TY  - JOUR
AU  - Savković, Miljan
AU  - Simić-Ogrizović, Sanja
AU  - Dopsaj, Violeta
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3903
AB  - Introduction: The aim of our study was to examine the relationship of hepcidin-25 with red blood cell and reticulocyte indices and to evaluate the diagnostic properties of hepcidin-25 in the assessment of positive iron balance in end-stage renal disease (ESRD) patients. Methods: Eighty anemic ESRD patients (hemoglobin < 110 g/L) were classified as having iron deficiency (ID, N = 20), iron sufficiency (IS, N = 29), and positive iron balance (PB, N = 31) using the conventional biomarkers for iron status evaluation. Hepcidin-25 was determined by a chemiluminescent direct ELISA. Results: Hepcidin-25 was significantly negatively correlated with the proportion of hypochromic erythrocytes (%HYPO) (P =.034) and immature reticulocyte fraction (P =.010) in ID and with the absolute reticulocyte concentration in ID (P =.048) and PB (P =.040). In multivariate models, hepcidin-25 was independently negatively associated with the mean reticulocyte hemoglobin content (CHr; β = −0.493, P =.004) and red blood cell size factor (RSf) (β = −0.334, P =.036) only in the PB group. The best hepcidin-25 value to exclude PB was 66.13 µg/L, showing a sensitivity of 61.3%, a specificity of 75.5%, and an AUC of 0.808. Conclusion: Our results suggest that hepcidin-25 levels are independently negatively associated with the iron demand for the most recent erythropoiesis only in PB. Hepcidin-25 performed acceptable in discriminating anemic ESRD patients with positive iron balance and may prove to be a useful additional tool in the evaluation of iron status.
PB  - John Wiley & Sons Ltd
T2  - International Journal of Laboratory Hematology
T1  - Assessment of positive iron balance in end-stage renal disease: Could hepcidin-25 be useful?
VL  - 43
IS  - 5
SP  - 1159
EP  - 1167
DO  - 10.1111/ijlh.13539
ER  - 

@article{
author = "Savković, Miljan and Simić-Ogrizović, Sanja and Dopsaj, Violeta",
year = "2021",
abstract = "Introduction: The aim of our study was to examine the relationship of hepcidin-25 with red blood cell and reticulocyte indices and to evaluate the diagnostic properties of hepcidin-25 in the assessment of positive iron balance in end-stage renal disease (ESRD) patients. Methods: Eighty anemic ESRD patients (hemoglobin < 110 g/L) were classified as having iron deficiency (ID, N = 20), iron sufficiency (IS, N = 29), and positive iron balance (PB, N = 31) using the conventional biomarkers for iron status evaluation. Hepcidin-25 was determined by a chemiluminescent direct ELISA. Results: Hepcidin-25 was significantly negatively correlated with the proportion of hypochromic erythrocytes (%HYPO) (P =.034) and immature reticulocyte fraction (P =.010) in ID and with the absolute reticulocyte concentration in ID (P =.048) and PB (P =.040). In multivariate models, hepcidin-25 was independently negatively associated with the mean reticulocyte hemoglobin content (CHr; β = −0.493, P =.004) and red blood cell size factor (RSf) (β = −0.334, P =.036) only in the PB group. The best hepcidin-25 value to exclude PB was 66.13 µg/L, showing a sensitivity of 61.3%, a specificity of 75.5%, and an AUC of 0.808. Conclusion: Our results suggest that hepcidin-25 levels are independently negatively associated with the iron demand for the most recent erythropoiesis only in PB. Hepcidin-25 performed acceptable in discriminating anemic ESRD patients with positive iron balance and may prove to be a useful additional tool in the evaluation of iron status.",
publisher = "John Wiley & Sons Ltd",
journal = "International Journal of Laboratory Hematology",
title = "Assessment of positive iron balance in end-stage renal disease: Could hepcidin-25 be useful?",
volume = "43",
number = "5",
pages = "1159-1167",
doi = "10.1111/ijlh.13539"
}

Savković, M., Simić-Ogrizović, S.,& Dopsaj, V.. (2021). Assessment of positive iron balance in end-stage renal disease: Could hepcidin-25 be useful?. in International Journal of Laboratory Hematology
John Wiley & Sons Ltd., 43(5), 1159-1167.
https://doi.org/10.1111/ijlh.13539

Savković M, Simić-Ogrizović S, Dopsaj V. Assessment of positive iron balance in end-stage renal disease: Could hepcidin-25 be useful?. in International Journal of Laboratory Hematology. 2021;43(5):1159-1167.
doi:10.1111/ijlh.13539 .

Savković, Miljan, Simić-Ogrizović, Sanja, Dopsaj, Violeta, "Assessment of positive iron balance in end-stage renal disease: Could hepcidin-25 be useful?" in International Journal of Laboratory Hematology, 43, no. 5 (2021):1159-1167,
https://doi.org/10.1111/ijlh.13539 . .

TY  - JOUR
AU  - Savković, Miljan
AU  - Simić-Ogrizović, Sanja
AU  - Dopsaj, Violeta
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3778
AB  - This study aimed to investigate the factors that are independently associated with hepcidin-25 and its relationship with doses of erythropoiesis-stimulating agents (ESAs) and intravenous iron in stable maintenance hemodialysis patients (smHD) stratified by ESAs administration. In 103 adult smHD (ESAs therapy (N = 64) and ESAs-free (N = 39)), median values of biologically active hepcidin-25 (chemiluminescent direct ELISA assay) and ferritin levels were significantly higher whereas red blood cell count, hemoglobin, and hematocrit values were lower in ESAs therapy compared to ESAs-free group (P <.001, for all). Our results suggest that ESAs-independent smHD exhibit supposedly normal hepcidin-25 levels and preserved iron homeostasis, with a lower degree of anemia. The results of our multivariable model indicate that hepcidin-25 levels are independently and positively associated with iron stores and inflammation, and inversely with active erythropoiesis, regardless of ESAs administration. Maintenance ESAs and the intravenous iron dose were not related to hepcidin-25 levels.
PB  - Blackwell Publishing Ltd
T2  - Therapeutic Apheresis and Dialysis
T1  - Factors associated with hepcidin-25 levels in maintenance hemodialysis patients
DO  - 10.1111/1744-9987.13617
ER  - 

@article{
author = "Savković, Miljan and Simić-Ogrizović, Sanja and Dopsaj, Violeta",
year = "2021",
abstract = "This study aimed to investigate the factors that are independently associated with hepcidin-25 and its relationship with doses of erythropoiesis-stimulating agents (ESAs) and intravenous iron in stable maintenance hemodialysis patients (smHD) stratified by ESAs administration. In 103 adult smHD (ESAs therapy (N = 64) and ESAs-free (N = 39)), median values of biologically active hepcidin-25 (chemiluminescent direct ELISA assay) and ferritin levels were significantly higher whereas red blood cell count, hemoglobin, and hematocrit values were lower in ESAs therapy compared to ESAs-free group (P <.001, for all). Our results suggest that ESAs-independent smHD exhibit supposedly normal hepcidin-25 levels and preserved iron homeostasis, with a lower degree of anemia. The results of our multivariable model indicate that hepcidin-25 levels are independently and positively associated with iron stores and inflammation, and inversely with active erythropoiesis, regardless of ESAs administration. Maintenance ESAs and the intravenous iron dose were not related to hepcidin-25 levels.",
publisher = "Blackwell Publishing Ltd",
journal = "Therapeutic Apheresis and Dialysis",
title = "Factors associated with hepcidin-25 levels in maintenance hemodialysis patients",
doi = "10.1111/1744-9987.13617"
}

Savković, M., Simić-Ogrizović, S.,& Dopsaj, V.. (2021). Factors associated with hepcidin-25 levels in maintenance hemodialysis patients. in Therapeutic Apheresis and Dialysis
Blackwell Publishing Ltd..
https://doi.org/10.1111/1744-9987.13617

Savković M, Simić-Ogrizović S, Dopsaj V. Factors associated with hepcidin-25 levels in maintenance hemodialysis patients. in Therapeutic Apheresis and Dialysis. 2021;.
doi:10.1111/1744-9987.13617 .

Savković, Miljan, Simić-Ogrizović, Sanja, Dopsaj, Violeta, "Factors associated with hepcidin-25 levels in maintenance hemodialysis patients" in Therapeutic Apheresis and Dialysis (2021),
https://doi.org/10.1111/1744-9987.13617 . .

TY  - JOUR
AU  - Dopsaj, Violeta
AU  - Topić, Aleksandra
AU  - Savković, Miljan
AU  - Milinković, Neda
AU  - Novaković, Ivana
AU  - Cujić, Danica
AU  - Simić-Ogrizović, Sanja
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3366
AB  - Background. Influence of TMPRSS6 A736V and HFE (C282Y and H63D) polymorphisms on serum hepcidin-25 levels and iron status parameters in end-stage renal disease (ESRD) patients stratified according to gender has not been previously investigated. In addition, we aimed to evaluate the diagnostic accuracy of the parameters to separate iron-deficiency anemia (IDA) from anemia of chronic disease. Materials and Methods. Iron status parameters and genetic analysis were performed in 126 ESRD patients and in 31 IDA patients as the control group. Results. ESRD patients had significantly higher ferritin and hepcidin-25 ( lt 0.001) relative to IDA patients. Cut-off values with the best diagnostic accuracy were found for hepcidin 9.32ng/mL, ferritin 48.2g/L, transferrin saturation 16.8%, and MCV 81fL. Interaction between gender and HFE haplotypes for the hepcidin-25 and ferritin levels in ESRD patients (p=0.005, partial eta squared=0.09; p=0.027, partial eta squared=0.06, respectively) was found. Serum transferrin was influenced by the combined effect of gender and TMPRSS6 A736V polymorphism in ESRD patients (p=0.002, partial eta squared=0.07). Conclusion. Our findings could contribute to the further investigation of mechanisms involved in the pathophysiology and important gender-related involvement of the TMPRSS6 and HFE polymorphisms on anemia in ESRD patients.
PB  - Hindawi Ltd, London
T2  - Disease Markers
T1  - Associations of Common Variants in HFE and TMPRSS6 Genes with Hepcidin-25 and Iron Status Parameters in Patients with End-Stage Renal Disease
DO  - 10.1155/2019/4864370
ER  - 

@article{
author = "Dopsaj, Violeta and Topić, Aleksandra and Savković, Miljan and Milinković, Neda and Novaković, Ivana and Cujić, Danica and Simić-Ogrizović, Sanja",
year = "2019",
abstract = "Background. Influence of TMPRSS6 A736V and HFE (C282Y and H63D) polymorphisms on serum hepcidin-25 levels and iron status parameters in end-stage renal disease (ESRD) patients stratified according to gender has not been previously investigated. In addition, we aimed to evaluate the diagnostic accuracy of the parameters to separate iron-deficiency anemia (IDA) from anemia of chronic disease. Materials and Methods. Iron status parameters and genetic analysis were performed in 126 ESRD patients and in 31 IDA patients as the control group. Results. ESRD patients had significantly higher ferritin and hepcidin-25 ( lt 0.001) relative to IDA patients. Cut-off values with the best diagnostic accuracy were found for hepcidin 9.32ng/mL, ferritin 48.2g/L, transferrin saturation 16.8%, and MCV 81fL. Interaction between gender and HFE haplotypes for the hepcidin-25 and ferritin levels in ESRD patients (p=0.005, partial eta squared=0.09; p=0.027, partial eta squared=0.06, respectively) was found. Serum transferrin was influenced by the combined effect of gender and TMPRSS6 A736V polymorphism in ESRD patients (p=0.002, partial eta squared=0.07). Conclusion. Our findings could contribute to the further investigation of mechanisms involved in the pathophysiology and important gender-related involvement of the TMPRSS6 and HFE polymorphisms on anemia in ESRD patients.",
publisher = "Hindawi Ltd, London",
journal = "Disease Markers",
title = "Associations of Common Variants in HFE and TMPRSS6 Genes with Hepcidin-25 and Iron Status Parameters in Patients with End-Stage Renal Disease",
doi = "10.1155/2019/4864370"
}

Dopsaj, V., Topić, A., Savković, M., Milinković, N., Novaković, I., Cujić, D.,& Simić-Ogrizović, S.. (2019). Associations of Common Variants in HFE and TMPRSS6 Genes with Hepcidin-25 and Iron Status Parameters in Patients with End-Stage Renal Disease. in Disease Markers
Hindawi Ltd, London..
https://doi.org/10.1155/2019/4864370

Dopsaj V, Topić A, Savković M, Milinković N, Novaković I, Cujić D, Simić-Ogrizović S. Associations of Common Variants in HFE and TMPRSS6 Genes with Hepcidin-25 and Iron Status Parameters in Patients with End-Stage Renal Disease. in Disease Markers. 2019;.
doi:10.1155/2019/4864370 .

Dopsaj, Violeta, Topić, Aleksandra, Savković, Miljan, Milinković, Neda, Novaković, Ivana, Cujić, Danica, Simić-Ogrizović, Sanja, "Associations of Common Variants in HFE and TMPRSS6 Genes with Hepcidin-25 and Iron Status Parameters in Patients with End-Stage Renal Disease" in Disease Markers (2019),
https://doi.org/10.1155/2019/4864370 . .

TY  - JOUR
AU  - Radović, Mina
AU  - Bojić, Suzana
AU  - Kotur-Stevuljević, Jelena
AU  - Lezaić, Višnja
AU  - Milicić, Biljana
AU  - Velinović, Miloš
AU  - Karan, Radmila
AU  - Simić-Ogrizović, Sanja
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3311
AB  - Background: Cardiac surgery-associated acute kidney injury (CSA-AKI) frequently occurs in patients assessed as low-risk for developing CSA-AKI. Neutrophil Gelatinase-Associated Lipocalin (NGAL), Kidney Injury Molecule-1 (KIM-1) and lactate are promising biomarkers of CSA-AKI but have not yet been explored in low-risk patients. Aim: To evaluate urinary NGAL (uNGAL), KIM-1 and lactate as biomarkers of CSA-AKI in patients with low-risk for developing CSA-AKI. Methods: This prospective, observational study included 100 adult elective cardiac surgery patients assessed as low-risk for developing CSA-AKI. UNGAL, KIM-1 and lactate were measured preoperatively, at the end of cardiopulmonary bypass (CPB) and 3, 12, 24 and 48 h later. Results: Fifteen patients developed CSA-AKI. Patients with CSA-AKI had significantly higher lactate but similar uNGAL and KIM-1 levels compared to patients without CSA-AKI. Unlike uNGAL and KIM-1, postoperative lactate was good biomarker of CSA-AKI with the highest odds ratio (OR) 2.7 [1.4-4.9] 24 h after CPB. Peak lactate concentration >= 4 mmol/L carried dramatically higher risk for developing CSA-AKI (OR 6.3 [1.9-20.5]). Conclusions: Unlike uNGAL and KIM-1, postoperative lactate was significant independent predictor of CSA-AKI with the highest odds ratio 24 h after CPB.
PB  - Društvo medicinskih biohemičara Srbije, Beograd i Versita
T2  - Journal of Medical Biochemistry
T1  - Serum lactate as reliable biomarker of acute kidney injury in low-risk cardiac surgery patients
VL  - 38
IS  - 2
SP  - 118
EP  - 125
DO  - 10.2478/jomb-2018-0018
ER  - 

@article{
author = "Radović, Mina and Bojić, Suzana and Kotur-Stevuljević, Jelena and Lezaić, Višnja and Milicić, Biljana and Velinović, Miloš and Karan, Radmila and Simić-Ogrizović, Sanja",
year = "2019",
abstract = "Background: Cardiac surgery-associated acute kidney injury (CSA-AKI) frequently occurs in patients assessed as low-risk for developing CSA-AKI. Neutrophil Gelatinase-Associated Lipocalin (NGAL), Kidney Injury Molecule-1 (KIM-1) and lactate are promising biomarkers of CSA-AKI but have not yet been explored in low-risk patients. Aim: To evaluate urinary NGAL (uNGAL), KIM-1 and lactate as biomarkers of CSA-AKI in patients with low-risk for developing CSA-AKI. Methods: This prospective, observational study included 100 adult elective cardiac surgery patients assessed as low-risk for developing CSA-AKI. UNGAL, KIM-1 and lactate were measured preoperatively, at the end of cardiopulmonary bypass (CPB) and 3, 12, 24 and 48 h later. Results: Fifteen patients developed CSA-AKI. Patients with CSA-AKI had significantly higher lactate but similar uNGAL and KIM-1 levels compared to patients without CSA-AKI. Unlike uNGAL and KIM-1, postoperative lactate was good biomarker of CSA-AKI with the highest odds ratio (OR) 2.7 [1.4-4.9] 24 h after CPB. Peak lactate concentration >= 4 mmol/L carried dramatically higher risk for developing CSA-AKI (OR 6.3 [1.9-20.5]). Conclusions: Unlike uNGAL and KIM-1, postoperative lactate was significant independent predictor of CSA-AKI with the highest odds ratio 24 h after CPB.",
publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita",
journal = "Journal of Medical Biochemistry",
title = "Serum lactate as reliable biomarker of acute kidney injury in low-risk cardiac surgery patients",
volume = "38",
number = "2",
pages = "118-125",
doi = "10.2478/jomb-2018-0018"
}

Radović, M., Bojić, S., Kotur-Stevuljević, J., Lezaić, V., Milicić, B., Velinović, M., Karan, R.,& Simić-Ogrizović, S.. (2019). Serum lactate as reliable biomarker of acute kidney injury in low-risk cardiac surgery patients. in Journal of Medical Biochemistry
Društvo medicinskih biohemičara Srbije, Beograd i Versita., 38(2), 118-125.
https://doi.org/10.2478/jomb-2018-0018

Radović M, Bojić S, Kotur-Stevuljević J, Lezaić V, Milicić B, Velinović M, Karan R, Simić-Ogrizović S. Serum lactate as reliable biomarker of acute kidney injury in low-risk cardiac surgery patients. in Journal of Medical Biochemistry. 2019;38(2):118-125.
doi:10.2478/jomb-2018-0018 .

Radović, Mina, Bojić, Suzana, Kotur-Stevuljević, Jelena, Lezaić, Višnja, Milicić, Biljana, Velinović, Miloš, Karan, Radmila, Simić-Ogrizović, Sanja, "Serum lactate as reliable biomarker of acute kidney injury in low-risk cardiac surgery patients" in Journal of Medical Biochemistry, 38, no. 2 (2019):118-125,
https://doi.org/10.2478/jomb-2018-0018 . .

TY  - JOUR
AU  - Ninić, Ana
AU  - Sopić, Miron
AU  - Munjas, Jelena
AU  - Spasojević-Kalimanovska, Vesna
AU  - Kotur-Stevuljević, Jelena
AU  - Bogavac-Stanojević, Nataša
AU  - Ivanišević, Jasmina
AU  - Simić-Ogrizović, Sanja
AU  - Kravljaca, Milica
AU  - Jelić-Ivanović, Zorana
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3060
AB  - Background: Chronic renal failure, particularly end-stage renal disease, is a serious health problem associated with a high mortality rate. Uremic syndrome leads to increased oxidative stress, inflammation, and dyslipidemia. Aims: To examine superoxide dismutase isoenzyme gene expression in peripheral blood mononuclear cells of patients on hemodialysis and to determine the associations between superoxide dismutase isoenzyme gene expression, oxidative stress, and non-enzymatic antioxidative protection. Study Design: Case control study. Methods: This study included 33 patients on hemodialysis (age, 55.33 +/- 15.31 years old) and 33 apparently healthy controls (age, 45.37 +/- 8.92 years old). Superoxide dismutase isoenzyme messenger ribonucleic acid levels were determined by real-time polymerase chain reaction. General biochemical parameters, high sensitivity C-reactive protein, total antioxidant status, thiobarbituric acid-reactive substances, and the superoxide anion radical were also determined. Results: Normalized Cu/Zn superoxide dismutase and Mn superoxide dismutase messenger ribonucleic acid levels were significantly higher in patients than controls (p lt 0.001 and p=0.011). A significant negative correlation was detected between normalized Cu/Zn superoxide dismutase messenger ribonucleic acid levels and total protein total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and total antioxidant status. Normalized Mn superoxide dismutase messenger ribonucleic acid levels were negatively correlated with total protein and total antioxidant status. A multiple regression analysis revealed independent associations between total antioxidant status and normalized Cu/Zn superoxide dismutase (p=0.038) and between total antioxidant status and normalized Mn superoxide dismutase messenger ribonucleic acid levels (p=0.038 and p=0.018, respectively). Conclusion: The superoxide dismutase isoenzyme gene is expressed at a higher rate in patients with end-stage renal failure, probably due to increased oxidative stress and attenuated antioxidative defense. The plasma total antioxidant status is an independent predictor of normalized superoxide dismutase isoenzyme messenger ribonucleic acid levels.
PB  - Galenos Yayincilik, Findikzade
T2  - Balkan Medical Journal
T1  - Association Between Superoxide Dismutase Isoenzyme Gene Expression and Total Antioxidant Status in Patients with an End-Stage Renal Disease
VL  - 35
IS  - 6
SP  - 431
EP  - 436
DO  - 10.4274/balkanmedj.2018.0170
ER  - 

@article{
author = "Ninić, Ana and Sopić, Miron and Munjas, Jelena and Spasojević-Kalimanovska, Vesna and Kotur-Stevuljević, Jelena and Bogavac-Stanojević, Nataša and Ivanišević, Jasmina and Simić-Ogrizović, Sanja and Kravljaca, Milica and Jelić-Ivanović, Zorana",
year = "2018",
abstract = "Background: Chronic renal failure, particularly end-stage renal disease, is a serious health problem associated with a high mortality rate. Uremic syndrome leads to increased oxidative stress, inflammation, and dyslipidemia. Aims: To examine superoxide dismutase isoenzyme gene expression in peripheral blood mononuclear cells of patients on hemodialysis and to determine the associations between superoxide dismutase isoenzyme gene expression, oxidative stress, and non-enzymatic antioxidative protection. Study Design: Case control study. Methods: This study included 33 patients on hemodialysis (age, 55.33 +/- 15.31 years old) and 33 apparently healthy controls (age, 45.37 +/- 8.92 years old). Superoxide dismutase isoenzyme messenger ribonucleic acid levels were determined by real-time polymerase chain reaction. General biochemical parameters, high sensitivity C-reactive protein, total antioxidant status, thiobarbituric acid-reactive substances, and the superoxide anion radical were also determined. Results: Normalized Cu/Zn superoxide dismutase and Mn superoxide dismutase messenger ribonucleic acid levels were significantly higher in patients than controls (p lt 0.001 and p=0.011). A significant negative correlation was detected between normalized Cu/Zn superoxide dismutase messenger ribonucleic acid levels and total protein total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and total antioxidant status. Normalized Mn superoxide dismutase messenger ribonucleic acid levels were negatively correlated with total protein and total antioxidant status. A multiple regression analysis revealed independent associations between total antioxidant status and normalized Cu/Zn superoxide dismutase (p=0.038) and between total antioxidant status and normalized Mn superoxide dismutase messenger ribonucleic acid levels (p=0.038 and p=0.018, respectively). Conclusion: The superoxide dismutase isoenzyme gene is expressed at a higher rate in patients with end-stage renal failure, probably due to increased oxidative stress and attenuated antioxidative defense. The plasma total antioxidant status is an independent predictor of normalized superoxide dismutase isoenzyme messenger ribonucleic acid levels.",
publisher = "Galenos Yayincilik, Findikzade",
journal = "Balkan Medical Journal",
title = "Association Between Superoxide Dismutase Isoenzyme Gene Expression and Total Antioxidant Status in Patients with an End-Stage Renal Disease",
volume = "35",
number = "6",
pages = "431-436",
doi = "10.4274/balkanmedj.2018.0170"
}

Ninić, A., Sopić, M., Munjas, J., Spasojević-Kalimanovska, V., Kotur-Stevuljević, J., Bogavac-Stanojević, N., Ivanišević, J., Simić-Ogrizović, S., Kravljaca, M.,& Jelić-Ivanović, Z.. (2018). Association Between Superoxide Dismutase Isoenzyme Gene Expression and Total Antioxidant Status in Patients with an End-Stage Renal Disease. in Balkan Medical Journal
Galenos Yayincilik, Findikzade., 35(6), 431-436.
https://doi.org/10.4274/balkanmedj.2018.0170

Ninić A, Sopić M, Munjas J, Spasojević-Kalimanovska V, Kotur-Stevuljević J, Bogavac-Stanojević N, Ivanišević J, Simić-Ogrizović S, Kravljaca M, Jelić-Ivanović Z. Association Between Superoxide Dismutase Isoenzyme Gene Expression and Total Antioxidant Status in Patients with an End-Stage Renal Disease. in Balkan Medical Journal. 2018;35(6):431-436.
doi:10.4274/balkanmedj.2018.0170 .

Ninić, Ana, Sopić, Miron, Munjas, Jelena, Spasojević-Kalimanovska, Vesna, Kotur-Stevuljević, Jelena, Bogavac-Stanojević, Nataša, Ivanišević, Jasmina, Simić-Ogrizović, Sanja, Kravljaca, Milica, Jelić-Ivanović, Zorana, "Association Between Superoxide Dismutase Isoenzyme Gene Expression and Total Antioxidant Status in Patients with an End-Stage Renal Disease" in Balkan Medical Journal, 35, no. 6 (2018):431-436,
https://doi.org/10.4274/balkanmedj.2018.0170 . .

TY  - JOUR
AU  - Miljković, Milica
AU  - Stefanović, Aleksandra
AU  - Simić-Ogrizović, Sanja
AU  - Vekić, Jelena
AU  - Bogavac-Stanojević, Nataša
AU  - Cerne, Darko
AU  - Kocbek, Petra
AU  - Marc, Janja
AU  - Jelić-Ivanović, Zorana
AU  - Spasojević-Kalimanovska, Vesna
AU  - Kotur-Stevuljević, Jelena
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3085
AB  - Some cardiovascular complications in patients with chronic kidney disease and end-stage renal disease may be caused by structurally and functionally modified lipoproteins. Redox status (advanced oxidation protein products [AOPPs]), prooxidant-antioxidant balance, total protein sulfhydryl (SH-groups), and paraoxonase 1 (PON1) activity were assessed in 77 renal patients and 20 controls. Lipoproteins were isolated using ultracentrifugation. PON1, PON3, and pentraxin-3 concentration were determined by enzyme-linked immunosorbent assay (ELISA). Dyslipidemia-Oxy-Inflammation (DOI) score was calculated as a sum of dyslipidemia, oxidative stress, and inflammation scores. The dyslipidemia score (P  lt  .001), oxy score (P  lt  .01), inflammation score (P  lt  .001), and the DOI score (P  lt  .001) were higher in patient groups compared with controls. The very-low-density lipoprotein (VLDL) fraction contained the highest amount of AOPP (P  lt  .001) compared with other lipoprotein fractions in all groups. The low-density lipoprotein (LDL) fraction contained elevated AOPP in all groups compared with the high-density lipoprotein (HDL) fraction (P  lt  .001). Significant positive correlation was observed between AOPP in LDL fraction and DOI score (rho = 0.510, P  lt  .01). Dyslipidemia, oxidative stress, and inflammation play an interactive role in renal disease and are mutually associated with redox status in VLDL, LDL, and HDL lipoproteins in plasma of renal patients.
PB  - Sage Publications Inc, Thousand Oaks
T2  - Angiology
T1  - Association of Dyslipidemia, Oxidative Stress, and Inflammation With Redox Status in VLDL, LDL, and HDL Lipoproteins in Patients With Renal Disease
VL  - 69
IS  - 10
SP  - 861
EP  - 870
DO  - 10.1177/0003319718780041
ER  - 

@article{
author = "Miljković, Milica and Stefanović, Aleksandra and Simić-Ogrizović, Sanja and Vekić, Jelena and Bogavac-Stanojević, Nataša and Cerne, Darko and Kocbek, Petra and Marc, Janja and Jelić-Ivanović, Zorana and Spasojević-Kalimanovska, Vesna and Kotur-Stevuljević, Jelena",
year = "2018",
abstract = "Some cardiovascular complications in patients with chronic kidney disease and end-stage renal disease may be caused by structurally and functionally modified lipoproteins. Redox status (advanced oxidation protein products [AOPPs]), prooxidant-antioxidant balance, total protein sulfhydryl (SH-groups), and paraoxonase 1 (PON1) activity were assessed in 77 renal patients and 20 controls. Lipoproteins were isolated using ultracentrifugation. PON1, PON3, and pentraxin-3 concentration were determined by enzyme-linked immunosorbent assay (ELISA). Dyslipidemia-Oxy-Inflammation (DOI) score was calculated as a sum of dyslipidemia, oxidative stress, and inflammation scores. The dyslipidemia score (P  lt  .001), oxy score (P  lt  .01), inflammation score (P  lt  .001), and the DOI score (P  lt  .001) were higher in patient groups compared with controls. The very-low-density lipoprotein (VLDL) fraction contained the highest amount of AOPP (P  lt  .001) compared with other lipoprotein fractions in all groups. The low-density lipoprotein (LDL) fraction contained elevated AOPP in all groups compared with the high-density lipoprotein (HDL) fraction (P  lt  .001). Significant positive correlation was observed between AOPP in LDL fraction and DOI score (rho = 0.510, P  lt  .01). Dyslipidemia, oxidative stress, and inflammation play an interactive role in renal disease and are mutually associated with redox status in VLDL, LDL, and HDL lipoproteins in plasma of renal patients.",
publisher = "Sage Publications Inc, Thousand Oaks",
journal = "Angiology",
title = "Association of Dyslipidemia, Oxidative Stress, and Inflammation With Redox Status in VLDL, LDL, and HDL Lipoproteins in Patients With Renal Disease",
volume = "69",
number = "10",
pages = "861-870",
doi = "10.1177/0003319718780041"
}

Miljković, M., Stefanović, A., Simić-Ogrizović, S., Vekić, J., Bogavac-Stanojević, N., Cerne, D., Kocbek, P., Marc, J., Jelić-Ivanović, Z., Spasojević-Kalimanovska, V.,& Kotur-Stevuljević, J.. (2018). Association of Dyslipidemia, Oxidative Stress, and Inflammation With Redox Status in VLDL, LDL, and HDL Lipoproteins in Patients With Renal Disease. in Angiology
Sage Publications Inc, Thousand Oaks., 69(10), 861-870.
https://doi.org/10.1177/0003319718780041

Miljković M, Stefanović A, Simić-Ogrizović S, Vekić J, Bogavac-Stanojević N, Cerne D, Kocbek P, Marc J, Jelić-Ivanović Z, Spasojević-Kalimanovska V, Kotur-Stevuljević J. Association of Dyslipidemia, Oxidative Stress, and Inflammation With Redox Status in VLDL, LDL, and HDL Lipoproteins in Patients With Renal Disease. in Angiology. 2018;69(10):861-870.
doi:10.1177/0003319718780041 .

Miljković, Milica, Stefanović, Aleksandra, Simić-Ogrizović, Sanja, Vekić, Jelena, Bogavac-Stanojević, Nataša, Cerne, Darko, Kocbek, Petra, Marc, Janja, Jelić-Ivanović, Zorana, Spasojević-Kalimanovska, Vesna, Kotur-Stevuljević, Jelena, "Association of Dyslipidemia, Oxidative Stress, and Inflammation With Redox Status in VLDL, LDL, and HDL Lipoproteins in Patients With Renal Disease" in Angiology, 69, no. 10 (2018):861-870,
https://doi.org/10.1177/0003319718780041 . .

TY  - JOUR
AU  - Miljković, Milica
AU  - Stefanović, Aleksandra
AU  - Vekić, Jelena
AU  - Zeljković, Aleksandra
AU  - Gojković, Tamara
AU  - Simić-Ogrizović, Sanja
AU  - Bogavac-Stanojević, Nataša
AU  - Cerne, Darko
AU  - Ilić, Jasmina
AU  - Stefanović, Ivan
AU  - Jelić-Ivanović, Zorana
AU  - Spasojević-Kalimanovska, Vesna
AU  - Kotur-Stevuljević, Jelena
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3067
AB  - Introduction: Cardiovascular complications, as the main cause of mortality in renal patients, are followed with altered lipoproteins composition. Considering that paraoxonase-1 (PON1) is an anti-oxidative enzyme located mainly on HDL particles, the current study has aim to investigate whether failure of kidney function leads to changes in the distribution of PON1 activity between different HDL subclasses. Materials and methods: In 77 renal patients (21 chronic kidney disease (CKD) and 56 end stage renal disease (ESRD) patients on dialysis) and 20 healthy subjects PON1 activity on HDL2 and HDL3 subclasses was determined by zymogram method that combines gradient gel electrophoresis separation of HDL subclasses and measurement of PON1 activity in the same gel. Results: Serum paraoxonase (p  lt  0.01) and arylesterase activity (p  lt  0.001) of PON1 as well as its concentration (p  lt  0.01) were significantly lower in CKD and ESRD patients compared to controls. Relative proportion of HDL3 subclasses was higher in ESRD patients than in healthy participants, while HDL2 subclasses was significantly decreased in CKD (p  lt  0.05) and ESRD (p  lt  0.001) patients, as compared to controls. Furthermore, control subjects had higher PON1 activity on HDL2 (CKD and ESRD patients p  lt  0.001) and HDL3 (CKD p  lt  0.05; ESRD patients p  lt  0.001) subclasses in comparison with the both patients groups. Also, significant negative correlation was found between paraoxonase activity of PON1 in serum and creatinine concentration (rho = -0.373, p  lt  0.01). Conclusions: This study showed that altered HDL subclasses distribution, changed PON1 activities on different HDL subclasses as well as diminished anti-oxidative protection could be important factors in atherosclerosis development in CKD and ESRD patients.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Clinical Biochemistry
T1  - Activity of paraoxonase 1 (PON1) on HDL2 and HDL3 subclasses in renal disease
VL  - 60
SP  - 52
EP  - 58
DO  - 10.1016/j.clinbiochem.2018.08.006
ER  - 

@article{
author = "Miljković, Milica and Stefanović, Aleksandra and Vekić, Jelena and Zeljković, Aleksandra and Gojković, Tamara and Simić-Ogrizović, Sanja and Bogavac-Stanojević, Nataša and Cerne, Darko and Ilić, Jasmina and Stefanović, Ivan and Jelić-Ivanović, Zorana and Spasojević-Kalimanovska, Vesna and Kotur-Stevuljević, Jelena",
year = "2018",
abstract = "Introduction: Cardiovascular complications, as the main cause of mortality in renal patients, are followed with altered lipoproteins composition. Considering that paraoxonase-1 (PON1) is an anti-oxidative enzyme located mainly on HDL particles, the current study has aim to investigate whether failure of kidney function leads to changes in the distribution of PON1 activity between different HDL subclasses. Materials and methods: In 77 renal patients (21 chronic kidney disease (CKD) and 56 end stage renal disease (ESRD) patients on dialysis) and 20 healthy subjects PON1 activity on HDL2 and HDL3 subclasses was determined by zymogram method that combines gradient gel electrophoresis separation of HDL subclasses and measurement of PON1 activity in the same gel. Results: Serum paraoxonase (p  lt  0.01) and arylesterase activity (p  lt  0.001) of PON1 as well as its concentration (p  lt  0.01) were significantly lower in CKD and ESRD patients compared to controls. Relative proportion of HDL3 subclasses was higher in ESRD patients than in healthy participants, while HDL2 subclasses was significantly decreased in CKD (p  lt  0.05) and ESRD (p  lt  0.001) patients, as compared to controls. Furthermore, control subjects had higher PON1 activity on HDL2 (CKD and ESRD patients p  lt  0.001) and HDL3 (CKD p  lt  0.05; ESRD patients p  lt  0.001) subclasses in comparison with the both patients groups. Also, significant negative correlation was found between paraoxonase activity of PON1 in serum and creatinine concentration (rho = -0.373, p  lt  0.01). Conclusions: This study showed that altered HDL subclasses distribution, changed PON1 activities on different HDL subclasses as well as diminished anti-oxidative protection could be important factors in atherosclerosis development in CKD and ESRD patients.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Clinical Biochemistry",
title = "Activity of paraoxonase 1 (PON1) on HDL2 and HDL3 subclasses in renal disease",
volume = "60",
pages = "52-58",
doi = "10.1016/j.clinbiochem.2018.08.006"
}

Miljković, M., Stefanović, A., Vekić, J., Zeljković, A., Gojković, T., Simić-Ogrizović, S., Bogavac-Stanojević, N., Cerne, D., Ilić, J., Stefanović, I., Jelić-Ivanović, Z., Spasojević-Kalimanovska, V.,& Kotur-Stevuljević, J.. (2018). Activity of paraoxonase 1 (PON1) on HDL2 and HDL3 subclasses in renal disease. in Clinical Biochemistry
Pergamon-Elsevier Science Ltd, Oxford., 60, 52-58.
https://doi.org/10.1016/j.clinbiochem.2018.08.006

Miljković M, Stefanović A, Vekić J, Zeljković A, Gojković T, Simić-Ogrizović S, Bogavac-Stanojević N, Cerne D, Ilić J, Stefanović I, Jelić-Ivanović Z, Spasojević-Kalimanovska V, Kotur-Stevuljević J. Activity of paraoxonase 1 (PON1) on HDL2 and HDL3 subclasses in renal disease. in Clinical Biochemistry. 2018;60:52-58.
doi:10.1016/j.clinbiochem.2018.08.006 .

Miljković, Milica, Stefanović, Aleksandra, Vekić, Jelena, Zeljković, Aleksandra, Gojković, Tamara, Simić-Ogrizović, Sanja, Bogavac-Stanojević, Nataša, Cerne, Darko, Ilić, Jasmina, Stefanović, Ivan, Jelić-Ivanović, Zorana, Spasojević-Kalimanovska, Vesna, Kotur-Stevuljević, Jelena, "Activity of paraoxonase 1 (PON1) on HDL2 and HDL3 subclasses in renal disease" in Clinical Biochemistry, 60 (2018):52-58,
https://doi.org/10.1016/j.clinbiochem.2018.08.006 . .

TY  - JOUR
AU  - Bojić, Suzana
AU  - Kotur-Stevuljević, Jelena
AU  - Aleksić, Aleksandra
AU  - Gacić, Jasna
AU  - Memon, Lidija
AU  - Simić-Ogrizović, Sanja
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3166
AB  - Background. The role of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in sepsis after major abdominal surgery and sepsis-associated organ dysfunction is unexplored. Materials and Methods. Fifty-three patients with sepsis after major abdominal surgery were compared to 50 operated and 50 nonoperated controls. MMP-9, TIMP-1, biomarkers of inflammation, kidney and liver injury, coagulation, and metabolic disorders were measured daily during 96 h following diagnosis of sepsis and once in controls. MMP-9/TIMP-1 ratios and disease severity scores were calculated. Use of vasopressors/inotropes, mechanical ventilation, and survival were recorded. Results. Septic patients had lower MMP-9 and MMP-9/TIMP-1 ratios but higher TIMP-1 levels compared to controls. AUC-ROC for diagnosis of sepsis was 0.940 and 0.854 for TIMP-1 and 0.924 and 0.788 for MMP-9/TIMP-1 ratio (sepsis versus nonoperated and sepsis versus operated controls, resp.). Lower MMP-9 and MMP-9/TIMP-1 ratio and higher TIMP-1 levels were associated with shorter survival. MMP-9, TIMP-1, and MMP-9/TIMP-1 ratio correlated with biomarkers of inflammation, kidney and liver injury, coagulation, metabolic disorders, and disease severity scores. Use of vasopressors/inotropes was associated with higher TIMP-1 levels. Conclusions. MMP-9, TIMP-1, and MMP-9/TIMP ratio were good diagnostic or prognostic biomarkers of sepsis after major abdominal surgery and were linked to sepsis-associated organ dysfunction.
PB  - Hindawi Ltd, London
T2  - Disease Markers
T1  - Matrix Metalloproteinase-9 and Tissue Inhibitor of Matrix Metalloproteinase-1 in Sepsis after Major Abdominal Surgery
DO  - 10.1155/2018/5064684
ER  - 

@article{
author = "Bojić, Suzana and Kotur-Stevuljević, Jelena and Aleksić, Aleksandra and Gacić, Jasna and Memon, Lidija and Simić-Ogrizović, Sanja",
year = "2018",
abstract = "Background. The role of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in sepsis after major abdominal surgery and sepsis-associated organ dysfunction is unexplored. Materials and Methods. Fifty-three patients with sepsis after major abdominal surgery were compared to 50 operated and 50 nonoperated controls. MMP-9, TIMP-1, biomarkers of inflammation, kidney and liver injury, coagulation, and metabolic disorders were measured daily during 96 h following diagnosis of sepsis and once in controls. MMP-9/TIMP-1 ratios and disease severity scores were calculated. Use of vasopressors/inotropes, mechanical ventilation, and survival were recorded. Results. Septic patients had lower MMP-9 and MMP-9/TIMP-1 ratios but higher TIMP-1 levels compared to controls. AUC-ROC for diagnosis of sepsis was 0.940 and 0.854 for TIMP-1 and 0.924 and 0.788 for MMP-9/TIMP-1 ratio (sepsis versus nonoperated and sepsis versus operated controls, resp.). Lower MMP-9 and MMP-9/TIMP-1 ratio and higher TIMP-1 levels were associated with shorter survival. MMP-9, TIMP-1, and MMP-9/TIMP-1 ratio correlated with biomarkers of inflammation, kidney and liver injury, coagulation, metabolic disorders, and disease severity scores. Use of vasopressors/inotropes was associated with higher TIMP-1 levels. Conclusions. MMP-9, TIMP-1, and MMP-9/TIMP ratio were good diagnostic or prognostic biomarkers of sepsis after major abdominal surgery and were linked to sepsis-associated organ dysfunction.",
publisher = "Hindawi Ltd, London",
journal = "Disease Markers",
title = "Matrix Metalloproteinase-9 and Tissue Inhibitor of Matrix Metalloproteinase-1 in Sepsis after Major Abdominal Surgery",
doi = "10.1155/2018/5064684"
}

Bojić, S., Kotur-Stevuljević, J., Aleksić, A., Gacić, J., Memon, L.,& Simić-Ogrizović, S.. (2018). Matrix Metalloproteinase-9 and Tissue Inhibitor of Matrix Metalloproteinase-1 in Sepsis after Major Abdominal Surgery. in Disease Markers
Hindawi Ltd, London..
https://doi.org/10.1155/2018/5064684

Bojić S, Kotur-Stevuljević J, Aleksić A, Gacić J, Memon L, Simić-Ogrizović S. Matrix Metalloproteinase-9 and Tissue Inhibitor of Matrix Metalloproteinase-1 in Sepsis after Major Abdominal Surgery. in Disease Markers. 2018;.
doi:10.1155/2018/5064684 .

Bojić, Suzana, Kotur-Stevuljević, Jelena, Aleksić, Aleksandra, Gacić, Jasna, Memon, Lidija, Simić-Ogrizović, Sanja, "Matrix Metalloproteinase-9 and Tissue Inhibitor of Matrix Metalloproteinase-1 in Sepsis after Major Abdominal Surgery" in Disease Markers (2018),
https://doi.org/10.1155/2018/5064684 . .

TY  - CONF
AU  - Munjas, Jelena
AU  - Sopić, Miron
AU  - Spasojević-Kalimanovska, Vesna
AU  - Bogavac-Stanojević, Nataša
AU  - Simić-Ogrizović, Sanja
AU  - Kravljaca, Milica
AU  - Jelić-Ivanović, Zorana
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2927
PB  - Elsevier Ireland Ltd, Clare
C3  - Atherosclerosis
T1  - Association of peripheral blood mononuclear cells adenylate cyclase-associated protein 1 mRNA with chronic kidney disease
VL  - 263
SP  - e198
EP  - e198
DO  - 10.1016/j.atherosclerosis.2017.06.636
ER  - 

@conference{
author = "Munjas, Jelena and Sopić, Miron and Spasojević-Kalimanovska, Vesna and Bogavac-Stanojević, Nataša and Simić-Ogrizović, Sanja and Kravljaca, Milica and Jelić-Ivanović, Zorana",
year = "2017",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Atherosclerosis",
title = "Association of peripheral blood mononuclear cells adenylate cyclase-associated protein 1 mRNA with chronic kidney disease",
volume = "263",
pages = "e198-e198",
doi = "10.1016/j.atherosclerosis.2017.06.636"
}

Munjas, J., Sopić, M., Spasojević-Kalimanovska, V., Bogavac-Stanojević, N., Simić-Ogrizović, S., Kravljaca, M.,& Jelić-Ivanović, Z.. (2017). Association of peripheral blood mononuclear cells adenylate cyclase-associated protein 1 mRNA with chronic kidney disease. in Atherosclerosis
Elsevier Ireland Ltd, Clare., 263, e198-e198.
https://doi.org/10.1016/j.atherosclerosis.2017.06.636

Munjas J, Sopić M, Spasojević-Kalimanovska V, Bogavac-Stanojević N, Simić-Ogrizović S, Kravljaca M, Jelić-Ivanović Z. Association of peripheral blood mononuclear cells adenylate cyclase-associated protein 1 mRNA with chronic kidney disease. in Atherosclerosis. 2017;263:e198-e198.
doi:10.1016/j.atherosclerosis.2017.06.636 .

Munjas, Jelena, Sopić, Miron, Spasojević-Kalimanovska, Vesna, Bogavac-Stanojević, Nataša, Simić-Ogrizović, Sanja, Kravljaca, Milica, Jelić-Ivanović, Zorana, "Association of peripheral blood mononuclear cells adenylate cyclase-associated protein 1 mRNA with chronic kidney disease" in Atherosclerosis, 263 (2017):e198-e198,
https://doi.org/10.1016/j.atherosclerosis.2017.06.636 . .

TY  - CONF
AU  - Jordanova, Elena
AU  - Simić-Ogrizović, Sanja
AU  - Samardžić, Vladimir
AU  - Dopsaj, Violeta
AU  - Bokan, Ljiljana
AU  - Peruničič-Peković, Gordana
AU  - Tica-Jeftić, Jelena
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2931
PB  - Oxford Univ Press, Oxford
C3  - Nephrology Dialysis Transplantation
T1  - Is there any importance to determine of uromodulin serum concentration in patients with long term diabetes mellitus type 2
VL  - 32
IS  - Supplement 3
SP  - iii545
EP  - iii545
DO  - 10.1093/ndt/gfx168.MP325
ER  - 

@conference{
author = "Jordanova, Elena and Simić-Ogrizović, Sanja and Samardžić, Vladimir and Dopsaj, Violeta and Bokan, Ljiljana and Peruničič-Peković, Gordana and Tica-Jeftić, Jelena",
year = "2017",
publisher = "Oxford Univ Press, Oxford",
journal = "Nephrology Dialysis Transplantation",
title = "Is there any importance to determine of uromodulin serum concentration in patients with long term diabetes mellitus type 2",
volume = "32",
number = "Supplement 3",
pages = "iii545-iii545",
doi = "10.1093/ndt/gfx168.MP325"
}

Jordanova, E., Simić-Ogrizović, S., Samardžić, V., Dopsaj, V., Bokan, L., Peruničič-Peković, G.,& Tica-Jeftić, J.. (2017). Is there any importance to determine of uromodulin serum concentration in patients with long term diabetes mellitus type 2. in Nephrology Dialysis Transplantation
Oxford Univ Press, Oxford., 32(Supplement 3), iii545-iii545.
https://doi.org/10.1093/ndt/gfx168.MP325

Jordanova E, Simić-Ogrizović S, Samardžić V, Dopsaj V, Bokan L, Peruničič-Peković G, Tica-Jeftić J. Is there any importance to determine of uromodulin serum concentration in patients with long term diabetes mellitus type 2. in Nephrology Dialysis Transplantation. 2017;32(Supplement 3):iii545-iii545.
doi:10.1093/ndt/gfx168.MP325 .

Jordanova, Elena, Simić-Ogrizović, Sanja, Samardžić, Vladimir, Dopsaj, Violeta, Bokan, Ljiljana, Peruničič-Peković, Gordana, Tica-Jeftić, Jelena, "Is there any importance to determine of uromodulin serum concentration in patients with long term diabetes mellitus type 2" in Nephrology Dialysis Transplantation, 32, no. Supplement 3 (2017):iii545-iii545,
https://doi.org/10.1093/ndt/gfx168.MP325 . .

TY  - CONF
AU  - Miljković, Milica
AU  - Kotur-Stevuljević, Jelena
AU  - Stefanović, Aleksandra
AU  - Simić-Ogrizović, Sanja
AU  - Bogavac-Stanojević, Nataša
AU  - Cerne, Darko
AU  - Jelić-Ivanović, Zorana
AU  - Spasojević-Kalimanovska, Vesna
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2928
PB  - Elsevier Ireland Ltd, Clare
C3  - Atherosclerosis
T1  - Advanced oxidation protein products (AOPPs) in lipoprotein subfractions in patients with different stages of renal disease
VL  - 263
SP  - e190
EP  - e190
DO  - 10.1016/j.atherosclerosis.2017.06.609
ER  - 

@conference{
author = "Miljković, Milica and Kotur-Stevuljević, Jelena and Stefanović, Aleksandra and Simić-Ogrizović, Sanja and Bogavac-Stanojević, Nataša and Cerne, Darko and Jelić-Ivanović, Zorana and Spasojević-Kalimanovska, Vesna",
year = "2017",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Atherosclerosis",
title = "Advanced oxidation protein products (AOPPs) in lipoprotein subfractions in patients with different stages of renal disease",
volume = "263",
pages = "e190-e190",
doi = "10.1016/j.atherosclerosis.2017.06.609"
}

Miljković, M., Kotur-Stevuljević, J., Stefanović, A., Simić-Ogrizović, S., Bogavac-Stanojević, N., Cerne, D., Jelić-Ivanović, Z.,& Spasojević-Kalimanovska, V.. (2017). Advanced oxidation protein products (AOPPs) in lipoprotein subfractions in patients with different stages of renal disease. in Atherosclerosis
Elsevier Ireland Ltd, Clare., 263, e190-e190.
https://doi.org/10.1016/j.atherosclerosis.2017.06.609

Miljković M, Kotur-Stevuljević J, Stefanović A, Simić-Ogrizović S, Bogavac-Stanojević N, Cerne D, Jelić-Ivanović Z, Spasojević-Kalimanovska V. Advanced oxidation protein products (AOPPs) in lipoprotein subfractions in patients with different stages of renal disease. in Atherosclerosis. 2017;263:e190-e190.
doi:10.1016/j.atherosclerosis.2017.06.609 .

Miljković, Milica, Kotur-Stevuljević, Jelena, Stefanović, Aleksandra, Simić-Ogrizović, Sanja, Bogavac-Stanojević, Nataša, Cerne, Darko, Jelić-Ivanović, Zorana, Spasojević-Kalimanovska, Vesna, "Advanced oxidation protein products (AOPPs) in lipoprotein subfractions in patients with different stages of renal disease" in Atherosclerosis, 263 (2017):e190-e190,
https://doi.org/10.1016/j.atherosclerosis.2017.06.609 . .

TY  - JOUR
AU  - Miljković, Milica
AU  - Stefanović, Aleksandra
AU  - Bogavac-Stanojević, Nataša
AU  - Simić-Ogrizović, Sanja
AU  - Dumić, Jerka
AU  - Cerne, Darko
AU  - Jelić-Ivanović, Zorana
AU  - Kotur-Stevuljević, Jelena
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2886
AB  - Inflammation, apoptosis and extracellular remodeling play significant roles in cardiovascular disease (CVD) underlying the major causes of mortality in renal patients. In 19 pre-dialysis patients, 21 dialysis patients and 20 control subjects, the concentrations of pentraxin-3, galectin-3, MMP-9 and TIMP-1 were determined by ELISA. CVD risk was calculated according to the Framingham risk score algorithm. Pentraxin-3 was increased in renal patients compared to healthy controls (p lt 0.001). In contrast, galectin-3 was reduced in hemodialysis patients compared to pre-dialysis patients and controls (p lt 0.001). In addition, MMP-9 and TIMP-1 were elevated in renal patients compared to controls (p lt 0.01 and p lt 0.001, respectively). Logistic regression analyses disclosed associations of galectin-3, MMP-9, pentraxin-3 and glomerular filtration with calculated CVD risk score. Combined testing of pentraxin-3, galectin-3, MMP-9 and glomerular filtration rate can discriminate renal patients with high and low risk of a coronary event.
PB  - Sestre Milosrdnice Univ Hospital, Zagreb
T2  - Acta Clinica Croatica
T1  - Association of pentraxin-3, galectin-3 and matrix metalloproteinase-9/TIMP-1 with cardiovascular risk in renal disease patients
VL  - 56
IS  - 4
SP  - 673
EP  - 680
DO  - 10.20471/acc.2017.56.04.14
ER  - 

@article{
author = "Miljković, Milica and Stefanović, Aleksandra and Bogavac-Stanojević, Nataša and Simić-Ogrizović, Sanja and Dumić, Jerka and Cerne, Darko and Jelić-Ivanović, Zorana and Kotur-Stevuljević, Jelena",
year = "2017",
abstract = "Inflammation, apoptosis and extracellular remodeling play significant roles in cardiovascular disease (CVD) underlying the major causes of mortality in renal patients. In 19 pre-dialysis patients, 21 dialysis patients and 20 control subjects, the concentrations of pentraxin-3, galectin-3, MMP-9 and TIMP-1 were determined by ELISA. CVD risk was calculated according to the Framingham risk score algorithm. Pentraxin-3 was increased in renal patients compared to healthy controls (p lt 0.001). In contrast, galectin-3 was reduced in hemodialysis patients compared to pre-dialysis patients and controls (p lt 0.001). In addition, MMP-9 and TIMP-1 were elevated in renal patients compared to controls (p lt 0.01 and p lt 0.001, respectively). Logistic regression analyses disclosed associations of galectin-3, MMP-9, pentraxin-3 and glomerular filtration with calculated CVD risk score. Combined testing of pentraxin-3, galectin-3, MMP-9 and glomerular filtration rate can discriminate renal patients with high and low risk of a coronary event.",
publisher = "Sestre Milosrdnice Univ Hospital, Zagreb",
journal = "Acta Clinica Croatica",
title = "Association of pentraxin-3, galectin-3 and matrix metalloproteinase-9/TIMP-1 with cardiovascular risk in renal disease patients",
volume = "56",
number = "4",
pages = "673-680",
doi = "10.20471/acc.2017.56.04.14"
}

Miljković, M., Stefanović, A., Bogavac-Stanojević, N., Simić-Ogrizović, S., Dumić, J., Cerne, D., Jelić-Ivanović, Z.,& Kotur-Stevuljević, J.. (2017). Association of pentraxin-3, galectin-3 and matrix metalloproteinase-9/TIMP-1 with cardiovascular risk in renal disease patients. in Acta Clinica Croatica
Sestre Milosrdnice Univ Hospital, Zagreb., 56(4), 673-680.
https://doi.org/10.20471/acc.2017.56.04.14

Miljković M, Stefanović A, Bogavac-Stanojević N, Simić-Ogrizović S, Dumić J, Cerne D, Jelić-Ivanović Z, Kotur-Stevuljević J. Association of pentraxin-3, galectin-3 and matrix metalloproteinase-9/TIMP-1 with cardiovascular risk in renal disease patients. in Acta Clinica Croatica. 2017;56(4):673-680.
doi:10.20471/acc.2017.56.04.14 .

Miljković, Milica, Stefanović, Aleksandra, Bogavac-Stanojević, Nataša, Simić-Ogrizović, Sanja, Dumić, Jerka, Cerne, Darko, Jelić-Ivanović, Zorana, Kotur-Stevuljević, Jelena, "Association of pentraxin-3, galectin-3 and matrix metalloproteinase-9/TIMP-1 with cardiovascular risk in renal disease patients" in Acta Clinica Croatica, 56, no. 4 (2017):673-680,
https://doi.org/10.20471/acc.2017.56.04.14 . .

TY  - CONF
AU  - Miljković, Milica
AU  - Kotur-Stevuljević, Jelena
AU  - Stefanović, Aleksandra
AU  - Vekić, Jelena
AU  - Zeljković, Aleksandra
AU  - Gojković, Tamara
AU  - Simić-Ogrizović, Sanja
AU  - Spasojević-Kalimanovska, Vesna
AU  - Jelić-Ivanović, Zorana
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2615
PB  - Elsevier Ireland Ltd, Clare
C3  - Atherosclerosis
T1  - Renal disease is associated with modified PON1 distribution at HDL subclasses
VL  - 252
SP  - e224
EP  - e224
DO  - 10.1016/j.atherosclerosis.2016.07.195
ER  - 

@conference{
author = "Miljković, Milica and Kotur-Stevuljević, Jelena and Stefanović, Aleksandra and Vekić, Jelena and Zeljković, Aleksandra and Gojković, Tamara and Simić-Ogrizović, Sanja and Spasojević-Kalimanovska, Vesna and Jelić-Ivanović, Zorana",
year = "2016",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Atherosclerosis",
title = "Renal disease is associated with modified PON1 distribution at HDL subclasses",
volume = "252",
pages = "e224-e224",
doi = "10.1016/j.atherosclerosis.2016.07.195"
}

Miljković, M., Kotur-Stevuljević, J., Stefanović, A., Vekić, J., Zeljković, A., Gojković, T., Simić-Ogrizović, S., Spasojević-Kalimanovska, V.,& Jelić-Ivanović, Z.. (2016). Renal disease is associated with modified PON1 distribution at HDL subclasses. in Atherosclerosis
Elsevier Ireland Ltd, Clare., 252, e224-e224.
https://doi.org/10.1016/j.atherosclerosis.2016.07.195

Miljković M, Kotur-Stevuljević J, Stefanović A, Vekić J, Zeljković A, Gojković T, Simić-Ogrizović S, Spasojević-Kalimanovska V, Jelić-Ivanović Z. Renal disease is associated with modified PON1 distribution at HDL subclasses. in Atherosclerosis. 2016;252:e224-e224.
doi:10.1016/j.atherosclerosis.2016.07.195 .

Miljković, Milica, Kotur-Stevuljević, Jelena, Stefanović, Aleksandra, Vekić, Jelena, Zeljković, Aleksandra, Gojković, Tamara, Simić-Ogrizović, Sanja, Spasojević-Kalimanovska, Vesna, Jelić-Ivanović, Zorana, "Renal disease is associated with modified PON1 distribution at HDL subclasses" in Atherosclerosis, 252 (2016):e224-e224,
https://doi.org/10.1016/j.atherosclerosis.2016.07.195 . .

TY  - JOUR
AU  - Sopić, Miron
AU  - Joksić, Jelena
AU  - Spasojević-Kalimanovska, Vesna
AU  - Bogavac-Stanojević, Nataša
AU  - Simić-Ogrizović, Sanja
AU  - Kravljaca, Milica
AU  - Jelić-Ivanović, Zorana
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2750
AB  - Background: Since the rise in plasma adiponectin levels in chronic kidney disease (CKD) patients has not yet been elucidated, we sought to investigate if patients on hemodialysis (HD) have altered expression of adiponectin receptors in peripheral blood mononuclear cells (PBMCs) compared to healthy subjects. Methods: This study included 31 patients with chronic kidney disease on HD and 33 healthy subjects (CG). Circulating adiponectin levels were measured by ELISA while AdipoR1 and AdipoR2 mRNA levels in PBMCs were determined by real-time PCR. Results: Plasma adiponectin levels were significantly higher in patients compared to control group (P=0.036). After adjustment for age, BMI and creatinine, this difference became even more significant (P=0.004). In both groups adiponectin correlated with creatinine (CG: r=-0.472, P=0.006; HD: r=-0.375, P=0.038), triglycerides (CG: r=0.490, P=0.004; HD: r=-0.488, P=0.005), insulin (CG: r=-0.386, P=0.038; HD: r=-0.506, P=0.012) and high density lipoprotein cholesterol (HDL-C) (CG: r=-0.672, P lt 0.001; HD: r=-0.584, P=0.001). Significantly lower expression of PBMCs AdipoR1 mRNA was found in patients compared to CG (P=0.034), while AdipoR2 mRNA levels were similarly expressed in PBMCs in both groups. Conclusions: Complex pathological processes in CKD cause downregulation of AdipoR1 which could ultimately influence AdipoR1 protein levels leading to a state of adiponectin resistance.
PB  - Društvo medicinskih biohemičara Srbije, Beograd i Versita
T2  - Journal of Medical Biochemistry
T1  - Downregulation of AdipoR1 is Associated with Increased Circulating Adiponectin Levels in Serbian Chronic Kidney Disease Patients
VL  - 35
IS  - 4
SP  - 436
EP  - 442
DO  - 10.1515/jomb-2016-0007
ER  - 

@article{
author = "Sopić, Miron and Joksić, Jelena and Spasojević-Kalimanovska, Vesna and Bogavac-Stanojević, Nataša and Simić-Ogrizović, Sanja and Kravljaca, Milica and Jelić-Ivanović, Zorana",
year = "2016",
abstract = "Background: Since the rise in plasma adiponectin levels in chronic kidney disease (CKD) patients has not yet been elucidated, we sought to investigate if patients on hemodialysis (HD) have altered expression of adiponectin receptors in peripheral blood mononuclear cells (PBMCs) compared to healthy subjects. Methods: This study included 31 patients with chronic kidney disease on HD and 33 healthy subjects (CG). Circulating adiponectin levels were measured by ELISA while AdipoR1 and AdipoR2 mRNA levels in PBMCs were determined by real-time PCR. Results: Plasma adiponectin levels were significantly higher in patients compared to control group (P=0.036). After adjustment for age, BMI and creatinine, this difference became even more significant (P=0.004). In both groups adiponectin correlated with creatinine (CG: r=-0.472, P=0.006; HD: r=-0.375, P=0.038), triglycerides (CG: r=0.490, P=0.004; HD: r=-0.488, P=0.005), insulin (CG: r=-0.386, P=0.038; HD: r=-0.506, P=0.012) and high density lipoprotein cholesterol (HDL-C) (CG: r=-0.672, P lt 0.001; HD: r=-0.584, P=0.001). Significantly lower expression of PBMCs AdipoR1 mRNA was found in patients compared to CG (P=0.034), while AdipoR2 mRNA levels were similarly expressed in PBMCs in both groups. Conclusions: Complex pathological processes in CKD cause downregulation of AdipoR1 which could ultimately influence AdipoR1 protein levels leading to a state of adiponectin resistance.",
publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita",
journal = "Journal of Medical Biochemistry",
title = "Downregulation of AdipoR1 is Associated with Increased Circulating Adiponectin Levels in Serbian Chronic Kidney Disease Patients",
volume = "35",
number = "4",
pages = "436-442",
doi = "10.1515/jomb-2016-0007"
}

Sopić, M., Joksić, J., Spasojević-Kalimanovska, V., Bogavac-Stanojević, N., Simić-Ogrizović, S., Kravljaca, M.,& Jelić-Ivanović, Z.. (2016). Downregulation of AdipoR1 is Associated with Increased Circulating Adiponectin Levels in Serbian Chronic Kidney Disease Patients. in Journal of Medical Biochemistry
Društvo medicinskih biohemičara Srbije, Beograd i Versita., 35(4), 436-442.
https://doi.org/10.1515/jomb-2016-0007

Sopić M, Joksić J, Spasojević-Kalimanovska V, Bogavac-Stanojević N, Simić-Ogrizović S, Kravljaca M, Jelić-Ivanović Z. Downregulation of AdipoR1 is Associated with Increased Circulating Adiponectin Levels in Serbian Chronic Kidney Disease Patients. in Journal of Medical Biochemistry. 2016;35(4):436-442.
doi:10.1515/jomb-2016-0007 .

Sopić, Miron, Joksić, Jelena, Spasojević-Kalimanovska, Vesna, Bogavac-Stanojević, Nataša, Simić-Ogrizović, Sanja, Kravljaca, Milica, Jelić-Ivanović, Zorana, "Downregulation of AdipoR1 is Associated with Increased Circulating Adiponectin Levels in Serbian Chronic Kidney Disease Patients" in Journal of Medical Biochemistry, 35, no. 4 (2016):436-442,
https://doi.org/10.1515/jomb-2016-0007 . .

TY  - JOUR
AU  - Miljković, Milica
AU  - Kotur-Stevuljević, Jelena
AU  - Stefanović, Aleksandra
AU  - Zeljković, Aleksandra
AU  - Vekić, Jelena
AU  - Gojković, Tamara
AU  - Bogavac-Stanojević, Nataša
AU  - Nikolić, Milan
AU  - Simić-Ogrizović, Sanja
AU  - Spasojević-Kalimanovska, Vesna
AU  - Jelić-Ivanović, Zorana
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2724
AB  - Unfavorable lipid profile is a major risk factor for cardiovascular disease in renal pathology. In this study, we compared chronic renal patients and healthy controls with different LDL phenotypes (A or B) in respect of various biochemical parameters related to cardiovascular disease. Oxidative stress and anti-oxidative defense parameters [thiobarbituric acid-reacting substances (TBARS), total oxidative status (TOS), total anti-oxidative status (TAS), total protein sulfhydryl (-SH) groups], as well as red blood cell cholesterol distribution were assessed in 40 renal patients and 40 control subjects by standardized assays. LDL particle diameters were determined by polyacrylamide gradient gel electrophoresis. LDL particles are subdivided according to their size into large LDL A phenotype (diameter > 25.5 nm) and small LDL B phenotype (diameter aecurrency sign25.5 nm). Renal patients with LDL A phenotype had increased oxidative stress (TOS: p  lt  0.01, and TBARS: p  lt  0.001) and decreased total SH- groups (p  lt  0.001) compared to controls with the same LDL phenotype. A notable decrease in hemoglobin-cholesterol adduct was detected in patients with LDL A phenotype (p  lt  0.001) and LDL B phenotype (p  lt  0.05) compared with appropriate controls. LDL B phenotype was characterized with increased TBARS (p  lt  0.05) compared with LDL A phenotype in control group. Increased oxidative stress, decreased anti-oxidative defense followed with unfavorable changes in hemoglobin-cholesterol binding capacity, could have important influence on cardiovascular disease risk in renal patients regardless of LDL phenotype.
PB  - Springer, Dordrecht
T2  - International Urology and Nephrology
T1  - Oxidative stress and hemoglobin-cholesterol adduct in renal patients with different LDL phenotypes
VL  - 48
IS  - 10
SP  - 1683
EP  - 1690
DO  - 10.1007/s11255-016-1358-0
ER  - 

@article{
author = "Miljković, Milica and Kotur-Stevuljević, Jelena and Stefanović, Aleksandra and Zeljković, Aleksandra and Vekić, Jelena and Gojković, Tamara and Bogavac-Stanojević, Nataša and Nikolić, Milan and Simić-Ogrizović, Sanja and Spasojević-Kalimanovska, Vesna and Jelić-Ivanović, Zorana",
year = "2016",
abstract = "Unfavorable lipid profile is a major risk factor for cardiovascular disease in renal pathology. In this study, we compared chronic renal patients and healthy controls with different LDL phenotypes (A or B) in respect of various biochemical parameters related to cardiovascular disease. Oxidative stress and anti-oxidative defense parameters [thiobarbituric acid-reacting substances (TBARS), total oxidative status (TOS), total anti-oxidative status (TAS), total protein sulfhydryl (-SH) groups], as well as red blood cell cholesterol distribution were assessed in 40 renal patients and 40 control subjects by standardized assays. LDL particle diameters were determined by polyacrylamide gradient gel electrophoresis. LDL particles are subdivided according to their size into large LDL A phenotype (diameter > 25.5 nm) and small LDL B phenotype (diameter aecurrency sign25.5 nm). Renal patients with LDL A phenotype had increased oxidative stress (TOS: p  lt  0.01, and TBARS: p  lt  0.001) and decreased total SH- groups (p  lt  0.001) compared to controls with the same LDL phenotype. A notable decrease in hemoglobin-cholesterol adduct was detected in patients with LDL A phenotype (p  lt  0.001) and LDL B phenotype (p  lt  0.05) compared with appropriate controls. LDL B phenotype was characterized with increased TBARS (p  lt  0.05) compared with LDL A phenotype in control group. Increased oxidative stress, decreased anti-oxidative defense followed with unfavorable changes in hemoglobin-cholesterol binding capacity, could have important influence on cardiovascular disease risk in renal patients regardless of LDL phenotype.",
publisher = "Springer, Dordrecht",
journal = "International Urology and Nephrology",
title = "Oxidative stress and hemoglobin-cholesterol adduct in renal patients with different LDL phenotypes",
volume = "48",
number = "10",
pages = "1683-1690",
doi = "10.1007/s11255-016-1358-0"
}

Miljković, M., Kotur-Stevuljević, J., Stefanović, A., Zeljković, A., Vekić, J., Gojković, T., Bogavac-Stanojević, N., Nikolić, M., Simić-Ogrizović, S., Spasojević-Kalimanovska, V.,& Jelić-Ivanović, Z.. (2016). Oxidative stress and hemoglobin-cholesterol adduct in renal patients with different LDL phenotypes. in International Urology and Nephrology
Springer, Dordrecht., 48(10), 1683-1690.
https://doi.org/10.1007/s11255-016-1358-0

Miljković M, Kotur-Stevuljević J, Stefanović A, Zeljković A, Vekić J, Gojković T, Bogavac-Stanojević N, Nikolić M, Simić-Ogrizović S, Spasojević-Kalimanovska V, Jelić-Ivanović Z. Oxidative stress and hemoglobin-cholesterol adduct in renal patients with different LDL phenotypes. in International Urology and Nephrology. 2016;48(10):1683-1690.
doi:10.1007/s11255-016-1358-0 .

Miljković, Milica, Kotur-Stevuljević, Jelena, Stefanović, Aleksandra, Zeljković, Aleksandra, Vekić, Jelena, Gojković, Tamara, Bogavac-Stanojević, Nataša, Nikolić, Milan, Simić-Ogrizović, Sanja, Spasojević-Kalimanovska, Vesna, Jelić-Ivanović, Zorana, "Oxidative stress and hemoglobin-cholesterol adduct in renal patients with different LDL phenotypes" in International Urology and Nephrology, 48, no. 10 (2016):1683-1690,
https://doi.org/10.1007/s11255-016-1358-0 . .

TY  - CONF
AU  - Miljković, Milica
AU  - Kotur-Stevuljević, Jelena
AU  - Stefanović, Aleksandra
AU  - Zeljković, Aleksandra
AU  - Vekić, Jelena
AU  - Gojković, Tamara
AU  - Bogavac-Stanojević, Nataša
AU  - Nikolić, M.
AU  - Simić-Ogrizović, Sanja
AU  - Spasojević-Kalimanovska, Vesna
AU  - Jelić-Ivanović, Zorana
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2448
PB  - Elsevier Ireland Ltd, Clare
C3  - Atherosclerosis
T1  - Potential markers in the assessment of risk for development of atherosclerosis in patients with chronic renal disease
VL  - 241
IS  - 1
SP  - e184
EP  - e184
DO  - 10.1016/j.atherosclerosis.2015.04.912
ER  - 

@conference{
author = "Miljković, Milica and Kotur-Stevuljević, Jelena and Stefanović, Aleksandra and Zeljković, Aleksandra and Vekić, Jelena and Gojković, Tamara and Bogavac-Stanojević, Nataša and Nikolić, M. and Simić-Ogrizović, Sanja and Spasojević-Kalimanovska, Vesna and Jelić-Ivanović, Zorana",
year = "2015",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Atherosclerosis",
title = "Potential markers in the assessment of risk for development of atherosclerosis in patients with chronic renal disease",
volume = "241",
number = "1",
pages = "e184-e184",
doi = "10.1016/j.atherosclerosis.2015.04.912"
}

Miljković, M., Kotur-Stevuljević, J., Stefanović, A., Zeljković, A., Vekić, J., Gojković, T., Bogavac-Stanojević, N., Nikolić, M., Simić-Ogrizović, S., Spasojević-Kalimanovska, V.,& Jelić-Ivanović, Z.. (2015). Potential markers in the assessment of risk for development of atherosclerosis in patients with chronic renal disease. in Atherosclerosis
Elsevier Ireland Ltd, Clare., 241(1), e184-e184.
https://doi.org/10.1016/j.atherosclerosis.2015.04.912

Miljković M, Kotur-Stevuljević J, Stefanović A, Zeljković A, Vekić J, Gojković T, Bogavac-Stanojević N, Nikolić M, Simić-Ogrizović S, Spasojević-Kalimanovska V, Jelić-Ivanović Z. Potential markers in the assessment of risk for development of atherosclerosis in patients with chronic renal disease. in Atherosclerosis. 2015;241(1):e184-e184.
doi:10.1016/j.atherosclerosis.2015.04.912 .

Miljković, Milica, Kotur-Stevuljević, Jelena, Stefanović, Aleksandra, Zeljković, Aleksandra, Vekić, Jelena, Gojković, Tamara, Bogavac-Stanojević, Nataša, Nikolić, M., Simić-Ogrizović, Sanja, Spasojević-Kalimanovska, Vesna, Jelić-Ivanović, Zorana, "Potential markers in the assessment of risk for development of atherosclerosis in patients with chronic renal disease" in Atherosclerosis, 241, no. 1 (2015):e184-e184,
https://doi.org/10.1016/j.atherosclerosis.2015.04.912 . .

TY  - JOUR
AU  - Bojić, Suzana
AU  - Kotur-Stevuljević, Jelena
AU  - Kalezić, Nevena
AU  - Stevanović, Predrag
AU  - Jelić-Ivanović, Zorana
AU  - Bilanović, Dragoljub
AU  - Memon, Lidija
AU  - Damnjanović, Mladen
AU  - Kalaba, Zdravko
AU  - Simić-Ogrizović, Sanja
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2313
AB  - Sepsis-associated acute kidney injury (SA-AKI) severely impacts morbidity and mortality in surgical patients with sepsis. Matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix rnetalloproteinase-1 (TIMP-1) have an important role in pathophysiology of sepsis but they have been unexplored in SA-AKI. We aimed to investigate the role of MMP-9 and TIMP-1 in septic surgical patients with SA-AKI and to evaluate them as diagnostic biomarkers of SA-AKI. This prospective observational study compared 53 major abdominal surgery patients with sepsis divided into SA-AKI (n = 37) and non-SA-AKI (n = 16) group to 50 controls without sepsis matched by age, gender, comorbidities and type of surgery. Blood and urine samples from septic patients were collected on admission to ICU and 24, 48, 72 and 96 h later and once from the controls. The levels of MMP-9, TIMP-1, neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1, urea and creatinine were measured. MMP-9/TIMP-1 ratio and disease severity scores, such as Sequential Organ Failure Assessment (SOFA), were calculated. Septic patients with SA-AKI had higher serum TIMP-1 levels and lower serum MMP-9 levels and lower MMP-9/TIMP ratio, compared to septic patients without SA-AKI and controls. The levels of these biomarkers did not change significantly over time. MMP-9, TIMP-1 and MMP-9/TIMP-1 ratio correlated with urea, creatinine, NGAL, and SOFA scores. Moreover, using the area under ROC curve, we showed that TIMP-1 and MMP-9/TIMP-1 ratio, but not MMP-9, were good diagnostic biomarkers of SA-AKI. We report for the first time the potential diagnostic value of TIMP-1 and MMP-9/TIMP-1 ratio in SA-AKI.
PB  - Tohoku Univ Medical Press, Sendai
T2  - Toxicological and Environmental Chemistry
T1  - Diagnostic Value of Matrix Metalloproteinase-9 and Tissue Inhibitor of Matrix Metalloproteinase-1 in Sepsis-Associated Acute Kidney Injury
VL  - 237
IS  - 2
SP  - 103
EP  - 109
DO  - 10.1620/tjem.237.103
ER  - 

@article{
author = "Bojić, Suzana and Kotur-Stevuljević, Jelena and Kalezić, Nevena and Stevanović, Predrag and Jelić-Ivanović, Zorana and Bilanović, Dragoljub and Memon, Lidija and Damnjanović, Mladen and Kalaba, Zdravko and Simić-Ogrizović, Sanja",
year = "2015",
abstract = "Sepsis-associated acute kidney injury (SA-AKI) severely impacts morbidity and mortality in surgical patients with sepsis. Matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix rnetalloproteinase-1 (TIMP-1) have an important role in pathophysiology of sepsis but they have been unexplored in SA-AKI. We aimed to investigate the role of MMP-9 and TIMP-1 in septic surgical patients with SA-AKI and to evaluate them as diagnostic biomarkers of SA-AKI. This prospective observational study compared 53 major abdominal surgery patients with sepsis divided into SA-AKI (n = 37) and non-SA-AKI (n = 16) group to 50 controls without sepsis matched by age, gender, comorbidities and type of surgery. Blood and urine samples from septic patients were collected on admission to ICU and 24, 48, 72 and 96 h later and once from the controls. The levels of MMP-9, TIMP-1, neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1, urea and creatinine were measured. MMP-9/TIMP-1 ratio and disease severity scores, such as Sequential Organ Failure Assessment (SOFA), were calculated. Septic patients with SA-AKI had higher serum TIMP-1 levels and lower serum MMP-9 levels and lower MMP-9/TIMP ratio, compared to septic patients without SA-AKI and controls. The levels of these biomarkers did not change significantly over time. MMP-9, TIMP-1 and MMP-9/TIMP-1 ratio correlated with urea, creatinine, NGAL, and SOFA scores. Moreover, using the area under ROC curve, we showed that TIMP-1 and MMP-9/TIMP-1 ratio, but not MMP-9, were good diagnostic biomarkers of SA-AKI. We report for the first time the potential diagnostic value of TIMP-1 and MMP-9/TIMP-1 ratio in SA-AKI.",
publisher = "Tohoku Univ Medical Press, Sendai",
journal = "Toxicological and Environmental Chemistry",
title = "Diagnostic Value of Matrix Metalloproteinase-9 and Tissue Inhibitor of Matrix Metalloproteinase-1 in Sepsis-Associated Acute Kidney Injury",
volume = "237",
number = "2",
pages = "103-109",
doi = "10.1620/tjem.237.103"
}

Bojić, S., Kotur-Stevuljević, J., Kalezić, N., Stevanović, P., Jelić-Ivanović, Z., Bilanović, D., Memon, L., Damnjanović, M., Kalaba, Z.,& Simić-Ogrizović, S.. (2015). Diagnostic Value of Matrix Metalloproteinase-9 and Tissue Inhibitor of Matrix Metalloproteinase-1 in Sepsis-Associated Acute Kidney Injury. in Toxicological and Environmental Chemistry
Tohoku Univ Medical Press, Sendai., 237(2), 103-109.
https://doi.org/10.1620/tjem.237.103

Bojić S, Kotur-Stevuljević J, Kalezić N, Stevanović P, Jelić-Ivanović Z, Bilanović D, Memon L, Damnjanović M, Kalaba Z, Simić-Ogrizović S. Diagnostic Value of Matrix Metalloproteinase-9 and Tissue Inhibitor of Matrix Metalloproteinase-1 in Sepsis-Associated Acute Kidney Injury. in Toxicological and Environmental Chemistry. 2015;237(2):103-109.
doi:10.1620/tjem.237.103 .

Bojić, Suzana, Kotur-Stevuljević, Jelena, Kalezić, Nevena, Stevanović, Predrag, Jelić-Ivanović, Zorana, Bilanović, Dragoljub, Memon, Lidija, Damnjanović, Mladen, Kalaba, Zdravko, Simić-Ogrizović, Sanja, "Diagnostic Value of Matrix Metalloproteinase-9 and Tissue Inhibitor of Matrix Metalloproteinase-1 in Sepsis-Associated Acute Kidney Injury" in Toxicological and Environmental Chemistry, 237, no. 2 (2015):103-109,
https://doi.org/10.1620/tjem.237.103 . .

TY  - JOUR
AU  - Zeljković, Aleksandra
AU  - Bogavac-Stanojević, Nataša
AU  - Simić-Ogrizović, Sanja
AU  - Vekić, Jelena
AU  - Spasojević-Kalimanovska, Vesna
AU  - Kravljača, Milica
AU  - Stošović, Milan
AU  - Savić, Jasna
AU  - Gojković, Tamara
AU  - Stefanović, Aleksan
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2121
AB  - Dyslipidemia is a common metabolic disorder in chronic kidney disease (CKD) and is largely responsible for development of cardiovascular complications in these patients. It has been noticed that characteristics of lipid disorders vary according to the degree of renal failure. In this study, we investigated concentrations of cholesterol and apolipoprotein B in small, dense low-density lipoproteins (sdLDL-C and sdLDL-apoB) in pre-dialysis (PD) and hemodialysis (HD) stage of CKD. In addition, we explored independent contribution of sdLDL-C and sdLDL-apoB to progression of CKD. We recruited 38 PD and 41 HD patients in this study. Concentrations of sdLDL-C and sdLDL-apoB were determined by heparin-magnesium precipitation method. Other biochemical parameters were measured by routine laboratory methods. Concentrations of sdLDL-C and sdLDL-apoB were significantly higher in PD than in HD patients (P lt 0,001). SdLDL-C (OR=0,122; P lt 0,001) and sdLDL-apoB (OR=0,109; P lt 0,001) were identified as predictors of progression of CKD towards HD stage. Both of examined parameters were independently associated with the disease progression after adjustment for other lipid and non-lipid risk markers, with an exception for adjustment for urea concentration. Assessment of sdLDL-C and sdLDL-apoB in different stages of CKD could be beneficial in term of prediction of risk for cardiovascular disease development and prediction of progression of CKD itself.
AB  - Dislipidemija je uobičajen metabolički poremećaj u hroničnoj bubrežnoj bolesti (HBB) i u velikoj meri je odgovorna za nastanak kasnijih kardiovaskularnih komplikacija kod ovih pacijenata. Uočeno je da karakteristike dislipidemije variraju u zavisnosti od stadijuma HBB. U ovom radu ispitivali smo koncentracije holesterola i apolipoproteina B u malim, gustim česticama lipoproteina niske gustine (sdLDL-h i sdLDL-apoB) u predijaliznom (PD) i hemodijaliznom (HD) stadijumu HBB, kao i njihov nezavisni potencijal u predviđanju progresije HBB. U studiji je učestvovalo 38 PD i 41 HD pacijent. Koncentracije sdLDL-h i sdLDL-apoB određene su nakon selektivne precipitacije sa heparinom i Mg-solima, a koncentracije ostalih biohemijskih parametara rutinskim metodama. Koncentracije sdLDL-h i sdLDL-apoB bile su značajno više kod PD u odnosu na HD pacijente (P lt 0,001). SdLDL-h (OR=0,122; P lt 0,001) i sdLDL-apoB (OR=0,109; P lt 0,001) identifikovani su kao značajni prediktori progresije bolesti od PD do HD stadijuma, a nezavisan prediktivni potencijal zadržali su i u prisustvu drugih lipidnih i nelipidnih faktora rizika, osim uree. Određivanje sdLDL-h i sdLDL-apoB kod pacijenata u različitim stadijumima HBB može biti korisno u smislu predviđanja rizika za nastanak aterosklerotskih promena, kao i predviđanja progresije same HBB.
PB  - Most Art doo, Beograd
T2  - MD - Medical data
T1  - The role of small, dense LDL cholesterol in progression of chronic kidney disease
T1  - Uloga holesterola u malim, gustim LDL česticama u progresiji hronične bubrežne bolesti
VL  - 6
IS  - 3
SP  - 253
EP  - 257
UR  - https://hdl.handle.net/21.15107/rcub_farfar_2121
ER  - 

@article{
author = "Zeljković, Aleksandra and Bogavac-Stanojević, Nataša and Simić-Ogrizović, Sanja and Vekić, Jelena and Spasojević-Kalimanovska, Vesna and Kravljača, Milica and Stošović, Milan and Savić, Jasna and Gojković, Tamara and Stefanović, Aleksan",
year = "2014",
abstract = "Dyslipidemia is a common metabolic disorder in chronic kidney disease (CKD) and is largely responsible for development of cardiovascular complications in these patients. It has been noticed that characteristics of lipid disorders vary according to the degree of renal failure. In this study, we investigated concentrations of cholesterol and apolipoprotein B in small, dense low-density lipoproteins (sdLDL-C and sdLDL-apoB) in pre-dialysis (PD) and hemodialysis (HD) stage of CKD. In addition, we explored independent contribution of sdLDL-C and sdLDL-apoB to progression of CKD. We recruited 38 PD and 41 HD patients in this study. Concentrations of sdLDL-C and sdLDL-apoB were determined by heparin-magnesium precipitation method. Other biochemical parameters were measured by routine laboratory methods. Concentrations of sdLDL-C and sdLDL-apoB were significantly higher in PD than in HD patients (P lt 0,001). SdLDL-C (OR=0,122; P lt 0,001) and sdLDL-apoB (OR=0,109; P lt 0,001) were identified as predictors of progression of CKD towards HD stage. Both of examined parameters were independently associated with the disease progression after adjustment for other lipid and non-lipid risk markers, with an exception for adjustment for urea concentration. Assessment of sdLDL-C and sdLDL-apoB in different stages of CKD could be beneficial in term of prediction of risk for cardiovascular disease development and prediction of progression of CKD itself., Dislipidemija je uobičajen metabolički poremećaj u hroničnoj bubrežnoj bolesti (HBB) i u velikoj meri je odgovorna za nastanak kasnijih kardiovaskularnih komplikacija kod ovih pacijenata. Uočeno je da karakteristike dislipidemije variraju u zavisnosti od stadijuma HBB. U ovom radu ispitivali smo koncentracije holesterola i apolipoproteina B u malim, gustim česticama lipoproteina niske gustine (sdLDL-h i sdLDL-apoB) u predijaliznom (PD) i hemodijaliznom (HD) stadijumu HBB, kao i njihov nezavisni potencijal u predviđanju progresije HBB. U studiji je učestvovalo 38 PD i 41 HD pacijent. Koncentracije sdLDL-h i sdLDL-apoB određene su nakon selektivne precipitacije sa heparinom i Mg-solima, a koncentracije ostalih biohemijskih parametara rutinskim metodama. Koncentracije sdLDL-h i sdLDL-apoB bile su značajno više kod PD u odnosu na HD pacijente (P lt 0,001). SdLDL-h (OR=0,122; P lt 0,001) i sdLDL-apoB (OR=0,109; P lt 0,001) identifikovani su kao značajni prediktori progresije bolesti od PD do HD stadijuma, a nezavisan prediktivni potencijal zadržali su i u prisustvu drugih lipidnih i nelipidnih faktora rizika, osim uree. Određivanje sdLDL-h i sdLDL-apoB kod pacijenata u različitim stadijumima HBB može biti korisno u smislu predviđanja rizika za nastanak aterosklerotskih promena, kao i predviđanja progresije same HBB.",
publisher = "Most Art doo, Beograd",
journal = "MD - Medical data",
title = "The role of small, dense LDL cholesterol in progression of chronic kidney disease, Uloga holesterola u malim, gustim LDL česticama u progresiji hronične bubrežne bolesti",
volume = "6",
number = "3",
pages = "253-257",
url = "https://hdl.handle.net/21.15107/rcub_farfar_2121"
}

Zeljković, A., Bogavac-Stanojević, N., Simić-Ogrizović, S., Vekić, J., Spasojević-Kalimanovska, V., Kravljača, M., Stošović, M., Savić, J., Gojković, T.,& Stefanović, A.. (2014). The role of small, dense LDL cholesterol in progression of chronic kidney disease. in MD - Medical data
Most Art doo, Beograd., 6(3), 253-257.
https://hdl.handle.net/21.15107/rcub_farfar_2121

Zeljković A, Bogavac-Stanojević N, Simić-Ogrizović S, Vekić J, Spasojević-Kalimanovska V, Kravljača M, Stošović M, Savić J, Gojković T, Stefanović A. The role of small, dense LDL cholesterol in progression of chronic kidney disease. in MD - Medical data. 2014;6(3):253-257.
https://hdl.handle.net/21.15107/rcub_farfar_2121 .

Zeljković, Aleksandra, Bogavac-Stanojević, Nataša, Simić-Ogrizović, Sanja, Vekić, Jelena, Spasojević-Kalimanovska, Vesna, Kravljača, Milica, Stošović, Milan, Savić, Jasna, Gojković, Tamara, Stefanović, Aleksan, "The role of small, dense LDL cholesterol in progression of chronic kidney disease" in MD - Medical data, 6, no. 3 (2014):253-257,
https://hdl.handle.net/21.15107/rcub_farfar_2121 .

TY  - JOUR
AU  - Bojić, Suzana
AU  - Kotur-Stevuljević, Jelena
AU  - Kalezić, Nevena
AU  - Jelić-Ivanović, Zorana
AU  - Stefanović, Aleksandra
AU  - Palibrk, Ivan
AU  - Memon, Lidija
AU  - Kalaba, Zdravko
AU  - Stojanović, Marina
AU  - Simić-Ogrizović, Sanja
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2226
AB  - Introduction. State of severe oxidative stress is encountered in sepsis. Paraoxonase 1 (PON1) protects against oxidative stress but also undergoes inactivation upon that condition. We investigated PON1 activity in surgical patients with sepsis in relation to oxidative stress status, inflammation, disease severity, and survival. Methods. Prospective observational study. Sixty-nine surgical patients with sepsis were compared to 69 age/sex matched healthy controls. PON1 paraoxonase and diazoxonase activities, selected biochemical, hematological and oxidative stress parameters were measured on admission to ICU and 24, 48, 72, and 96 hours later. Disease severity scores were calculated daily. Results. Septic patients had significantly lower PON1 activities compared to control group at all time points. PON1 activities had good capacity to differentiate septic patients from healthy controls. Low PON1 activities were associated with higher disease severity scores and higher risk of death. Correlation between PON1 activity and markers of inflammation failed to reach significance. Decrease in PON1 activity was correlated with an increase in reducing components in plasma. Conclusion. Our study demonstrated lower PON1 activity in surgical patients with sepsis compared to healthy controls. PON1 activity also reflected severity of the disease. Low PON1 activity was associated with higher mortality of surgical patients with sepsis.
PB  - Hindawi Ltd, London
T2  - Disease Markers
T1  - Low Paraoxonase 1 Activity Predicts Mortality in Surgical Patients with Sepsis
DO  - 10.1155/2014/427378
ER  - 

@article{
author = "Bojić, Suzana and Kotur-Stevuljević, Jelena and Kalezić, Nevena and Jelić-Ivanović, Zorana and Stefanović, Aleksandra and Palibrk, Ivan and Memon, Lidija and Kalaba, Zdravko and Stojanović, Marina and Simić-Ogrizović, Sanja",
year = "2014",
abstract = "Introduction. State of severe oxidative stress is encountered in sepsis. Paraoxonase 1 (PON1) protects against oxidative stress but also undergoes inactivation upon that condition. We investigated PON1 activity in surgical patients with sepsis in relation to oxidative stress status, inflammation, disease severity, and survival. Methods. Prospective observational study. Sixty-nine surgical patients with sepsis were compared to 69 age/sex matched healthy controls. PON1 paraoxonase and diazoxonase activities, selected biochemical, hematological and oxidative stress parameters were measured on admission to ICU and 24, 48, 72, and 96 hours later. Disease severity scores were calculated daily. Results. Septic patients had significantly lower PON1 activities compared to control group at all time points. PON1 activities had good capacity to differentiate septic patients from healthy controls. Low PON1 activities were associated with higher disease severity scores and higher risk of death. Correlation between PON1 activity and markers of inflammation failed to reach significance. Decrease in PON1 activity was correlated with an increase in reducing components in plasma. Conclusion. Our study demonstrated lower PON1 activity in surgical patients with sepsis compared to healthy controls. PON1 activity also reflected severity of the disease. Low PON1 activity was associated with higher mortality of surgical patients with sepsis.",
publisher = "Hindawi Ltd, London",
journal = "Disease Markers",
title = "Low Paraoxonase 1 Activity Predicts Mortality in Surgical Patients with Sepsis",
doi = "10.1155/2014/427378"
}

Bojić, S., Kotur-Stevuljević, J., Kalezić, N., Jelić-Ivanović, Z., Stefanović, A., Palibrk, I., Memon, L., Kalaba, Z., Stojanović, M.,& Simić-Ogrizović, S.. (2014). Low Paraoxonase 1 Activity Predicts Mortality in Surgical Patients with Sepsis. in Disease Markers
Hindawi Ltd, London..
https://doi.org/10.1155/2014/427378

Bojić S, Kotur-Stevuljević J, Kalezić N, Jelić-Ivanović Z, Stefanović A, Palibrk I, Memon L, Kalaba Z, Stojanović M, Simić-Ogrizović S. Low Paraoxonase 1 Activity Predicts Mortality in Surgical Patients with Sepsis. in Disease Markers. 2014;.
doi:10.1155/2014/427378 .

Bojić, Suzana, Kotur-Stevuljević, Jelena, Kalezić, Nevena, Jelić-Ivanović, Zorana, Stefanović, Aleksandra, Palibrk, Ivan, Memon, Lidija, Kalaba, Zdravko, Stojanović, Marina, Simić-Ogrizović, Sanja, "Low Paraoxonase 1 Activity Predicts Mortality in Surgical Patients with Sepsis" in Disease Markers (2014),
https://doi.org/10.1155/2014/427378 . .

TY  - JOUR
AU  - Savić, Jasna
AU  - Zeljković, Aleksandra
AU  - Bogavac-Stanojević, Nataša
AU  - Simić-Ogrizović, Sanja
AU  - Kravljaca, Milica
AU  - Stošović, Milan
AU  - Vekić, Jelena
AU  - Spasojević-Kalimanovska, Vesna
AU  - Jelić-Ivanović, Zorana
AU  - Gojković, Tamara
AU  - Spasić, Slavica
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2126
AB  - Background. Dyslipidemia is a common feature of chronic kidney disease (CKD). Although it has been observed that the pattern of lipid abnormalities can vary according to the stage of CKD, there is lack of data concerning the distribution of lipoprotein subclasses at various stages of the disease. In addition, association of proatherogenic small, dense low-density lipoprotein (sdLDL) subclasses with markers of inflammation, such is galectin-3, is not sufficiently explored. The aim of this study was to analyze concentrations and relative proportions of sdLDL-cholesterol (sdLDL-C) and galectin-3 in patients with CKD, with respect to the stage of the disease. Also, we sought possible independent associations of galectin-3 and sdLDL-C. Methods. The study involved 100 hemodialysis (HD) and 50 pre-dialysis patients, together with 94 healthy individuals. SdLDL-C was measured by heparin-magnesium precipitation method. Galectin-3 was measured by ELISA technique. Results. Galectin-3 levels were higher in pre-dialysis and HD patients than in the control group (p  lt  0.01). The concentration of sdLDL-C was highest in the pre-dialysis group and lowest in HD patients (p  lt  0.01). CKD patients with increased galectin-3 concentrations had significantly higher relative proportions of cholesterol in sdLDL (% sdLDL-C) than their counterparts with lower galectin-3 levels (p  lt  0.05). Relative proportion of sdLDL-C was shown to be an independent determinant of galectin-3 concentration. Conclusions. Our results demonstrated alterations in concentrations and proportions of sdLDL-C according to the stages of CKD. The observed independent associations of % sdLDL-C and galectin-3 provide further insight into their complex interaction during the progression of atherosclerosis in CKD.
PB  - Informa Healthcare, London
T2  - Scandinavian Journal of Clinical and Laboratory Investigation
T1  - Association of small, dense low-density lipoprotein cholesterol and galectin-3 in patients with chronic kidney disease
VL  - 74
IS  - 7
SP  - 637
EP  - 643
DO  - 10.3109/00365513.2014.928944
ER  - 

@article{
author = "Savić, Jasna and Zeljković, Aleksandra and Bogavac-Stanojević, Nataša and Simić-Ogrizović, Sanja and Kravljaca, Milica and Stošović, Milan and Vekić, Jelena and Spasojević-Kalimanovska, Vesna and Jelić-Ivanović, Zorana and Gojković, Tamara and Spasić, Slavica",
year = "2014",
abstract = "Background. Dyslipidemia is a common feature of chronic kidney disease (CKD). Although it has been observed that the pattern of lipid abnormalities can vary according to the stage of CKD, there is lack of data concerning the distribution of lipoprotein subclasses at various stages of the disease. In addition, association of proatherogenic small, dense low-density lipoprotein (sdLDL) subclasses with markers of inflammation, such is galectin-3, is not sufficiently explored. The aim of this study was to analyze concentrations and relative proportions of sdLDL-cholesterol (sdLDL-C) and galectin-3 in patients with CKD, with respect to the stage of the disease. Also, we sought possible independent associations of galectin-3 and sdLDL-C. Methods. The study involved 100 hemodialysis (HD) and 50 pre-dialysis patients, together with 94 healthy individuals. SdLDL-C was measured by heparin-magnesium precipitation method. Galectin-3 was measured by ELISA technique. Results. Galectin-3 levels were higher in pre-dialysis and HD patients than in the control group (p  lt  0.01). The concentration of sdLDL-C was highest in the pre-dialysis group and lowest in HD patients (p  lt  0.01). CKD patients with increased galectin-3 concentrations had significantly higher relative proportions of cholesterol in sdLDL (% sdLDL-C) than their counterparts with lower galectin-3 levels (p  lt  0.05). Relative proportion of sdLDL-C was shown to be an independent determinant of galectin-3 concentration. Conclusions. Our results demonstrated alterations in concentrations and proportions of sdLDL-C according to the stages of CKD. The observed independent associations of % sdLDL-C and galectin-3 provide further insight into their complex interaction during the progression of atherosclerosis in CKD.",
publisher = "Informa Healthcare, London",
journal = "Scandinavian Journal of Clinical and Laboratory Investigation",
title = "Association of small, dense low-density lipoprotein cholesterol and galectin-3 in patients with chronic kidney disease",
volume = "74",
number = "7",
pages = "637-643",
doi = "10.3109/00365513.2014.928944"
}

Savić, J., Zeljković, A., Bogavac-Stanojević, N., Simić-Ogrizović, S., Kravljaca, M., Stošović, M., Vekić, J., Spasojević-Kalimanovska, V., Jelić-Ivanović, Z., Gojković, T.,& Spasić, S.. (2014). Association of small, dense low-density lipoprotein cholesterol and galectin-3 in patients with chronic kidney disease. in Scandinavian Journal of Clinical and Laboratory Investigation
Informa Healthcare, London., 74(7), 637-643.
https://doi.org/10.3109/00365513.2014.928944

Savić J, Zeljković A, Bogavac-Stanojević N, Simić-Ogrizović S, Kravljaca M, Stošović M, Vekić J, Spasojević-Kalimanovska V, Jelić-Ivanović Z, Gojković T, Spasić S. Association of small, dense low-density lipoprotein cholesterol and galectin-3 in patients with chronic kidney disease. in Scandinavian Journal of Clinical and Laboratory Investigation. 2014;74(7):637-643.
doi:10.3109/00365513.2014.928944 .

Savić, Jasna, Zeljković, Aleksandra, Bogavac-Stanojević, Nataša, Simić-Ogrizović, Sanja, Kravljaca, Milica, Stošović, Milan, Vekić, Jelena, Spasojević-Kalimanovska, Vesna, Jelić-Ivanović, Zorana, Gojković, Tamara, Spasić, Slavica, "Association of small, dense low-density lipoprotein cholesterol and galectin-3 in patients with chronic kidney disease" in Scandinavian Journal of Clinical and Laboratory Investigation, 74, no. 7 (2014):637-643,
https://doi.org/10.3109/00365513.2014.928944 . .

TY  - JOUR
AU  - Memon, Lidija
AU  - Spasojević-Kalimanovska, Vesna
AU  - Bogavac-Stanojević, Nataša
AU  - Kotur-Stevuljević, Jelena
AU  - Simić-Ogrizović, Sanja
AU  - Giga, Vojislav
AU  - Dopsaj, Violeta
AU  - Jelić-Ivanović, Zorana
AU  - Spasić, Slavica
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1897
AB  - BackgroundThe aim of the study was to determine the clinical usefulness of N-terminal pro-B-type natriuretic peptide (NT-proBNP) and symmetric dimethylarginine (SDMA) for detection of renal and left ventricular (LV) diastolic dysfunction in chronic kidney disease (CKD) patients and renal transplant (RT) recipients. MethodsWe included 98 CKD and 44 RT patients. We assessed LV function using pulsed-wave Doppler ultrasound. Diastolic dysfunction was defined when the E:A ratio was  lt 1. ResultsIndependent predictors of NT-proBNP levels were age, creatinine, and albumin in CKD patients and age and urea in RT patients. Determinants of SDMA in CKD patients were glomerular filtration rate (GFR) and NT-proBNP and creatinine in RT patients. In RT patients with diastolic dysfunction, NT-proBNP and SDMA were significantly higher than in patients without diastolic dysfunction (F = 7.478, P  lt  0.011; F = 2.631, P  lt  0.017). After adjustment for GFR, the differences were not seen. In CKD patients adjusted NT-proBNP and SDMA values for GFR were not significantly higher in patients with diastolic dysfunction than in patients without diastolic dysfunction. ConclusionsNT-proBNP is useful for detection of LV diastolic dysfunction in RT recipients. When evaluating both NT-proBNP and SDMA it is necessary to consider GFR as a confounding factor.
PB  - Wiley, Hoboken
T2  - Journal of Clinical Laboratory Analysis
T1  - Are Levels of NT-proBNP and SDMA Useful to Determine Diastolic Dysfunction in Chronic Kidney Disease and Renal Transplant Patients?
VL  - 27
IS  - 6
SP  - 461
EP  - 470
DO  - 10.1002/jcla.21628
ER  - 

@article{
author = "Memon, Lidija and Spasojević-Kalimanovska, Vesna and Bogavac-Stanojević, Nataša and Kotur-Stevuljević, Jelena and Simić-Ogrizović, Sanja and Giga, Vojislav and Dopsaj, Violeta and Jelić-Ivanović, Zorana and Spasić, Slavica",
year = "2013",
abstract = "BackgroundThe aim of the study was to determine the clinical usefulness of N-terminal pro-B-type natriuretic peptide (NT-proBNP) and symmetric dimethylarginine (SDMA) for detection of renal and left ventricular (LV) diastolic dysfunction in chronic kidney disease (CKD) patients and renal transplant (RT) recipients. MethodsWe included 98 CKD and 44 RT patients. We assessed LV function using pulsed-wave Doppler ultrasound. Diastolic dysfunction was defined when the E:A ratio was  lt 1. ResultsIndependent predictors of NT-proBNP levels were age, creatinine, and albumin in CKD patients and age and urea in RT patients. Determinants of SDMA in CKD patients were glomerular filtration rate (GFR) and NT-proBNP and creatinine in RT patients. In RT patients with diastolic dysfunction, NT-proBNP and SDMA were significantly higher than in patients without diastolic dysfunction (F = 7.478, P  lt  0.011; F = 2.631, P  lt  0.017). After adjustment for GFR, the differences were not seen. In CKD patients adjusted NT-proBNP and SDMA values for GFR were not significantly higher in patients with diastolic dysfunction than in patients without diastolic dysfunction. ConclusionsNT-proBNP is useful for detection of LV diastolic dysfunction in RT recipients. When evaluating both NT-proBNP and SDMA it is necessary to consider GFR as a confounding factor.",
publisher = "Wiley, Hoboken",
journal = "Journal of Clinical Laboratory Analysis",
title = "Are Levels of NT-proBNP and SDMA Useful to Determine Diastolic Dysfunction in Chronic Kidney Disease and Renal Transplant Patients?",
volume = "27",
number = "6",
pages = "461-470",
doi = "10.1002/jcla.21628"
}

Memon, L., Spasojević-Kalimanovska, V., Bogavac-Stanojević, N., Kotur-Stevuljević, J., Simić-Ogrizović, S., Giga, V., Dopsaj, V., Jelić-Ivanović, Z.,& Spasić, S.. (2013). Are Levels of NT-proBNP and SDMA Useful to Determine Diastolic Dysfunction in Chronic Kidney Disease and Renal Transplant Patients?. in Journal of Clinical Laboratory Analysis
Wiley, Hoboken., 27(6), 461-470.
https://doi.org/10.1002/jcla.21628

Memon L, Spasojević-Kalimanovska V, Bogavac-Stanojević N, Kotur-Stevuljević J, Simić-Ogrizović S, Giga V, Dopsaj V, Jelić-Ivanović Z, Spasić S. Are Levels of NT-proBNP and SDMA Useful to Determine Diastolic Dysfunction in Chronic Kidney Disease and Renal Transplant Patients?. in Journal of Clinical Laboratory Analysis. 2013;27(6):461-470.
doi:10.1002/jcla.21628 .

Memon, Lidija, Spasojević-Kalimanovska, Vesna, Bogavac-Stanojević, Nataša, Kotur-Stevuljević, Jelena, Simić-Ogrizović, Sanja, Giga, Vojislav, Dopsaj, Violeta, Jelić-Ivanović, Zorana, Spasić, Slavica, "Are Levels of NT-proBNP and SDMA Useful to Determine Diastolic Dysfunction in Chronic Kidney Disease and Renal Transplant Patients?" in Journal of Clinical Laboratory Analysis, 27, no. 6 (2013):461-470,
https://doi.org/10.1002/jcla.21628 . .

TY  - JOUR
AU  - Lezaić, Višnja
AU  - Petković, Nenad
AU  - Marić, Ivko
AU  - Miljković, Branislava
AU  - Vučićević, Katarina
AU  - Simić-Ogrizović, Sanja
AU  - Pejović, Vesna
AU  - Đukanović, Ljubica
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1882
AB  - Background: Balkan endemic nephropathy (BEN) hemodialysis patients require a higher dose of recombinant human erythropoietin for maintaining target hemoglobin level than patients with other kidney diseases. Objectives: Comparison of the pharmacokinetics of beta-erythropoietin given subcutaneously to hemodialysis patients with BEN or other kidney diseases (non-BEN). Methods: Recombinant human erythropoietin (75U/kg) was administered subcutaneously to 10 BEN and 14 non-BEN hemodialysis patients. The predose plasma level of erythropoietin (Epo) was subtracted from all postdose levels. The relevant pharmacokinetic parameters were calculated after noncompartmental pharmacokinetic analysis using Kinetica software (Thermo Scientific, ver.5.0). Results: Although basal plasma Epo concentration was similar in BEN (20.1 +/- 10.3U/L) and non-BEN (15.1 +/- 8.1U/L; p=.1964) patients, there were significant differences between the groups for elimination rate constant (0.016 +/- 0.006 vs 0.026 +/- 0.011 hr(-1); p=.020) and elimination half-life (50.24 +/- 19.12 vs 33.79 +/- 18.91 hr, p=.048). These differences remained significant after adjustment for patient characteristics (age, sex, hennodialysis duration, ferritin, PTH and ACEI use). No significant differences between groups were found in maximal Epo concentration, time to maximum Epo concentration, area under the curve from time of dosing extrapolated to infinity, clearance, mean residence time of Epo between groups both before and after adjustment. Conclusion: Pharmacokinetic analysis of beta-erythropoietin detected a significantly longer elimination half-life in BEN than in non BEN patients. This finding needs to be confirmed in a well-controlled study with a larger sample size.
PB  - Soc Espanola Nefrologia Dr Rafael Matesanz, Madrid
T2  - Nefrologia
T1  - The Pharmacokinetics of Recombinant Human Erythropoietin in Balkan Endemic Nephropathy Patients
VL  - 33
IS  - 4
SP  - 478
EP  - 485
DO  - 10.3265/Nefrologia.pre2013.Apr.11800
ER  - 

@article{
author = "Lezaić, Višnja and Petković, Nenad and Marić, Ivko and Miljković, Branislava and Vučićević, Katarina and Simić-Ogrizović, Sanja and Pejović, Vesna and Đukanović, Ljubica",
year = "2013",
abstract = "Background: Balkan endemic nephropathy (BEN) hemodialysis patients require a higher dose of recombinant human erythropoietin for maintaining target hemoglobin level than patients with other kidney diseases. Objectives: Comparison of the pharmacokinetics of beta-erythropoietin given subcutaneously to hemodialysis patients with BEN or other kidney diseases (non-BEN). Methods: Recombinant human erythropoietin (75U/kg) was administered subcutaneously to 10 BEN and 14 non-BEN hemodialysis patients. The predose plasma level of erythropoietin (Epo) was subtracted from all postdose levels. The relevant pharmacokinetic parameters were calculated after noncompartmental pharmacokinetic analysis using Kinetica software (Thermo Scientific, ver.5.0). Results: Although basal plasma Epo concentration was similar in BEN (20.1 +/- 10.3U/L) and non-BEN (15.1 +/- 8.1U/L; p=.1964) patients, there were significant differences between the groups for elimination rate constant (0.016 +/- 0.006 vs 0.026 +/- 0.011 hr(-1); p=.020) and elimination half-life (50.24 +/- 19.12 vs 33.79 +/- 18.91 hr, p=.048). These differences remained significant after adjustment for patient characteristics (age, sex, hennodialysis duration, ferritin, PTH and ACEI use). No significant differences between groups were found in maximal Epo concentration, time to maximum Epo concentration, area under the curve from time of dosing extrapolated to infinity, clearance, mean residence time of Epo between groups both before and after adjustment. Conclusion: Pharmacokinetic analysis of beta-erythropoietin detected a significantly longer elimination half-life in BEN than in non BEN patients. This finding needs to be confirmed in a well-controlled study with a larger sample size.",
publisher = "Soc Espanola Nefrologia Dr Rafael Matesanz, Madrid",
journal = "Nefrologia",
title = "The Pharmacokinetics of Recombinant Human Erythropoietin in Balkan Endemic Nephropathy Patients",
volume = "33",
number = "4",
pages = "478-485",
doi = "10.3265/Nefrologia.pre2013.Apr.11800"
}

Lezaić, V., Petković, N., Marić, I., Miljković, B., Vučićević, K., Simić-Ogrizović, S., Pejović, V.,& Đukanović, L.. (2013). The Pharmacokinetics of Recombinant Human Erythropoietin in Balkan Endemic Nephropathy Patients. in Nefrologia
Soc Espanola Nefrologia Dr Rafael Matesanz, Madrid., 33(4), 478-485.
https://doi.org/10.3265/Nefrologia.pre2013.Apr.11800

Lezaić V, Petković N, Marić I, Miljković B, Vučićević K, Simić-Ogrizović S, Pejović V, Đukanović L. The Pharmacokinetics of Recombinant Human Erythropoietin in Balkan Endemic Nephropathy Patients. in Nefrologia. 2013;33(4):478-485.
doi:10.3265/Nefrologia.pre2013.Apr.11800 .

Lezaić, Višnja, Petković, Nenad, Marić, Ivko, Miljković, Branislava, Vučićević, Katarina, Simić-Ogrizović, Sanja, Pejović, Vesna, Đukanović, Ljubica, "The Pharmacokinetics of Recombinant Human Erythropoietin in Balkan Endemic Nephropathy Patients" in Nefrologia, 33, no. 4 (2013):478-485,
https://doi.org/10.3265/Nefrologia.pre2013.Apr.11800 . .

TY  - JOUR
AU  - Memon, Lidija
AU  - Spasojević-Kalimanovska, Vesna
AU  - Bogavac-Stanojević, Nataša
AU  - Kotur-Stevuljević, Jelena
AU  - Simić-Ogrizović, Sanja
AU  - Giga, Vojislav
AU  - Dopsaj, Violeta
AU  - Jelić-Ivanović, Zorana
AU  - Spasić, Slavica
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1859
AB  - Objectives. The study was designed to evaluate associations between symmetric dimethylarginine (SDMA), inflammation, and superoxide anion (O-2(center dot-)) with endothelial function and to determine their potential for screening of endothelial dysfunction in patients with chronic kidney disease (CKD) and renal transplant (RT) recipients. Materials and Methods. We included 64 CKD and 52 RT patients. Patients were stratified according to brachial artery flow-mediated dilation (FMD). Results. Logistic regression analysis showed that high SDMA and high sensitive C-reactive protein (hs-CRP) were associated with impaired FMD in CKD and RT patients, after adjustment for glomerular filtration rate. The ability of inflammation, SDMA, and O-2(center dot-) to detect impaired FMD was investigated by receiving operative characteristic analysis. Hs-CRP (area under the curves (AUC) = 0.754, P  lt  0.001), IL-6 (AUC = 0.699, P = 0.002), and SDMA (AUC = 0.689, P = 0.007) had the highest ability to detect impaired FMD. SDMA in combination with inflammatory parameters and/or O-2(center dot-) had better screening performance than SDMA alone. Conclusions. Our results indicate a strong predictable association between hs-CRP, SDMA, and endothelial dysfunction in CKD patients and RT recipients. The individual marker that showed the strongest discriminative ability for endothelial dysfunction is hs-CRP, but its usefulness as a discriminatory marker for efficient diagnosis of endothelial dysfunction should be examined in prospective studies.
PB  - Hindawi Ltd, London
T2  - Disease Markers
T1  - Assessment of Endothelial Dysfunction: The Role of Symmetrical Dimethylarginine and Proinflammatory Markers in Chronic Kidney Disease and Renal Transplant Recipients
SP  - 173
EP  - 180
DO  - 10.1155/2013/306908
ER  - 

@article{
author = "Memon, Lidija and Spasojević-Kalimanovska, Vesna and Bogavac-Stanojević, Nataša and Kotur-Stevuljević, Jelena and Simić-Ogrizović, Sanja and Giga, Vojislav and Dopsaj, Violeta and Jelić-Ivanović, Zorana and Spasić, Slavica",
year = "2013",
abstract = "Objectives. The study was designed to evaluate associations between symmetric dimethylarginine (SDMA), inflammation, and superoxide anion (O-2(center dot-)) with endothelial function and to determine their potential for screening of endothelial dysfunction in patients with chronic kidney disease (CKD) and renal transplant (RT) recipients. Materials and Methods. We included 64 CKD and 52 RT patients. Patients were stratified according to brachial artery flow-mediated dilation (FMD). Results. Logistic regression analysis showed that high SDMA and high sensitive C-reactive protein (hs-CRP) were associated with impaired FMD in CKD and RT patients, after adjustment for glomerular filtration rate. The ability of inflammation, SDMA, and O-2(center dot-) to detect impaired FMD was investigated by receiving operative characteristic analysis. Hs-CRP (area under the curves (AUC) = 0.754, P  lt  0.001), IL-6 (AUC = 0.699, P = 0.002), and SDMA (AUC = 0.689, P = 0.007) had the highest ability to detect impaired FMD. SDMA in combination with inflammatory parameters and/or O-2(center dot-) had better screening performance than SDMA alone. Conclusions. Our results indicate a strong predictable association between hs-CRP, SDMA, and endothelial dysfunction in CKD patients and RT recipients. The individual marker that showed the strongest discriminative ability for endothelial dysfunction is hs-CRP, but its usefulness as a discriminatory marker for efficient diagnosis of endothelial dysfunction should be examined in prospective studies.",
publisher = "Hindawi Ltd, London",
journal = "Disease Markers",
title = "Assessment of Endothelial Dysfunction: The Role of Symmetrical Dimethylarginine and Proinflammatory Markers in Chronic Kidney Disease and Renal Transplant Recipients",
pages = "173-180",
doi = "10.1155/2013/306908"
}

Memon, L., Spasojević-Kalimanovska, V., Bogavac-Stanojević, N., Kotur-Stevuljević, J., Simić-Ogrizović, S., Giga, V., Dopsaj, V., Jelić-Ivanović, Z.,& Spasić, S.. (2013). Assessment of Endothelial Dysfunction: The Role of Symmetrical Dimethylarginine and Proinflammatory Markers in Chronic Kidney Disease and Renal Transplant Recipients. in Disease Markers
Hindawi Ltd, London., 173-180.
https://doi.org/10.1155/2013/306908

Memon L, Spasojević-Kalimanovska V, Bogavac-Stanojević N, Kotur-Stevuljević J, Simić-Ogrizović S, Giga V, Dopsaj V, Jelić-Ivanović Z, Spasić S. Assessment of Endothelial Dysfunction: The Role of Symmetrical Dimethylarginine and Proinflammatory Markers in Chronic Kidney Disease and Renal Transplant Recipients. in Disease Markers. 2013;:173-180.
doi:10.1155/2013/306908 .

Memon, Lidija, Spasojević-Kalimanovska, Vesna, Bogavac-Stanojević, Nataša, Kotur-Stevuljević, Jelena, Simić-Ogrizović, Sanja, Giga, Vojislav, Dopsaj, Violeta, Jelić-Ivanović, Zorana, Spasić, Slavica, "Assessment of Endothelial Dysfunction: The Role of Symmetrical Dimethylarginine and Proinflammatory Markers in Chronic Kidney Disease and Renal Transplant Recipients" in Disease Markers (2013):173-180,
https://doi.org/10.1155/2013/306908 . .

TY  - JOUR
AU  - Simić-Ogrizović, Sanja
AU  - Bojić, Suzana
AU  - Basta-Jovanović, Gordana
AU  - Radojević, Sanja
AU  - Pavlović, Jelena
AU  - Kotur-Stevuljević, Jelena
AU  - Dopsaj, Violeta
AU  - Naumović, Radomir
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1842
AB  - Objectives. Retrospective study was designed to examine the importance of tissue kidney injury molecule-1 (KIM-1) expression in predicting kidney function in sixty patients (27 males) aged 34.15 +/- 12.23 years with different kidney diseases over three years after kidney biopsy. Materials and Methods. Tissue KIM-1 expression was determined immunohistochemically and KIM-1 staining was scored semiquantitatively, as well as tubulointerstitialis (TIN), inflammation, atrophy, and fibrosis. Kidney function (MDRD formula) and proteinuria/day were evaluated at the time of biopsy (GFR0) and 6, 12, 24, and 36 months later Results. Significantly positive correlations between tissue KIM-1 expression and age (r = 0.313), TIN inflammation (r = 0.456), fibrosis (r = 0.317), and proteinuria at 6 months (r = 0.394) as well as negative correlations with GFR0 (r = -0.572), GFR6 (r = -0.442), GFR24 (r = -0.398), and GFR36 (r = -0.412) were found. Meanwhile, TIN inflammation was the best predictor of all measured kidney functions during three years, while tissue KIM-1 expression (p = 0.016) was a predictor only at 6 months after biopsy. Conclusion. Tissue KIM-1 expression significantly predicts kidney function solely at 6 months after biopsy, when the effects of immune and nonimmune treatments are the strongest.
PB  - Hindawi Publishing Corporation, New York
T2  - Disease Markers
T1  - Tissue Kidney Injury Molecule-1 Expression in the Prediction of Renal Function for Several Years after Kidney Biopsy
SP  - 567
EP  - 572
DO  - 10.1155/2013/183246
ER  - 

@article{
author = "Simić-Ogrizović, Sanja and Bojić, Suzana and Basta-Jovanović, Gordana and Radojević, Sanja and Pavlović, Jelena and Kotur-Stevuljević, Jelena and Dopsaj, Violeta and Naumović, Radomir",
year = "2013",
abstract = "Objectives. Retrospective study was designed to examine the importance of tissue kidney injury molecule-1 (KIM-1) expression in predicting kidney function in sixty patients (27 males) aged 34.15 +/- 12.23 years with different kidney diseases over three years after kidney biopsy. Materials and Methods. Tissue KIM-1 expression was determined immunohistochemically and KIM-1 staining was scored semiquantitatively, as well as tubulointerstitialis (TIN), inflammation, atrophy, and fibrosis. Kidney function (MDRD formula) and proteinuria/day were evaluated at the time of biopsy (GFR0) and 6, 12, 24, and 36 months later Results. Significantly positive correlations between tissue KIM-1 expression and age (r = 0.313), TIN inflammation (r = 0.456), fibrosis (r = 0.317), and proteinuria at 6 months (r = 0.394) as well as negative correlations with GFR0 (r = -0.572), GFR6 (r = -0.442), GFR24 (r = -0.398), and GFR36 (r = -0.412) were found. Meanwhile, TIN inflammation was the best predictor of all measured kidney functions during three years, while tissue KIM-1 expression (p = 0.016) was a predictor only at 6 months after biopsy. Conclusion. Tissue KIM-1 expression significantly predicts kidney function solely at 6 months after biopsy, when the effects of immune and nonimmune treatments are the strongest.",
publisher = "Hindawi Publishing Corporation, New York",
journal = "Disease Markers",
title = "Tissue Kidney Injury Molecule-1 Expression in the Prediction of Renal Function for Several Years after Kidney Biopsy",
pages = "567-572",
doi = "10.1155/2013/183246"
}

Simić-Ogrizović, S., Bojić, S., Basta-Jovanović, G., Radojević, S., Pavlović, J., Kotur-Stevuljević, J., Dopsaj, V.,& Naumović, R.. (2013). Tissue Kidney Injury Molecule-1 Expression in the Prediction of Renal Function for Several Years after Kidney Biopsy. in Disease Markers
Hindawi Publishing Corporation, New York., 567-572.
https://doi.org/10.1155/2013/183246

Simić-Ogrizović S, Bojić S, Basta-Jovanović G, Radojević S, Pavlović J, Kotur-Stevuljević J, Dopsaj V, Naumović R. Tissue Kidney Injury Molecule-1 Expression in the Prediction of Renal Function for Several Years after Kidney Biopsy. in Disease Markers. 2013;:567-572.
doi:10.1155/2013/183246 .

Simić-Ogrizović, Sanja, Bojić, Suzana, Basta-Jovanović, Gordana, Radojević, Sanja, Pavlović, Jelena, Kotur-Stevuljević, Jelena, Dopsaj, Violeta, Naumović, Radomir, "Tissue Kidney Injury Molecule-1 Expression in the Prediction of Renal Function for Several Years after Kidney Biopsy" in Disease Markers (2013):567-572,
https://doi.org/10.1155/2013/183246 . .

TY  - JOUR
AU  - Simić-Ogrizović, Sanja
AU  - Bogavac-Stanojević, Nataša
AU  - Vucković, Maja
AU  - Dopsaj, Violeta
AU  - Giga, Vojislav
AU  - Kravljaca, Milica
AU  - Stošović, Milan
AU  - Lezaić, Višnja
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1719
AB  - The best treatment for end stage renal disease (ESRD) patients is kidney transplantation, but the renal transplant recipients still have a higher incidence of cardiovascular events compared with general population. Cardiovascular risk factors were imposed long before ESRD, as the majority of patients starting dialysis or kidney transplantation already have signs of advanced atherosclerosis. Artery calcification is an organized, regulated process similar to bone formation. Coronary artery calcification (CAC) is found frequently in advanced atherosclerotic lesions and could be a useful marker of them. We evaluated the prevalence of CAC in 49 stable renal transplant recipients and in 48 age- and gender-matched patients with chronic kidney disease (CKD) in stages 2-5 not requiring dialysis to assess risk factors associated with CAC. Computed tomography was used for CAC detection and quantification (CAC score). The prevalence of CAC was 43.8% in transplant recipients and 16.7% in CKD patients (p  lt  0.001). Transplant recipients with CAC were significantly older and had longer duration of CKD and/or dialysis than recipients without CAC. In contrast, the serum levels of fetuin A (an inhibitor of vascular calcification) and albumin were significantly lower in CKD patients with CAC than those without CAC. During the observation period (30 months), 30 patients, including 23 CKD patients, began dialysis, and 4 transplant recipients and 2 CKD patients died. Independent predictors of mortality were age, serum amyloid A and the CAC score. In conclusion, the examination and prevention of risk factors associated with atherosclerosis should be started at the beginning of renal failure.
PB  - Tohoku Univ Medical Press, Sendai
T2  - Toxicological and Environmental Chemistry
T1  - Risk Factors Associated with Coronary Artery Calcification Should Be Examined before Kidney Transplantation
VL  - 226
IS  - 2
SP  - 137
EP  - 144
DO  - 10.1620/tjem.226.137
ER  - 

@article{
author = "Simić-Ogrizović, Sanja and Bogavac-Stanojević, Nataša and Vucković, Maja and Dopsaj, Violeta and Giga, Vojislav and Kravljaca, Milica and Stošović, Milan and Lezaić, Višnja",
year = "2012",
abstract = "The best treatment for end stage renal disease (ESRD) patients is kidney transplantation, but the renal transplant recipients still have a higher incidence of cardiovascular events compared with general population. Cardiovascular risk factors were imposed long before ESRD, as the majority of patients starting dialysis or kidney transplantation already have signs of advanced atherosclerosis. Artery calcification is an organized, regulated process similar to bone formation. Coronary artery calcification (CAC) is found frequently in advanced atherosclerotic lesions and could be a useful marker of them. We evaluated the prevalence of CAC in 49 stable renal transplant recipients and in 48 age- and gender-matched patients with chronic kidney disease (CKD) in stages 2-5 not requiring dialysis to assess risk factors associated with CAC. Computed tomography was used for CAC detection and quantification (CAC score). The prevalence of CAC was 43.8% in transplant recipients and 16.7% in CKD patients (p  lt  0.001). Transplant recipients with CAC were significantly older and had longer duration of CKD and/or dialysis than recipients without CAC. In contrast, the serum levels of fetuin A (an inhibitor of vascular calcification) and albumin were significantly lower in CKD patients with CAC than those without CAC. During the observation period (30 months), 30 patients, including 23 CKD patients, began dialysis, and 4 transplant recipients and 2 CKD patients died. Independent predictors of mortality were age, serum amyloid A and the CAC score. In conclusion, the examination and prevention of risk factors associated with atherosclerosis should be started at the beginning of renal failure.",
publisher = "Tohoku Univ Medical Press, Sendai",
journal = "Toxicological and Environmental Chemistry",
title = "Risk Factors Associated with Coronary Artery Calcification Should Be Examined before Kidney Transplantation",
volume = "226",
number = "2",
pages = "137-144",
doi = "10.1620/tjem.226.137"
}

Simić-Ogrizović, S., Bogavac-Stanojević, N., Vucković, M., Dopsaj, V., Giga, V., Kravljaca, M., Stošović, M.,& Lezaić, V.. (2012). Risk Factors Associated with Coronary Artery Calcification Should Be Examined before Kidney Transplantation. in Toxicological and Environmental Chemistry
Tohoku Univ Medical Press, Sendai., 226(2), 137-144.
https://doi.org/10.1620/tjem.226.137

Simić-Ogrizović S, Bogavac-Stanojević N, Vucković M, Dopsaj V, Giga V, Kravljaca M, Stošović M, Lezaić V. Risk Factors Associated with Coronary Artery Calcification Should Be Examined before Kidney Transplantation. in Toxicological and Environmental Chemistry. 2012;226(2):137-144.
doi:10.1620/tjem.226.137 .

Simić-Ogrizović, Sanja, Bogavac-Stanojević, Nataša, Vucković, Maja, Dopsaj, Violeta, Giga, Vojislav, Kravljaca, Milica, Stošović, Milan, Lezaić, Višnja, "Risk Factors Associated with Coronary Artery Calcification Should Be Examined before Kidney Transplantation" in Toxicological and Environmental Chemistry, 226, no. 2 (2012):137-144,
https://doi.org/10.1620/tjem.226.137 . .