TY  - JOUR
AU  - Mijatović, Stefan
AU  - Antić-Stanković, Jelena
AU  - Čolović Čalovski, Ivana, Ivana
AU  - Dubljanin, Eleonora
AU  - Pljevljakušić, Dejan
AU  - Bigović, Dubravka
AU  - Džamić, Aleksandar
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4292
AB  - The aim of our study was to determine the susceptibility of 15 Candida albicans sputum isolates on fluconazole and caspofungin, as well as the antifungal potential of Lavandula angustifolia essential oil (LAEO). The commercial LAEO was analyzed using gas chromatography-mass spectrometry. The antifungal activity was evaluated using EUCAST protocol. A killing assay was performed to evaluate kinetics of 2% LAEO within 30 min treatment. LAEO with major constituents’ linalool (33.4%) and linalyl acetate (30.5%) effective inhibited grows of C. albicans in concentration range 0.5–2%. Fluconazole activity was noted in 67% of the isolates with MICs in range 0.06–1 µg/mL. Surprisingly, 40% of isolates were non-wild-type (non-WT), while MICs for WT ranged between 0.125–0.25 µg/mL. There were no significant differences in the LAEO MICs among fluconazole-resistant and fluconazole-susceptible sputum strains (p = 0.31) and neither among caspofungin non-WT and WT isolates (p = 0.79). The 2% LAEO rapidly achieved 50% growth reduction in all tested strains between 0.2 and 3.5 min. Within 30 min, the same LAEO concentration exhibited a 99.9% reduction in 27% isolates. This study demonstrated that 2% solution of LAEO showed a significant antifungal activity which is equally effective against fluconazole and caspofungin susceptible and less-susceptible strains.
PB  - MDPI
T2  - Molecules
T1  - Antifungal Activity of Lavandula angustifolia Essential Oil against Candida albicans: Time-Kill Study on Pediatric Sputum Isolates
VL  - 27
IS  - 19
DO  - 10.3390/molecules27196300
ER  - 

@article{
author = "Mijatović, Stefan and Antić-Stanković, Jelena and Čolović Čalovski, Ivana, Ivana and Dubljanin, Eleonora and Pljevljakušić, Dejan and Bigović, Dubravka and Džamić, Aleksandar",
year = "2022",
abstract = "The aim of our study was to determine the susceptibility of 15 Candida albicans sputum isolates on fluconazole and caspofungin, as well as the antifungal potential of Lavandula angustifolia essential oil (LAEO). The commercial LAEO was analyzed using gas chromatography-mass spectrometry. The antifungal activity was evaluated using EUCAST protocol. A killing assay was performed to evaluate kinetics of 2% LAEO within 30 min treatment. LAEO with major constituents’ linalool (33.4%) and linalyl acetate (30.5%) effective inhibited grows of C. albicans in concentration range 0.5–2%. Fluconazole activity was noted in 67% of the isolates with MICs in range 0.06–1 µg/mL. Surprisingly, 40% of isolates were non-wild-type (non-WT), while MICs for WT ranged between 0.125–0.25 µg/mL. There were no significant differences in the LAEO MICs among fluconazole-resistant and fluconazole-susceptible sputum strains (p = 0.31) and neither among caspofungin non-WT and WT isolates (p = 0.79). The 2% LAEO rapidly achieved 50% growth reduction in all tested strains between 0.2 and 3.5 min. Within 30 min, the same LAEO concentration exhibited a 99.9% reduction in 27% isolates. This study demonstrated that 2% solution of LAEO showed a significant antifungal activity which is equally effective against fluconazole and caspofungin susceptible and less-susceptible strains.",
publisher = "MDPI",
journal = "Molecules",
title = "Antifungal Activity of Lavandula angustifolia Essential Oil against Candida albicans: Time-Kill Study on Pediatric Sputum Isolates",
volume = "27",
number = "19",
doi = "10.3390/molecules27196300"
}

Mijatović, S., Antić-Stanković, J., Čolović Čalovski, I. I., Dubljanin, E., Pljevljakušić, D., Bigović, D.,& Džamić, A.. (2022). Antifungal Activity of Lavandula angustifolia Essential Oil against Candida albicans: Time-Kill Study on Pediatric Sputum Isolates. in Molecules
MDPI., 27(19).
https://doi.org/10.3390/molecules27196300

Mijatović S, Antić-Stanković J, Čolović Čalovski II, Dubljanin E, Pljevljakušić D, Bigović D, Džamić A. Antifungal Activity of Lavandula angustifolia Essential Oil against Candida albicans: Time-Kill Study on Pediatric Sputum Isolates. in Molecules. 2022;27(19).
doi:10.3390/molecules27196300 .

Mijatović, Stefan, Antić-Stanković, Jelena, Čolović Čalovski, Ivana, Ivana, Dubljanin, Eleonora, Pljevljakušić, Dejan, Bigović, Dubravka, Džamić, Aleksandar, "Antifungal Activity of Lavandula angustifolia Essential Oil against Candida albicans: Time-Kill Study on Pediatric Sputum Isolates" in Molecules, 27, no. 19 (2022),
https://doi.org/10.3390/molecules27196300 . .