TY  - JOUR
AU  - Erić-Jovanović, S
AU  - Agbaba, Danica
AU  - Živanov-Stakić, Dobrila
AU  - Vladimirov, S
PY  - 1998
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/197
AB  - The objective of this investigation was to develop a HPTLC method for the determination of ceftriaxone, cefixime and cefotaxime, cephalosporins widely used in clinical practice, High performance TLC of cephalosporins was performed on pre-coated silica gel HPTLC plates with concentrating zone (2.5 x 10 cm) by development in mobile phase ethyl acetate-acetone-methanol-water (5:2.5:2.5:1.5 v/v/v/v). A TLC scanner set at 270 nm was used for direct evaluation of the chromatograms in reflectance/absorbance mode. The calibration curves were established as dependence of peak height (linear and polynomial regression) and peak area (polynomial regression) versus ng level (125-500 ng for all cephalosporins investigated). Relative standard deviations obtained from calibration curves was compared. Precision (RSD: 1.12-2.91% (peak height versus ng) and RSD: 1.05-2.75% (peak area versus ng)), and detection limits (ng level) was validated and found to be satisfactory. The method was found to be reproducible and convenient for quantitative analysis of ceftriaxone, cefixime and cefotaxime in their raw materials and their dosage forms.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Journal of Pharmaceutical and Biomedical Analysis
T1  - HPTLC determination of ceftriaxone, cefixime and cefotaxime in dosage forms
VL  - 18
IS  - 4-5
SP  - 893
EP  - 898
DO  - 10.1016/S0731-7085(98)00274-X
ER  - 

@article{
author = "Erić-Jovanović, S and Agbaba, Danica and Živanov-Stakić, Dobrila and Vladimirov, S",
year = "1998",
abstract = "The objective of this investigation was to develop a HPTLC method for the determination of ceftriaxone, cefixime and cefotaxime, cephalosporins widely used in clinical practice, High performance TLC of cephalosporins was performed on pre-coated silica gel HPTLC plates with concentrating zone (2.5 x 10 cm) by development in mobile phase ethyl acetate-acetone-methanol-water (5:2.5:2.5:1.5 v/v/v/v). A TLC scanner set at 270 nm was used for direct evaluation of the chromatograms in reflectance/absorbance mode. The calibration curves were established as dependence of peak height (linear and polynomial regression) and peak area (polynomial regression) versus ng level (125-500 ng for all cephalosporins investigated). Relative standard deviations obtained from calibration curves was compared. Precision (RSD: 1.12-2.91% (peak height versus ng) and RSD: 1.05-2.75% (peak area versus ng)), and detection limits (ng level) was validated and found to be satisfactory. The method was found to be reproducible and convenient for quantitative analysis of ceftriaxone, cefixime and cefotaxime in their raw materials and their dosage forms.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Journal of Pharmaceutical and Biomedical Analysis",
title = "HPTLC determination of ceftriaxone, cefixime and cefotaxime in dosage forms",
volume = "18",
number = "4-5",
pages = "893-898",
doi = "10.1016/S0731-7085(98)00274-X"
}

Erić-Jovanović, S., Agbaba, D., Živanov-Stakić, D.,& Vladimirov, S.. (1998). HPTLC determination of ceftriaxone, cefixime and cefotaxime in dosage forms. in Journal of Pharmaceutical and Biomedical Analysis
Pergamon-Elsevier Science Ltd, Oxford., 18(4-5), 893-898.
https://doi.org/10.1016/S0731-7085(98)00274-X

Erić-Jovanović S, Agbaba D, Živanov-Stakić D, Vladimirov S. HPTLC determination of ceftriaxone, cefixime and cefotaxime in dosage forms. in Journal of Pharmaceutical and Biomedical Analysis. 1998;18(4-5):893-898.
doi:10.1016/S0731-7085(98)00274-X .

Erić-Jovanović, S, Agbaba, Danica, Živanov-Stakić, Dobrila, Vladimirov, S, "HPTLC determination of ceftriaxone, cefixime and cefotaxime in dosage forms" in Journal of Pharmaceutical and Biomedical Analysis, 18, no. 4-5 (1998):893-898,
https://doi.org/10.1016/S0731-7085(98)00274-X . .

TY  - JOUR
AU  - Agbaba, Danica
AU  - Erić-Jovanović, S
AU  - Živanov-Stakić, Dobrila
AU  - Vladimirov, S
PY  - 1998
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/202
AB  - The objective of this investigation was to develop an HPTLC method for the determination of ceftriaxone, cefixime and cefotaxime, cephalosporins widely used in clinical practice. High performance thin-layer chromatography of cephalosporins was performed on pre-coated silica gel HPTLC plates with concentration zones (2.5×10cm), development with mobile phase ethylacetate-acetone-methanol-water (5:2.5:2.5:1.5 v/v). A TLC scanner (Camag, Muttenz, Switzerland) set at 270 nm was used for direct evaluation of the chromatograms in reflectance/absorbance mode. The calibration curves were established dependant of peak height (linear and polinomial regression) and peak area (polinomial regression) vs ng level (125-500 ng for all cephalosporins investigated). Coefficients of variation obtained from calibration curves were compared. Precision (c.v.: 1.12-2.91% (peak height vs ng) and c.v.: 1.05-2.75% (peak area vs ng)), and detection limits (ng level) were found to be satisfactory. The method is reproducible and convenient for quantitative analysis of ceftriaxone, cefixime and cefotaxime raw materials and their different dosage forms.
PB  - APB Algemene Pharmaceutische Bond
T2  - Journal de Pharmacie de Belgique
T1  - HPTLC determination of ceftriaxone, cefixime and cefotaxime in dosage forms
VL  - 53
IS  - 3
SP  - 150
UR  - https://hdl.handle.net/21.15107/rcub_farfar_202
ER  - 

@article{
author = "Agbaba, Danica and Erić-Jovanović, S and Živanov-Stakić, Dobrila and Vladimirov, S",
year = "1998",
abstract = "The objective of this investigation was to develop an HPTLC method for the determination of ceftriaxone, cefixime and cefotaxime, cephalosporins widely used in clinical practice. High performance thin-layer chromatography of cephalosporins was performed on pre-coated silica gel HPTLC plates with concentration zones (2.5×10cm), development with mobile phase ethylacetate-acetone-methanol-water (5:2.5:2.5:1.5 v/v). A TLC scanner (Camag, Muttenz, Switzerland) set at 270 nm was used for direct evaluation of the chromatograms in reflectance/absorbance mode. The calibration curves were established dependant of peak height (linear and polinomial regression) and peak area (polinomial regression) vs ng level (125-500 ng for all cephalosporins investigated). Coefficients of variation obtained from calibration curves were compared. Precision (c.v.: 1.12-2.91% (peak height vs ng) and c.v.: 1.05-2.75% (peak area vs ng)), and detection limits (ng level) were found to be satisfactory. The method is reproducible and convenient for quantitative analysis of ceftriaxone, cefixime and cefotaxime raw materials and their different dosage forms.",
publisher = "APB Algemene Pharmaceutische Bond",
journal = "Journal de Pharmacie de Belgique",
title = "HPTLC determination of ceftriaxone, cefixime and cefotaxime in dosage forms",
volume = "53",
number = "3",
pages = "150",
url = "https://hdl.handle.net/21.15107/rcub_farfar_202"
}

Agbaba, D., Erić-Jovanović, S., Živanov-Stakić, D.,& Vladimirov, S.. (1998). HPTLC determination of ceftriaxone, cefixime and cefotaxime in dosage forms. in Journal de Pharmacie de Belgique
APB Algemene Pharmaceutische Bond., 53(3), 150.
https://hdl.handle.net/21.15107/rcub_farfar_202

Agbaba D, Erić-Jovanović S, Živanov-Stakić D, Vladimirov S. HPTLC determination of ceftriaxone, cefixime and cefotaxime in dosage forms. in Journal de Pharmacie de Belgique. 1998;53(3):150.
https://hdl.handle.net/21.15107/rcub_farfar_202 .

Agbaba, Danica, Erić-Jovanović, S, Živanov-Stakić, Dobrila, Vladimirov, S, "HPTLC determination of ceftriaxone, cefixime and cefotaxime in dosage forms" in Journal de Pharmacie de Belgique, 53, no. 3 (1998):150,
https://hdl.handle.net/21.15107/rcub_farfar_202 .