NIPAM). [GRAPHICS]",
publisher = "Taylor & Francis As, Oslo",
journal = "International Journal of Polymeric Materials and Polymeric Biomaterials",
title = "Thermosensitive hydrogels for modified release of ellagic acid obtained from Alchemilla vulgaris L. extract",
volume = "67",
number = "9",
pages = "553-563",
doi = "10.1080/00914037.2017.1354202"
}

Ilić-Stojanović, S., Nikolić, V. D., Kundaković, T., Savić, I., Savić-Gajić, I., Jocić, E.,& Nikolić, L.. (2018). Thermosensitive hydrogels for modified release of ellagic acid obtained from Alchemilla vulgaris L. extract. in International Journal of Polymeric Materials and Polymeric Biomaterials
Taylor & Francis As, Oslo., 67(9), 553-563.
https://doi.org/10.1080/00914037.2017.1354202

Ilić-Stojanović S, Nikolić VD, Kundaković T, Savić I, Savić-Gajić I, Jocić E, Nikolić L. Thermosensitive hydrogels for modified release of ellagic acid obtained from Alchemilla vulgaris L. extract. in International Journal of Polymeric Materials and Polymeric Biomaterials. 2018;67(9):553-563.
doi:10.1080/00914037.2017.1354202 .

Ilić-Stojanović, Snežana, Nikolić, Vesna D., Kundaković, Tatjana, Savić, Ivan, Savić-Gajić, Ivana, Jocić, Emilija, Nikolić, Ljubiša, "Thermosensitive hydrogels for modified release of ellagic acid obtained from Alchemilla vulgaris L. extract" in International Journal of Polymeric Materials and Polymeric Biomaterials, 67, no. 9 (2018):553-563,
https://doi.org/10.1080/00914037.2017.1354202 . .

TY  - JOUR
AU  - Ilić-Stojanović, Snežana
AU  - Nikolić, Vesna D.
AU  - Kundaković, Tatjana
AU  - Savić, Ivan
AU  - Savić-Gajić, Ivana
AU  - Jocić, Emilija
AU  - Nikolić, Ljubiša
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3155
AB  - Stimulus-sensitive hydrogels are used as carriers for modified release of pharmaceuticals. The synthesis of thermosensitive hydrogels poly(N-isopropylacrylamide), p(NIPAM), and poly(N-isopropylacrylamide-co-2-hydroxypropyl methacrylate), p(NIPAM-HPMet), is performed. The synthesized hydrogels are characterized using FTIR and scanning electron microscope methods and swelling properties, and applied for modified release of ellagic acid (EA). This work presents the selective extraction of EA, as a natural antioxidant, from the aerial parts of Alchemilla vulgaris L. EA and A. vulgaris extract are incorporated into p(NIPAM) and p(NIPAM-HPMet) hydrogels and characterized by FTIR method. The EA content in the extract by the UHPLC-DAD-HESI-MS/MS method is determined (0.64mgcm(-3)). The total flavonoids content in the A. vulgaris extract was determined by the spectrophotometric method. Antioxidant activity of the A. vulgaris extract and EA is examined using the 2,2-diphenyl-1-picrylhydrazyl assay. The p(NIPAM-HPMet) shows a better incorporation and release at 37 degrees C of EA standard and A. vulgaris extract (98.87 and 96.45% respectively), compared with p(NIPAM). [GRAPHICS]
PB  - Taylor & Francis As, Oslo
T2  - International Journal of Polymeric Materials and Polymeric Biomaterials
T1  - Thermosensitive hydrogels for modified release of ellagic acid obtained from Alchemilla vulgaris L. extract
VL  - 67
IS  - 9
SP  - 553
EP  - 563
DO  - 10.1080/00914037.2017.1354202
ER  - 

@article{
author = "Ilić-Stojanović, Snežana and Nikolić, Vesna D. and Kundaković, Tatjana and Savić, Ivan and Savić-Gajić, Ivana and Jocić, Emilija and Nikolić, Ljubiša",
year = "2018",
abstract = "Stimulus-sensitive hydrogels are used as carriers for modified release of pharmaceuticals. The synthesis of thermosensitive hydrogels poly(N-isopropylacrylamide), p(NIPAM), and poly(N-isopropylacrylamide-co-2-hydroxypropyl methacrylate), p(NIPAM-HPMet), is performed. The synthesized hydrogels are characterized using FTIR and scanning electron microscope methods and swelling properties, and applied for modified release of ellagic acid (EA). This work presents the selective extraction of EA, as a natural antioxidant, from the aerial parts of Alchemilla vulgaris L. EA and A. vulgaris extract are incorporated into p(NIPAM) and p(NIPAM-HPMet) hydrogels and characterized by FTIR method. The EA content in the extract by the UHPLC-DAD-HESI-MS/MS method is determined (0.64mgcm(-3)). The total flavonoids content in the A. vulgaris extract was determined by the spectrophotometric method. Antioxidant activity of the A. vulgaris extract and EA is examined using the 2,2-diphenyl-1-picrylhydrazyl assay. The p(NIPAM-HPMet) shows a better incorporation and release at 37 degrees C of EA standard and A. vulgaris extract (98.87 and 96.45% respectively), compared with p(NIPAM). [GRAPHICS]",
publisher = "Taylor & Francis As, Oslo",
journal = "International Journal of Polymeric Materials and Polymeric Biomaterials",
title = "Thermosensitive hydrogels for modified release of ellagic acid obtained from Alchemilla vulgaris L. extract",
volume = "67",
number = "9",
pages = "553-563",
doi = "10.1080/00914037.2017.1354202"
}

Ilić-Stojanović, S., Nikolić, V. D., Kundaković, T., Savić, I., Savić-Gajić, I., Jocić, E.,& Nikolić, L.. (2018). Thermosensitive hydrogels for modified release of ellagic acid obtained from Alchemilla vulgaris L. extract. in International Journal of Polymeric Materials and Polymeric Biomaterials
Taylor & Francis As, Oslo., 67(9), 553-563.
https://doi.org/10.1080/00914037.2017.1354202

Ilić-Stojanović S, Nikolić VD, Kundaković T, Savić I, Savić-Gajić I, Jocić E, Nikolić L. Thermosensitive hydrogels for modified release of ellagic acid obtained from Alchemilla vulgaris L. extract. in International Journal of Polymeric Materials and Polymeric Biomaterials. 2018;67(9):553-563.
doi:10.1080/00914037.2017.1354202 .

Ilić-Stojanović, Snežana, Nikolić, Vesna D., Kundaković, Tatjana, Savić, Ivan, Savić-Gajić, Ivana, Jocić, Emilija, Nikolić, Ljubiša, "Thermosensitive hydrogels for modified release of ellagic acid obtained from Alchemilla vulgaris L. extract" in International Journal of Polymeric Materials and Polymeric Biomaterials, 67, no. 9 (2018):553-563,
https://doi.org/10.1080/00914037.2017.1354202 . .

TY  - JOUR
AU  - Savić, Ivan
AU  - Nikolić, Vesna D.
AU  - Savić-Gajić, Ivana
AU  - Nikolić, Ljubiša
AU  - Ibrić, Svetlana
AU  - Gajić, Dragoljub G.
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2471
AB  - The process of amygdalin extraction from plum seeds was optimized using central composite design (CCD) and multilayer perceptron (MLP). The effect of time, ethanol concentration, solid-to-liquid ratio, and temperature on the amygdalin content in the extracts was estimated using both mathematical models. The MLP 4-3-1 with exponential function in hidden layer and linear function in output layer was used for describing the extraction process. MLP model was more superior compared with CCD model due to better prediction ability. According to MLP model, the suggested optimal conditions are: time of 120 min, 100% (v/v) ethanol, solid-to liquid ratio of 1:25 (m/v) and temperature of 34.4 degrees C. The predicted value of amygdalin content in the dried extract (25.42 g per 100 g) at these conditions was experimentally confirmed (25.30 g per 100 g of dried extract). Amygdalin (>90%) was isolated from the complex extraction mixture and structurally characterized by FT-IR, UV, and MS methods.
PB  - Frontiers Media Sa, Lausanne
T2  - Frontiers in Plant Science
T1  - Optimization of technological procedure for amygdalin isolation from plum seeds (Pruni domesticae semen)
VL  - 6
DO  - 10.3389/fpls.2015.00276
ER  - 

@article{
author = "Savić, Ivan and Nikolić, Vesna D. and Savić-Gajić, Ivana and Nikolić, Ljubiša and Ibrić, Svetlana and Gajić, Dragoljub G.",
year = "2015",
abstract = "The process of amygdalin extraction from plum seeds was optimized using central composite design (CCD) and multilayer perceptron (MLP). The effect of time, ethanol concentration, solid-to-liquid ratio, and temperature on the amygdalin content in the extracts was estimated using both mathematical models. The MLP 4-3-1 with exponential function in hidden layer and linear function in output layer was used for describing the extraction process. MLP model was more superior compared with CCD model due to better prediction ability. According to MLP model, the suggested optimal conditions are: time of 120 min, 100% (v/v) ethanol, solid-to liquid ratio of 1:25 (m/v) and temperature of 34.4 degrees C. The predicted value of amygdalin content in the dried extract (25.42 g per 100 g) at these conditions was experimentally confirmed (25.30 g per 100 g of dried extract). Amygdalin (>90%) was isolated from the complex extraction mixture and structurally characterized by FT-IR, UV, and MS methods.",
publisher = "Frontiers Media Sa, Lausanne",
journal = "Frontiers in Plant Science",
title = "Optimization of technological procedure for amygdalin isolation from plum seeds (Pruni domesticae semen)",
volume = "6",
doi = "10.3389/fpls.2015.00276"
}

Savić, I., Nikolić, V. D., Savić-Gajić, I., Nikolić, L., Ibrić, S.,& Gajić, D. G.. (2015). Optimization of technological procedure for amygdalin isolation from plum seeds (Pruni domesticae semen). in Frontiers in Plant Science
Frontiers Media Sa, Lausanne., 6.
https://doi.org/10.3389/fpls.2015.00276

Savić I, Nikolić VD, Savić-Gajić I, Nikolić L, Ibrić S, Gajić DG. Optimization of technological procedure for amygdalin isolation from plum seeds (Pruni domesticae semen). in Frontiers in Plant Science. 2015;6.
doi:10.3389/fpls.2015.00276 .

Savić, Ivan, Nikolić, Vesna D., Savić-Gajić, Ivana, Nikolić, Ljubiša, Ibrić, Svetlana, Gajić, Dragoljub G., "Optimization of technological procedure for amygdalin isolation from plum seeds (Pruni domesticae semen)" in Frontiers in Plant Science, 6 (2015),
https://doi.org/10.3389/fpls.2015.00276 . .

TY  - JOUR
AU  - Nikolić, Vesna D.
AU  - Stanković, Mihajlo
AU  - Nikolić, Ljubiša
AU  - Nikolić, Goran
AU  - Ilić-Stojanović, Snežana
AU  - Popsavin, Mirjana
AU  - Zlatković, Sasa
AU  - Kundaković, Tatjana
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1992
AB  - Molecular inclusion complexes of usnic acid (UA) with beta-cyclodextrin (beta-CD) and 2-hydroxypropyl beta-cyclodextrin (HP beta-CD) were prepared by the co-precipitation method in the solid state in the molar ratio of 1:1. Structural complexes characterization was based on different methods, FTIR, H-1 NMR, XRD and DSC. Parallel to the complex by the above methods, corresponding physical mixtures of UA with cyclodextrins and complexing agents (beta-CD, HP beta-CD and UA) were analyzed. The results of DSC analysis showed that, at around 200 A degrees C, the endothermal peak in the complexes with cyclodextrins originating from the UA melting has disappeared. Complex diffractogram patterns do not contain peaks characteristic for the pure UA. They are more appropriate to cyclodextrin diffractogram. This fact points to the molecular encapsulation of UA in the cyclodextrin cavity. Chemical shifts in H-1 NMR spectra after the inclusion of UA into the cyclodextrin cavity, especially H-3 protons (0.0012 and 0.0102 ppm in the beta-CD and HP beta-CD, respectively) and H-5 and H-6 (0.0134 ppm) and hydrogen from CH3 (0.0073 ppm) HP beta-CD also points to the formation of molecular inclusion complexes. The improved solubility of UA in water was achieved by molecular incapsulation. In the complex with beta-CD the solubility is 0.3 mg/cm(3), with HP beta-CD 4.2 mg/cm(3) while the uncomplexed UA solubility is 0.06 mg/cm(3). The microbial activity of UA and both complexes was tested against eight bacteria and two fungi and during the test no reduced activity of UA in the complexes was observed.
PB  - Springer, Dordrecht
T2  - Journal of Inclusion Phenomena and Macrocyclic Chemistry
T1  - Inclusion complexes with cyclodextrin and usnic acid
VL  - 76
IS  - 1-2
SP  - 173
EP  - 182
DO  - 10.1007/s10847-012-0187-8
ER  - 

@article{
author = "Nikolić, Vesna D. and Stanković, Mihajlo and Nikolić, Ljubiša and Nikolić, Goran and Ilić-Stojanović, Snežana and Popsavin, Mirjana and Zlatković, Sasa and Kundaković, Tatjana",
year = "2013",
abstract = "Molecular inclusion complexes of usnic acid (UA) with beta-cyclodextrin (beta-CD) and 2-hydroxypropyl beta-cyclodextrin (HP beta-CD) were prepared by the co-precipitation method in the solid state in the molar ratio of 1:1. Structural complexes characterization was based on different methods, FTIR, H-1 NMR, XRD and DSC. Parallel to the complex by the above methods, corresponding physical mixtures of UA with cyclodextrins and complexing agents (beta-CD, HP beta-CD and UA) were analyzed. The results of DSC analysis showed that, at around 200 A degrees C, the endothermal peak in the complexes with cyclodextrins originating from the UA melting has disappeared. Complex diffractogram patterns do not contain peaks characteristic for the pure UA. They are more appropriate to cyclodextrin diffractogram. This fact points to the molecular encapsulation of UA in the cyclodextrin cavity. Chemical shifts in H-1 NMR spectra after the inclusion of UA into the cyclodextrin cavity, especially H-3 protons (0.0012 and 0.0102 ppm in the beta-CD and HP beta-CD, respectively) and H-5 and H-6 (0.0134 ppm) and hydrogen from CH3 (0.0073 ppm) HP beta-CD also points to the formation of molecular inclusion complexes. The improved solubility of UA in water was achieved by molecular incapsulation. In the complex with beta-CD the solubility is 0.3 mg/cm(3), with HP beta-CD 4.2 mg/cm(3) while the uncomplexed UA solubility is 0.06 mg/cm(3). The microbial activity of UA and both complexes was tested against eight bacteria and two fungi and during the test no reduced activity of UA in the complexes was observed.",
publisher = "Springer, Dordrecht",
journal = "Journal of Inclusion Phenomena and Macrocyclic Chemistry",
title = "Inclusion complexes with cyclodextrin and usnic acid",
volume = "76",
number = "1-2",
pages = "173-182",
doi = "10.1007/s10847-012-0187-8"
}

Nikolić, V. D., Stanković, M., Nikolić, L., Nikolić, G., Ilić-Stojanović, S., Popsavin, M., Zlatković, S.,& Kundaković, T.. (2013). Inclusion complexes with cyclodextrin and usnic acid. in Journal of Inclusion Phenomena and Macrocyclic Chemistry
Springer, Dordrecht., 76(1-2), 173-182.
https://doi.org/10.1007/s10847-012-0187-8

Nikolić VD, Stanković M, Nikolić L, Nikolić G, Ilić-Stojanović S, Popsavin M, Zlatković S, Kundaković T. Inclusion complexes with cyclodextrin and usnic acid. in Journal of Inclusion Phenomena and Macrocyclic Chemistry. 2013;76(1-2):173-182.
doi:10.1007/s10847-012-0187-8 .

Nikolić, Vesna D., Stanković, Mihajlo, Nikolić, Ljubiša, Nikolić, Goran, Ilić-Stojanović, Snežana, Popsavin, Mirjana, Zlatković, Sasa, Kundaković, Tatjana, "Inclusion complexes with cyclodextrin and usnic acid" in Journal of Inclusion Phenomena and Macrocyclic Chemistry, 76, no. 1-2 (2013):173-182,
https://doi.org/10.1007/s10847-012-0187-8 . .

TY  - JOUR
AU  - Nikolić, Vesna D.
AU  - Savić, Ivan
AU  - Savić, Ivana
AU  - Nikolić, Ljubiša
AU  - Stanković, Mihajlo
AU  - Marinković, Valentina
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1573
AB  - Paclitaxel is isolated from the Pacific yew. It can be obtained from the European yew, but only after chemical modification of the isolated compound by a semi-synthesis procedure. The procedure for total synthesis of paclitaxel is very complicated, involving multiple steps, and the yields of paclitaxel are meagre. This substance is also a metabolite of certain kinds of fungus. The microbiological pathway for producing paclitaxel compared with isolation from plant material involves shorter procuction times but a small yield. Cyclodextrins are usually used for improving the solubility of paclitaxel in aqueous media, with polymeric and other substances added. Paclitaxel has anticancer activity and use for preparing the formulations intravenously administrated to patients with tumors. The paclitaxel concentration in these formulations is determined using validated HPLC methods.
PB  - Versita, Warsaw
T2  - Central European Journal of Medicine
T1  - Paclitaxel as an anticancer agent: isolation, activity, synthesis and stability
VL  - 6
IS  - 5
SP  - 527
EP  - 536
DO  - 10.2478/s11536-011-0074-5
ER  - 

@article{
author = "Nikolić, Vesna D. and Savić, Ivan and Savić, Ivana and Nikolić, Ljubiša and Stanković, Mihajlo and Marinković, Valentina",
year = "2011",
abstract = "Paclitaxel is isolated from the Pacific yew. It can be obtained from the European yew, but only after chemical modification of the isolated compound by a semi-synthesis procedure. The procedure for total synthesis of paclitaxel is very complicated, involving multiple steps, and the yields of paclitaxel are meagre. This substance is also a metabolite of certain kinds of fungus. The microbiological pathway for producing paclitaxel compared with isolation from plant material involves shorter procuction times but a small yield. Cyclodextrins are usually used for improving the solubility of paclitaxel in aqueous media, with polymeric and other substances added. Paclitaxel has anticancer activity and use for preparing the formulations intravenously administrated to patients with tumors. The paclitaxel concentration in these formulations is determined using validated HPLC methods.",
publisher = "Versita, Warsaw",
journal = "Central European Journal of Medicine",
title = "Paclitaxel as an anticancer agent: isolation, activity, synthesis and stability",
volume = "6",
number = "5",
pages = "527-536",
doi = "10.2478/s11536-011-0074-5"
}

Nikolić, V. D., Savić, I., Savić, I., Nikolić, L., Stanković, M.,& Marinković, V.. (2011). Paclitaxel as an anticancer agent: isolation, activity, synthesis and stability. in Central European Journal of Medicine
Versita, Warsaw., 6(5), 527-536.
https://doi.org/10.2478/s11536-011-0074-5

Nikolić VD, Savić I, Savić I, Nikolić L, Stanković M, Marinković V. Paclitaxel as an anticancer agent: isolation, activity, synthesis and stability. in Central European Journal of Medicine. 2011;6(5):527-536.
doi:10.2478/s11536-011-0074-5 .

Nikolić, Vesna D., Savić, Ivan, Savić, Ivana, Nikolić, Ljubiša, Stanković, Mihajlo, Marinković, Valentina, "Paclitaxel as an anticancer agent: isolation, activity, synthesis and stability" in Central European Journal of Medicine, 6, no. 5 (2011):527-536,
https://doi.org/10.2478/s11536-011-0074-5 . .