TY  - JOUR
AU  - Ivanišević, Ivana
AU  - Peco-Antić, Amira
AU  - Vulicević, Irena
AU  - Hercog, Đorđe
AU  - Milovanović, Vladimir
AU  - Kotur-Stevuljević, Jelena
AU  - Stefanović, Aleksandra
AU  - Kocev, Nikola
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1995
AB  - Acute kidney injury (AKI) is a common postoperative complication following cardiopulmonary bypass (CPB) surgery. New biomarkers to identify patients with early AKI (before increases in serum creatinine) are needed to facilitate appropriate treatment. This study aimed to test the role of urinary liver fatty-acid-binding protein (L-FABP) as an early biomarker for AKI in children undergoing CPB surgery. This is a case-control study of children undergoing CPB. AKI was defined as 50 % increase in serum creatinine at 48 h after surgery. For each patient, five serum and urine samples were obtained corresponding to time 0 h (presurgery) and 2, 6, 24, and 48 h after surgery. Twenty-seven patients, median age 360 days, were enrolled. AKI developed in 11 patients (41 %); three needed renal replacement therapy (peritoneal dialysis); there were two deaths. There were significant differences between patients with and without AKI in L-FABP levels at 2, 6, and 48 h after surgery, length of hospital stay, and CPB time; there were no differences in gender, patient age, and body weight. L-FABP was normalized to urinary creatinine concentration at all time points, with area under the receiver operator curve (AUC ROC) 0.867 at 2 and 6 h postoperatively. Correlation coefficient between L-FABP and length of hospital stay after surgery was statistically significant (r = 0.722, p value = 0.000). Our results suggest that urinary L-FABP can be used to diagnose AKI earlier than rise in serum creatinine in children undergoing CPB.
PB  - Springer, New York
T2  - Pediatric Nephrology
T1  - L-FABP can be an early marker of acute kidney injury in children
VL  - 28
IS  - 6
SP  - 963
EP  - 969
DO  - 10.1007/s00467-013-2421-z
ER  - 

@article{
author = "Ivanišević, Ivana and Peco-Antić, Amira and Vulicević, Irena and Hercog, Đorđe and Milovanović, Vladimir and Kotur-Stevuljević, Jelena and Stefanović, Aleksandra and Kocev, Nikola",
year = "2013",
abstract = "Acute kidney injury (AKI) is a common postoperative complication following cardiopulmonary bypass (CPB) surgery. New biomarkers to identify patients with early AKI (before increases in serum creatinine) are needed to facilitate appropriate treatment. This study aimed to test the role of urinary liver fatty-acid-binding protein (L-FABP) as an early biomarker for AKI in children undergoing CPB surgery. This is a case-control study of children undergoing CPB. AKI was defined as 50 % increase in serum creatinine at 48 h after surgery. For each patient, five serum and urine samples were obtained corresponding to time 0 h (presurgery) and 2, 6, 24, and 48 h after surgery. Twenty-seven patients, median age 360 days, were enrolled. AKI developed in 11 patients (41 %); three needed renal replacement therapy (peritoneal dialysis); there were two deaths. There were significant differences between patients with and without AKI in L-FABP levels at 2, 6, and 48 h after surgery, length of hospital stay, and CPB time; there were no differences in gender, patient age, and body weight. L-FABP was normalized to urinary creatinine concentration at all time points, with area under the receiver operator curve (AUC ROC) 0.867 at 2 and 6 h postoperatively. Correlation coefficient between L-FABP and length of hospital stay after surgery was statistically significant (r = 0.722, p value = 0.000). Our results suggest that urinary L-FABP can be used to diagnose AKI earlier than rise in serum creatinine in children undergoing CPB.",
publisher = "Springer, New York",
journal = "Pediatric Nephrology",
title = "L-FABP can be an early marker of acute kidney injury in children",
volume = "28",
number = "6",
pages = "963-969",
doi = "10.1007/s00467-013-2421-z"
}

Ivanišević, I., Peco-Antić, A., Vulicević, I., Hercog, Đ., Milovanović, V., Kotur-Stevuljević, J., Stefanović, A.,& Kocev, N.. (2013). L-FABP can be an early marker of acute kidney injury in children. in Pediatric Nephrology
Springer, New York., 28(6), 963-969.
https://doi.org/10.1007/s00467-013-2421-z

Ivanišević I, Peco-Antić A, Vulicević I, Hercog Đ, Milovanović V, Kotur-Stevuljević J, Stefanović A, Kocev N. L-FABP can be an early marker of acute kidney injury in children. in Pediatric Nephrology. 2013;28(6):963-969.
doi:10.1007/s00467-013-2421-z .

Ivanišević, Ivana, Peco-Antić, Amira, Vulicević, Irena, Hercog, Đorđe, Milovanović, Vladimir, Kotur-Stevuljević, Jelena, Stefanović, Aleksandra, Kocev, Nikola, "L-FABP can be an early marker of acute kidney injury in children" in Pediatric Nephrology, 28, no. 6 (2013):963-969,
https://doi.org/10.1007/s00467-013-2421-z . .

TY  - JOUR
AU  - Peco-Antić, Amira
AU  - Ivanišević, Ivana
AU  - Vulicević, Irena
AU  - Kotur-Stevuljević, Jelena
AU  - Ilić, Slobodan
AU  - Ivanišević, Jasmina
AU  - Miljković, Milica
AU  - Kocev, Nikola
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1893
AB  - Objectives: Acute kidney injury (AKI) is a significant problem in children undergoing cardiopulmonary bypass (CPB). The aims of this study were to assess the diagnostic validity of serum CysC (sCysC), serum neutrophil gelatinase lipocalin (sNGAL), urine neutrophil gelatinase lipocalin (uNGAL), urine kidney injury molecule (uKIM)-1, and urine liver fatty acid-binding protein (uL-FABP) to predict AKI presence and severity in children undergoing CPB. Design and methods: We performed a prospective single-center evaluation of sCysC, sNGAL, uNGAL, uKIM-1 and uL-FABP at 0, 2, 6, 24 and 48 h postoperatively in children undergoing CPB during cardiac surgery. AKI was defined as >= 25% decrease in the estimated creatinine clearance (eCCl) from pre-operative baseline at 48 h after surgery. Results: Of the 112 patients, 18 patients (16.1%) developed AKI; four of them needed acute dialysis treatment and three AKI patients died. In the AKI compared to the non-AM group, sCysC at 2 h, and uNGAL and uL-FABP at 2-48 h were significantly increased, as well as CPB, aortic cross clamp time and length of hospital stay. Biomarkers increased with worsening AKI severity. At 2 h after CPB the best accuracy for diagnosis of AKI had uL-FABP and sCysC with area under the receiver operator curve (AUC) of 0.89 and 0.73, respectively. At 6 and 24 h after CPB the best AUC was found for uL-FABP (0.75 and 0.87 respectively) and for uNGAL (0.70 and 0.93, respectively). Conclusions: sCysC, uNGAL and uL-FABP are reliable early predictors for AKI after CPB. By allowing earlier timing of injury and earlier intervention, they could improve AKI outcome.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Clinical Biochemistry
T1  - Biomarkers of acute kidney injury in pediatric cardiac surgery
VL  - 46
IS  - 13-14
SP  - 1244
EP  - 1251
DO  - 10.1016/j.clinbiochem.2013.07.008
ER  - 

@article{
author = "Peco-Antić, Amira and Ivanišević, Ivana and Vulicević, Irena and Kotur-Stevuljević, Jelena and Ilić, Slobodan and Ivanišević, Jasmina and Miljković, Milica and Kocev, Nikola",
year = "2013",
abstract = "Objectives: Acute kidney injury (AKI) is a significant problem in children undergoing cardiopulmonary bypass (CPB). The aims of this study were to assess the diagnostic validity of serum CysC (sCysC), serum neutrophil gelatinase lipocalin (sNGAL), urine neutrophil gelatinase lipocalin (uNGAL), urine kidney injury molecule (uKIM)-1, and urine liver fatty acid-binding protein (uL-FABP) to predict AKI presence and severity in children undergoing CPB. Design and methods: We performed a prospective single-center evaluation of sCysC, sNGAL, uNGAL, uKIM-1 and uL-FABP at 0, 2, 6, 24 and 48 h postoperatively in children undergoing CPB during cardiac surgery. AKI was defined as >= 25% decrease in the estimated creatinine clearance (eCCl) from pre-operative baseline at 48 h after surgery. Results: Of the 112 patients, 18 patients (16.1%) developed AKI; four of them needed acute dialysis treatment and three AKI patients died. In the AKI compared to the non-AM group, sCysC at 2 h, and uNGAL and uL-FABP at 2-48 h were significantly increased, as well as CPB, aortic cross clamp time and length of hospital stay. Biomarkers increased with worsening AKI severity. At 2 h after CPB the best accuracy for diagnosis of AKI had uL-FABP and sCysC with area under the receiver operator curve (AUC) of 0.89 and 0.73, respectively. At 6 and 24 h after CPB the best AUC was found for uL-FABP (0.75 and 0.87 respectively) and for uNGAL (0.70 and 0.93, respectively). Conclusions: sCysC, uNGAL and uL-FABP are reliable early predictors for AKI after CPB. By allowing earlier timing of injury and earlier intervention, they could improve AKI outcome.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Clinical Biochemistry",
title = "Biomarkers of acute kidney injury in pediatric cardiac surgery",
volume = "46",
number = "13-14",
pages = "1244-1251",
doi = "10.1016/j.clinbiochem.2013.07.008"
}

Peco-Antić, A., Ivanišević, I., Vulicević, I., Kotur-Stevuljević, J., Ilić, S., Ivanišević, J., Miljković, M.,& Kocev, N.. (2013). Biomarkers of acute kidney injury in pediatric cardiac surgery. in Clinical Biochemistry
Pergamon-Elsevier Science Ltd, Oxford., 46(13-14), 1244-1251.
https://doi.org/10.1016/j.clinbiochem.2013.07.008

Peco-Antić A, Ivanišević I, Vulicević I, Kotur-Stevuljević J, Ilić S, Ivanišević J, Miljković M, Kocev N. Biomarkers of acute kidney injury in pediatric cardiac surgery. in Clinical Biochemistry. 2013;46(13-14):1244-1251.
doi:10.1016/j.clinbiochem.2013.07.008 .

Peco-Antić, Amira, Ivanišević, Ivana, Vulicević, Irena, Kotur-Stevuljević, Jelena, Ilić, Slobodan, Ivanišević, Jasmina, Miljković, Milica, Kocev, Nikola, "Biomarkers of acute kidney injury in pediatric cardiac surgery" in Clinical Biochemistry, 46, no. 13-14 (2013):1244-1251,
https://doi.org/10.1016/j.clinbiochem.2013.07.008 . .

TY  - CONF
AU  - Peco-Antić, Amira
AU  - Vukicević, Irena
AU  - Kotur, Jelena
AU  - Hercog, Đorđe
AU  - Milovanović, Vladimir
AU  - Ivanišević, Jasmina
AU  - Ivanišević, Ivana
AU  - Miljković, Milica
AU  - Kocev, Nikola
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1741
PB  - Springer, New York
C3  - Pediatric Nephrology
T1  - Biomarkers of acute kidney injury in pediatric cardiac surgery
VL  - 27
IS  - 9
SP  - 1620
EP  - 1620
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1741
ER  - 

@conference{
author = "Peco-Antić, Amira and Vukicević, Irena and Kotur, Jelena and Hercog, Đorđe and Milovanović, Vladimir and Ivanišević, Jasmina and Ivanišević, Ivana and Miljković, Milica and Kocev, Nikola",
year = "2012",
publisher = "Springer, New York",
journal = "Pediatric Nephrology",
title = "Biomarkers of acute kidney injury in pediatric cardiac surgery",
volume = "27",
number = "9",
pages = "1620-1620",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1741"
}

Peco-Antić, A., Vukicević, I., Kotur, J., Hercog, Đ., Milovanović, V., Ivanišević, J., Ivanišević, I., Miljković, M.,& Kocev, N.. (2012). Biomarkers of acute kidney injury in pediatric cardiac surgery. in Pediatric Nephrology
Springer, New York., 27(9), 1620-1620.
https://hdl.handle.net/21.15107/rcub_farfar_1741

Peco-Antić A, Vukicević I, Kotur J, Hercog Đ, Milovanović V, Ivanišević J, Ivanišević I, Miljković M, Kocev N. Biomarkers of acute kidney injury in pediatric cardiac surgery. in Pediatric Nephrology. 2012;27(9):1620-1620.
https://hdl.handle.net/21.15107/rcub_farfar_1741 .

Peco-Antić, Amira, Vukicević, Irena, Kotur, Jelena, Hercog, Đorđe, Milovanović, Vladimir, Ivanišević, Jasmina, Ivanišević, Ivana, Miljković, Milica, Kocev, Nikola, "Biomarkers of acute kidney injury in pediatric cardiac surgery" in Pediatric Nephrology, 27, no. 9 (2012):1620-1620,
https://hdl.handle.net/21.15107/rcub_farfar_1741 .

TY  - JOUR
AU  - Stepanović-Petrović, Radica
AU  - Tomić, Maja
AU  - Vučković, Sonja M.
AU  - Kocev, Nikola
AU  - Ugrešić, Nenad
AU  - Prostran, Milica
AU  - Bošković, Bogdan
PY  - 2008
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1092
AB  - Background/Aims: The purpose of this study was to investigate the involvement of GABAergic mechanisms in the antihyperalgesic effect of carbamazepine and oxcarbazepine by examining the effect of bicuculline ( GABA A receptor antagonist) on these effects of antiepileptic drugs. Methods: Rats were intraplantarly (i.pl.) injected with the proinflammatory compound concanavalin A ( Con A). A paw-pressure test was used to determine: ( 1) the development of hyperalgesia induced by Con A; ( 2) the effects of carbamazepine/ oxcarbazepine on Con A-induced hyperalgesia, and ( 3) the effects of bicuculline on the carbamazepine/ oxcarbazepine antihyperalgesia. Results: Intraperitoneally injected bicuculline (0.5 - 1 mg/kg, i.p.) exhibited significant suppression of the systemic antihyperalgesic effects of carbamazepine ( 27 mg/ kg, i.p.) and oxcarbazepine ( 80 mg/ kg, i.p.). When applied intraplantarly, bicuculline ( 0.14 mg/ paw, i.pl.) did not produce any change in the peripheral antihyperalgesic effects of carbamazepine ( 0.14 mg/ paw, i.pl.) and oxcarbazepine (0.5 mg/paw, i.pl.). Bicuculline alone did not produce an intrinsic effect in the paw-pressure test. Conclusion: These results indicate that the antihyperalgesic effects of carbamazepine and oxcarbazepine against inflammatory hyperalgesia involve in part the GABAergic inhibitory modulation of pain transmission at central, but not at peripheral sites, which is mediated via GABA A receptor activation. Copyright
PB  - Karger, Basel
T2  - Pharmacology
T1  - GABAergic mechanisms are involved in the antihyperalgesic effects of carbamazepine and oxcarbazepine in a rat model of inflammatory hyperalgesia
VL  - 82
IS  - 1
SP  - 53
EP  - 58
DO  - 10.1159/000127841
ER  - 

@article{
author = "Stepanović-Petrović, Radica and Tomić, Maja and Vučković, Sonja M. and Kocev, Nikola and Ugrešić, Nenad and Prostran, Milica and Bošković, Bogdan",
year = "2008",
abstract = "Background/Aims: The purpose of this study was to investigate the involvement of GABAergic mechanisms in the antihyperalgesic effect of carbamazepine and oxcarbazepine by examining the effect of bicuculline ( GABA A receptor antagonist) on these effects of antiepileptic drugs. Methods: Rats were intraplantarly (i.pl.) injected with the proinflammatory compound concanavalin A ( Con A). A paw-pressure test was used to determine: ( 1) the development of hyperalgesia induced by Con A; ( 2) the effects of carbamazepine/ oxcarbazepine on Con A-induced hyperalgesia, and ( 3) the effects of bicuculline on the carbamazepine/ oxcarbazepine antihyperalgesia. Results: Intraperitoneally injected bicuculline (0.5 - 1 mg/kg, i.p.) exhibited significant suppression of the systemic antihyperalgesic effects of carbamazepine ( 27 mg/ kg, i.p.) and oxcarbazepine ( 80 mg/ kg, i.p.). When applied intraplantarly, bicuculline ( 0.14 mg/ paw, i.pl.) did not produce any change in the peripheral antihyperalgesic effects of carbamazepine ( 0.14 mg/ paw, i.pl.) and oxcarbazepine (0.5 mg/paw, i.pl.). Bicuculline alone did not produce an intrinsic effect in the paw-pressure test. Conclusion: These results indicate that the antihyperalgesic effects of carbamazepine and oxcarbazepine against inflammatory hyperalgesia involve in part the GABAergic inhibitory modulation of pain transmission at central, but not at peripheral sites, which is mediated via GABA A receptor activation. Copyright",
publisher = "Karger, Basel",
journal = "Pharmacology",
title = "GABAergic mechanisms are involved in the antihyperalgesic effects of carbamazepine and oxcarbazepine in a rat model of inflammatory hyperalgesia",
volume = "82",
number = "1",
pages = "53-58",
doi = "10.1159/000127841"
}

Stepanović-Petrović, R., Tomić, M., Vučković, S. M., Kocev, N., Ugrešić, N., Prostran, M.,& Bošković, B.. (2008). GABAergic mechanisms are involved in the antihyperalgesic effects of carbamazepine and oxcarbazepine in a rat model of inflammatory hyperalgesia. in Pharmacology
Karger, Basel., 82(1), 53-58.
https://doi.org/10.1159/000127841

Stepanović-Petrović R, Tomić M, Vučković SM, Kocev N, Ugrešić N, Prostran M, Bošković B. GABAergic mechanisms are involved in the antihyperalgesic effects of carbamazepine and oxcarbazepine in a rat model of inflammatory hyperalgesia. in Pharmacology. 2008;82(1):53-58.
doi:10.1159/000127841 .

Stepanović-Petrović, Radica, Tomić, Maja, Vučković, Sonja M., Kocev, Nikola, Ugrešić, Nenad, Prostran, Milica, Bošković, Bogdan, "GABAergic mechanisms are involved in the antihyperalgesic effects of carbamazepine and oxcarbazepine in a rat model of inflammatory hyperalgesia" in Pharmacology, 82, no. 1 (2008):53-58,
https://doi.org/10.1159/000127841 . .