TY  - JOUR
AU  - Radovanović, Ana M.
AU  - Cupara, Snežana
AU  - Popović, Suzana L. J.
AU  - Tomović, Marina T.
AU  - Slavkovska, Violeta
AU  - Janković, Slobodan
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1869
AB  - Potentilla reptans L. belongs to the least studied of the plants from Rosaceae family, Potentilla genus. There are no data on cytotoxicity of P. reptans extracts, though traditionaly it was used as anti-inflammatory and antiinfective. The aim of these studies was to investigate potential antitumor activity of aqueous extracts (rhizome and aerial parts) of P. reptans on 4T1 mouse breast cancer cell line._Aqueous extracts of rhizome and aerial parts of P. reptans were tested for cytotoxicity by the MTT colorimetric assay on 4T1 cancer cell line in concentration range 100-800 mu g/mL. Aqueous extracts of P. reptans rhizome and aerial parts show concentration dependent cytotoxic effect in the range of tested concentrations. IC50 value of P. reptans rhizome extract was 280.51 +/- 1.16 mu g/mL. IC50 value of P. reptans aerial parts extract was 310.79 +/- 1.22 mu g/mL. The significant difference in cytotoxicity among tested concentrations was observed. Aqueous extracts of P. mptans rhizome and aerial parts demonstrated weak cytotoxic activity on 4T1 mouse breast cancer cell line, which is in correlation with current cytotoxicity data for aqueous herbal extracts. Rhizome extract of P. reptans has slightly higher antitumor activity than aerial parts extract. The results represent the first report on cytotoxicity for this plant and further research on human cell lines is indicated.
PB  - Polskie Towarzystwo Farmaceutyczne, Warsaw
T2  - Acta Poloniae Pharmaceutica - Drug Research
T1  - Cytotoxic effect of Potentilla reptans L. rhizome and aerial part extracts
VL  - 70
IS  - 5
SP  - 851
EP  - 854
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1869
ER  - 

@article{
author = "Radovanović, Ana M. and Cupara, Snežana and Popović, Suzana L. J. and Tomović, Marina T. and Slavkovska, Violeta and Janković, Slobodan",
year = "2013",
abstract = "Potentilla reptans L. belongs to the least studied of the plants from Rosaceae family, Potentilla genus. There are no data on cytotoxicity of P. reptans extracts, though traditionaly it was used as anti-inflammatory and antiinfective. The aim of these studies was to investigate potential antitumor activity of aqueous extracts (rhizome and aerial parts) of P. reptans on 4T1 mouse breast cancer cell line._Aqueous extracts of rhizome and aerial parts of P. reptans were tested for cytotoxicity by the MTT colorimetric assay on 4T1 cancer cell line in concentration range 100-800 mu g/mL. Aqueous extracts of P. reptans rhizome and aerial parts show concentration dependent cytotoxic effect in the range of tested concentrations. IC50 value of P. reptans rhizome extract was 280.51 +/- 1.16 mu g/mL. IC50 value of P. reptans aerial parts extract was 310.79 +/- 1.22 mu g/mL. The significant difference in cytotoxicity among tested concentrations was observed. Aqueous extracts of P. mptans rhizome and aerial parts demonstrated weak cytotoxic activity on 4T1 mouse breast cancer cell line, which is in correlation with current cytotoxicity data for aqueous herbal extracts. Rhizome extract of P. reptans has slightly higher antitumor activity than aerial parts extract. The results represent the first report on cytotoxicity for this plant and further research on human cell lines is indicated.",
publisher = "Polskie Towarzystwo Farmaceutyczne, Warsaw",
journal = "Acta Poloniae Pharmaceutica - Drug Research",
title = "Cytotoxic effect of Potentilla reptans L. rhizome and aerial part extracts",
volume = "70",
number = "5",
pages = "851-854",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1869"
}

Radovanović, A. M., Cupara, S., Popović, S. L. J., Tomović, M. T., Slavkovska, V.,& Janković, S.. (2013). Cytotoxic effect of Potentilla reptans L. rhizome and aerial part extracts. in Acta Poloniae Pharmaceutica - Drug Research
Polskie Towarzystwo Farmaceutyczne, Warsaw., 70(5), 851-854.
https://hdl.handle.net/21.15107/rcub_farfar_1869

Radovanović AM, Cupara S, Popović SLJ, Tomović MT, Slavkovska V, Janković S. Cytotoxic effect of Potentilla reptans L. rhizome and aerial part extracts. in Acta Poloniae Pharmaceutica - Drug Research. 2013;70(5):851-854.
https://hdl.handle.net/21.15107/rcub_farfar_1869 .

Radovanović, Ana M., Cupara, Snežana, Popović, Suzana L. J., Tomović, Marina T., Slavkovska, Violeta, Janković, Slobodan, "Cytotoxic effect of Potentilla reptans L. rhizome and aerial part extracts" in Acta Poloniae Pharmaceutica - Drug Research, 70, no. 5 (2013):851-854,
https://hdl.handle.net/21.15107/rcub_farfar_1869 .

TY  - JOUR
AU  - Cupara, Snežana
AU  - Šobajić, Slađana
AU  - Tadić, Vanja M.
AU  - Arsić, I
AU  - Đorđević, S.
AU  - Runjaić-Antić, Dušanka
AU  - Đorđević, Brižita
PY  - 2010
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1356
AB  - Sea buckthorn (Hippophae rhamnoides L., Elaeagnaceae), is a thorny bush or small tree, native to Europe and Asia. Sea buckthorn fruit is rich in oil and carotenes which are found both in pericarp and seeds. Fruit and seed oils have significantly different fatty acid profiles and carotene levels. Previously reported data on the content of fatty acids and the carotenes in the oil are based on the fresh fruits. However, sea buckthorn fruits for traditional herbal use are available commonly in dry form. The goal of work was to analyze the content of fatty acids and carotenes in the fruit pericarp oil and seed oil obtained from dry sea buckthorn fruits. Physical and Chemical constants of the oils were also determined. It was found that the oil yield from pericarp and seeds were 18,8 and 7,4 respectively (expressed in g of oil per 100 g of dry plant material). The composition of fatty acids was determined by GC in the methyl ester form. The main fatty acids in pericarp oil were palmitic, palmitoleic, and oleic acids (35,2 %, 28,5 %, and 29,9 % respectively). Seed oil was, on the other hand, rich in oleic, linoleic and alpha-linolenic acids (23,7 %, 37,6 %, 20,5 % respectively). The content of carotenes in oil obtained from fresh sources varies extremely within different subspecies and it is influenced strongly by methods of oil isolation. The common reported levels of carotenes in pericarp and seed oil obtained from fresh fruits are 100-500mg/100g and 20-100 mg/100 g respectively. Our findings have significantly lower values then the average reported data, which points that dehydration of sea buckthorn berries influences negatively upon the content of carotenes, and then fatty oil content remains roughly the same as in fresh fruits. From medical point of view and dried fruits are a valuable source of polyunsaturated fatty acids and monounsaturated you have a favorable effect primarily on the cardiovascular system.
PB  - Drunpp-Sarajevo, Sarajevo
T2  - HealthMed
T1  - Dry sea buckthorn berries (Hippophae rhamnoides L.) - fatty acid and carotene content in pericarp and seed oil
VL  - 4
IS  - 4
SP  - 788
EP  - 791
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1356
ER  - 

@article{
author = "Cupara, Snežana and Šobajić, Slađana and Tadić, Vanja M. and Arsić, I and Đorđević, S. and Runjaić-Antić, Dušanka and Đorđević, Brižita",
year = "2010",
abstract = "Sea buckthorn (Hippophae rhamnoides L., Elaeagnaceae), is a thorny bush or small tree, native to Europe and Asia. Sea buckthorn fruit is rich in oil and carotenes which are found both in pericarp and seeds. Fruit and seed oils have significantly different fatty acid profiles and carotene levels. Previously reported data on the content of fatty acids and the carotenes in the oil are based on the fresh fruits. However, sea buckthorn fruits for traditional herbal use are available commonly in dry form. The goal of work was to analyze the content of fatty acids and carotenes in the fruit pericarp oil and seed oil obtained from dry sea buckthorn fruits. Physical and Chemical constants of the oils were also determined. It was found that the oil yield from pericarp and seeds were 18,8 and 7,4 respectively (expressed in g of oil per 100 g of dry plant material). The composition of fatty acids was determined by GC in the methyl ester form. The main fatty acids in pericarp oil were palmitic, palmitoleic, and oleic acids (35,2 %, 28,5 %, and 29,9 % respectively). Seed oil was, on the other hand, rich in oleic, linoleic and alpha-linolenic acids (23,7 %, 37,6 %, 20,5 % respectively). The content of carotenes in oil obtained from fresh sources varies extremely within different subspecies and it is influenced strongly by methods of oil isolation. The common reported levels of carotenes in pericarp and seed oil obtained from fresh fruits are 100-500mg/100g and 20-100 mg/100 g respectively. Our findings have significantly lower values then the average reported data, which points that dehydration of sea buckthorn berries influences negatively upon the content of carotenes, and then fatty oil content remains roughly the same as in fresh fruits. From medical point of view and dried fruits are a valuable source of polyunsaturated fatty acids and monounsaturated you have a favorable effect primarily on the cardiovascular system.",
publisher = "Drunpp-Sarajevo, Sarajevo",
journal = "HealthMed",
title = "Dry sea buckthorn berries (Hippophae rhamnoides L.) - fatty acid and carotene content in pericarp and seed oil",
volume = "4",
number = "4",
pages = "788-791",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1356"
}

Cupara, S., Šobajić, S., Tadić, V. M., Arsić, I., Đorđević, S., Runjaić-Antić, D.,& Đorđević, B.. (2010). Dry sea buckthorn berries (Hippophae rhamnoides L.) - fatty acid and carotene content in pericarp and seed oil. in HealthMed
Drunpp-Sarajevo, Sarajevo., 4(4), 788-791.
https://hdl.handle.net/21.15107/rcub_farfar_1356

Cupara S, Šobajić S, Tadić VM, Arsić I, Đorđević S, Runjaić-Antić D, Đorđević B. Dry sea buckthorn berries (Hippophae rhamnoides L.) - fatty acid and carotene content in pericarp and seed oil. in HealthMed. 2010;4(4):788-791.
https://hdl.handle.net/21.15107/rcub_farfar_1356 .

Cupara, Snežana, Šobajić, Slađana, Tadić, Vanja M., Arsić, I, Đorđević, S., Runjaić-Antić, Dušanka, Đorđević, Brižita, "Dry sea buckthorn berries (Hippophae rhamnoides L.) - fatty acid and carotene content in pericarp and seed oil" in HealthMed, 4, no. 4 (2010):788-791,
https://hdl.handle.net/21.15107/rcub_farfar_1356 .

TY  - JOUR
AU  - Cupara, Snežana
AU  - Arsić, Ivana A.
AU  - Šobajić, Slađana
AU  - Đorđević, Sofija
AU  - Runjaić-Antić, Dušanka
AU  - Ristić, Mihailo
AU  - Psodorov, Đorđe
PY  - 2007
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1017
AB  - Since nowadays the link between nutrition and health has been established, the industry of food and pharmaceuticals developed a new category- functional food. Medicinal plants became significant for production of functional food, because the biological activities. Sea buckthorn - Hippophae rhamnoides L., is a shrub with fruits that are false, soft and flashy berries. Fresh ripe fruits are commonly used as a rich source of vitamin C and B and fatty oil from fruits and seeds, which is a significant source of carotenoids, vitamins A, D, E and essential fatty acids (EFA). The aim of this paper is to estimate commercially available sample of sea buckthorn as potential constituent of functional food by quantification of EFA and total tocopherols content. The dominant components are oleic and linoleic acid (22,9% and 35,4%), while total tocopherols were 88,6mg/100g. So, tested oil sample could be used in functional food. .
AB  - Zbog potvrđene povezanosti ishrane i zdravlja, prehrambena i farmaceutska industrija su razvile novu kategoriju proizvoda - funkcionalnu hranu. Lekovite biljke, kao nosioci bioloških aktivnosti, postale su značajne u proizvodnji funkcionalne hrane. Pasji trn - Hippophae rhamnoides L. (Eleagnaceae) je listopadni žbun sa plodovima u obliku mesnate koštunice. Koristi se svež zreo plod bogat vitaminima B i C i masno ulje iz plodova i semena koje sadrži visok procenat karotenoida, vitamina A, D i E i esencijalnih masnih kiselina. Cilj rada je procena kvaliteta komercijalno dostupnog uzorka masnog ulja pasjeg trna kao potencijalne sirovine za funkcionalnu hranu. Određen je sadržaj esencijalnih masnih kiselina (EMK) i tokoferola. Rezultati su pokazali da su dominantne komponente oleinska i linolna kiselina zastupljene u količini od 22,9%, odnosno 35,4%, dok je količina ukupnih tokoferola 88,6 mg/100g. Zbog visokog sadržaja EMK i značajnog tokoferola, ovo ulje se može koristiti kao dodatak u proizvodnji funkcionalne hrane. .
PB  - Univerzitet u Nišu - Tehnološki fakultet, Leskovac
T2  - Zbornik radova Tehnološkog fakulteta, Leskovac
T1  - Sea buckthorn as potential constituent of functional food
T1  - Pasji trn - potencijalni sastojak funkcionalne hrane
IS  - 16
SP  - 193
EP  - 197
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1017
ER  - 

@article{
author = "Cupara, Snežana and Arsić, Ivana A. and Šobajić, Slađana and Đorđević, Sofija and Runjaić-Antić, Dušanka and Ristić, Mihailo and Psodorov, Đorđe",
year = "2007",
abstract = "Since nowadays the link between nutrition and health has been established, the industry of food and pharmaceuticals developed a new category- functional food. Medicinal plants became significant for production of functional food, because the biological activities. Sea buckthorn - Hippophae rhamnoides L., is a shrub with fruits that are false, soft and flashy berries. Fresh ripe fruits are commonly used as a rich source of vitamin C and B and fatty oil from fruits and seeds, which is a significant source of carotenoids, vitamins A, D, E and essential fatty acids (EFA). The aim of this paper is to estimate commercially available sample of sea buckthorn as potential constituent of functional food by quantification of EFA and total tocopherols content. The dominant components are oleic and linoleic acid (22,9% and 35,4%), while total tocopherols were 88,6mg/100g. So, tested oil sample could be used in functional food. ., Zbog potvrđene povezanosti ishrane i zdravlja, prehrambena i farmaceutska industrija su razvile novu kategoriju proizvoda - funkcionalnu hranu. Lekovite biljke, kao nosioci bioloških aktivnosti, postale su značajne u proizvodnji funkcionalne hrane. Pasji trn - Hippophae rhamnoides L. (Eleagnaceae) je listopadni žbun sa plodovima u obliku mesnate koštunice. Koristi se svež zreo plod bogat vitaminima B i C i masno ulje iz plodova i semena koje sadrži visok procenat karotenoida, vitamina A, D i E i esencijalnih masnih kiselina. Cilj rada je procena kvaliteta komercijalno dostupnog uzorka masnog ulja pasjeg trna kao potencijalne sirovine za funkcionalnu hranu. Određen je sadržaj esencijalnih masnih kiselina (EMK) i tokoferola. Rezultati su pokazali da su dominantne komponente oleinska i linolna kiselina zastupljene u količini od 22,9%, odnosno 35,4%, dok je količina ukupnih tokoferola 88,6 mg/100g. Zbog visokog sadržaja EMK i značajnog tokoferola, ovo ulje se može koristiti kao dodatak u proizvodnji funkcionalne hrane. .",
publisher = "Univerzitet u Nišu - Tehnološki fakultet, Leskovac",
journal = "Zbornik radova Tehnološkog fakulteta, Leskovac",
title = "Sea buckthorn as potential constituent of functional food, Pasji trn - potencijalni sastojak funkcionalne hrane",
number = "16",
pages = "193-197",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1017"
}

Cupara, S., Arsić, I. A., Šobajić, S., Đorđević, S., Runjaić-Antić, D., Ristić, M.,& Psodorov, Đ.. (2007). Sea buckthorn as potential constituent of functional food. in Zbornik radova Tehnološkog fakulteta, Leskovac
Univerzitet u Nišu - Tehnološki fakultet, Leskovac.(16), 193-197.
https://hdl.handle.net/21.15107/rcub_farfar_1017

Cupara S, Arsić IA, Šobajić S, Đorđević S, Runjaić-Antić D, Ristić M, Psodorov Đ. Sea buckthorn as potential constituent of functional food. in Zbornik radova Tehnološkog fakulteta, Leskovac. 2007;(16):193-197.
https://hdl.handle.net/21.15107/rcub_farfar_1017 .

Cupara, Snežana, Arsić, Ivana A., Šobajić, Slađana, Đorđević, Sofija, Runjaić-Antić, Dušanka, Ristić, Mihailo, Psodorov, Đorđe, "Sea buckthorn as potential constituent of functional food" in Zbornik radova Tehnološkog fakulteta, Leskovac, no. 16 (2007):193-197,
https://hdl.handle.net/21.15107/rcub_farfar_1017 .