TY  - JOUR
AU  - Mirković, Dušica
AU  - Ibrić, Svetlana
AU  - Balanc, Bojana
AU  - Knez, Željko
AU  - Bugarski, Branko
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2996
AB  - The aim of this study was to develop, characterize and evaluate concentrated nanoemulsions (20%) for parenteral nutrition. Those systems were developed by the high-pressure homogenization method. Optimal conditions for the nanoemulsion production were identified using 2(4-1) fractional factorial design. The characterization of physicochemical parameters was carried out immediately after the nanoemulsion production, and after 10 and 30 days. The biological control was conducted 30 days after their preparation as well. The oil phase contained the combination of the soybean (SO) and fish oil (FO) as well as the fish oil and medium-chain triglycerides (MCT), while the aqueous phase was composed of water for injections. The egg yolk phospholipids (EP) were used as surfactants alone, or in combination with Poloxamer 188 (PI). The obtained results were in accordance with the literature date e.i. quality requirements for parenteral emulsions (the droplet diameter  lt = 500 nm, PDI  lt = 0.25, absolute value of zeta-potential >= 25 mV, pH-value in the range of 6-9). It was shown that the combination of two surfactants (the egg yolk phospholipids that provides the electrostatic stabilization and Poloxamer 188-steric stabilizer) used as emulsifiers ensures the optimal quality of the obtained nanoemulsions for parenteral nutrition.
PB  - Elsevier Science BV, Amsterdam
T2  - Journal of Drug Delivery Science and Technology
T1  - Evaluation of the impact of critical quality attributes and critical process parameters on quality and stability of parenteral nutrition nanoemulsions
VL  - 39
SP  - 341
EP  - 347
DO  - 10.1016/j.jddst.2017.04.004
ER  - 

@article{
author = "Mirković, Dušica and Ibrić, Svetlana and Balanc, Bojana and Knez, Željko and Bugarski, Branko",
year = "2017",
abstract = "The aim of this study was to develop, characterize and evaluate concentrated nanoemulsions (20%) for parenteral nutrition. Those systems were developed by the high-pressure homogenization method. Optimal conditions for the nanoemulsion production were identified using 2(4-1) fractional factorial design. The characterization of physicochemical parameters was carried out immediately after the nanoemulsion production, and after 10 and 30 days. The biological control was conducted 30 days after their preparation as well. The oil phase contained the combination of the soybean (SO) and fish oil (FO) as well as the fish oil and medium-chain triglycerides (MCT), while the aqueous phase was composed of water for injections. The egg yolk phospholipids (EP) were used as surfactants alone, or in combination with Poloxamer 188 (PI). The obtained results were in accordance with the literature date e.i. quality requirements for parenteral emulsions (the droplet diameter  lt = 500 nm, PDI  lt = 0.25, absolute value of zeta-potential >= 25 mV, pH-value in the range of 6-9). It was shown that the combination of two surfactants (the egg yolk phospholipids that provides the electrostatic stabilization and Poloxamer 188-steric stabilizer) used as emulsifiers ensures the optimal quality of the obtained nanoemulsions for parenteral nutrition.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Journal of Drug Delivery Science and Technology",
title = "Evaluation of the impact of critical quality attributes and critical process parameters on quality and stability of parenteral nutrition nanoemulsions",
volume = "39",
pages = "341-347",
doi = "10.1016/j.jddst.2017.04.004"
}

Mirković, D., Ibrić, S., Balanc, B., Knez, Ž.,& Bugarski, B.. (2017). Evaluation of the impact of critical quality attributes and critical process parameters on quality and stability of parenteral nutrition nanoemulsions. in Journal of Drug Delivery Science and Technology
Elsevier Science BV, Amsterdam., 39, 341-347.
https://doi.org/10.1016/j.jddst.2017.04.004

Mirković D, Ibrić S, Balanc B, Knez Ž, Bugarski B. Evaluation of the impact of critical quality attributes and critical process parameters on quality and stability of parenteral nutrition nanoemulsions. in Journal of Drug Delivery Science and Technology. 2017;39:341-347.
doi:10.1016/j.jddst.2017.04.004 .

Mirković, Dušica, Ibrić, Svetlana, Balanc, Bojana, Knez, Željko, Bugarski, Branko, "Evaluation of the impact of critical quality attributes and critical process parameters on quality and stability of parenteral nutrition nanoemulsions" in Journal of Drug Delivery Science and Technology, 39 (2017):341-347,
https://doi.org/10.1016/j.jddst.2017.04.004 . .