TY  - CONF
AU  - Stojković, Tatjana
AU  - Rose, Olaf
AU  - Woltersdorf, Ronja
AU  - Marinković, Valentina
AU  - Manser, Tanja
AU  - Jaehde, Ulrich
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3180
PB  - Springer, Dordrecht
C3  - International Journal of Clinical Pharmacy
T1  - Failure mode and effects analysis: a useful tool for prospective risk assessment in community pharmacies
VL  - 40
IS  - 1
SP  - 215
EP  - 215
DO  - 10.1007/s11096-017-0565-9
ER  - 

@conference{
author = "Stojković, Tatjana and Rose, Olaf and Woltersdorf, Ronja and Marinković, Valentina and Manser, Tanja and Jaehde, Ulrich",
year = "2018",
publisher = "Springer, Dordrecht",
journal = "International Journal of Clinical Pharmacy",
title = "Failure mode and effects analysis: a useful tool for prospective risk assessment in community pharmacies",
volume = "40",
number = "1",
pages = "215-215",
doi = "10.1007/s11096-017-0565-9"
}

Stojković, T., Rose, O., Woltersdorf, R., Marinković, V., Manser, T.,& Jaehde, U.. (2018). Failure mode and effects analysis: a useful tool for prospective risk assessment in community pharmacies. in International Journal of Clinical Pharmacy
Springer, Dordrecht., 40(1), 215-215.
https://doi.org/10.1007/s11096-017-0565-9

Stojković T, Rose O, Woltersdorf R, Marinković V, Manser T, Jaehde U. Failure mode and effects analysis: a useful tool for prospective risk assessment in community pharmacies. in International Journal of Clinical Pharmacy. 2018;40(1):215-215.
doi:10.1007/s11096-017-0565-9 .

Stojković, Tatjana, Rose, Olaf, Woltersdorf, Ronja, Marinković, Valentina, Manser, Tanja, Jaehde, Ulrich, "Failure mode and effects analysis: a useful tool for prospective risk assessment in community pharmacies" in International Journal of Clinical Pharmacy, 40, no. 1 (2018):215-215,
https://doi.org/10.1007/s11096-017-0565-9 . .

TY  - JOUR
AU  - Stojković, Tatjana
AU  - Rose, Olaf
AU  - Woltersdorf, Ronja
AU  - Marinković, Valentina
AU  - Manser, Tanja
AU  - Jaehde, Ulrich
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3181
AB  - BackgroundMedicine dispensing represents an error-prone activity, carrying a considerable risk for patients. ObjectiveTo prospectively identify and prioritize potential failure modes in the medicine dispensing process as well as to develop corrective actions for patient safety improvement in German community pharmacies. MethodFailure mode and effects analysis was performed in 2 community pharmacies in North Rhine-Westphalia, Germany, in October 2016. A 9-member team was assembled, comprising of a leader and process experts who prospectively assessed the medicine dispensing process by brainstorming, quantified the attributed risks, proposed corrective actions, and reassessed the risks. ResultsThe analysis identified 39 failure modes, out of which the highest criticality scores were assigned to inadequate assessment of therapy appropriateness (Risk Priority Number 45), reluctance to deviate from rebate contracts (36), and dispensing the wrong medicine (30). The corrective actions proposed demonstrated a considerable potential for risk reduction in most failure modes, the most effective of which were introducing obligatory continuous education for pharmacists, organizing communication training, and implementing electronic prescribing. ConclusionThis analysis not only detected various potential safety issues concerning the dispensing in Germany but also strongly indicated that application of failure mode and effects analysis could be highly effective in prospective risk reduction in community pharmacies.
PB  - Wiley, Hoboken
T2  - International Journal of Health Planning and Management
T1  - Prospective systemic risk analysis of the dispensing process in German community pharmacies
VL  - 33
IS  - 1
DO  - 10.1002/hpm.2479
ER  - 

@article{
author = "Stojković, Tatjana and Rose, Olaf and Woltersdorf, Ronja and Marinković, Valentina and Manser, Tanja and Jaehde, Ulrich",
year = "2018",
abstract = "BackgroundMedicine dispensing represents an error-prone activity, carrying a considerable risk for patients. ObjectiveTo prospectively identify and prioritize potential failure modes in the medicine dispensing process as well as to develop corrective actions for patient safety improvement in German community pharmacies. MethodFailure mode and effects analysis was performed in 2 community pharmacies in North Rhine-Westphalia, Germany, in October 2016. A 9-member team was assembled, comprising of a leader and process experts who prospectively assessed the medicine dispensing process by brainstorming, quantified the attributed risks, proposed corrective actions, and reassessed the risks. ResultsThe analysis identified 39 failure modes, out of which the highest criticality scores were assigned to inadequate assessment of therapy appropriateness (Risk Priority Number 45), reluctance to deviate from rebate contracts (36), and dispensing the wrong medicine (30). The corrective actions proposed demonstrated a considerable potential for risk reduction in most failure modes, the most effective of which were introducing obligatory continuous education for pharmacists, organizing communication training, and implementing electronic prescribing. ConclusionThis analysis not only detected various potential safety issues concerning the dispensing in Germany but also strongly indicated that application of failure mode and effects analysis could be highly effective in prospective risk reduction in community pharmacies.",
publisher = "Wiley, Hoboken",
journal = "International Journal of Health Planning and Management",
title = "Prospective systemic risk analysis of the dispensing process in German community pharmacies",
volume = "33",
number = "1",
doi = "10.1002/hpm.2479"
}

Stojković, T., Rose, O., Woltersdorf, R., Marinković, V., Manser, T.,& Jaehde, U.. (2018). Prospective systemic risk analysis of the dispensing process in German community pharmacies. in International Journal of Health Planning and Management
Wiley, Hoboken., 33(1).
https://doi.org/10.1002/hpm.2479

Stojković T, Rose O, Woltersdorf R, Marinković V, Manser T, Jaehde U. Prospective systemic risk analysis of the dispensing process in German community pharmacies. in International Journal of Health Planning and Management. 2018;33(1).
doi:10.1002/hpm.2479 .

Stojković, Tatjana, Rose, Olaf, Woltersdorf, Ronja, Marinković, Valentina, Manser, Tanja, Jaehde, Ulrich, "Prospective systemic risk analysis of the dispensing process in German community pharmacies" in International Journal of Health Planning and Management, 33, no. 1 (2018),
https://doi.org/10.1002/hpm.2479 . .

TY  - CONF
AU  - Stojković, Tatjana
AU  - Marinković, Valentina
AU  - Manser, Tanja
AU  - Woltersdorf, Ronja
AU  - Rose, Olaf
AU  - Jaehde, Ulrich
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3029
PB  - Springer
C3  - International Journal of Clinical Pharmacy
T1  - Comparing findings from prospective risk analyses of the dispensing processes in Serbian and German community pharmacies
VL  - 39
IS  - 3
SP  - 605
EP  - 606
DO  - 10.1007/s11096-017-0462-2
ER  - 

@conference{
author = "Stojković, Tatjana and Marinković, Valentina and Manser, Tanja and Woltersdorf, Ronja and Rose, Olaf and Jaehde, Ulrich",
year = "2017",
publisher = "Springer",
journal = "International Journal of Clinical Pharmacy",
title = "Comparing findings from prospective risk analyses of the dispensing processes in Serbian and German community pharmacies",
volume = "39",
number = "3",
pages = "605-606",
doi = "10.1007/s11096-017-0462-2"
}

Stojković, T., Marinković, V., Manser, T., Woltersdorf, R., Rose, O.,& Jaehde, U.. (2017). Comparing findings from prospective risk analyses of the dispensing processes in Serbian and German community pharmacies. in International Journal of Clinical Pharmacy
Springer., 39(3), 605-606.
https://doi.org/10.1007/s11096-017-0462-2

Stojković T, Marinković V, Manser T, Woltersdorf R, Rose O, Jaehde U. Comparing findings from prospective risk analyses of the dispensing processes in Serbian and German community pharmacies. in International Journal of Clinical Pharmacy. 2017;39(3):605-606.
doi:10.1007/s11096-017-0462-2 .

Stojković, Tatjana, Marinković, Valentina, Manser, Tanja, Woltersdorf, Ronja, Rose, Olaf, Jaehde, Ulrich, "Comparing findings from prospective risk analyses of the dispensing processes in Serbian and German community pharmacies" in International Journal of Clinical Pharmacy, 39, no. 3 (2017):605-606,
https://doi.org/10.1007/s11096-017-0462-2 . .

TY  - JOUR
AU  - Vezmar, Sandra
AU  - Bode, Udo
AU  - Jaehde, Ulrich
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1167
AB  - Intrathecal and/or high-dose intravenous administration of methotrexate (MTX) in the treatment of malignancies such as acute lymphoblastic leukaemia (ALL) has been associated with cases of mild to severe neurotoxicity. The pathogenic mechanism of neurotoxicity is not clear possibly MTX-associated biochemical alterations of the folate and methyl-transfer metabolic pathways play an important role. We report a case of an adult patient treated for ALL relapse with signs of chronic leukoencephalopathy associated with MTX administration. In order to assess alterations in the folate and methyl-transfer pathway we determined 5-methyltetrahydrofolate (5-methyl-THF), S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) in the cerebrospinal fluid (CSF) of the patient. Three CSF samples were obtained by lumbar punction within a four-month period. Concentrations of the metabolites were measured using validated bioanalytical methods based on HPLC with UV and fluorescence detection. The results showed two-fold lower 5-methyl-THF levels (29.3-31.8 nmol/L) in all obtained samples compared to reference values. SAM concentrations were even more than five-fold lower in two samples (5-34.2 nmol/L). SAH concentrations were in the range 7.5-14.3 nmol/L. Our patient had pronounced alterations in the folate and methyl-transfer pathway which indicate that MTX-associated biochemical alterations of these pathways may play an important role in the development of leukoencephalopathy.
PB  - Društvo medicinskih biohemičara Srbije, Beograd i Versita
T2  - Journal of Medical Biochemistry
T1  - Methotrexate-associated biochemical alterations in a patient with chronic neurotoxicity
VL  - 28
IS  - 1
SP  - 11
EP  - 15
DO  - 10.2478/v10011-008-0027-y
ER  - 

@article{
author = "Vezmar, Sandra and Bode, Udo and Jaehde, Ulrich",
year = "2009",
abstract = "Intrathecal and/or high-dose intravenous administration of methotrexate (MTX) in the treatment of malignancies such as acute lymphoblastic leukaemia (ALL) has been associated with cases of mild to severe neurotoxicity. The pathogenic mechanism of neurotoxicity is not clear possibly MTX-associated biochemical alterations of the folate and methyl-transfer metabolic pathways play an important role. We report a case of an adult patient treated for ALL relapse with signs of chronic leukoencephalopathy associated with MTX administration. In order to assess alterations in the folate and methyl-transfer pathway we determined 5-methyltetrahydrofolate (5-methyl-THF), S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) in the cerebrospinal fluid (CSF) of the patient. Three CSF samples were obtained by lumbar punction within a four-month period. Concentrations of the metabolites were measured using validated bioanalytical methods based on HPLC with UV and fluorescence detection. The results showed two-fold lower 5-methyl-THF levels (29.3-31.8 nmol/L) in all obtained samples compared to reference values. SAM concentrations were even more than five-fold lower in two samples (5-34.2 nmol/L). SAH concentrations were in the range 7.5-14.3 nmol/L. Our patient had pronounced alterations in the folate and methyl-transfer pathway which indicate that MTX-associated biochemical alterations of these pathways may play an important role in the development of leukoencephalopathy.",
publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita",
journal = "Journal of Medical Biochemistry",
title = "Methotrexate-associated biochemical alterations in a patient with chronic neurotoxicity",
volume = "28",
number = "1",
pages = "11-15",
doi = "10.2478/v10011-008-0027-y"
}

Vezmar, S., Bode, U.,& Jaehde, U.. (2009). Methotrexate-associated biochemical alterations in a patient with chronic neurotoxicity. in Journal of Medical Biochemistry
Društvo medicinskih biohemičara Srbije, Beograd i Versita., 28(1), 11-15.
https://doi.org/10.2478/v10011-008-0027-y

Vezmar S, Bode U, Jaehde U. Methotrexate-associated biochemical alterations in a patient with chronic neurotoxicity. in Journal of Medical Biochemistry. 2009;28(1):11-15.
doi:10.2478/v10011-008-0027-y .

Vezmar, Sandra, Bode, Udo, Jaehde, Ulrich, "Methotrexate-associated biochemical alterations in a patient with chronic neurotoxicity" in Journal of Medical Biochemistry, 28, no. 1 (2009):11-15,
https://doi.org/10.2478/v10011-008-0027-y . .

TY  - JOUR
AU  - Vezmar, Sandra
AU  - Becker, Achim
AU  - Bode, Udo
AU  - Jaehde, Ulrich
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1230
PB  - Wiley, Hoboken
T2  - Pediatric Blood & Cancer
T1  - Methotrexate-Associated Neurotoxicity Is Not Only Insufficient Leucovorin Rescue
VL  - 53
IS  - 1
SP  - 127
EP  - 128
DO  - 10.1002/pbc.21986
ER  - 

@article{
author = "Vezmar, Sandra and Becker, Achim and Bode, Udo and Jaehde, Ulrich",
year = "2009",
publisher = "Wiley, Hoboken",
journal = "Pediatric Blood & Cancer",
title = "Methotrexate-Associated Neurotoxicity Is Not Only Insufficient Leucovorin Rescue",
volume = "53",
number = "1",
pages = "127-128",
doi = "10.1002/pbc.21986"
}

Vezmar, S., Becker, A., Bode, U.,& Jaehde, U.. (2009). Methotrexate-Associated Neurotoxicity Is Not Only Insufficient Leucovorin Rescue. in Pediatric Blood & Cancer
Wiley, Hoboken., 53(1), 127-128.
https://doi.org/10.1002/pbc.21986

Vezmar S, Becker A, Bode U, Jaehde U. Methotrexate-Associated Neurotoxicity Is Not Only Insufficient Leucovorin Rescue. in Pediatric Blood & Cancer. 2009;53(1):127-128.
doi:10.1002/pbc.21986 .

Vezmar, Sandra, Becker, Achim, Bode, Udo, Jaehde, Ulrich, "Methotrexate-Associated Neurotoxicity Is Not Only Insufficient Leucovorin Rescue" in Pediatric Blood & Cancer, 53, no. 1 (2009):127-128,
https://doi.org/10.1002/pbc.21986 . .