TY  - JOUR
AU  - Cvetković, Dragan J.
AU  - Stanojević, Ljiljana P.
AU  - Kundaković, Tatjana
AU  - Zlatković, Saša Ž.
AU  - Nikolić, Goran
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2315
AB  - Antioxidant and antimicrobial activities of a new phyto-gel were studied in this work. The formulated gel is composed of propilene glycol extracts of St. John's worth (H. perforatum L.), comfrey (S. officinale L.), yarrow (A. millefolium L.), horsetail (E. arvense L.) and Na-usniate. The antioxidant activity was determined for the gel and each investigated extract of the gel separately by the DPPH test. The total phenols and flavonoids content was determined spectrophotometrically, for the gel and each investigated extracts. The antimicrobial activity of the gel and each compound separately was tested in vitro on the following microorganisms: Staphylococcus aureus, Micrococcus luteus, Bacillus subtilis, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Candida albicans and Aspergillus niger. The antioxidant activity of the investigated samples decreases in the series: H. perforatum (EC50 = 1.04 mg/mL) > Na-usniate (EC50 = 4.16 mg/mL) > A. millefolium (EC50 = 7.60 mg/mL) > gel (EC50 = 23.47 mg/mL) > S. officinale (EC50 = 30.10 mg/mL) > E. arvense (EC50 = 44.70 mg/mL). The formulated phyto-gel showed the antimicrobial activity. The results suggest that the obtained phyto-gel is a good source of natural antioxidants and antimicrobial agents, and it has potential as an alternative to synthetic products in pharmaceutical and cosmetic industries.
AB  - U radu je ispitivana antioksidativna i antimikrobna aktivnost fitogela - formulacija gela sa propilen-glikolnim ekstraktima H. perforatum, S. officinale, A. millefolium, E. arvense i Na-usninatom. Primenom DPPH testa određena je antioksidativna aktivnost svih ispitivanih ekstrakata, Na-usninata i gela. Primenom spektrofotometrijskih metoda određen je sadržaj ukupnih fenola i flavonoida u ekstraktima i formulisanom gelu. Antimikrobna aktivnost gela, kao i njegovih pojedinačnih komponenata, je ispitivana in vitro na sledećim mikroorganizmima: Staphylococcus aureus, Micrococcus luteus, Bacillus subtilis, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Candida albicans i Aspergillus niger. Antioksidativna aktivnost ispitivanih uzoraka opada u nizu: H. perforatum (EC50=1,04 mg/ml) > Na-usnate (EC50=4,16 mg/ml) > A. millefolium (EC50=7,60 mg/ml) > gel (EC50=23,47 mg/ml) > S. officinale (EC50=30,10 mg/ml) > E. arvense (EC50 44,70 mg/ml). Formulisani fitogel je pokazao i antimikrobnu aktivnost. Dobijeni rezultati pokazuju da ispitivani fitogel predstavlja izvor prirodnih antioksidanasa i antimikrobnih agenasa, sa mogućom primenom u farmaceutsko-kozmetičkoj industriji kao alternativa sintetičkim proizvodima.
PB  - Univerzitet u Nišu - Tehnološki fakultet, Leskovac
T2  - Advanced Technologies
T1  - Antioxidant and antimicrobial activity of a new generation phyto-gel
T1  - Antioksidativna i antimikrobna aktivnost fitogela novije generacije
VL  - 4
IS  - 2
SP  - 11
EP  - 18
DO  - 10.5937/savteh1502011C
ER  - 

@article{
author = "Cvetković, Dragan J. and Stanojević, Ljiljana P. and Kundaković, Tatjana and Zlatković, Saša Ž. and Nikolić, Goran",
year = "2015",
abstract = "Antioxidant and antimicrobial activities of a new phyto-gel were studied in this work. The formulated gel is composed of propilene glycol extracts of St. John's worth (H. perforatum L.), comfrey (S. officinale L.), yarrow (A. millefolium L.), horsetail (E. arvense L.) and Na-usniate. The antioxidant activity was determined for the gel and each investigated extract of the gel separately by the DPPH test. The total phenols and flavonoids content was determined spectrophotometrically, for the gel and each investigated extracts. The antimicrobial activity of the gel and each compound separately was tested in vitro on the following microorganisms: Staphylococcus aureus, Micrococcus luteus, Bacillus subtilis, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Candida albicans and Aspergillus niger. The antioxidant activity of the investigated samples decreases in the series: H. perforatum (EC50 = 1.04 mg/mL) > Na-usniate (EC50 = 4.16 mg/mL) > A. millefolium (EC50 = 7.60 mg/mL) > gel (EC50 = 23.47 mg/mL) > S. officinale (EC50 = 30.10 mg/mL) > E. arvense (EC50 = 44.70 mg/mL). The formulated phyto-gel showed the antimicrobial activity. The results suggest that the obtained phyto-gel is a good source of natural antioxidants and antimicrobial agents, and it has potential as an alternative to synthetic products in pharmaceutical and cosmetic industries., U radu je ispitivana antioksidativna i antimikrobna aktivnost fitogela - formulacija gela sa propilen-glikolnim ekstraktima H. perforatum, S. officinale, A. millefolium, E. arvense i Na-usninatom. Primenom DPPH testa određena je antioksidativna aktivnost svih ispitivanih ekstrakata, Na-usninata i gela. Primenom spektrofotometrijskih metoda određen je sadržaj ukupnih fenola i flavonoida u ekstraktima i formulisanom gelu. Antimikrobna aktivnost gela, kao i njegovih pojedinačnih komponenata, je ispitivana in vitro na sledećim mikroorganizmima: Staphylococcus aureus, Micrococcus luteus, Bacillus subtilis, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Candida albicans i Aspergillus niger. Antioksidativna aktivnost ispitivanih uzoraka opada u nizu: H. perforatum (EC50=1,04 mg/ml) > Na-usnate (EC50=4,16 mg/ml) > A. millefolium (EC50=7,60 mg/ml) > gel (EC50=23,47 mg/ml) > S. officinale (EC50=30,10 mg/ml) > E. arvense (EC50 44,70 mg/ml). Formulisani fitogel je pokazao i antimikrobnu aktivnost. Dobijeni rezultati pokazuju da ispitivani fitogel predstavlja izvor prirodnih antioksidanasa i antimikrobnih agenasa, sa mogućom primenom u farmaceutsko-kozmetičkoj industriji kao alternativa sintetičkim proizvodima.",
publisher = "Univerzitet u Nišu - Tehnološki fakultet, Leskovac",
journal = "Advanced Technologies",
title = "Antioxidant and antimicrobial activity of a new generation phyto-gel, Antioksidativna i antimikrobna aktivnost fitogela novije generacije",
volume = "4",
number = "2",
pages = "11-18",
doi = "10.5937/savteh1502011C"
}

Cvetković, D. J., Stanojević, L. P., Kundaković, T., Zlatković, S. Ž.,& Nikolić, G.. (2015). Antioxidant and antimicrobial activity of a new generation phyto-gel. in Advanced Technologies
Univerzitet u Nišu - Tehnološki fakultet, Leskovac., 4(2), 11-18.
https://doi.org/10.5937/savteh1502011C

Cvetković DJ, Stanojević LP, Kundaković T, Zlatković SŽ, Nikolić G. Antioxidant and antimicrobial activity of a new generation phyto-gel. in Advanced Technologies. 2015;4(2):11-18.
doi:10.5937/savteh1502011C .

Cvetković, Dragan J., Stanojević, Ljiljana P., Kundaković, Tatjana, Zlatković, Saša Ž., Nikolić, Goran, "Antioxidant and antimicrobial activity of a new generation phyto-gel" in Advanced Technologies, 4, no. 2 (2015):11-18,
https://doi.org/10.5937/savteh1502011C . .