Bogavac-Stanojević, Nataša

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Authority KeyName Variants
orcid::0000-0001-7004-4701
  • Bogavac-Stanojević, Nataša (148)
Projects
Interactive role of dyslipidemia, oxidative stress and inflammation in atherosclerosis and other diseases: genetic and biochemical markers Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200161 (University of Belgrade, Faculty of Pharmacy)
Ispitivanje biohemijskih i genetičkih faktora rizika kao uzročnika i markera ateroskleroze i drugih oboljenja: analitički i klinički aspekti Rare Diseases:Molecular Pathophysiology, Diagnostic and Therapeutic Modalities and Social, Ethical and Legal Aspects
Starenje i bolesti bubrega: razvoj strategije za rano otkrivanje, prevenciju i lečenje Bayer d.o.o
bioMerieux company Pharmanova Ltd, Obrenovac, Serbia
Hemofarm Vrac, a member of Stada group Development of molecules with antiinflammatory and cardioprotective activity: structural modifications, modelling, physicochemical characterization and formulation investigations
Cell Cycle Aberrations and the Impact of Oxidative Stress in Neurodegenerative Processes and Malignant Transformation of the Cell Pharmacological analysis of effects of biologically active substances on isolated smooth muscles from human gastrointestinal and urogenital tract
A multidisciplinary study of relevance to the etiopathogenesis, diagnosis, and current treatment of the disorders affecting thoracoabdominal aorta and its branches Biomarkers of organ damage and dysfunction
Biomarkers for kidney diseases: diagnostic and prognostic significance Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200015 (University of Belgrade, Institute for Medical Research)
Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200042 (University of Belgrade, Institute of Molecular Genetics and Genetic Engineering) info:eu-repo/grantAgreement/MESTD/inst-2020/200043/RS/
Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200043 (Institute of Oncology and Radiology of Serbia, Belgrade) Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200110 (University of Belgrade, Faculty of Medicine)
The interaction of xenobiotics with biological systems Ministry for Scientific/Technological Development, Higher Education and Information Society, Government of Republic of Srpska (Grant. No. 1257023)
Ministry of Education, Science and Technological Development, Republic of Serbia Richter Gedeon Nyrt
Slovenian Research Agency (Grants P3-0298 and J3-5511) The European Cooperation inScience and Technology (COST) for funding activitiesenabling design and distribution of the survey throughCOST action CA21147 - European Network on Optimis-ing Treatment with Therapeutic Antibodies in chronicinflammatory diseases (ENOTTA), with Dr Mulleman asprincipal investigator
The study was supported by COST BM904. This investigation was financially supported by the Innovation Fund Republic of Serbia, Innovation vouchers Programme No. 152/2018

Author's Bibliography

Treatment of vascular non-iatrogenic injuries of upper and lower extremities in tertiary vascular center

Davidović, Lazar B.; Končar, Igor B.; Dragaš, Marko V.; Marković, Miroslav D.; Bogavac-Stanojević, Nataša; Vujčić, Aleksandra D.; Mitrović, Aleksandar C.; Ilić, Nikola S.; Trailović, R.D.; Kostić, Dušan M.

TY  - JOUR
AU  - Davidović, Lazar B.
AU  - Končar, Igor B.
AU  - Dragaš, Marko V.
AU  - Marković, Miroslav D.
AU  - Bogavac-Stanojević, Nataša
AU  - Vujčić, Aleksandra D.
AU  - Mitrović, Aleksandar C.
AU  - Ilić, Nikola S.
AU  - Trailović, R.D.
AU  - Kostić, Dušan M.
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4430
AB  - BACKGROUND: The purpose of this study was to examine demographic and baseline characteristics of patients with vascular injuries of extremities and to define the most relevant factors which influenced an early outcome, as well as limb salvage after the management of vascular trauma. METHODS: This study used the database that included 395 patients with peripheral arterial injuries, who were treated in the tertiary vascular university center in the period between 2005-2020. Exclusion criteria were isolated thoracic, abdominal and neck injuries as well as iatrogenic injuries and injuries of intravenous addicts. Univariate binary logistic regression analysis and multiple logistic regression were used to determine risk factors for lomb loss (after vascular reconstruction) or mortality. Decision to perform primary amputation (without vascular reconstruction) was based on surgeons' preference and experience. RESULTS: Out of 395 vascular injuries treated in the period 2005-2020, 210 (53.2%) presented with non-iatrogenic vascular injuries of upper and lower extremities were analyzed. According to the univariate regression analysis, hemorrhage as the main clinical manifestation on admission (P=0.035) and early reintervention (P=0.048) increased, while an early patency of repaired artery (0.010) significantly decreased a 30-day amputation rate. Multivariate logistic regression analysis of these three variables showed that only early patency of repaired artery significantly decreased the early amputation rate (P=0.009). CONCLUSIONS: Based on presented experience, the patency of vascular reconstruction plays a crucial role in limb salvage in patients with non-iatrogenic peripheral vascular injuries. All factors that might influence the patency should be in focus of improvement.
PB  - Edizioni Minerva Medica
T2  - The Journal of cardiovascular surgery
T1  - Treatment of vascular non-iatrogenic injuries of upper and lower extremities in tertiary vascular center
VL  - 64
IS  - 1
SP  - 74
EP  - 81
DO  - 10.23736/S0021-9509.22.12243-3
ER  - 
@article{
author = "Davidović, Lazar B. and Končar, Igor B. and Dragaš, Marko V. and Marković, Miroslav D. and Bogavac-Stanojević, Nataša and Vujčić, Aleksandra D. and Mitrović, Aleksandar C. and Ilić, Nikola S. and Trailović, R.D. and Kostić, Dušan M.",
abstract = "BACKGROUND: The purpose of this study was to examine demographic and baseline characteristics of patients with vascular injuries of extremities and to define the most relevant factors which influenced an early outcome, as well as limb salvage after the management of vascular trauma. METHODS: This study used the database that included 395 patients with peripheral arterial injuries, who were treated in the tertiary vascular university center in the period between 2005-2020. Exclusion criteria were isolated thoracic, abdominal and neck injuries as well as iatrogenic injuries and injuries of intravenous addicts. Univariate binary logistic regression analysis and multiple logistic regression were used to determine risk factors for lomb loss (after vascular reconstruction) or mortality. Decision to perform primary amputation (without vascular reconstruction) was based on surgeons' preference and experience. RESULTS: Out of 395 vascular injuries treated in the period 2005-2020, 210 (53.2%) presented with non-iatrogenic vascular injuries of upper and lower extremities were analyzed. According to the univariate regression analysis, hemorrhage as the main clinical manifestation on admission (P=0.035) and early reintervention (P=0.048) increased, while an early patency of repaired artery (0.010) significantly decreased a 30-day amputation rate. Multivariate logistic regression analysis of these three variables showed that only early patency of repaired artery significantly decreased the early amputation rate (P=0.009). CONCLUSIONS: Based on presented experience, the patency of vascular reconstruction plays a crucial role in limb salvage in patients with non-iatrogenic peripheral vascular injuries. All factors that might influence the patency should be in focus of improvement.",
publisher = "Edizioni Minerva Medica",
journal = "The Journal of cardiovascular surgery",
title = "Treatment of vascular non-iatrogenic injuries of upper and lower extremities in tertiary vascular center",
volume = "64",
number = "1",
pages = "74-81",
doi = "10.23736/S0021-9509.22.12243-3"
}
Davidović, L. B., Končar, I. B., Dragaš, M. V., Marković, M. D., Bogavac-Stanojević, N., Vujčić, A. D., Mitrović, A. C., Ilić, N. S., Trailović, R.D.,& Kostić, D. M..Treatment of vascular non-iatrogenic injuries of upper and lower extremities in tertiary vascular center. in The Journal of cardiovascular surgery
Edizioni Minerva Medica., 64(1), 74-81.
https://doi.org/10.23736/S0021-9509.22.12243-3
Davidović LB, Končar IB, Dragaš MV, Marković MD, Bogavac-Stanojević N, Vujčić AD, Mitrović AC, Ilić NS, Trailović R, Kostić DM. Treatment of vascular non-iatrogenic injuries of upper and lower extremities in tertiary vascular center. in The Journal of cardiovascular surgery.64(1):74-81.
doi:10.23736/S0021-9509.22.12243-3 .
Davidović, Lazar B., Končar, Igor B., Dragaš, Marko V., Marković, Miroslav D., Bogavac-Stanojević, Nataša, Vujčić, Aleksandra D., Mitrović, Aleksandar C., Ilić, Nikola S., Trailović, R.D., Kostić, Dušan M., "Treatment of vascular non-iatrogenic injuries of upper and lower extremities in tertiary vascular center" in The Journal of cardiovascular surgery, 64, no. 1:74-81,
https://doi.org/10.23736/S0021-9509.22.12243-3 . .

Therapeutic drug monitoring of monoclonal antibodies in chronic inflammatory diseases: A snapshot of laboratories and applications across Europe

Skrede, Silje; Bogavac-Stanojević, Nataša; Dreesen, Erwin; Nielsen, Elisabet; Zaninotto, Martina; Mulleman, Denis

(John Wiley and Sons Inc, 2024)

TY  - JOUR
AU  - Skrede, Silje
AU  - Bogavac-Stanojević, Nataša
AU  - Dreesen, Erwin
AU  - Nielsen, Elisabet
AU  - Zaninotto, Martina
AU  - Mulleman, Denis
PY  - 2024
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5532
AB  - The European Cooperation in Science and Technology (COST) action ENOTTA (The European Network on Optimising Treatment with Therapeutic Antibodies in chronic inflammatory diseases) was launched in 2022. To pave the way for harmonization of analytical methods for quantitation of serum levels of therapeutic antibodies in research and clinical settings, ENOTTA recently performed an online survey mapping laboratories in the field. The survey, which contained 30 questions surrounding therapeutic drug monitoring of relevant drugs and anti-drug antibodies, was distributed via the ENOTTA and European Federation of Clinical Chemistry and Laboratory networks. Among 63 respondents across Europe, 45 reported analytical activity, with a range of utilized methods. Future engagement of as many sites as possible will enable comparison of methodologies and facilitate progress in the field.
PB  - John Wiley and Sons Inc
T2  - Basic and Clinical Pharmacology and Toxicology
T1  - Therapeutic drug monitoring of monoclonal antibodies in chronic inflammatory diseases: A snapshot of laboratories and applications across Europe
DO  - 10.1111/bcpt.13983
ER  - 
@article{
author = "Skrede, Silje and Bogavac-Stanojević, Nataša and Dreesen, Erwin and Nielsen, Elisabet and Zaninotto, Martina and Mulleman, Denis",
year = "2024",
abstract = "The European Cooperation in Science and Technology (COST) action ENOTTA (The European Network on Optimising Treatment with Therapeutic Antibodies in chronic inflammatory diseases) was launched in 2022. To pave the way for harmonization of analytical methods for quantitation of serum levels of therapeutic antibodies in research and clinical settings, ENOTTA recently performed an online survey mapping laboratories in the field. The survey, which contained 30 questions surrounding therapeutic drug monitoring of relevant drugs and anti-drug antibodies, was distributed via the ENOTTA and European Federation of Clinical Chemistry and Laboratory networks. Among 63 respondents across Europe, 45 reported analytical activity, with a range of utilized methods. Future engagement of as many sites as possible will enable comparison of methodologies and facilitate progress in the field.",
publisher = "John Wiley and Sons Inc",
journal = "Basic and Clinical Pharmacology and Toxicology",
title = "Therapeutic drug monitoring of monoclonal antibodies in chronic inflammatory diseases: A snapshot of laboratories and applications across Europe",
doi = "10.1111/bcpt.13983"
}
Skrede, S., Bogavac-Stanojević, N., Dreesen, E., Nielsen, E., Zaninotto, M.,& Mulleman, D.. (2024). Therapeutic drug monitoring of monoclonal antibodies in chronic inflammatory diseases: A snapshot of laboratories and applications across Europe. in Basic and Clinical Pharmacology and Toxicology
John Wiley and Sons Inc..
https://doi.org/10.1111/bcpt.13983
Skrede S, Bogavac-Stanojević N, Dreesen E, Nielsen E, Zaninotto M, Mulleman D. Therapeutic drug monitoring of monoclonal antibodies in chronic inflammatory diseases: A snapshot of laboratories and applications across Europe. in Basic and Clinical Pharmacology and Toxicology. 2024;.
doi:10.1111/bcpt.13983 .
Skrede, Silje, Bogavac-Stanojević, Nataša, Dreesen, Erwin, Nielsen, Elisabet, Zaninotto, Martina, Mulleman, Denis, "Therapeutic drug monitoring of monoclonal antibodies in chronic inflammatory diseases: A snapshot of laboratories and applications across Europe" in Basic and Clinical Pharmacology and Toxicology (2024),
https://doi.org/10.1111/bcpt.13983 . .

Supplementary material for the article: Kotur-Stevuljević, J.; Roksandić-Milenković, M.; Dimić, N. ...et. al. Leukocyte telomere dynamic change in patients with mild to moderate COVID-19 during three weeks of follow-up: relation with therapy

Kotur-Stevuljević, Jelena; Roksandić-Milenković, Marina; Dimić, Nemanja; Dimić, Dejan; Ćujić, Danica; Vekić, Jelena; Guzonjić, Azra; Gagić, Jelena; Timotijević, Ljiljana; Žujović, Dejan; Gnjatović, Marija; Todorović, Aleksandra; Bogavac-Stanojević, Nataša

(Hindawi, 2023)

TY  - DATA
AU  - Kotur-Stevuljević, Jelena
AU  - Roksandić-Milenković, Marina
AU  - Dimić, Nemanja
AU  - Dimić, Dejan
AU  - Ćujić, Danica
AU  - Vekić, Jelena
AU  - Guzonjić, Azra
AU  - Gagić, Jelena
AU  - Timotijević, Ljiljana
AU  - Žujović, Dejan
AU  - Gnjatović, Marija
AU  - Todorović, Aleksandra
AU  - Bogavac-Stanojević, Nataša
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5108
AB  - Background A three-year COVID-19 pandemic revealed a spectrum of disease severity and clinical manifestations. The most intriguing part of this phenomenon lays in interindividual variability in COVID-19 course among patients, which is attributable to patient's age, comorbidities and general health status. Focus of this follow-up study was to assess leukocyte telomere length change in mild-to-moderate COVID-19 patients and concomitant influence of inflammation, oxidative stress (OS), pulmonary involvement and implemented therapy on the course of the disease.

Material and methods Routine biochemical/haematological parameters, markers of OS (prooxidants and antioxidants), vitamin D, IgM and IgG antibodies level and relative length of leukocyte telomeres (rLTL) were measured at three time-points (at diagnosis, after 14 and 21 days from the disease onset) in blood samples of 31 consecutive COVID-19 patients, with a mild (n=16) and moderate (n=15) form of the disease, treated on an outpatient basis.

Results Although the patients had reduced rLTL at baseline (median: 0.592; 25th – 75th percentiles: 0.518-0.724), it significantly increased during the follow-up (median: 0.773; 25th – 75th percentiles: 0.615-0.923; P<0.01). The rate of telomere attrition was associated with the extent of OS and pulmonary involvement. During follow-up, the burden of OS was reduced, while antioxidative defence mechanisms were recovered. The use of antibiotics and N-acetylcysteine-propolis supplementation was associated with telomere lengthening.

Conclusion Results of this study revealed significant interaction between OS, inflammation and leukocyte telomere length attrition in COVID-19. Our data suggest that rRTL can be a biomarker that enables more precise therapy decision and accurate patient status estimation.
PB  - Hindawi
T1  - Supplementary material for the article: Kotur-Stevuljević, J.; Roksandić-Milenković, M.; Dimić, N. ...et. al. Leukocyte telomere dynamic change in patients with mild to moderate COVID-19 during three weeks of follow-up: relation with therapy
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5108
ER  - 
@misc{
author = "Kotur-Stevuljević, Jelena and Roksandić-Milenković, Marina and Dimić, Nemanja and Dimić, Dejan and Ćujić, Danica and Vekić, Jelena and Guzonjić, Azra and Gagić, Jelena and Timotijević, Ljiljana and Žujović, Dejan and Gnjatović, Marija and Todorović, Aleksandra and Bogavac-Stanojević, Nataša",
year = "2023",
abstract = "Background A three-year COVID-19 pandemic revealed a spectrum of disease severity and clinical manifestations. The most intriguing part of this phenomenon lays in interindividual variability in COVID-19 course among patients, which is attributable to patient's age, comorbidities and general health status. Focus of this follow-up study was to assess leukocyte telomere length change in mild-to-moderate COVID-19 patients and concomitant influence of inflammation, oxidative stress (OS), pulmonary involvement and implemented therapy on the course of the disease.

Material and methods Routine biochemical/haematological parameters, markers of OS (prooxidants and antioxidants), vitamin D, IgM and IgG antibodies level and relative length of leukocyte telomeres (rLTL) were measured at three time-points (at diagnosis, after 14 and 21 days from the disease onset) in blood samples of 31 consecutive COVID-19 patients, with a mild (n=16) and moderate (n=15) form of the disease, treated on an outpatient basis.

Results Although the patients had reduced rLTL at baseline (median: 0.592; 25th – 75th percentiles: 0.518-0.724), it significantly increased during the follow-up (median: 0.773; 25th – 75th percentiles: 0.615-0.923; P<0.01). The rate of telomere attrition was associated with the extent of OS and pulmonary involvement. During follow-up, the burden of OS was reduced, while antioxidative defence mechanisms were recovered. The use of antibiotics and N-acetylcysteine-propolis supplementation was associated with telomere lengthening.

Conclusion Results of this study revealed significant interaction between OS, inflammation and leukocyte telomere length attrition in COVID-19. Our data suggest that rRTL can be a biomarker that enables more precise therapy decision and accurate patient status estimation.",
publisher = "Hindawi",
title = "Supplementary material for the article: Kotur-Stevuljević, J.; Roksandić-Milenković, M.; Dimić, N. ...et. al. Leukocyte telomere dynamic change in patients with mild to moderate COVID-19 during three weeks of follow-up: relation with therapy",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5108"
}
Kotur-Stevuljević, J., Roksandić-Milenković, M., Dimić, N., Dimić, D., Ćujić, D., Vekić, J., Guzonjić, A., Gagić, J., Timotijević, L., Žujović, D., Gnjatović, M., Todorović, A.,& Bogavac-Stanojević, N.. (2023). Supplementary material for the article: Kotur-Stevuljević, J.; Roksandić-Milenković, M.; Dimić, N. ...et. al. Leukocyte telomere dynamic change in patients with mild to moderate COVID-19 during three weeks of follow-up: relation with therapy. 
Hindawi..
https://hdl.handle.net/21.15107/rcub_farfar_5108
Kotur-Stevuljević J, Roksandić-Milenković M, Dimić N, Dimić D, Ćujić D, Vekić J, Guzonjić A, Gagić J, Timotijević L, Žujović D, Gnjatović M, Todorović A, Bogavac-Stanojević N. Supplementary material for the article: Kotur-Stevuljević, J.; Roksandić-Milenković, M.; Dimić, N. ...et. al. Leukocyte telomere dynamic change in patients with mild to moderate COVID-19 during three weeks of follow-up: relation with therapy. 2023;.
https://hdl.handle.net/21.15107/rcub_farfar_5108 .
Kotur-Stevuljević, Jelena, Roksandić-Milenković, Marina, Dimić, Nemanja, Dimić, Dejan, Ćujić, Danica, Vekić, Jelena, Guzonjić, Azra, Gagić, Jelena, Timotijević, Ljiljana, Žujović, Dejan, Gnjatović, Marija, Todorović, Aleksandra, Bogavac-Stanojević, Nataša, "Supplementary material for the article: Kotur-Stevuljević, J.; Roksandić-Milenković, M.; Dimić, N. ...et. al. Leukocyte telomere dynamic change in patients with mild to moderate COVID-19 during three weeks of follow-up: relation with therapy" (2023),
https://hdl.handle.net/21.15107/rcub_farfar_5108 .

SMART Pharmacists Serving the New Needs of the Post-COVID Patients, Leaving No-One Behind

Šipetić, Tatjana; Rajković, Dragana; Bogavac-Stanojević, Nataša; Marinković, Valentina; Meštrović, Arijana; Rouse, Michael J.

(MDPI, 2023)

TY  - JOUR
AU  - Šipetić, Tatjana
AU  - Rajković, Dragana
AU  - Bogavac-Stanojević, Nataša
AU  - Marinković, Valentina
AU  - Meštrović, Arijana
AU  - Rouse, Michael J.
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5517
AB  - This study aims to demonstrate the improvements in clinical symptoms in patients with post-COVID syndrome after a community pharmacy-based intervention in Serbia. The Pharmaceutical Chamber of Serbia ("Chamber") invited pharmacists to deliver post-COVID patient care counselling, supported by the SMART Pharmacist Program, offering education and guidance. Present symptoms, duration and patient self-reported severity of symptoms on a scale of 1-5 on the first visit were recorded. After the counselling and proposed self-medication treatment, the time of the follow-up visit and the severity of the recorded symptoms were also recorded. The prospective data collection lasted from December 2021 to September 2022. In total, 871 patients with post-COVID symptoms were included in the study, served by 53 pharmacists. The most frequently reported post-COVID symptoms coincided with the literature, mostly related to the respiratory system (51.2%), immunity status (32.2%), fatigue and exhaustion (30.7%), skin, hair and nails (27.4%) and cognitive functions (27.9%). A total of 26.5% of patients were referred to their family physician (general practitioner), and 69.5% returned to the pharmacist for a follow-up visit. On the first visit, the median severity of patients' symptoms was three, while on the second visit it dropped to one. The pharmacists' intervention led to a significant improvement in the post-COVID patients' condition.
PB  - MDPI
T2  - Pharmacy
T1  - SMART Pharmacists Serving the New Needs of the Post-COVID Patients, Leaving No-One Behind
VL  - 11
IS  - 2
SP  - 61
DO  - 10.3390/pharmacy11020061
ER  - 
@article{
author = "Šipetić, Tatjana and Rajković, Dragana and Bogavac-Stanojević, Nataša and Marinković, Valentina and Meštrović, Arijana and Rouse, Michael J.",
year = "2023",
abstract = "This study aims to demonstrate the improvements in clinical symptoms in patients with post-COVID syndrome after a community pharmacy-based intervention in Serbia. The Pharmaceutical Chamber of Serbia ("Chamber") invited pharmacists to deliver post-COVID patient care counselling, supported by the SMART Pharmacist Program, offering education and guidance. Present symptoms, duration and patient self-reported severity of symptoms on a scale of 1-5 on the first visit were recorded. After the counselling and proposed self-medication treatment, the time of the follow-up visit and the severity of the recorded symptoms were also recorded. The prospective data collection lasted from December 2021 to September 2022. In total, 871 patients with post-COVID symptoms were included in the study, served by 53 pharmacists. The most frequently reported post-COVID symptoms coincided with the literature, mostly related to the respiratory system (51.2%), immunity status (32.2%), fatigue and exhaustion (30.7%), skin, hair and nails (27.4%) and cognitive functions (27.9%). A total of 26.5% of patients were referred to their family physician (general practitioner), and 69.5% returned to the pharmacist for a follow-up visit. On the first visit, the median severity of patients' symptoms was three, while on the second visit it dropped to one. The pharmacists' intervention led to a significant improvement in the post-COVID patients' condition.",
publisher = "MDPI",
journal = "Pharmacy",
title = "SMART Pharmacists Serving the New Needs of the Post-COVID Patients, Leaving No-One Behind",
volume = "11",
number = "2",
pages = "61",
doi = "10.3390/pharmacy11020061"
}
Šipetić, T., Rajković, D., Bogavac-Stanojević, N., Marinković, V., Meštrović, A.,& Rouse, M. J.. (2023). SMART Pharmacists Serving the New Needs of the Post-COVID Patients, Leaving No-One Behind. in Pharmacy
MDPI., 11(2), 61.
https://doi.org/10.3390/pharmacy11020061
Šipetić T, Rajković D, Bogavac-Stanojević N, Marinković V, Meštrović A, Rouse MJ. SMART Pharmacists Serving the New Needs of the Post-COVID Patients, Leaving No-One Behind. in Pharmacy. 2023;11(2):61.
doi:10.3390/pharmacy11020061 .
Šipetić, Tatjana, Rajković, Dragana, Bogavac-Stanojević, Nataša, Marinković, Valentina, Meštrović, Arijana, Rouse, Michael J., "SMART Pharmacists Serving the New Needs of the Post-COVID Patients, Leaving No-One Behind" in Pharmacy, 11, no. 2 (2023):61,
https://doi.org/10.3390/pharmacy11020061 . .
1

The influence of various sample storage conditions and sample microbial contamination on concentrations of routine biochemical parameters

Gojković, Tamara; Vladimirov, Sandra; Antonić, Tamara; Bogavac-Stanojević, Nataša; Novović, Katarina; Spasojević-Kalimanovska, Vesna; Filipić, Brankica

(Journal of Medical Biochemistry, 2023)

TY  - JOUR
AU  - Gojković, Tamara
AU  - Vladimirov, Sandra
AU  - Antonić, Tamara
AU  - Bogavac-Stanojević, Nataša
AU  - Novović, Katarina
AU  - Spasojević-Kalimanovska, Vesna
AU  - Filipić, Brankica
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5421
AB  - Background: The pre-analytical (PA) phase is the most vulnerable phase of laboratory testing procedure, with critical procedures-collection, handling, sample transport, and time and temperature of sample storage. The aim of this study was to examine if different anticoagulants, storage conditions, and freeze-thaw cycles (FTCs) influence the concentrations of basic biochemical parameters. In parallel, the presence and the effect of sample microbiological contamination during routine laboratory work were examined.

Methods: Two plasma pools (EDTA, and sodium-fluoride/potassium oxalate plasma (NaF)) were stored at +4C˚/-20˚C. Total cholesterol (TC), glucose, triglycerides (TG), urea, total protein (TP), and albumin concentrations were measured using Ilab 300+. Sample microbiological contamination was determined by 16S rRNA sequence analysis. The experiment encompassed a 5 day-period: Day 1–fresh sample, Day 2–1st FTC, Day 3–2nd FTC, Day 4–3rd FTC, Day 5–4th FTC. The appearance of bacteria in two consecutive samples was the experiment's endpoint.

Results: During 4 FTCs there were no changes in plasma urea concentrations. Glucose was stable in EDTA+4˚C and NaF- 20˚C until the 3rd FTC (P=0.008, P=0.042, respectively). Changes in protein concentrations followed the zig-zag pattern. TG concentrations changed significantly in the EDTA-20˚C sample after 1st and 4th FTCs (P=0.022, P=0.010, respectively). In NaF samples no contamination was observed during 4 FTCs.

 

Conclusions: Urea and glucose concentrations were robust. Changes in lipid and protein concentrations after FTCs follow complex patterns. Bacterial growth was not observed in NaF plasma samples. This can promote NaF use in analytical procedures in which microbiological contamination affects the quality of analysis.
AB  - Uvod: Preanaliti~ka (PA) faza je slo`en proces koji ~ine:
prikupljanje, rukovanje, transport i skladi{tenje uzoraka, i
predstavlja najzna~ajniji izvor laboratorijskih gre{aka. Cilj
ovog istra`ivanja je bio da se ispita stabilnost osnovnih
biohemijskih parametara u zavisnosti od uslova skladi{tenja
uzoraka i broja ciklusa zamrzavanja-odmrzavanja (FTC).
Pored toga, ispitivano je prisustvo bakterijske kontaminacije
uzoraka tokom rutinskog laboratorijskog rada.
Metode: Dva »pool«-a plazme (etilendiaminotetrasir}etna
kiselina (EDTA) i natrijum-fluorid/kalijum oksalat (NaF)) su
skladi{tena na +4 ˚C/-20 ˚C. Koncentracije ukupnog
holesterola (TC), glukoze, triglicerida (TG), uree i albumina
su odre|ene kori{}enjem BioSystems reagenasa (holesterol
oksidaza/peroksidaza, glukoza oksidaza/peroksidaza,
glice rol fosfat oksidaza/peroksidaza, ureaza/salicilat, od-
nosno bromkrezol zeleno metodama, sukcesivno) na Ilab
300+ analizatoru. Bakterijska kontaminacija uzoraka je
potvr|ena 16S rRNA sekvencioniranjem. Eksperiment je
sproveden tokom 5 uzastopnih dana: 1. dan – sve` uzorak,
2. dan – 1. FTC, 3. dan –2. FTC, 4. dan – 3. FTC, 5. dan
– 4. FTC. Zavr{nu ta~ku eksperimenta predstavljala je
pojava bakterija u dva uzastopna uzorka.
Rezultati: Tokom 4 FTC koncentracije uree u plazmi se nisu
zna~ajno razlikovale. Koncentracija glukoze je bila stabilna
u EDTA +4 ˚C i NaF -20 ˚C do 3.FTC (P=0,008,
P=0,042, redom). Koncentracije TG su se zna~ajno pro-
menile u uzorku EDTA -20 ˚C nakon 1. i 4. FTC-a (P=0,022, P=0,010, redom). U uzorcima NaF plazme
nije do{lo do bakterijske kontaminacije tokom 4. FTC.
Zaklju~ak: Koncentracije uree i glukoze su bile stabilne
tokom trajanja eksperimenta. Promene u koncentracijama
lipida nakon FTC prate slo`ene obrasce. Rast bakterija nije
prime}en u uzorcima NaF plazme, te upotreba ovog anti-
koagulansa mo`e biti opravdana u analiti~kim proce -
durama podlo`nim uticaju mikrobiolo{ke kontaminacije.
PB  - Journal of Medical Biochemistry
T2  - Journal of Medical Biochemistry
T1  - The influence of various sample storage conditions and sample microbial contamination on concentrations of routine biochemical parameters
T1  - Uticaj različitih uslova čuvanja uzoraka i kontaminacije uzoraka bakterijama na koncentracije rutinskih biohemijskih parametara
VL  - 43
IS  - 1
DO  - https://doi.org/10.5937/jomb0-40360
ER  - 
@article{
author = "Gojković, Tamara and Vladimirov, Sandra and Antonić, Tamara and Bogavac-Stanojević, Nataša and Novović, Katarina and Spasojević-Kalimanovska, Vesna and Filipić, Brankica",
year = "2023",
abstract = "Background: The pre-analytical (PA) phase is the most vulnerable phase of laboratory testing procedure, with critical procedures-collection, handling, sample transport, and time and temperature of sample storage. The aim of this study was to examine if different anticoagulants, storage conditions, and freeze-thaw cycles (FTCs) influence the concentrations of basic biochemical parameters. In parallel, the presence and the effect of sample microbiological contamination during routine laboratory work were examined.

Methods: Two plasma pools (EDTA, and sodium-fluoride/potassium oxalate plasma (NaF)) were stored at +4C˚/-20˚C. Total cholesterol (TC), glucose, triglycerides (TG), urea, total protein (TP), and albumin concentrations were measured using Ilab 300+. Sample microbiological contamination was determined by 16S rRNA sequence analysis. The experiment encompassed a 5 day-period: Day 1–fresh sample, Day 2–1st FTC, Day 3–2nd FTC, Day 4–3rd FTC, Day 5–4th FTC. The appearance of bacteria in two consecutive samples was the experiment's endpoint.

Results: During 4 FTCs there were no changes in plasma urea concentrations. Glucose was stable in EDTA+4˚C and NaF- 20˚C until the 3rd FTC (P=0.008, P=0.042, respectively). Changes in protein concentrations followed the zig-zag pattern. TG concentrations changed significantly in the EDTA-20˚C sample after 1st and 4th FTCs (P=0.022, P=0.010, respectively). In NaF samples no contamination was observed during 4 FTCs.

 

Conclusions: Urea and glucose concentrations were robust. Changes in lipid and protein concentrations after FTCs follow complex patterns. Bacterial growth was not observed in NaF plasma samples. This can promote NaF use in analytical procedures in which microbiological contamination affects the quality of analysis., Uvod: Preanaliti~ka (PA) faza je slo`en proces koji ~ine:
prikupljanje, rukovanje, transport i skladi{tenje uzoraka, i
predstavlja najzna~ajniji izvor laboratorijskih gre{aka. Cilj
ovog istra`ivanja je bio da se ispita stabilnost osnovnih
biohemijskih parametara u zavisnosti od uslova skladi{tenja
uzoraka i broja ciklusa zamrzavanja-odmrzavanja (FTC).
Pored toga, ispitivano je prisustvo bakterijske kontaminacije
uzoraka tokom rutinskog laboratorijskog rada.
Metode: Dva »pool«-a plazme (etilendiaminotetrasir}etna
kiselina (EDTA) i natrijum-fluorid/kalijum oksalat (NaF)) su
skladi{tena na +4 ˚C/-20 ˚C. Koncentracije ukupnog
holesterola (TC), glukoze, triglicerida (TG), uree i albumina
su odre|ene kori{}enjem BioSystems reagenasa (holesterol
oksidaza/peroksidaza, glukoza oksidaza/peroksidaza,
glice rol fosfat oksidaza/peroksidaza, ureaza/salicilat, od-
nosno bromkrezol zeleno metodama, sukcesivno) na Ilab
300+ analizatoru. Bakterijska kontaminacija uzoraka je
potvr|ena 16S rRNA sekvencioniranjem. Eksperiment je
sproveden tokom 5 uzastopnih dana: 1. dan – sve` uzorak,
2. dan – 1. FTC, 3. dan –2. FTC, 4. dan – 3. FTC, 5. dan
– 4. FTC. Zavr{nu ta~ku eksperimenta predstavljala je
pojava bakterija u dva uzastopna uzorka.
Rezultati: Tokom 4 FTC koncentracije uree u plazmi se nisu
zna~ajno razlikovale. Koncentracija glukoze je bila stabilna
u EDTA +4 ˚C i NaF -20 ˚C do 3.FTC (P=0,008,
P=0,042, redom). Koncentracije TG su se zna~ajno pro-
menile u uzorku EDTA -20 ˚C nakon 1. i 4. FTC-a (P=0,022, P=0,010, redom). U uzorcima NaF plazme
nije do{lo do bakterijske kontaminacije tokom 4. FTC.
Zaklju~ak: Koncentracije uree i glukoze su bile stabilne
tokom trajanja eksperimenta. Promene u koncentracijama
lipida nakon FTC prate slo`ene obrasce. Rast bakterija nije
prime}en u uzorcima NaF plazme, te upotreba ovog anti-
koagulansa mo`e biti opravdana u analiti~kim proce -
durama podlo`nim uticaju mikrobiolo{ke kontaminacije.",
publisher = "Journal of Medical Biochemistry",
journal = "Journal of Medical Biochemistry",
title = "The influence of various sample storage conditions and sample microbial contamination on concentrations of routine biochemical parameters, Uticaj različitih uslova čuvanja uzoraka i kontaminacije uzoraka bakterijama na koncentracije rutinskih biohemijskih parametara",
volume = "43",
number = "1",
doi = "https://doi.org/10.5937/jomb0-40360"
}
Gojković, T., Vladimirov, S., Antonić, T., Bogavac-Stanojević, N., Novović, K., Spasojević-Kalimanovska, V.,& Filipić, B.. (2023). The influence of various sample storage conditions and sample microbial contamination on concentrations of routine biochemical parameters. in Journal of Medical Biochemistry
Journal of Medical Biochemistry., 43(1).
https://doi.org/https://doi.org/10.5937/jomb0-40360
Gojković T, Vladimirov S, Antonić T, Bogavac-Stanojević N, Novović K, Spasojević-Kalimanovska V, Filipić B. The influence of various sample storage conditions and sample microbial contamination on concentrations of routine biochemical parameters. in Journal of Medical Biochemistry. 2023;43(1).
doi:https://doi.org/10.5937/jomb0-40360 .
Gojković, Tamara, Vladimirov, Sandra, Antonić, Tamara, Bogavac-Stanojević, Nataša, Novović, Katarina, Spasojević-Kalimanovska, Vesna, Filipić, Brankica, "The influence of various sample storage conditions and sample microbial contamination on concentrations of routine biochemical parameters" in Journal of Medical Biochemistry, 43, no. 1 (2023),
https://doi.org/https://doi.org/10.5937/jomb0-40360 . .

Analysis of redox status and HDL subclasses in patients with lymphoma and the associations with FDG-PET/CT findings

Mirjanić-Azarić, Bosa; Stanković, Siniša; Nezić, Lana; Radić-Savić, Žana; Malčić- Zanić, Dragana; Skrbić, Ranko; Kotur-Stevuljević, Jelena; Bogavac-Stanojević, Nataša

(Frontiers Media SA, 2023)

TY  - JOUR
AU  - Mirjanić-Azarić, Bosa
AU  - Stanković, Siniša
AU  - Nezić, Lana
AU  - Radić-Savić, Žana
AU  - Malčić- Zanić, Dragana
AU  - Skrbić, Ranko
AU  - Kotur-Stevuljević, Jelena
AU  - Bogavac-Stanojević, Nataša
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5286
AB  - Newer research points to alterations in the plasma redox status and the HDL subclass distributions in cancer. We aimed to assess the redox status and the HDL subclass distributions, lipids, and inflammatory markers in lymphoma patients in order to determine whether they were correlated with changes in FDG-PET/CT scans. At the beginning of this study, redox status, HDL subclasses, lipids, and inflammation biomarkers were determined in 58 patients with lymphoma (Hodgkin lymphoma, n=11 and non-Hodgkin lymphoma, n=47), and these same measurements were reassessed during their ensuing treatment (in 25 patients). Initially, the total oxidation status (TOS), the prooxidant–antioxidant balance (PAB), the OS index (OSI), the total protein sulfhydryl groups (SH-groups), and the advanced oxidation protein products (AOPP) were significantly higher in lymphoma patients as compared to healthy subjects, but the total antioxidant status (TAS) was significantly reduced. The PAB had a strong correlation with the CRP and interleukin-6 (rho=0.726, p[removed]
PB  - Frontiers Media SA
T2  - Frontiers in Oncology
T1  - Analysis of redox status and HDL subclasses in patients with lymphoma and the associations with FDG-PET/CT findings
VL  - 13
DO  - 10.3389/fonc.2023.1221414
ER  - 
@article{
author = "Mirjanić-Azarić, Bosa and Stanković, Siniša and Nezić, Lana and Radić-Savić, Žana and Malčić- Zanić, Dragana and Skrbić, Ranko and Kotur-Stevuljević, Jelena and Bogavac-Stanojević, Nataša",
year = "2023",
abstract = "Newer research points to alterations in the plasma redox status and the HDL subclass distributions in cancer. We aimed to assess the redox status and the HDL subclass distributions, lipids, and inflammatory markers in lymphoma patients in order to determine whether they were correlated with changes in FDG-PET/CT scans. At the beginning of this study, redox status, HDL subclasses, lipids, and inflammation biomarkers were determined in 58 patients with lymphoma (Hodgkin lymphoma, n=11 and non-Hodgkin lymphoma, n=47), and these same measurements were reassessed during their ensuing treatment (in 25 patients). Initially, the total oxidation status (TOS), the prooxidant–antioxidant balance (PAB), the OS index (OSI), the total protein sulfhydryl groups (SH-groups), and the advanced oxidation protein products (AOPP) were significantly higher in lymphoma patients as compared to healthy subjects, but the total antioxidant status (TAS) was significantly reduced. The PAB had a strong correlation with the CRP and interleukin-6 (rho=0.726, p[removed]",
publisher = "Frontiers Media SA",
journal = "Frontiers in Oncology",
title = "Analysis of redox status and HDL subclasses in patients with lymphoma and the associations with FDG-PET/CT findings",
volume = "13",
doi = "10.3389/fonc.2023.1221414"
}
Mirjanić-Azarić, B., Stanković, S., Nezić, L., Radić-Savić, Ž., Malčić- Zanić, D., Skrbić, R., Kotur-Stevuljević, J.,& Bogavac-Stanojević, N.. (2023). Analysis of redox status and HDL subclasses in patients with lymphoma and the associations with FDG-PET/CT findings. in Frontiers in Oncology
Frontiers Media SA., 13.
https://doi.org/10.3389/fonc.2023.1221414
Mirjanić-Azarić B, Stanković S, Nezić L, Radić-Savić Ž, Malčić- Zanić D, Skrbić R, Kotur-Stevuljević J, Bogavac-Stanojević N. Analysis of redox status and HDL subclasses in patients with lymphoma and the associations with FDG-PET/CT findings. in Frontiers in Oncology. 2023;13.
doi:10.3389/fonc.2023.1221414 .
Mirjanić-Azarić, Bosa, Stanković, Siniša, Nezić, Lana, Radić-Savić, Žana, Malčić- Zanić, Dragana, Skrbić, Ranko, Kotur-Stevuljević, Jelena, Bogavac-Stanojević, Nataša, "Analysis of redox status and HDL subclasses in patients with lymphoma and the associations with FDG-PET/CT findings" in Frontiers in Oncology, 13 (2023),
https://doi.org/10.3389/fonc.2023.1221414 . .
1

Analysis of the Prognostic Potential of Schlafen 11, Programmed Death Ligand 1, and Redox Status in Colorectal Cancer Patients

Miladinov, Marko; Rosić, Jovana; Erić, Katarina; Guzonjić, Azra; Jelenković, Jelenko; Bogavac-Stanojević, Nataša; Dimitrijević, Ivan; Kotur-Stevuljević, Jelena; Barišić, Goran

(MDPI, 2023)

TY  - JOUR
AU  - Miladinov, Marko
AU  - Rosić, Jovana
AU  - Erić, Katarina
AU  - Guzonjić, Azra
AU  - Jelenković, Jelenko
AU  - Bogavac-Stanojević, Nataša
AU  - Dimitrijević, Ivan
AU  - Kotur-Stevuljević, Jelena
AU  - Barišić, Goran
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5204
AB  - The Schlafen 11 (SLFN11) protein has recently emerged as pivotal in DNA damage conditions, with predictive potential for tumor response to cytotoxic chemotherapies. Recent discoveries also showed that the programmed death ligand 1 (PD-L1) protein can be found on malignant cells, providing an immune evasion mechanism exploited by different tumors. Additionally, excessive generation of free radicals, redox imbalance, and consequential DNA damage can affect intestinal cell homeostasis and lead to neoplastic transformation. Therefore, our study aimed to investigate the significance of SLFN11 and PD-L1 proteins and redox status parameters as prognostic biomarkers in CRC patients. This study included a total of 155 CRC patients. SLFN11 and PD-L1 serum levels were measured with ELISA and evaluated based on redox status parameters, sociodemographic and clinical characteristics, and survival. The following redox status parameters were investigated: spectrophotometrically measured superoxide dismutase (SOD), sulfhydryl (SH) groups, advanced oxidation protein products (AOPP), malondialdehyde (MDA), pro-oxidant–antioxidant balance (PAB), and superoxide anion (O2•–). The prooxidative score, antioxidative score, and OXY-SCORE were also calculated. The results showed significantly shorter survival in patients with higher OXY-SCOREs and higher levels of serum SLFN11, while only histopathology-analysis-related factors showed significant prognostic value. OXY-SCORE and SLFN11 levels may harbor prognostic potential in CRC patients.
PB  - MDPI
T2  - International Journal of Molecular Sciences
T1  - Analysis of the Prognostic Potential of Schlafen 11, Programmed Death Ligand 1, and Redox Status in Colorectal Cancer Patients
VL  - 24
IS  - 20
DO  - 10.3390/ijms242015083
ER  - 
@article{
author = "Miladinov, Marko and Rosić, Jovana and Erić, Katarina and Guzonjić, Azra and Jelenković, Jelenko and Bogavac-Stanojević, Nataša and Dimitrijević, Ivan and Kotur-Stevuljević, Jelena and Barišić, Goran",
year = "2023",
abstract = "The Schlafen 11 (SLFN11) protein has recently emerged as pivotal in DNA damage conditions, with predictive potential for tumor response to cytotoxic chemotherapies. Recent discoveries also showed that the programmed death ligand 1 (PD-L1) protein can be found on malignant cells, providing an immune evasion mechanism exploited by different tumors. Additionally, excessive generation of free radicals, redox imbalance, and consequential DNA damage can affect intestinal cell homeostasis and lead to neoplastic transformation. Therefore, our study aimed to investigate the significance of SLFN11 and PD-L1 proteins and redox status parameters as prognostic biomarkers in CRC patients. This study included a total of 155 CRC patients. SLFN11 and PD-L1 serum levels were measured with ELISA and evaluated based on redox status parameters, sociodemographic and clinical characteristics, and survival. The following redox status parameters were investigated: spectrophotometrically measured superoxide dismutase (SOD), sulfhydryl (SH) groups, advanced oxidation protein products (AOPP), malondialdehyde (MDA), pro-oxidant–antioxidant balance (PAB), and superoxide anion (O2•–). The prooxidative score, antioxidative score, and OXY-SCORE were also calculated. The results showed significantly shorter survival in patients with higher OXY-SCOREs and higher levels of serum SLFN11, while only histopathology-analysis-related factors showed significant prognostic value. OXY-SCORE and SLFN11 levels may harbor prognostic potential in CRC patients.",
publisher = "MDPI",
journal = "International Journal of Molecular Sciences",
title = "Analysis of the Prognostic Potential of Schlafen 11, Programmed Death Ligand 1, and Redox Status in Colorectal Cancer Patients",
volume = "24",
number = "20",
doi = "10.3390/ijms242015083"
}
Miladinov, M., Rosić, J., Erić, K., Guzonjić, A., Jelenković, J., Bogavac-Stanojević, N., Dimitrijević, I., Kotur-Stevuljević, J.,& Barišić, G.. (2023). Analysis of the Prognostic Potential of Schlafen 11, Programmed Death Ligand 1, and Redox Status in Colorectal Cancer Patients. in International Journal of Molecular Sciences
MDPI., 24(20).
https://doi.org/10.3390/ijms242015083
Miladinov M, Rosić J, Erić K, Guzonjić A, Jelenković J, Bogavac-Stanojević N, Dimitrijević I, Kotur-Stevuljević J, Barišić G. Analysis of the Prognostic Potential of Schlafen 11, Programmed Death Ligand 1, and Redox Status in Colorectal Cancer Patients. in International Journal of Molecular Sciences. 2023;24(20).
doi:10.3390/ijms242015083 .
Miladinov, Marko, Rosić, Jovana, Erić, Katarina, Guzonjić, Azra, Jelenković, Jelenko, Bogavac-Stanojević, Nataša, Dimitrijević, Ivan, Kotur-Stevuljević, Jelena, Barišić, Goran, "Analysis of the Prognostic Potential of Schlafen 11, Programmed Death Ligand 1, and Redox Status in Colorectal Cancer Patients" in International Journal of Molecular Sciences, 24, no. 20 (2023),
https://doi.org/10.3390/ijms242015083 . .

Redox Status and Telomere–Telomerase System Biomarkers in Patients with Acute Myocardial Infarction Using a Principal Component Analysis: Is There a Link?

Vukašinović, Aleksandra; Klisic, Aleksandra; Ostanek, Barbara; Kafedžić, Srđan; Zdravković, Marija; Ilić, Ivan; Sopić, Miron; Hinić, Saša; Stefanović, Milica; Bogavac-Stanojević, Nataša; Marc, Janja; Nešković, Aleksandar; Kotur-Stevuljević, Jelena

(MDPI, 2023)

TY  - JOUR
AU  - Vukašinović, Aleksandra
AU  - Klisic, Aleksandra
AU  - Ostanek, Barbara
AU  - Kafedžić, Srđan
AU  - Zdravković, Marija
AU  - Ilić, Ivan
AU  - Sopić, Miron
AU  - Hinić, Saša
AU  - Stefanović, Milica
AU  - Bogavac-Stanojević, Nataša
AU  - Marc, Janja
AU  - Nešković, Aleksandar
AU  - Kotur-Stevuljević, Jelena
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5078
AB  - In the present study, we examined redox status parameters in arterial and venous blood samples, its potential to predict the prognosis of acute myocardial infarction (AMI) patients assessed through its impact on the comprehensive grading SYNTAX score, and its clinical accuracy. Potential connections between common blood biomarkers, biomarkers of redox status, leukocyte telomere length, and telomerase enzyme activity in the acute myocardial infarction burden were assessed using principal component analysis (PCA). This study included 92 patients with acute myocardial infarction. Significantly higher levels of advanced oxidation protein products (AOPP), superoxide anion (O2•−), ischemia-modified albumin (IMA), and significantly lower levels of total oxidant status (TOS) and total protein sulfhydryl (SH-) groups were found in arterial blood than in the peripheral venous blood samples, while biomarkers of the telomere–telomerase system did not show statistical significance in the two compared sample types (p = 0.834 and p = 0.419). To better understand the effect of the examined biomarkers in the AMI patients on SYNTAX score, those biomarkers were grouped using PCA, which merged them into the four the most contributing factors. The “cholesterol–protein factor” and “oxidative–telomere factor” were independent predictors of higher SYNTAX score (OR = 0.338, p = 0.008 and OR = 0.427, p = 0.035, respectively), while the ability to discriminate STEMI from non-STEMI patients had only the “oxidative–telomere factor” (AUC = 0.860, p = 0.008). The results show that traditional cardiovascular risk factors, i.e., high total cholesterol together with high total serum proteins and haemoglobin, are associated with severe disease progression in much the same way as a combination of redox biomarkers (pro-oxidant-antioxidant balance, total antioxidant status, IMA) and telomere length.
PB  - MDPI
T2  - International Journal of Molecular Sciences
T1  - Redox Status and Telomere–Telomerase System Biomarkers in Patients with Acute Myocardial Infarction Using a Principal Component Analysis: Is There a Link?
VL  - 24
IS  - 18
DO  - 10.3390/ijms241814308
ER  - 
@article{
author = "Vukašinović, Aleksandra and Klisic, Aleksandra and Ostanek, Barbara and Kafedžić, Srđan and Zdravković, Marija and Ilić, Ivan and Sopić, Miron and Hinić, Saša and Stefanović, Milica and Bogavac-Stanojević, Nataša and Marc, Janja and Nešković, Aleksandar and Kotur-Stevuljević, Jelena",
year = "2023",
abstract = "In the present study, we examined redox status parameters in arterial and venous blood samples, its potential to predict the prognosis of acute myocardial infarction (AMI) patients assessed through its impact on the comprehensive grading SYNTAX score, and its clinical accuracy. Potential connections between common blood biomarkers, biomarkers of redox status, leukocyte telomere length, and telomerase enzyme activity in the acute myocardial infarction burden were assessed using principal component analysis (PCA). This study included 92 patients with acute myocardial infarction. Significantly higher levels of advanced oxidation protein products (AOPP), superoxide anion (O2•−), ischemia-modified albumin (IMA), and significantly lower levels of total oxidant status (TOS) and total protein sulfhydryl (SH-) groups were found in arterial blood than in the peripheral venous blood samples, while biomarkers of the telomere–telomerase system did not show statistical significance in the two compared sample types (p = 0.834 and p = 0.419). To better understand the effect of the examined biomarkers in the AMI patients on SYNTAX score, those biomarkers were grouped using PCA, which merged them into the four the most contributing factors. The “cholesterol–protein factor” and “oxidative–telomere factor” were independent predictors of higher SYNTAX score (OR = 0.338, p = 0.008 and OR = 0.427, p = 0.035, respectively), while the ability to discriminate STEMI from non-STEMI patients had only the “oxidative–telomere factor” (AUC = 0.860, p = 0.008). The results show that traditional cardiovascular risk factors, i.e., high total cholesterol together with high total serum proteins and haemoglobin, are associated with severe disease progression in much the same way as a combination of redox biomarkers (pro-oxidant-antioxidant balance, total antioxidant status, IMA) and telomere length.",
publisher = "MDPI",
journal = "International Journal of Molecular Sciences",
title = "Redox Status and Telomere–Telomerase System Biomarkers in Patients with Acute Myocardial Infarction Using a Principal Component Analysis: Is There a Link?",
volume = "24",
number = "18",
doi = "10.3390/ijms241814308"
}
Vukašinović, A., Klisic, A., Ostanek, B., Kafedžić, S., Zdravković, M., Ilić, I., Sopić, M., Hinić, S., Stefanović, M., Bogavac-Stanojević, N., Marc, J., Nešković, A.,& Kotur-Stevuljević, J.. (2023). Redox Status and Telomere–Telomerase System Biomarkers in Patients with Acute Myocardial Infarction Using a Principal Component Analysis: Is There a Link?. in International Journal of Molecular Sciences
MDPI., 24(18).
https://doi.org/10.3390/ijms241814308
Vukašinović A, Klisic A, Ostanek B, Kafedžić S, Zdravković M, Ilić I, Sopić M, Hinić S, Stefanović M, Bogavac-Stanojević N, Marc J, Nešković A, Kotur-Stevuljević J. Redox Status and Telomere–Telomerase System Biomarkers in Patients with Acute Myocardial Infarction Using a Principal Component Analysis: Is There a Link?. in International Journal of Molecular Sciences. 2023;24(18).
doi:10.3390/ijms241814308 .
Vukašinović, Aleksandra, Klisic, Aleksandra, Ostanek, Barbara, Kafedžić, Srđan, Zdravković, Marija, Ilić, Ivan, Sopić, Miron, Hinić, Saša, Stefanović, Milica, Bogavac-Stanojević, Nataša, Marc, Janja, Nešković, Aleksandar, Kotur-Stevuljević, Jelena, "Redox Status and Telomere–Telomerase System Biomarkers in Patients with Acute Myocardial Infarction Using a Principal Component Analysis: Is There a Link?" in International Journal of Molecular Sciences, 24, no. 18 (2023),
https://doi.org/10.3390/ijms241814308 . .

Pharmacotherapy literacy level and predictors of low literacy among diabetes mellitus type 2 patients in Serbia

Lević, Marija; Bogavac-Stanojević, Nataša; Ubavić, Stana; Krajnović, Dušanka

(BioMed Central Ltd, 2023)

TY  - JOUR
AU  - Lević, Marija
AU  - Bogavac-Stanojević, Nataša
AU  - Ubavić, Stana
AU  - Krajnović, Dušanka
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5037
AB  - Background: Pharmacotherapy literacy (PTHL) is a specific ability to safely access, appraise and understand the available information concerning medication and to calculate and act accordingly. The concept of PTHL is mostly unknown for the majority of diabetes mellitus type 2 (DMT2) patients in Serbia. With diabetes being one of the major public health problems in Serbia with a prevalence of 9.1%, this two-study research aims at constructing performance-based instrument and estimating the prevalence of PTHL levels and identification of predictors of low PTHL scores in patients with DMT2. Methods: Multistage study was performed to adapt the existing performance–based instrument (PTHL-SR) into specific questionnaire for DMT2 population (PTHL-DM instrument). PTHL levels were assessed through cross-sectional study categorising patients into groups of low, medium, and high PTHL levels. We considered 19 predictors for low PTHL scores, from sociodemographic characteristics, health behaviours and health characteristics, access to health-related information and empowerment-related indicators. Univariate and multivariate logistic regression analyses were used to determine independent predictors of low PTHL. Results: The final 15-item PTHL-DM instrument proved to have satisfactory reliability (KR20 = 0.475) and internal reliability [ICC for the whole instrument was 0.97 with 95% confidence intervals (0.95–0.99)]. Positive correlation (rho = 0.69) between PTHL-DM score (15 questions) and the total PTHL-SR score (14 questions) was also observed. It was demonstrated that the majority of 350 patients had low PTHL (62%), and only 5% high PTHL level. Mean score on PTHL-DM was 7.8 ± 2.3. Probability of low PTHL increased among smokers, patients with low interest in health and those who estimated their health as bad. Patients who used pharmacists as sourse of information were less likely to be pharmacotherapy illiterate. Combined therapy with insulin and Oral Hypoglycemic Agents was associated with higher PTHL. Conclusions: Our data indicate that specific PTHL-DM tool is objective, valid, and reliable. It was found that low level of PTHL prevailed among DMT2 patients. Medication literacy is influenced by age, residence, education, and family status. Patients with better health literacy also reported better health behaviours. Different patient empowerment programs and approaches aimed at raising PTHL would be essential to improve self-management and control of this widespread chronic disease in Serbia.
PB  - BioMed Central Ltd
T2  - BMC Public Health
T1  - Pharmacotherapy literacy level and predictors of low literacy among diabetes mellitus type 2 patients in Serbia
VL  - 23
IS  - 1
DO  - 10.1186/s12889-023-16639-y
ER  - 
@article{
author = "Lević, Marija and Bogavac-Stanojević, Nataša and Ubavić, Stana and Krajnović, Dušanka",
year = "2023",
abstract = "Background: Pharmacotherapy literacy (PTHL) is a specific ability to safely access, appraise and understand the available information concerning medication and to calculate and act accordingly. The concept of PTHL is mostly unknown for the majority of diabetes mellitus type 2 (DMT2) patients in Serbia. With diabetes being one of the major public health problems in Serbia with a prevalence of 9.1%, this two-study research aims at constructing performance-based instrument and estimating the prevalence of PTHL levels and identification of predictors of low PTHL scores in patients with DMT2. Methods: Multistage study was performed to adapt the existing performance–based instrument (PTHL-SR) into specific questionnaire for DMT2 population (PTHL-DM instrument). PTHL levels were assessed through cross-sectional study categorising patients into groups of low, medium, and high PTHL levels. We considered 19 predictors for low PTHL scores, from sociodemographic characteristics, health behaviours and health characteristics, access to health-related information and empowerment-related indicators. Univariate and multivariate logistic regression analyses were used to determine independent predictors of low PTHL. Results: The final 15-item PTHL-DM instrument proved to have satisfactory reliability (KR20 = 0.475) and internal reliability [ICC for the whole instrument was 0.97 with 95% confidence intervals (0.95–0.99)]. Positive correlation (rho = 0.69) between PTHL-DM score (15 questions) and the total PTHL-SR score (14 questions) was also observed. It was demonstrated that the majority of 350 patients had low PTHL (62%), and only 5% high PTHL level. Mean score on PTHL-DM was 7.8 ± 2.3. Probability of low PTHL increased among smokers, patients with low interest in health and those who estimated their health as bad. Patients who used pharmacists as sourse of information were less likely to be pharmacotherapy illiterate. Combined therapy with insulin and Oral Hypoglycemic Agents was associated with higher PTHL. Conclusions: Our data indicate that specific PTHL-DM tool is objective, valid, and reliable. It was found that low level of PTHL prevailed among DMT2 patients. Medication literacy is influenced by age, residence, education, and family status. Patients with better health literacy also reported better health behaviours. Different patient empowerment programs and approaches aimed at raising PTHL would be essential to improve self-management and control of this widespread chronic disease in Serbia.",
publisher = "BioMed Central Ltd",
journal = "BMC Public Health",
title = "Pharmacotherapy literacy level and predictors of low literacy among diabetes mellitus type 2 patients in Serbia",
volume = "23",
number = "1",
doi = "10.1186/s12889-023-16639-y"
}
Lević, M., Bogavac-Stanojević, N., Ubavić, S.,& Krajnović, D.. (2023). Pharmacotherapy literacy level and predictors of low literacy among diabetes mellitus type 2 patients in Serbia. in BMC Public Health
BioMed Central Ltd., 23(1).
https://doi.org/10.1186/s12889-023-16639-y
Lević M, Bogavac-Stanojević N, Ubavić S, Krajnović D. Pharmacotherapy literacy level and predictors of low literacy among diabetes mellitus type 2 patients in Serbia. in BMC Public Health. 2023;23(1).
doi:10.1186/s12889-023-16639-y .
Lević, Marija, Bogavac-Stanojević, Nataša, Ubavić, Stana, Krajnović, Dušanka, "Pharmacotherapy literacy level and predictors of low literacy among diabetes mellitus type 2 patients in Serbia" in BMC Public Health, 23, no. 1 (2023),
https://doi.org/10.1186/s12889-023-16639-y . .
1

The predictive role of biochemical markers on outcomes of severe covid-19 patients admitted to intensive care unit

Mirjanić-Azarić, Bosa; Pejić, Ivana; Mijić, Smiljana; Pejčić, Aleksandra; Đurđević-Svraka, Anita; Svraka, Dragan; Knežević, Darija; Milivojac, Tatjana; Bogavac-Stanojević, Nataša

(Society of Medical Biochemists of Serbia, 2023)

TY  - JOUR
AU  - Mirjanić-Azarić, Bosa
AU  - Pejić, Ivana
AU  - Mijić, Smiljana
AU  - Pejčić, Aleksandra
AU  - Đurđević-Svraka, Anita
AU  - Svraka, Dragan
AU  - Knežević, Darija
AU  - Milivojac, Tatjana
AU  - Bogavac-Stanojević, Nataša
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5025
AB  - Background: The pandemic of severe acute respiratory syndrome by coronavirus 2 (SARS-CoV-2) is a multi-system disease caused by a diffuse systemic process involving a complex interaction of the inflammatory, immunological and coagulative cascades. This study aims to identify the most effective biomarkers to predict poor outcome in intensive care unit (ICU) patients with severe COVID-19 disease. Methods: A single-centre retrospective observational study enrolled 69 deceased and 20 recovered patients treated in the ICU of the General Hospital Gradiska in the period from March 1, 2021. until April 1, 2022. We evaluated the leukocytes (WBC), lymphocytes (LYM), neutrophils (NEU), platelets (PLT), haemoglobin, neutrophil-lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), and systemic immune-inflammation index (SII). In addition, we evaluated the IL-6, ferritin, CRP, D-dimer, magnesium, bilirubin and lactate dehydrogenase. Results: Between deceased and recovered patients on admission to the ICU, there was a significant differencebetween the following parameters: WBC x10 9/L 11.50 (8.86–14.75) vs. 9.40 (5.90–11.90), p =0.026 ; NEU x10 9 /L 10.15 (7.81–12.74) vs. 8.60 (4.80–10.30) p=0.022 ; NLR 15.01 (10.60–24.33) vs. 9.45 (5.10– 14.90) p=0.02 ; SII 3712 (2240–6543) vs. 1949 (993–3720) p=0.003 . The magnesium level increased significantly over time in the patients who died, while the haemoglobin level and platelet count decreased. ROC analysis showed the following AUC values: WBC 0.774; NEU 0.781; NLR 0.786; SII 0.776; D-dimer 0.741, and bilirubin 0.713. Conclusion: In this retrospective study WBC, NEU, NLR, SII, D-dimer, and bilirubin determined at hospital admission had a high value in predicting death among patients with severe COVID-19.
AB  - Uvod: Pandemija teškog akutnog respiratornog sindroma koronavirusa 2 (SARS-CoV-2) je multisistemska bolest izazvana difuznim sistemskim procesom koji uključuje kompleksne interakcije inflamatornih, imunoloških i koagulacionih kaskadnih procesa. Cilj ove studije je da utvrdi najefikasnije biomarkere u proceni lošeg ishoda pacijenata u jedinici intenzivne nege (ICU) obolelih od teškog oblika bolesti COVID-19. Metode: Retrospektivna opservaciona studija je uključivala 69 preminulih i 20 preživelih pacijenata lečenih u ICU u Opštoj bolnici Gradiška u periodu od 01.03.2021. do 01.04.2022. godine. Procenjivane su vrednosti leukocita (WBC), limfocita (LYM), neutrofila (NEU), trombocita (PLT), hemoglobina, odnosa neutrofila i limfocita (NLR), odnosa trom bocita i limfocita (PLR), sistemskog inflama tornog indeksa (SII). Takođe, procenjivane su vrednosti inter leukina6, feritina, CRP, D-dimera, magnezijuma, bilirubina i aktivnost laktat dehidrogenaze. Rezultati: Prilikom prijema pacijenata u ICU postojala je značajna razlika u vrednostima sledećih parametara između preminulih i preživelih pacijenata: WBC x 109/L 11,50 (8,86-14,75) prema (vs.) 9,40 (5,90-11,90), p=0,026; NEU x109/L 10,15 (7,81-12,74) vs. 8,60 (4,80-10,30) p=0,022; NLR 15,01 (10,60-24,33) vs. 9,45 (5,10-14,90) p=0,02; SII 3712 (2240-6543) vs. 1949 (993-3720) p=0,003. Takođe, tokom vremena koncentracija magnezijuma je značajno rasla u grupi preminulih pacijenata, dok je koncentracija hemoglobina i broj trombocita opadao. ROC analiza je pokazala sledeće AUC vrednosti: WBC 0,774; NEU 0,781; NLR 0,786; SII 0,776; D-dimer 0,741 i bilirubin 0,713. Zaključak: U ovoj retrospektivnoj studiji WBC, NEU, NLR, SII, D-dimer i bilirubin, određeni pri prijemu u ICU, su imali visoku vrednost u predviđanju smrti između pacijenata s teškim COVID-19.

PB  - Society of Medical Biochemists of Serbia
T2  - Journal of Medical Biochemistry
T1  - The predictive role of biochemical markers on outcomes of severe covid-19 patients admitted to intensive care unit
T1  - Uloga biohemijskih markera u predviđanju ishoda teško obolelih covid-19 pacijenata primljenih na jedinicu intenzivnog lečenja
VL  - 42
IS  - 3
SP  - 513
EP  - 523
DO  - 10.5937/jomb0-40641
ER  - 
@article{
author = "Mirjanić-Azarić, Bosa and Pejić, Ivana and Mijić, Smiljana and Pejčić, Aleksandra and Đurđević-Svraka, Anita and Svraka, Dragan and Knežević, Darija and Milivojac, Tatjana and Bogavac-Stanojević, Nataša",
year = "2023",
abstract = "Background: The pandemic of severe acute respiratory syndrome by coronavirus 2 (SARS-CoV-2) is a multi-system disease caused by a diffuse systemic process involving a complex interaction of the inflammatory, immunological and coagulative cascades. This study aims to identify the most effective biomarkers to predict poor outcome in intensive care unit (ICU) patients with severe COVID-19 disease. Methods: A single-centre retrospective observational study enrolled 69 deceased and 20 recovered patients treated in the ICU of the General Hospital Gradiska in the period from March 1, 2021. until April 1, 2022. We evaluated the leukocytes (WBC), lymphocytes (LYM), neutrophils (NEU), platelets (PLT), haemoglobin, neutrophil-lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), and systemic immune-inflammation index (SII). In addition, we evaluated the IL-6, ferritin, CRP, D-dimer, magnesium, bilirubin and lactate dehydrogenase. Results: Between deceased and recovered patients on admission to the ICU, there was a significant differencebetween the following parameters: WBC x10 9/L 11.50 (8.86–14.75) vs. 9.40 (5.90–11.90), p =0.026 ; NEU x10 9 /L 10.15 (7.81–12.74) vs. 8.60 (4.80–10.30) p=0.022 ; NLR 15.01 (10.60–24.33) vs. 9.45 (5.10– 14.90) p=0.02 ; SII 3712 (2240–6543) vs. 1949 (993–3720) p=0.003 . The magnesium level increased significantly over time in the patients who died, while the haemoglobin level and platelet count decreased. ROC analysis showed the following AUC values: WBC 0.774; NEU 0.781; NLR 0.786; SII 0.776; D-dimer 0.741, and bilirubin 0.713. Conclusion: In this retrospective study WBC, NEU, NLR, SII, D-dimer, and bilirubin determined at hospital admission had a high value in predicting death among patients with severe COVID-19., Uvod: Pandemija teškog akutnog respiratornog sindroma koronavirusa 2 (SARS-CoV-2) je multisistemska bolest izazvana difuznim sistemskim procesom koji uključuje kompleksne interakcije inflamatornih, imunoloških i koagulacionih kaskadnih procesa. Cilj ove studije je da utvrdi najefikasnije biomarkere u proceni lošeg ishoda pacijenata u jedinici intenzivne nege (ICU) obolelih od teškog oblika bolesti COVID-19. Metode: Retrospektivna opservaciona studija je uključivala 69 preminulih i 20 preživelih pacijenata lečenih u ICU u Opštoj bolnici Gradiška u periodu od 01.03.2021. do 01.04.2022. godine. Procenjivane su vrednosti leukocita (WBC), limfocita (LYM), neutrofila (NEU), trombocita (PLT), hemoglobina, odnosa neutrofila i limfocita (NLR), odnosa trom bocita i limfocita (PLR), sistemskog inflama tornog indeksa (SII). Takođe, procenjivane su vrednosti inter leukina6, feritina, CRP, D-dimera, magnezijuma, bilirubina i aktivnost laktat dehidrogenaze. Rezultati: Prilikom prijema pacijenata u ICU postojala je značajna razlika u vrednostima sledećih parametara između preminulih i preživelih pacijenata: WBC x 109/L 11,50 (8,86-14,75) prema (vs.) 9,40 (5,90-11,90), p=0,026; NEU x109/L 10,15 (7,81-12,74) vs. 8,60 (4,80-10,30) p=0,022; NLR 15,01 (10,60-24,33) vs. 9,45 (5,10-14,90) p=0,02; SII 3712 (2240-6543) vs. 1949 (993-3720) p=0,003. Takođe, tokom vremena koncentracija magnezijuma je značajno rasla u grupi preminulih pacijenata, dok je koncentracija hemoglobina i broj trombocita opadao. ROC analiza je pokazala sledeće AUC vrednosti: WBC 0,774; NEU 0,781; NLR 0,786; SII 0,776; D-dimer 0,741 i bilirubin 0,713. Zaključak: U ovoj retrospektivnoj studiji WBC, NEU, NLR, SII, D-dimer i bilirubin, određeni pri prijemu u ICU, su imali visoku vrednost u predviđanju smrti između pacijenata s teškim COVID-19.
",
publisher = "Society of Medical Biochemists of Serbia",
journal = "Journal of Medical Biochemistry",
title = "The predictive role of biochemical markers on outcomes of severe covid-19 patients admitted to intensive care unit, Uloga biohemijskih markera u predviđanju ishoda teško obolelih covid-19 pacijenata primljenih na jedinicu intenzivnog lečenja",
volume = "42",
number = "3",
pages = "513-523",
doi = "10.5937/jomb0-40641"
}
Mirjanić-Azarić, B., Pejić, I., Mijić, S., Pejčić, A., Đurđević-Svraka, A., Svraka, D., Knežević, D., Milivojac, T.,& Bogavac-Stanojević, N.. (2023). The predictive role of biochemical markers on outcomes of severe covid-19 patients admitted to intensive care unit. in Journal of Medical Biochemistry
Society of Medical Biochemists of Serbia., 42(3), 513-523.
https://doi.org/10.5937/jomb0-40641
Mirjanić-Azarić B, Pejić I, Mijić S, Pejčić A, Đurđević-Svraka A, Svraka D, Knežević D, Milivojac T, Bogavac-Stanojević N. The predictive role of biochemical markers on outcomes of severe covid-19 patients admitted to intensive care unit. in Journal of Medical Biochemistry. 2023;42(3):513-523.
doi:10.5937/jomb0-40641 .
Mirjanić-Azarić, Bosa, Pejić, Ivana, Mijić, Smiljana, Pejčić, Aleksandra, Đurđević-Svraka, Anita, Svraka, Dragan, Knežević, Darija, Milivojac, Tatjana, Bogavac-Stanojević, Nataša, "The predictive role of biochemical markers on outcomes of severe covid-19 patients admitted to intensive care unit" in Journal of Medical Biochemistry, 42, no. 3 (2023):513-523,
https://doi.org/10.5937/jomb0-40641 . .

HDL Subclasses and the Distribution of Paraoxonase-1 Activity in Patients with ST-Segment Elevation Acute Myocardial Infarction

Đekić, Saška; Vekić, Jelena; Zeljković, Aleksandra; Kotur-Stevuljević, Jelena; Kafedžić, Srđan; Zdravković, Marija; Ilić, Ivan; Hinić, Saša; Cerović, Milivoje; Stefanović, Milica; Mihajlović, Marija; Nešković, Aleksandar; Bogavac-Stanojević, Nataša

(MDPI, 2023)

TY  - JOUR
AU  - Đekić, Saška
AU  - Vekić, Jelena
AU  - Zeljković, Aleksandra
AU  - Kotur-Stevuljević, Jelena
AU  - Kafedžić, Srđan
AU  - Zdravković, Marija
AU  - Ilić, Ivan
AU  - Hinić, Saša
AU  - Cerović, Milivoje
AU  - Stefanović, Milica
AU  - Mihajlović, Marija
AU  - Nešković, Aleksandar
AU  - Bogavac-Stanojević, Nataša
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4843
AB  - The aim of this multicentric study was to assess the impacts of oxidative stress, inflam-
mation, and the presence of small, dense, low-density lipoproteins (sdLDL) on the antioxidative
function of high-density lipoprotein (HDL) subclasses and the distribution of paraoxonase-1 (PON1)
activity within HDL in patients with ST-segment elevation acute myocardial infarction (STEMI). In
69 STEMI patients and 67 healthy control subjects, the lipoproteins’ subclasses were separated using
polyacrylamide gradient (3–31%) gel electrophoresis. The relative proportion of sdLDL and each
HDL subclass was evaluated by measuring the areas under the peaks of densitometric scans. The
distribution of the relative proportion of PON1 activity within the HDL subclasses (pPON1 within
HDL) was estimated using the zymogram method. The STEMI patients had significantly lower
proportions of HDL2a and HDL3a subclasses (p = 0.001 and p < 0.001, respectively) and lower pPON1
within HDL3b (p = 0.006), as well as higher proportions of HDL3b and HDL3c subclasses (p = 0.013
and p < 0.001, respectively) and higher pPON1 within HDL2 than the controls. Independent positive
associations between sdLDL and pPON1 within HDL3a and between malondialdehyde (MDA) and
pPON1 within HDL2b were shown in the STEMI group. The increased oxidative stress and increased
proportion of sdLDL in STEMI are closely related to the compromised antioxidative function of small
HDL3 particles and the altered pPON1 within HDL.
PB  - MDPI
T2  - International Journal of Molecular Sciences
T1  - HDL Subclasses and the Distribution of Paraoxonase-1 Activity in Patients with ST-Segment Elevation Acute Myocardial Infarction
VL  - 24
IS  - 11
DO  - 10.3390/ijms24119384
ER  - 
@article{
author = "Đekić, Saška and Vekić, Jelena and Zeljković, Aleksandra and Kotur-Stevuljević, Jelena and Kafedžić, Srđan and Zdravković, Marija and Ilić, Ivan and Hinić, Saša and Cerović, Milivoje and Stefanović, Milica and Mihajlović, Marija and Nešković, Aleksandar and Bogavac-Stanojević, Nataša",
year = "2023",
abstract = "The aim of this multicentric study was to assess the impacts of oxidative stress, inflam-
mation, and the presence of small, dense, low-density lipoproteins (sdLDL) on the antioxidative
function of high-density lipoprotein (HDL) subclasses and the distribution of paraoxonase-1 (PON1)
activity within HDL in patients with ST-segment elevation acute myocardial infarction (STEMI). In
69 STEMI patients and 67 healthy control subjects, the lipoproteins’ subclasses were separated using
polyacrylamide gradient (3–31%) gel electrophoresis. The relative proportion of sdLDL and each
HDL subclass was evaluated by measuring the areas under the peaks of densitometric scans. The
distribution of the relative proportion of PON1 activity within the HDL subclasses (pPON1 within
HDL) was estimated using the zymogram method. The STEMI patients had significantly lower
proportions of HDL2a and HDL3a subclasses (p = 0.001 and p < 0.001, respectively) and lower pPON1
within HDL3b (p = 0.006), as well as higher proportions of HDL3b and HDL3c subclasses (p = 0.013
and p < 0.001, respectively) and higher pPON1 within HDL2 than the controls. Independent positive
associations between sdLDL and pPON1 within HDL3a and between malondialdehyde (MDA) and
pPON1 within HDL2b were shown in the STEMI group. The increased oxidative stress and increased
proportion of sdLDL in STEMI are closely related to the compromised antioxidative function of small
HDL3 particles and the altered pPON1 within HDL.",
publisher = "MDPI",
journal = "International Journal of Molecular Sciences",
title = "HDL Subclasses and the Distribution of Paraoxonase-1 Activity in Patients with ST-Segment Elevation Acute Myocardial Infarction",
volume = "24",
number = "11",
doi = "10.3390/ijms24119384"
}
Đekić, S., Vekić, J., Zeljković, A., Kotur-Stevuljević, J., Kafedžić, S., Zdravković, M., Ilić, I., Hinić, S., Cerović, M., Stefanović, M., Mihajlović, M., Nešković, A.,& Bogavac-Stanojević, N.. (2023). HDL Subclasses and the Distribution of Paraoxonase-1 Activity in Patients with ST-Segment Elevation Acute Myocardial Infarction. in International Journal of Molecular Sciences
MDPI., 24(11).
https://doi.org/10.3390/ijms24119384
Đekić S, Vekić J, Zeljković A, Kotur-Stevuljević J, Kafedžić S, Zdravković M, Ilić I, Hinić S, Cerović M, Stefanović M, Mihajlović M, Nešković A, Bogavac-Stanojević N. HDL Subclasses and the Distribution of Paraoxonase-1 Activity in Patients with ST-Segment Elevation Acute Myocardial Infarction. in International Journal of Molecular Sciences. 2023;24(11).
doi:10.3390/ijms24119384 .
Đekić, Saška, Vekić, Jelena, Zeljković, Aleksandra, Kotur-Stevuljević, Jelena, Kafedžić, Srđan, Zdravković, Marija, Ilić, Ivan, Hinić, Saša, Cerović, Milivoje, Stefanović, Milica, Mihajlović, Marija, Nešković, Aleksandar, Bogavac-Stanojević, Nataša, "HDL Subclasses and the Distribution of Paraoxonase-1 Activity in Patients with ST-Segment Elevation Acute Myocardial Infarction" in International Journal of Molecular Sciences, 24, no. 11 (2023),
https://doi.org/10.3390/ijms24119384 . .
1
4
1

Analysis of the Professional Aspects of Medical Drugs Industry in the Republic of Serbia in Times of COVID-19 Pandemic

Milenković, Jovana; Lakić, Dragana; Bogavac-Stanojević, Nataša

(MDPI, 2023)

TY  - JOUR
AU  - Milenković, Jovana
AU  - Lakić, Dragana
AU  - Bogavac-Stanojević, Nataša
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4831
AB  - The research subject of this paper is the analysis of the attitudes of employees in pharmaceutical companies towards the business aspects of the pharmaceutical industry during and after the end of the pandemic in the Republic of Serbia. The aim is to examine the differences in the attitudes of employees, as well as to determine which variables predict the situations of endangering the professional reputation of pharmaceutical companies during the COVID-19 pandemic. The research was conducted by means of a survey during 2021 on a sample of 27 innovative and generic pharmaceutical companies. We used the SPSS program for descriptive statistics analysis, chi square test and binary logistic regression models. The findings show that there is a statistically significant difference in the expressed attitudes of employees in innovative and generic pharmaceutical companies in terms of coming to the office during the pandemic; the lack of medicines and medical devices used in the treatment of COVID-19 infections; the patient access to a chosen doctor; the expectations of the employees to continue working from home after the outbreak of the COVID-19 pandemic. The findings of the binary regression models show the slowdown in the supply chain, the access to doctors and working from the home office have not been perceived as creating situations of endangering professional reputations, that is, they contribute to the sustainable economic success. On the other hand, the introduction of digital technologies decreases the occurrence of conditions in which their professional reputation has been threatened.
PB  - MDPI
T2  - Sustainability
T1  - Analysis of the Professional Aspects of Medical Drugs Industry in the Republic of Serbia in Times of COVID-19 Pandemic
VL  - 15
IS  - 11
DO  - 10.3390/su15118584
ER  - 
@article{
author = "Milenković, Jovana and Lakić, Dragana and Bogavac-Stanojević, Nataša",
year = "2023",
abstract = "The research subject of this paper is the analysis of the attitudes of employees in pharmaceutical companies towards the business aspects of the pharmaceutical industry during and after the end of the pandemic in the Republic of Serbia. The aim is to examine the differences in the attitudes of employees, as well as to determine which variables predict the situations of endangering the professional reputation of pharmaceutical companies during the COVID-19 pandemic. The research was conducted by means of a survey during 2021 on a sample of 27 innovative and generic pharmaceutical companies. We used the SPSS program for descriptive statistics analysis, chi square test and binary logistic regression models. The findings show that there is a statistically significant difference in the expressed attitudes of employees in innovative and generic pharmaceutical companies in terms of coming to the office during the pandemic; the lack of medicines and medical devices used in the treatment of COVID-19 infections; the patient access to a chosen doctor; the expectations of the employees to continue working from home after the outbreak of the COVID-19 pandemic. The findings of the binary regression models show the slowdown in the supply chain, the access to doctors and working from the home office have not been perceived as creating situations of endangering professional reputations, that is, they contribute to the sustainable economic success. On the other hand, the introduction of digital technologies decreases the occurrence of conditions in which their professional reputation has been threatened.",
publisher = "MDPI",
journal = "Sustainability",
title = "Analysis of the Professional Aspects of Medical Drugs Industry in the Republic of Serbia in Times of COVID-19 Pandemic",
volume = "15",
number = "11",
doi = "10.3390/su15118584"
}
Milenković, J., Lakić, D.,& Bogavac-Stanojević, N.. (2023). Analysis of the Professional Aspects of Medical Drugs Industry in the Republic of Serbia in Times of COVID-19 Pandemic. in Sustainability
MDPI., 15(11).
https://doi.org/10.3390/su15118584
Milenković J, Lakić D, Bogavac-Stanojević N. Analysis of the Professional Aspects of Medical Drugs Industry in the Republic of Serbia in Times of COVID-19 Pandemic. in Sustainability. 2023;15(11).
doi:10.3390/su15118584 .
Milenković, Jovana, Lakić, Dragana, Bogavac-Stanojević, Nataša, "Analysis of the Professional Aspects of Medical Drugs Industry in the Republic of Serbia in Times of COVID-19 Pandemic" in Sustainability, 15, no. 11 (2023),
https://doi.org/10.3390/su15118584 . .

Abdominal aortic aneurysm volume and relative intraluminal thrombus volume might be auxiliary predictors of rupture—an observational cross-sectional study

Končar, I.; Nikolić, D.; Milošević, Z.; Bogavac-Stanojević, Nataša; Ilić, N.; Dragaš, M.; Sladojević, M.; Marković, M.; Vujčić, A.; Filipović, N.; Davidović, L.

(Frontiers Media S.A., 2023)

TY  - JOUR
AU  - Končar, I.
AU  - Nikolić, D.
AU  - Milošević, Z.
AU  - Bogavac-Stanojević, Nataša
AU  - Ilić, N.
AU  - Dragaš, M.
AU  - Sladojević, M.
AU  - Marković, M.
AU  - Vujčić, A.
AU  - Filipović, N.
AU  - Davidović, L.
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4772
AB  - Objectives: The study aimed to identify differences and compare anatomical and biomechanical features between elective and ruptured abdominal aortic aneurysms (AAAs). Methods: Data (clinical, anatomical, and biomechanical) of 98 patients with AAA, 75 (76.53%) asymptomatic (Group aAAA) and 23 (23.46%) ruptured AAA (Group rAAA), were prospectively collected and analyzed. Anatomical, morphological, and biomechanical imaging markers like peak wall stress (PWS) and rupture risk equivalent diameter (RRED), comorbid conditions, and demographics were compared between the groups. Biomechanical features were assessed by analysis of Digital Imaging and Communication in Medicine images by A4clinics (Vascops), and anatomical features were assessed by 3Surgery (Trimensio). Binary and multiple logistic regression analysis were used and adjusted for confounders. Accuracy was assessed using receiving operative characteristic (ROC) curve analysis. Results: In a multivariable model, including gender and age as confounder variables, maximal aneurysm diameter [MAD, odds ratio (OR) = 1.063], relative intraluminal thrombus (rILT, OR = 1.039), and total aneurysm volume (TAV, OR = 1.006) continued to be significant predictors of AAA rupture with PWS (OR = 1.010) and RRED (OR = 1.031). Area under the ROC curve values and correct classification (cc) for the same parameters and the model that combines MAD, TAV, and rILT were measured: MAD (0.790, cc = 75%), PWS (0.713, cc = 73%), RRED (0.717, cc = 55%), TAV (0.756, cc = 79%), rILT (0.656, cc = 60%), and MAD + TAV + rILT (0.797, cc = 82%). Conclusion: Based on our results, in addition to MAD, other important predictors of rupture that might be used during aneurysm surveillance are TAV and rILT. Biomechanical parameters (PWS, RRED) as valuable predictors should be assessed in prospective clinical trials. Similar studies on AAA smaller than 55 mm in diameter, even difficult to organize, would be of even greater clinical value. 2023 Koncar, Nikolic, Milosevic, Bogavac-Stanojevic, Ilic, Dragas, Sladojevic, Markovic, Vujcic, Filipovic and Davidovic.
PB  - Frontiers Media S.A.
T2  - Frontiers in Surgery
T1  - Abdominal aortic aneurysm volume and relative intraluminal thrombus volume might be auxiliary predictors of rupture—an observational cross-sectional study
VL  - 10
DO  - 10.3389/fsurg.2023.1095224
ER  - 
@article{
author = "Končar, I. and Nikolić, D. and Milošević, Z. and Bogavac-Stanojević, Nataša and Ilić, N. and Dragaš, M. and Sladojević, M. and Marković, M. and Vujčić, A. and Filipović, N. and Davidović, L.",
year = "2023",
abstract = "Objectives: The study aimed to identify differences and compare anatomical and biomechanical features between elective and ruptured abdominal aortic aneurysms (AAAs). Methods: Data (clinical, anatomical, and biomechanical) of 98 patients with AAA, 75 (76.53%) asymptomatic (Group aAAA) and 23 (23.46%) ruptured AAA (Group rAAA), were prospectively collected and analyzed. Anatomical, morphological, and biomechanical imaging markers like peak wall stress (PWS) and rupture risk equivalent diameter (RRED), comorbid conditions, and demographics were compared between the groups. Biomechanical features were assessed by analysis of Digital Imaging and Communication in Medicine images by A4clinics (Vascops), and anatomical features were assessed by 3Surgery (Trimensio). Binary and multiple logistic regression analysis were used and adjusted for confounders. Accuracy was assessed using receiving operative characteristic (ROC) curve analysis. Results: In a multivariable model, including gender and age as confounder variables, maximal aneurysm diameter [MAD, odds ratio (OR) = 1.063], relative intraluminal thrombus (rILT, OR = 1.039), and total aneurysm volume (TAV, OR = 1.006) continued to be significant predictors of AAA rupture with PWS (OR = 1.010) and RRED (OR = 1.031). Area under the ROC curve values and correct classification (cc) for the same parameters and the model that combines MAD, TAV, and rILT were measured: MAD (0.790, cc = 75%), PWS (0.713, cc = 73%), RRED (0.717, cc = 55%), TAV (0.756, cc = 79%), rILT (0.656, cc = 60%), and MAD + TAV + rILT (0.797, cc = 82%). Conclusion: Based on our results, in addition to MAD, other important predictors of rupture that might be used during aneurysm surveillance are TAV and rILT. Biomechanical parameters (PWS, RRED) as valuable predictors should be assessed in prospective clinical trials. Similar studies on AAA smaller than 55 mm in diameter, even difficult to organize, would be of even greater clinical value. 2023 Koncar, Nikolic, Milosevic, Bogavac-Stanojevic, Ilic, Dragas, Sladojevic, Markovic, Vujcic, Filipovic and Davidovic.",
publisher = "Frontiers Media S.A.",
journal = "Frontiers in Surgery",
title = "Abdominal aortic aneurysm volume and relative intraluminal thrombus volume might be auxiliary predictors of rupture—an observational cross-sectional study",
volume = "10",
doi = "10.3389/fsurg.2023.1095224"
}
Končar, I., Nikolić, D., Milošević, Z., Bogavac-Stanojević, N., Ilić, N., Dragaš, M., Sladojević, M., Marković, M., Vujčić, A., Filipović, N.,& Davidović, L.. (2023). Abdominal aortic aneurysm volume and relative intraluminal thrombus volume might be auxiliary predictors of rupture—an observational cross-sectional study. in Frontiers in Surgery
Frontiers Media S.A.., 10.
https://doi.org/10.3389/fsurg.2023.1095224
Končar I, Nikolić D, Milošević Z, Bogavac-Stanojević N, Ilić N, Dragaš M, Sladojević M, Marković M, Vujčić A, Filipović N, Davidović L. Abdominal aortic aneurysm volume and relative intraluminal thrombus volume might be auxiliary predictors of rupture—an observational cross-sectional study. in Frontiers in Surgery. 2023;10.
doi:10.3389/fsurg.2023.1095224 .
Končar, I., Nikolić, D., Milošević, Z., Bogavac-Stanojević, Nataša, Ilić, N., Dragaš, M., Sladojević, M., Marković, M., Vujčić, A., Filipović, N., Davidović, L., "Abdominal aortic aneurysm volume and relative intraluminal thrombus volume might be auxiliary predictors of rupture—an observational cross-sectional study" in Frontiers in Surgery, 10 (2023),
https://doi.org/10.3389/fsurg.2023.1095224 . .
1
2

Telomere-telomerase system status in patients with acute myocardial infarction with ST-segment elevation – relationship with oxidative stress

Vukašinović, Aleksandra; Ostanek, Barbara; Klisić, Aleksandra; Kafedžić, Srđan; Zdravković, Marija; Ilić, Ivan; Sopić, Miron; Hinić, Saša; Stefanović, Milica; Memon, Lidija; Gaković, Branka; Bogavac-Stanojević, Nataša; Spasojević-Kalimanovska, Vesna; Marc, Janja; Nešković, Aleksandar; Kotur-Stevuljević, Jelena

(Termedia Publishing House Ltd., 2023)

TY  - JOUR
AU  - Vukašinović, Aleksandra
AU  - Ostanek, Barbara
AU  - Klisić, Aleksandra
AU  - Kafedžić, Srđan
AU  - Zdravković, Marija
AU  - Ilić, Ivan
AU  - Sopić, Miron
AU  - Hinić, Saša
AU  - Stefanović, Milica
AU  - Memon, Lidija
AU  - Gaković, Branka
AU  - Bogavac-Stanojević, Nataša
AU  - Spasojević-Kalimanovska, Vesna
AU  - Marc, Janja
AU  - Nešković, Aleksandar
AU  - Kotur-Stevuljević, Jelena
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4677
AB  - Introduction: Telomeres are protective chromosomal ends. Short telomeres are a proven biomarker of biological aging. We aimed to find an association of telomere length and telomerase activity in circulating leukocytes and thromboaspirates of patients with acute myocardial infarction. Furthermore, association of the telomere-telomerase system with oxidative stress markers (as common risk factors for coronary artery disease (CAD)) was tested. Material and methods: Patients were selected from the patients admitted to the intensive care unit with acute myocardial infarction with ST-segment elevation (STEMI), with the following inclusion criteria – STEMI patients between 18 and 80 years old of both genders and candidates for primary percutaneous coronary intervention, with infarction pain present for a maximum of 12 h. In all the patients leukocyte telomere length, telomerase activity and scores related to oxidative-stress status (Protective, Damage and OXY) were evaluated. Results: Patients were divided into different groups: with stable angina pectoris (AP) (n = 22), acute myocardial infarction with: STEMI (n = 93), non-obstructive coronary arteries (MINOCA) (n = 7), blood vessel rupture (n = 6) at three time points, and compared to the group of 84 healthy subjects. Telomerase activity was significantly higher in all CAD sub-groups compared to the control group (AP = 0.373 (0.355–0.386), STEMI = 0.375 (0.349–0.395), MINOCA = 0.391 (0.366–0.401), blood vessel rupture = 0.360 (0.352–0.385) vs. CG = 0.069 (0.061–0.081), p < 0.001), while telomeres were significantly shorter in STEMI, MINOCA and blood vessel rupture groups compared to the control group (STEMI = 1.179 (0.931–1.376), MINOCA = 1.026 (0.951–1.070), blood vessel rupture = 1.089 (0.842–1.173) vs. CG = 1.329 (1.096–1.624), p = 0.030]. Values of OXY score were significantly higher in STEMI and MINOCA patients compared to the control group and AP patients (5.83 (4.55–7.54) and 10.28 (9.19–10.72) vs. 4.94 (3.29–6.18) and 4.18 (2.58–4.86), p < 0.001). Longer telomeres and higher telomerase activity were found in thromboaspirates, compared to the peripheral blood leukocytes in the same patients (1.25 (1.01–1.84) vs. 1.18 (0.909–1.516), p = 0.036; and 0.366 (0.367–0.379) vs. 0.366 (0.367–0.379), p < 0.001, respectively). In addition, telomere length and telomerase activity had good diagnostic ability to separate STEMI patients from healthy persons. Conclusions: Leukocyte telomere length and telomerase activity can differentiate CAD patients from healthy persons, and relate CAD to oxidative stress.
PB  - Termedia Publishing House Ltd.
T2  - Archives of Medical Science
T1  - Telomere-telomerase system status in patients with acute myocardial infarction with ST-segment elevation – relationship with oxidative stress
VL  - 19
IS  - 2
SP  - 313
EP  - 323
DO  - 10.5114/aoms/136074
ER  - 
@article{
author = "Vukašinović, Aleksandra and Ostanek, Barbara and Klisić, Aleksandra and Kafedžić, Srđan and Zdravković, Marija and Ilić, Ivan and Sopić, Miron and Hinić, Saša and Stefanović, Milica and Memon, Lidija and Gaković, Branka and Bogavac-Stanojević, Nataša and Spasojević-Kalimanovska, Vesna and Marc, Janja and Nešković, Aleksandar and Kotur-Stevuljević, Jelena",
year = "2023",
abstract = "Introduction: Telomeres are protective chromosomal ends. Short telomeres are a proven biomarker of biological aging. We aimed to find an association of telomere length and telomerase activity in circulating leukocytes and thromboaspirates of patients with acute myocardial infarction. Furthermore, association of the telomere-telomerase system with oxidative stress markers (as common risk factors for coronary artery disease (CAD)) was tested. Material and methods: Patients were selected from the patients admitted to the intensive care unit with acute myocardial infarction with ST-segment elevation (STEMI), with the following inclusion criteria – STEMI patients between 18 and 80 years old of both genders and candidates for primary percutaneous coronary intervention, with infarction pain present for a maximum of 12 h. In all the patients leukocyte telomere length, telomerase activity and scores related to oxidative-stress status (Protective, Damage and OXY) were evaluated. Results: Patients were divided into different groups: with stable angina pectoris (AP) (n = 22), acute myocardial infarction with: STEMI (n = 93), non-obstructive coronary arteries (MINOCA) (n = 7), blood vessel rupture (n = 6) at three time points, and compared to the group of 84 healthy subjects. Telomerase activity was significantly higher in all CAD sub-groups compared to the control group (AP = 0.373 (0.355–0.386), STEMI = 0.375 (0.349–0.395), MINOCA = 0.391 (0.366–0.401), blood vessel rupture = 0.360 (0.352–0.385) vs. CG = 0.069 (0.061–0.081), p < 0.001), while telomeres were significantly shorter in STEMI, MINOCA and blood vessel rupture groups compared to the control group (STEMI = 1.179 (0.931–1.376), MINOCA = 1.026 (0.951–1.070), blood vessel rupture = 1.089 (0.842–1.173) vs. CG = 1.329 (1.096–1.624), p = 0.030]. Values of OXY score were significantly higher in STEMI and MINOCA patients compared to the control group and AP patients (5.83 (4.55–7.54) and 10.28 (9.19–10.72) vs. 4.94 (3.29–6.18) and 4.18 (2.58–4.86), p < 0.001). Longer telomeres and higher telomerase activity were found in thromboaspirates, compared to the peripheral blood leukocytes in the same patients (1.25 (1.01–1.84) vs. 1.18 (0.909–1.516), p = 0.036; and 0.366 (0.367–0.379) vs. 0.366 (0.367–0.379), p < 0.001, respectively). In addition, telomere length and telomerase activity had good diagnostic ability to separate STEMI patients from healthy persons. Conclusions: Leukocyte telomere length and telomerase activity can differentiate CAD patients from healthy persons, and relate CAD to oxidative stress.",
publisher = "Termedia Publishing House Ltd.",
journal = "Archives of Medical Science",
title = "Telomere-telomerase system status in patients with acute myocardial infarction with ST-segment elevation – relationship with oxidative stress",
volume = "19",
number = "2",
pages = "313-323",
doi = "10.5114/aoms/136074"
}
Vukašinović, A., Ostanek, B., Klisić, A., Kafedžić, S., Zdravković, M., Ilić, I., Sopić, M., Hinić, S., Stefanović, M., Memon, L., Gaković, B., Bogavac-Stanojević, N., Spasojević-Kalimanovska, V., Marc, J., Nešković, A.,& Kotur-Stevuljević, J.. (2023). Telomere-telomerase system status in patients with acute myocardial infarction with ST-segment elevation – relationship with oxidative stress. in Archives of Medical Science
Termedia Publishing House Ltd.., 19(2), 313-323.
https://doi.org/10.5114/aoms/136074
Vukašinović A, Ostanek B, Klisić A, Kafedžić S, Zdravković M, Ilić I, Sopić M, Hinić S, Stefanović M, Memon L, Gaković B, Bogavac-Stanojević N, Spasojević-Kalimanovska V, Marc J, Nešković A, Kotur-Stevuljević J. Telomere-telomerase system status in patients with acute myocardial infarction with ST-segment elevation – relationship with oxidative stress. in Archives of Medical Science. 2023;19(2):313-323.
doi:10.5114/aoms/136074 .
Vukašinović, Aleksandra, Ostanek, Barbara, Klisić, Aleksandra, Kafedžić, Srđan, Zdravković, Marija, Ilić, Ivan, Sopić, Miron, Hinić, Saša, Stefanović, Milica, Memon, Lidija, Gaković, Branka, Bogavac-Stanojević, Nataša, Spasojević-Kalimanovska, Vesna, Marc, Janja, Nešković, Aleksandar, Kotur-Stevuljević, Jelena, "Telomere-telomerase system status in patients with acute myocardial infarction with ST-segment elevation – relationship with oxidative stress" in Archives of Medical Science, 19, no. 2 (2023):313-323,
https://doi.org/10.5114/aoms/136074 . .
2
3
4

An economic evaluation of phacoemulsification and extracapsular cataract extraction in cataract surgery

Radujević, Katarina; Bogavac-Stanojević, Nataša; Nedeljković, Rade; Lakić, Dragana

(Univerzitet odbrane - Vojnomedicinska akademija, Medicinski fakultet, 2023)

TY  - JOUR
AU  - Radujević, Katarina
AU  - Bogavac-Stanojević, Nataša
AU  - Nedeljković, Rade
AU  - Lakić, Dragana
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4658
AB  - Background/Aim. Cataract surgery is one of the most often
performed surgical interventions. The predominant method in
Western countries is phacoemulsification, while in developing
countries, the extracapsular cataract extraction (ECCE) method
remains popular. The aim of the study was to evaluate the cost-
effectiveness of these two cataract surgery techniques from the
provider’s perspective if operation complications were the out-
come of the interest. Methods. The data were obtained from
the Department of Ophthalmology of the General Hospital
Kruševac during a one-year period. A total of 1,179 surgeries
by five surgeons were performed. The cost-effectiveness was
evaluated using the decision tree. All probabilities were calcu-
lated based on the likelihood of the occurrence during the
study period. Only direct costs were considered, and values
were taken from the documentation at the hospital and the of-
ficial price list of health services. One- and two-way sensitivity analyses were performed. Results. The total cost per patient in
the phacoemulsification group was 71,008.70 Serbian dinars
(RSD), while the total cost in the ECCE group was 74,340.36
RSD. At the same time, phacoemulsification shows higher ef-
fectiveness than the ECCE method, with 87% and 57% of pa-
tients without complications, respectively. With these results,
phacoemulsification was the dominant strategy compared to
ECCE. The sensitivity analysis revealed that the results are sen-
sitive to the number of performed operations per year. Con-
clusion. The phacoemulsification technique seems to be the
preferred technique for cataract surgery. All the investment in
phacoemulsification equipment and consumables is justified if
the number of surgeries per year exceeds 350.
AB  - Uvod/Cilj. Operacija katarakte predstavlja jednu od najčešće
primenjivanih hirurških intervencija. U zapadnim zemljama,
dominantna tehnika je fakoemulzifikacija, dok je u zemljama u
razvoju najzastupljenija tehnika ekstrakapsularne ekstrakcije
(ECCE). Cilj rada bio je da se proceni ekonomska isplativost te
dve tehnike operacije katarakte iz perspektive pružaoca usluge,
ukoliko se kao ishod posmatraju komplikacije. Metode. Podaci
su dobijeni sa Očnog odeljenja Opšte bolnice Kruševac tokom
jednogodišnjeg perioda. Ukupno je izvedeno 1 179 operacija
od strane pet hirurga. Ekonomska isplativost je procenjena
primenom „drveta odlučivanja“. Verovatnoće za događaje su
izračunate na osnovu verovatnoće pojavljivanja tokom
navedenog perioda. U analizi su razmatrani samo direktni
troškovi, a vrednosti su preuzete iz prateće dokumentacije i
zvaničnog cenovnika zdravstvenih usluga. Sprovedena je
jednosmerna i dvosmerna analiza osetljivosti. Rezultati.Ukupni troškovi u grupi koja je bila podvrgnuta
fakoemulzifikaciji iznosili su 71 008.70 srpskih dinara (RSD),
dok su u ECC E grupi oni iznosili 74 340.36 RSD.
Istovremeno, fakoemulzifikacija je pokazala višu efikasnost u
odnosu na ECCE, 87% i 57% bolesnika bez komplikacija,
redom. Na osnovu dobijenih rezultata, fakoemulzifikacija je
bila dominantna strategija u poređenju sa ECCE. Analiza
osetljivosti pokazala je da su rezultati osetljivi na broj izvršenih
intervencija na godišnjem nivou. Zaključak.
Fakoemulzifikacija je ekonomski isplativija tehnika operacije
katarakte u odnosu na ECCE. Sva ulaganje u opremu i potrošni
materijal za fakoemulzifikaciju opravdani su ukoliko je broj
izvedenih operacija na godišnjem nivou preko 350.
PB  - Univerzitet odbrane - Vojnomedicinska akademija, Medicinski fakultet
T2  - Vojnosanitetski pregled
T1  - An economic evaluation of phacoemulsification and extracapsular cataract extraction in cataract surgery
T1  - Farmakoekonomska evaluacija fakoemulzifikacije i ekstrakapsularne ekstrakcije u operaciji katarakte
VL  - 80
IS  - 1
SP  - 50
EP  - 51
DO  - 10.2298/VSP210831013R
ER  - 
@article{
author = "Radujević, Katarina and Bogavac-Stanojević, Nataša and Nedeljković, Rade and Lakić, Dragana",
year = "2023",
abstract = "Background/Aim. Cataract surgery is one of the most often
performed surgical interventions. The predominant method in
Western countries is phacoemulsification, while in developing
countries, the extracapsular cataract extraction (ECCE) method
remains popular. The aim of the study was to evaluate the cost-
effectiveness of these two cataract surgery techniques from the
provider’s perspective if operation complications were the out-
come of the interest. Methods. The data were obtained from
the Department of Ophthalmology of the General Hospital
Kruševac during a one-year period. A total of 1,179 surgeries
by five surgeons were performed. The cost-effectiveness was
evaluated using the decision tree. All probabilities were calcu-
lated based on the likelihood of the occurrence during the
study period. Only direct costs were considered, and values
were taken from the documentation at the hospital and the of-
ficial price list of health services. One- and two-way sensitivity analyses were performed. Results. The total cost per patient in
the phacoemulsification group was 71,008.70 Serbian dinars
(RSD), while the total cost in the ECCE group was 74,340.36
RSD. At the same time, phacoemulsification shows higher ef-
fectiveness than the ECCE method, with 87% and 57% of pa-
tients without complications, respectively. With these results,
phacoemulsification was the dominant strategy compared to
ECCE. The sensitivity analysis revealed that the results are sen-
sitive to the number of performed operations per year. Con-
clusion. The phacoemulsification technique seems to be the
preferred technique for cataract surgery. All the investment in
phacoemulsification equipment and consumables is justified if
the number of surgeries per year exceeds 350., Uvod/Cilj. Operacija katarakte predstavlja jednu od najčešće
primenjivanih hirurških intervencija. U zapadnim zemljama,
dominantna tehnika je fakoemulzifikacija, dok je u zemljama u
razvoju najzastupljenija tehnika ekstrakapsularne ekstrakcije
(ECCE). Cilj rada bio je da se proceni ekonomska isplativost te
dve tehnike operacije katarakte iz perspektive pružaoca usluge,
ukoliko se kao ishod posmatraju komplikacije. Metode. Podaci
su dobijeni sa Očnog odeljenja Opšte bolnice Kruševac tokom
jednogodišnjeg perioda. Ukupno je izvedeno 1 179 operacija
od strane pet hirurga. Ekonomska isplativost je procenjena
primenom „drveta odlučivanja“. Verovatnoće za događaje su
izračunate na osnovu verovatnoće pojavljivanja tokom
navedenog perioda. U analizi su razmatrani samo direktni
troškovi, a vrednosti su preuzete iz prateće dokumentacije i
zvaničnog cenovnika zdravstvenih usluga. Sprovedena je
jednosmerna i dvosmerna analiza osetljivosti. Rezultati.Ukupni troškovi u grupi koja je bila podvrgnuta
fakoemulzifikaciji iznosili su 71 008.70 srpskih dinara (RSD),
dok su u ECC E grupi oni iznosili 74 340.36 RSD.
Istovremeno, fakoemulzifikacija je pokazala višu efikasnost u
odnosu na ECCE, 87% i 57% bolesnika bez komplikacija,
redom. Na osnovu dobijenih rezultata, fakoemulzifikacija je
bila dominantna strategija u poređenju sa ECCE. Analiza
osetljivosti pokazala je da su rezultati osetljivi na broj izvršenih
intervencija na godišnjem nivou. Zaključak.
Fakoemulzifikacija je ekonomski isplativija tehnika operacije
katarakte u odnosu na ECCE. Sva ulaganje u opremu i potrošni
materijal za fakoemulzifikaciju opravdani su ukoliko je broj
izvedenih operacija na godišnjem nivou preko 350.",
publisher = "Univerzitet odbrane - Vojnomedicinska akademija, Medicinski fakultet",
journal = "Vojnosanitetski pregled",
title = "An economic evaluation of phacoemulsification and extracapsular cataract extraction in cataract surgery, Farmakoekonomska evaluacija fakoemulzifikacije i ekstrakapsularne ekstrakcije u operaciji katarakte",
volume = "80",
number = "1",
pages = "50-51",
doi = "10.2298/VSP210831013R"
}
Radujević, K., Bogavac-Stanojević, N., Nedeljković, R.,& Lakić, D.. (2023). An economic evaluation of phacoemulsification and extracapsular cataract extraction in cataract surgery. in Vojnosanitetski pregled
Univerzitet odbrane - Vojnomedicinska akademija, Medicinski fakultet., 80(1), 50-51.
https://doi.org/10.2298/VSP210831013R
Radujević K, Bogavac-Stanojević N, Nedeljković R, Lakić D. An economic evaluation of phacoemulsification and extracapsular cataract extraction in cataract surgery. in Vojnosanitetski pregled. 2023;80(1):50-51.
doi:10.2298/VSP210831013R .
Radujević, Katarina, Bogavac-Stanojević, Nataša, Nedeljković, Rade, Lakić, Dragana, "An economic evaluation of phacoemulsification and extracapsular cataract extraction in cataract surgery" in Vojnosanitetski pregled, 80, no. 1 (2023):50-51,
https://doi.org/10.2298/VSP210831013R . .

Predictors of Inadequate Health Literacy among Patients with Type 2 Diabetes Mellitus: Assessment with Different Self-Reported Instruments

Lević, Marija; Bogavac-Stanojević, Nataša; Lakić, Dragana; Krajnović, Dušanka

(MDPI, 2023)

TY  - JOUR
AU  - Lević, Marija
AU  - Bogavac-Stanojević, Nataša
AU  - Lakić, Dragana
AU  - Krajnović, Dušanka
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4647
AB  - INTRODUCTION: Obtaining, understanding, interpreting, and acting on health information enables people with diabetes to engage and make health decisions in various contexts. Hence, inadequate health literacy (HL) could pose a problem in making self-care decisions and in self-management for diabetes. By applying multidimensional instruments to assess HL, it is possible to differentiate domains of functional, communicative, and critical HL. OBJECTIVES: Primarily, this study aimed to measure the prevalence of inadequate HL among type 2 diabetes mellitus patients and to analyze the predictors influencing health literacy levels. Secondly, we analyzed if different self-reported measures, unidimensional instruments (Brief Health Literacy instruments (BRIEF-4 and abbreviated version BRIEF-3), and multidimensional instruments (Functional, Communicative and Critical health literacy instrument (FCCHL)) have the same findings. METHODS: The cross-sectional study was conducted within one primary care institution in Serbia between March and September 2021. Data were collected through Serbian versions of BRIEF-4, BRIEF-3, and FCCHL-SR12. A chi-square test, Fisher's exact test, and simple logistic regression were used to measure the association between the associated factors and health literacy level. Multivariate analyses were performed with significant predictors from univariate analyses. RESULTS: Overall, 350 patients participated in the study. They were primarily males (55.4%) and had a mean age of 61.5 years (SD = 10.5), ranging from 31 to 82 years. The prevalence of inadequate HL was estimated to be 42.2% (FCCHL-SR12), 36.9% (BRIEF-3) and 33.8% (BRIEF-4). There are variations in the assessment of marginal and adequate HL by different instruments. The highest association was shown between BRIEF-3 and total FCCHL-SR12 score (0.204, p < 0.01). The total FCCHL-SR12 score correlates better with the abbreviated BRIEF instrument (BRIEF-3) than with BRIEF-4 (0.190, p < 0.01). All instruments indicated the highest levels for the communicative HL domain and the lowest for the functional HL domain with significant difference in functional HL between the functional HL of FCCHL-SR12 and both BRIEF-3 and BRIEF-4 (p = 0.006 and 0.008, respectively). Depending on applied instruments, we identified several variables (sociodemographic, access to health-related information, empowerment-related indicators, type of therapy, and frequency of drug administration) that could significantly predict inadequate HL. Probability of inadequate HL increased with older age, fewer children, lower education level, and higher consumption of alcohol. Only high education was associated with a lower probability of inadequate HL for all three instruments. CONCLUSIONS: The results we obtained indicate that patients in our study may have been more functionally illiterate, but differences between functional level could be observed if assessed by unidimensional and multidimensional instruments. The proportion of patients with inadequate HL is approximately similar as assessed by all three instruments. According to the association between HL and educational level in DMT2 patients we should investigate methods of further improvement.
PB  - MDPI
T2  - International journal of environmental research and public health
T1  - Predictors of Inadequate Health Literacy among Patients with Type 2 Diabetes Mellitus: Assessment with Different Self-Reported Instruments
VL  - 20
IS  - 6
DO  - 10.3390/ijerph20065190
ER  - 
@article{
author = "Lević, Marija and Bogavac-Stanojević, Nataša and Lakić, Dragana and Krajnović, Dušanka",
year = "2023",
abstract = "INTRODUCTION: Obtaining, understanding, interpreting, and acting on health information enables people with diabetes to engage and make health decisions in various contexts. Hence, inadequate health literacy (HL) could pose a problem in making self-care decisions and in self-management for diabetes. By applying multidimensional instruments to assess HL, it is possible to differentiate domains of functional, communicative, and critical HL. OBJECTIVES: Primarily, this study aimed to measure the prevalence of inadequate HL among type 2 diabetes mellitus patients and to analyze the predictors influencing health literacy levels. Secondly, we analyzed if different self-reported measures, unidimensional instruments (Brief Health Literacy instruments (BRIEF-4 and abbreviated version BRIEF-3), and multidimensional instruments (Functional, Communicative and Critical health literacy instrument (FCCHL)) have the same findings. METHODS: The cross-sectional study was conducted within one primary care institution in Serbia between March and September 2021. Data were collected through Serbian versions of BRIEF-4, BRIEF-3, and FCCHL-SR12. A chi-square test, Fisher's exact test, and simple logistic regression were used to measure the association between the associated factors and health literacy level. Multivariate analyses were performed with significant predictors from univariate analyses. RESULTS: Overall, 350 patients participated in the study. They were primarily males (55.4%) and had a mean age of 61.5 years (SD = 10.5), ranging from 31 to 82 years. The prevalence of inadequate HL was estimated to be 42.2% (FCCHL-SR12), 36.9% (BRIEF-3) and 33.8% (BRIEF-4). There are variations in the assessment of marginal and adequate HL by different instruments. The highest association was shown between BRIEF-3 and total FCCHL-SR12 score (0.204, p < 0.01). The total FCCHL-SR12 score correlates better with the abbreviated BRIEF instrument (BRIEF-3) than with BRIEF-4 (0.190, p < 0.01). All instruments indicated the highest levels for the communicative HL domain and the lowest for the functional HL domain with significant difference in functional HL between the functional HL of FCCHL-SR12 and both BRIEF-3 and BRIEF-4 (p = 0.006 and 0.008, respectively). Depending on applied instruments, we identified several variables (sociodemographic, access to health-related information, empowerment-related indicators, type of therapy, and frequency of drug administration) that could significantly predict inadequate HL. Probability of inadequate HL increased with older age, fewer children, lower education level, and higher consumption of alcohol. Only high education was associated with a lower probability of inadequate HL for all three instruments. CONCLUSIONS: The results we obtained indicate that patients in our study may have been more functionally illiterate, but differences between functional level could be observed if assessed by unidimensional and multidimensional instruments. The proportion of patients with inadequate HL is approximately similar as assessed by all three instruments. According to the association between HL and educational level in DMT2 patients we should investigate methods of further improvement.",
publisher = "MDPI",
journal = "International journal of environmental research and public health",
title = "Predictors of Inadequate Health Literacy among Patients with Type 2 Diabetes Mellitus: Assessment with Different Self-Reported Instruments",
volume = "20",
number = "6",
doi = "10.3390/ijerph20065190"
}
Lević, M., Bogavac-Stanojević, N., Lakić, D.,& Krajnović, D.. (2023). Predictors of Inadequate Health Literacy among Patients with Type 2 Diabetes Mellitus: Assessment with Different Self-Reported Instruments. in International journal of environmental research and public health
MDPI., 20(6).
https://doi.org/10.3390/ijerph20065190
Lević M, Bogavac-Stanojević N, Lakić D, Krajnović D. Predictors of Inadequate Health Literacy among Patients with Type 2 Diabetes Mellitus: Assessment with Different Self-Reported Instruments. in International journal of environmental research and public health. 2023;20(6).
doi:10.3390/ijerph20065190 .
Lević, Marija, Bogavac-Stanojević, Nataša, Lakić, Dragana, Krajnović, Dušanka, "Predictors of Inadequate Health Literacy among Patients with Type 2 Diabetes Mellitus: Assessment with Different Self-Reported Instruments" in International journal of environmental research and public health, 20, no. 6 (2023),
https://doi.org/10.3390/ijerph20065190 . .
1
3
1

Metabolic and inflammatory homeostasis disorders in the pathogenesis of colorectal cancer

Mihajlović, Marija; Ninić, Ana; Ostojić, Marija; Sopić, Miron; Stefanović, Aleksandra; Vekić, Jelena; Antonić, Tamara; Spasojević-Kalimanovska, Vesna; Bogavac-Stanojević, Nataša; Zeljković, Aleksandra

(Savez farmaceutskih udruženja Srbije (SFUS), 2022)

TY  - CONF
AU  - Mihajlović, Marija
AU  - Ninić, Ana
AU  - Ostojić, Marija
AU  - Sopić, Miron
AU  - Stefanović, Aleksandra
AU  - Vekić, Jelena
AU  - Antonić, Tamara
AU  - Spasojević-Kalimanovska, Vesna
AU  - Bogavac-Stanojević, Nataša
AU  - Zeljković, Aleksandra
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4645
AB  - In order to understand the metabolic and immune potential of adiponectin in
colorectal cancer (CRC), attention is drawn to its receptors: adiponectin receptor 1
(ADIPOR1) and adiponectin receptor 2 (ADIPOR2). Gene set enrichment analysis (GSEA) of
datasets based on malignant tissue samples and peripheral blood monocytes (PBMs) was
used to explore mRNA fingerprints of different signaling pathways best associated with
ADIPOR1/ADIPOR2 gene expression levels. Transcriptomic datasets GSE44076 (1) and
GSE47756 (2) were downloaded from the NCBI Gene Expression Omnibus database. In the
GSE44076 dataset, three groups were formed: 98 colon tumor tissue and matched tumor-
adjacent mucosa samples and tissue samples from 50 healthy volunteers. The other set
(GSE47756) contained information on PBMs' gene signature in CRC, by forming two groups:
38 samples from healthy subjects and 55 CRC patients. GSEA analysis of the GSE44076
dataset implied that ADIPOR1 mRNA levels were in negative association with MTORC1 and
TNF-α NF-κB signaling pathways in tumor tissue. At the same time, ADIPOR2 was positively
associated with metabolic gene sets such as cholesterol homeostasis, glycolysis and PPAR
signaling. Quite opposite to the GSE44076 dataset, GSEA analysisis of GSE47756 revealed
that ADIPOR1 was a metabolically active receptor in PBMs of CRC patients. Surprisingly, the
TNF-α NF-κB signaling pathway gene sets were positively associated with ADIPOR1 mRNA
levels in monocytes of the cancer group. Different types of metabolic and immune regulation
achieved through ADIPOR1/ADIPOR2 in tumor and PBMs suggest possible novel therapeutic
targets in CRC.
AB  - Da bi se razumeo metabolički i imuni potencijal adiponektina u kolorektalnom
karcinomu (CRC), pažnja se mora obratiti i na njegove receptore: adiponektinski receptor 1
(ADIPOR1) i adiponektinski receptor 2 (ADIPOR2). Gene set enrichment analiza (GSEA) dva
skupa podataka, zasnovanih na uzorcima malignog tkiva i na monocitima periferne krvi
(PBM) je korišćena da bi se obezbedili genetski otisci različitih signalnih puteva koji su bili
najbolje povezani sa ekspresijom gena ADIPOR1/ADIPOR2. Skupovi transkriptomskih
podataka GSE44076 (1) i GSE47756 (2) su preuzeti iz NCBI Gene Expression Omnibus baze
podataka. U skupu podataka GSE44076 formirane su tri grupe: 98 uparenih uzoraka
tumorskog tkiva debelog creva i susedne mukoze i uzorci tkiva 50 zdravih dobrovoljaca.
Drugi set (GSE47756) je sadržao informacije o otisku gena PBM u CRC sa formiranim dvema
grupama: 38 uzoraka zdravih subjekata i 55 pacijenata sa CRC. GSEA analiza skupa podataka
GSE44076 je implicira da su nivoi iRNK ADIPOR1 negativno korelirali sa MTORC1 i TNF-α
NF-κB signalnim putevima u tumorskom tkivu. Istovremeno, ADIPOR2 je bio pozitivno
povezan sa skupovima gena metaboličkih puteva kao što su homeostaza holesterola,
glikoliza i PPAR signalizacija. Nasuprot GSE44076 skupu podataka, GSEA analiza GSE47756
transkriptomskog seta je otkrila da je ADIPOR1 zapravo metabolički aktivan receptor u PBM
pacijenata sa CRC. Iznenađujuć e, setovi gena koji su se odnosili na signalni put TNF-α NF-κB
su bili pozitivno povezani sa nivoima iRNK ADIPOR1 u monocitima grupe sa karcinomom.
Različite vrste metaboličke i imune regulacije koje se postižu preko ADIPOR1/ADIPOR2 u
tumoru i PBM sugerišu moguć e nove terapeutske ciljeve u CRC.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - Metabolic and inflammatory homeostasis disorders in the pathogenesis of colorectal cancer
T1  - Poremećaji metaboličke i inflamatorne homeostaze u patogenezi kolorektalnog karcinoma
VL  - 72
IS  - 4 suplement
SP  - S622
EP  - S623
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4645
ER  - 
@conference{
author = "Mihajlović, Marija and Ninić, Ana and Ostojić, Marija and Sopić, Miron and Stefanović, Aleksandra and Vekić, Jelena and Antonić, Tamara and Spasojević-Kalimanovska, Vesna and Bogavac-Stanojević, Nataša and Zeljković, Aleksandra",
year = "2022",
abstract = "In order to understand the metabolic and immune potential of adiponectin in
colorectal cancer (CRC), attention is drawn to its receptors: adiponectin receptor 1
(ADIPOR1) and adiponectin receptor 2 (ADIPOR2). Gene set enrichment analysis (GSEA) of
datasets based on malignant tissue samples and peripheral blood monocytes (PBMs) was
used to explore mRNA fingerprints of different signaling pathways best associated with
ADIPOR1/ADIPOR2 gene expression levels. Transcriptomic datasets GSE44076 (1) and
GSE47756 (2) were downloaded from the NCBI Gene Expression Omnibus database. In the
GSE44076 dataset, three groups were formed: 98 colon tumor tissue and matched tumor-
adjacent mucosa samples and tissue samples from 50 healthy volunteers. The other set
(GSE47756) contained information on PBMs' gene signature in CRC, by forming two groups:
38 samples from healthy subjects and 55 CRC patients. GSEA analysis of the GSE44076
dataset implied that ADIPOR1 mRNA levels were in negative association with MTORC1 and
TNF-α NF-κB signaling pathways in tumor tissue. At the same time, ADIPOR2 was positively
associated with metabolic gene sets such as cholesterol homeostasis, glycolysis and PPAR
signaling. Quite opposite to the GSE44076 dataset, GSEA analysisis of GSE47756 revealed
that ADIPOR1 was a metabolically active receptor in PBMs of CRC patients. Surprisingly, the
TNF-α NF-κB signaling pathway gene sets were positively associated with ADIPOR1 mRNA
levels in monocytes of the cancer group. Different types of metabolic and immune regulation
achieved through ADIPOR1/ADIPOR2 in tumor and PBMs suggest possible novel therapeutic
targets in CRC., Da bi se razumeo metabolički i imuni potencijal adiponektina u kolorektalnom
karcinomu (CRC), pažnja se mora obratiti i na njegove receptore: adiponektinski receptor 1
(ADIPOR1) i adiponektinski receptor 2 (ADIPOR2). Gene set enrichment analiza (GSEA) dva
skupa podataka, zasnovanih na uzorcima malignog tkiva i na monocitima periferne krvi
(PBM) je korišćena da bi se obezbedili genetski otisci različitih signalnih puteva koji su bili
najbolje povezani sa ekspresijom gena ADIPOR1/ADIPOR2. Skupovi transkriptomskih
podataka GSE44076 (1) i GSE47756 (2) su preuzeti iz NCBI Gene Expression Omnibus baze
podataka. U skupu podataka GSE44076 formirane su tri grupe: 98 uparenih uzoraka
tumorskog tkiva debelog creva i susedne mukoze i uzorci tkiva 50 zdravih dobrovoljaca.
Drugi set (GSE47756) je sadržao informacije o otisku gena PBM u CRC sa formiranim dvema
grupama: 38 uzoraka zdravih subjekata i 55 pacijenata sa CRC. GSEA analiza skupa podataka
GSE44076 je implicira da su nivoi iRNK ADIPOR1 negativno korelirali sa MTORC1 i TNF-α
NF-κB signalnim putevima u tumorskom tkivu. Istovremeno, ADIPOR2 je bio pozitivno
povezan sa skupovima gena metaboličkih puteva kao što su homeostaza holesterola,
glikoliza i PPAR signalizacija. Nasuprot GSE44076 skupu podataka, GSEA analiza GSE47756
transkriptomskog seta je otkrila da je ADIPOR1 zapravo metabolički aktivan receptor u PBM
pacijenata sa CRC. Iznenađujuć e, setovi gena koji su se odnosili na signalni put TNF-α NF-κB
su bili pozitivno povezani sa nivoima iRNK ADIPOR1 u monocitima grupe sa karcinomom.
Različite vrste metaboličke i imune regulacije koje se postižu preko ADIPOR1/ADIPOR2 u
tumoru i PBM sugerišu moguć e nove terapeutske ciljeve u CRC.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Metabolic and inflammatory homeostasis disorders in the pathogenesis of colorectal cancer, Poremećaji metaboličke i inflamatorne homeostaze u patogenezi kolorektalnog karcinoma",
volume = "72",
number = "4 suplement",
pages = "S622-S623",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4645"
}
Mihajlović, M., Ninić, A., Ostojić, M., Sopić, M., Stefanović, A., Vekić, J., Antonić, T., Spasojević-Kalimanovska, V., Bogavac-Stanojević, N.,& Zeljković, A.. (2022). Metabolic and inflammatory homeostasis disorders in the pathogenesis of colorectal cancer. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 72(4 suplement), S622-S623.
https://hdl.handle.net/21.15107/rcub_farfar_4645
Mihajlović M, Ninić A, Ostojić M, Sopić M, Stefanović A, Vekić J, Antonić T, Spasojević-Kalimanovska V, Bogavac-Stanojević N, Zeljković A. Metabolic and inflammatory homeostasis disorders in the pathogenesis of colorectal cancer. in Arhiv za farmaciju. 2022;72(4 suplement):S622-S623.
https://hdl.handle.net/21.15107/rcub_farfar_4645 .
Mihajlović, Marija, Ninić, Ana, Ostojić, Marija, Sopić, Miron, Stefanović, Aleksandra, Vekić, Jelena, Antonić, Tamara, Spasojević-Kalimanovska, Vesna, Bogavac-Stanojević, Nataša, Zeljković, Aleksandra, "Metabolic and inflammatory homeostasis disorders in the pathogenesis of colorectal cancer" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S622-S623,
https://hdl.handle.net/21.15107/rcub_farfar_4645 .

Assessment of health literacy in the population of chronic patients by using of FCCHL questionnaire

Šesto, Sofija; Lević, Marija; Milošević-Georgiev, Andrijana; Stanojlović, Marijana; Radojković, Jovana; Radojičić, Milica; Femić, Ivana; Bogavac-Stanojević, Nataša; Krajnović, Dušanka

(Savez farmaceutskih udruženja Srbije (SFUS), 2022)

TY  - CONF
AU  - Šesto, Sofija
AU  - Lević, Marija
AU  - Milošević-Georgiev, Andrijana
AU  - Stanojlović, Marijana
AU  - Radojković, Jovana
AU  - Radojičić, Milica
AU  - Femić, Ivana
AU  - Bogavac-Stanojević, Nataša
AU  - Krajnović, Dušanka
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4545
AB  - Health literacy (HL) is an important determinant of health, which has a significant role
in the management of chronic diseases and therapy (1, 2). The aim was to assess functional,
communicative, critical, and total HL and evaluate differences in literacy levels. A cross-
sectional study was performed on a sample in health institutions (pharmacies, health
centers) in urban and rural areas during 2021/2022. A validated version of the FCCHL
questionnaire was used, which assessed HL, in relation to age, gender, place of residence,
chronic disease, marital status, number of children, level of education, employment, smoking
and self-assessment of health. In the sample of 349 chronic patients, women (58.2%) and
diabetics (71.9%) dominated. Although the majority (87.1%) showed adequate HL, there are
differences among patients according to HL levels, except for gender and smoking. There is
the least difference in relation to the level of functional HL, and the most difference is shown
in critical HL. Chronic patients who had a higher level of education, live in Belgrade, parents
and married (χ2 = 28.36, p <0.001, χ2 = 4.19, p <0.05, χ2 = 6.56, p (0.05, χ2 = 14.99, p <0.05,
respectively) had statistically significant higher levels of critical HL. We concluded that the
application of the FCCHL questionnaire can reveal differences in the levels of total HL and
more importantly critical and communicative literacy. These results may be important to
clinicians in practice to easier identify patients who need help with management and use of
information for better disease control.
AB  - Zdravstvena pismenost (HL) je važna odrednica zdravlja, koja ima značajnu ulogu u
upravljanju hroničnim bolestima i terapijom (1, 2). Cilj ovog istraživanja je bila procena
funkcionalne, komunikativne, kritičke i ukupne HL i procene razlika u nivoima pismenosti
kod hroničnih pacijenata. Studija preseka na uzorku u zdravstvenim ustanovama (apoteke,
domovi zdravlja) urađena je u gradskoj i ruralnoj sredini tokom 2021/2022 godine,
korišćenjem validirane verzije FCCHL upitnika, kojim je procenjena HL, u odnosu na: godine,
pol, mesto stanovanja, hronično oboljenje, bračni status, broj dece, stepen obrazovanja, radni
status, pušenje i samoprocenu zdravlja. U uzorku od 349 hroničnih pacijenata, dominanirale
su žene (58,2%) i dijabetičari (71,9%). Iako je većina (87,1%) pokazala adekvatnu HL,
postoje razlike među pacijentima prema nivoima HL, osim prema polu i pušačkom statusu.
Najmanje je razlika u odnosu na nivo funkcionalne HL, a najviše je razlika pokazano kod
kritičke HL. Hronični pacijenti koji su imali veći stepena obrazovanja, stanuju u Beogradu,
roditelji i koji žive u braku (χ2= 28,36, p < 0,001, χ2= 4,19, p < 0,05, χ2 = 6,56, p < 0,05, χ2 =
14,99, p < 0,05, redom), bili su statistički značajno višeg nivoa kritičke HL. Zaključujemo da
se primenom FCCHL upitnika mogu otkriti razlike u nivoima ne samo ukupne HL, već što je
značajnije kritičke i interaktivne prismenosti, što bi trebalo da bude u fokusu daljih
istraživanja. Ovi rezultati mogu biti od značaja kliničarima u praksi da lakše uoče pacijente
kojima je potrebna pomoć u vezi sa upravljanjem i primenom informacija radi bolje kontrole
bolesti.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - Assessment of health literacy in the population of chronic patients by using of FCCHL questionnaire
T1  - Procena zdravstvene pismenosti u populaciji hroničnih pacijenata primenom FCCHL upitnika
VL  - 72
IS  - 4 suplement
SP  - S335
EP  - S336
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4545
ER  - 
@conference{
author = "Šesto, Sofija and Lević, Marija and Milošević-Georgiev, Andrijana and Stanojlović, Marijana and Radojković, Jovana and Radojičić, Milica and Femić, Ivana and Bogavac-Stanojević, Nataša and Krajnović, Dušanka",
year = "2022",
abstract = "Health literacy (HL) is an important determinant of health, which has a significant role
in the management of chronic diseases and therapy (1, 2). The aim was to assess functional,
communicative, critical, and total HL and evaluate differences in literacy levels. A cross-
sectional study was performed on a sample in health institutions (pharmacies, health
centers) in urban and rural areas during 2021/2022. A validated version of the FCCHL
questionnaire was used, which assessed HL, in relation to age, gender, place of residence,
chronic disease, marital status, number of children, level of education, employment, smoking
and self-assessment of health. In the sample of 349 chronic patients, women (58.2%) and
diabetics (71.9%) dominated. Although the majority (87.1%) showed adequate HL, there are
differences among patients according to HL levels, except for gender and smoking. There is
the least difference in relation to the level of functional HL, and the most difference is shown
in critical HL. Chronic patients who had a higher level of education, live in Belgrade, parents
and married (χ2 = 28.36, p <0.001, χ2 = 4.19, p <0.05, χ2 = 6.56, p (0.05, χ2 = 14.99, p <0.05,
respectively) had statistically significant higher levels of critical HL. We concluded that the
application of the FCCHL questionnaire can reveal differences in the levels of total HL and
more importantly critical and communicative literacy. These results may be important to
clinicians in practice to easier identify patients who need help with management and use of
information for better disease control., Zdravstvena pismenost (HL) je važna odrednica zdravlja, koja ima značajnu ulogu u
upravljanju hroničnim bolestima i terapijom (1, 2). Cilj ovog istraživanja je bila procena
funkcionalne, komunikativne, kritičke i ukupne HL i procene razlika u nivoima pismenosti
kod hroničnih pacijenata. Studija preseka na uzorku u zdravstvenim ustanovama (apoteke,
domovi zdravlja) urađena je u gradskoj i ruralnoj sredini tokom 2021/2022 godine,
korišćenjem validirane verzije FCCHL upitnika, kojim je procenjena HL, u odnosu na: godine,
pol, mesto stanovanja, hronično oboljenje, bračni status, broj dece, stepen obrazovanja, radni
status, pušenje i samoprocenu zdravlja. U uzorku od 349 hroničnih pacijenata, dominanirale
su žene (58,2%) i dijabetičari (71,9%). Iako je većina (87,1%) pokazala adekvatnu HL,
postoje razlike među pacijentima prema nivoima HL, osim prema polu i pušačkom statusu.
Najmanje je razlika u odnosu na nivo funkcionalne HL, a najviše je razlika pokazano kod
kritičke HL. Hronični pacijenti koji su imali veći stepena obrazovanja, stanuju u Beogradu,
roditelji i koji žive u braku (χ2= 28,36, p < 0,001, χ2= 4,19, p < 0,05, χ2 = 6,56, p < 0,05, χ2 =
14,99, p < 0,05, redom), bili su statistički značajno višeg nivoa kritičke HL. Zaključujemo da
se primenom FCCHL upitnika mogu otkriti razlike u nivoima ne samo ukupne HL, već što je
značajnije kritičke i interaktivne prismenosti, što bi trebalo da bude u fokusu daljih
istraživanja. Ovi rezultati mogu biti od značaja kliničarima u praksi da lakše uoče pacijente
kojima je potrebna pomoć u vezi sa upravljanjem i primenom informacija radi bolje kontrole
bolesti.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Assessment of health literacy in the population of chronic patients by using of FCCHL questionnaire, Procena zdravstvene pismenosti u populaciji hroničnih pacijenata primenom FCCHL upitnika",
volume = "72",
number = "4 suplement",
pages = "S335-S336",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4545"
}
Šesto, S., Lević, M., Milošević-Georgiev, A., Stanojlović, M., Radojković, J., Radojičić, M., Femić, I., Bogavac-Stanojević, N.,& Krajnović, D.. (2022). Assessment of health literacy in the population of chronic patients by using of FCCHL questionnaire. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 72(4 suplement), S335-S336.
https://hdl.handle.net/21.15107/rcub_farfar_4545
Šesto S, Lević M, Milošević-Georgiev A, Stanojlović M, Radojković J, Radojičić M, Femić I, Bogavac-Stanojević N, Krajnović D. Assessment of health literacy in the population of chronic patients by using of FCCHL questionnaire. in Arhiv za farmaciju. 2022;72(4 suplement):S335-S336.
https://hdl.handle.net/21.15107/rcub_farfar_4545 .
Šesto, Sofija, Lević, Marija, Milošević-Georgiev, Andrijana, Stanojlović, Marijana, Radojković, Jovana, Radojičić, Milica, Femić, Ivana, Bogavac-Stanojević, Nataša, Krajnović, Dušanka, "Assessment of health literacy in the population of chronic patients by using of FCCHL questionnaire" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S335-S336,
https://hdl.handle.net/21.15107/rcub_farfar_4545 .

Oxidative stress and telomere length in COVID-19 patients

Guzonjić, Azra; Roksandić Milenković, Marina; Dimić, Dejan; Dimić, Nemanja; Timotijević, Ljiljana; Sopić, Miron; Vekić, Jelena; Bogavac-Stanojević, Nataša; Kotur-Stevuljević, Jelena

(Savez farmaceutskih udruženja Srbije (SFUS), 2022)

TY  - CONF
AU  - Guzonjić, Azra
AU  - Roksandić Milenković, Marina
AU  - Dimić, Dejan
AU  - Dimić, Nemanja
AU  - Timotijević, Ljiljana
AU  - Sopić, Miron
AU  - Vekić, Jelena
AU  - Bogavac-Stanojević, Nataša
AU  - Kotur-Stevuljević, Jelena
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4510
AB  - The pathogenesis of the COVID-19 infection caused by the SARS-CoV-2 coronavirus is
the subject of active research worldwide. As a complex disease, it is suspected that oxidative
stress plays a role in its pathogenesis and contributes to the progressive shortening of
telomeres. Patients aged 25–84 years (n=31) were monitored at the time of diagnosis, as
well as at control on the 14th and 21st days. Redox status parameters were determined: total
oxidant status (TOS), superoxide anion radical (O2.-), prooxidant-antioxidant balance (PAB),
advanced protein oxidation products (AOPP), malondialdehyde (MDA), and ischemia-
modified albumin (IMA) as prooxidants and total antioxidant status (TAS), superoxide-
dismutase (SOD) and paraoxonase 1 (PON1) enzyme activity, total antioxidant and total
oxidant status ratio (TAS/TOS), and total sulfhydryl groups (SHG) as antioxidants. Patients
have the shortest telomeres at diagnosis and their length increases during recovery. A
statistically significant difference in rTL was shown in patients at the time of diagnosis and
after 21 days (p=0.008). rTL has a statistically significant negative correlation with SHG in
patients at the time of diagnosis (ρ=-0.386, p=0.038), as well as in patients after 14 days (ρ =-
0.389, p=0.037). After 21 days, a statistically significant positive correlation was shown
between rTL and SOD (ρ =0.381, p=0.046). The obtained results indicate progressive
shortening of telomeres caused by COVID-19 infection, impaired redox status, as well as the
change of these parameters during recovery, which confirms the link between oxidative
stress and rTL, as well as the participation of these processes in the pathogenesis of COVID-
19.
AB  - Patogeneza COVID-19 infekcije izazvane koronavirusom SARS-CoV-2 je predmet
aktivnog istraživanja širom sveta. Kako je u pitanju složena bolest, smatra se da i u njenoj
patogenezi leži oksidativni stres, koji doprinosi progesivnom skraćivanju telomera. Pacijenti
starosti 25-84 godina (n=31) praćeni su u trenutku postavljanja dijagnoze, kao i na kontroli
14. i 21. dana. Parametri redoks statusa određivani su iz seruma ili plazme odgovarajućim
spektrofotometrijskim metodama, dok je iz leukocita periferne krvi merena relativna dužina
telomera (rTL) pomoću qPCR metode. Od parametara oksidativnog statusa određivani su:
totalni oksidantni status (TOS), superoksidni anjon radikal (O2.- ), prooksidantno-
antioksidantni balans (PAB), uznapredovali produkti oksidacije proteina (AOPP),
malondialdehid (MDA), ishemijom modifikovan albumin (IMA). Kao parametri
antioksidativne zaštite određivani su: totalni antioksidantni status (TAS), aktivnost enzima
superoksid-dismutaze (SOD) i paraoksonaze 1 (PON1), odnos totalnog antioksidantnog i
totalnog oksidantnog statusa (TAS/TOS), kao i ukupne sulfhidrilne grupe (SHG). Pacijenti u
trenutku postavljanja dijagnoze imaju najkraće telomere i njihova dužina se povećava tokom
oporavka. Pokazana je statistički značajna razlika u rTL kod pacijenata u trenutku
postavljanja dijagnoze i nakon 21 dan (p=0,008). rTL je u statistički značajnoj negativnoj
korelaciji sa SHG kod pacijenata u trenutku postavljanja dijagnoze (ρ=-0,386, p=0,038), kao i
kod pacijenata nakon 14 dana oporavka (ρ=-0,389, p=0,037). Nakon 21 dan, pokazana je
statistički značajna pozitivna korelacija između rTL i SOD (ρ=0,381, p=0,046). Dobijeni
rezultati ukazuju na progresivno skraćenje telomera izazvano COVID-19 infekcijom, narušen
redoks status, kao i na promenu ovih parametara tokom oporavka, koja potvrđuje vezu
između oksidativnog stresa i rTL, kao i učešće ovih procesa u patogenezi COVID-19.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - Oxidative stress and telomere length in COVID-19 patients
T1  - Oksidativni stres i dužina telomera kod COVID‐19 pacijenata
VL  - 72
IS  - 4 suplement
SP  - S231
EP  - S232
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4510
ER  - 
@conference{
author = "Guzonjić, Azra and Roksandić Milenković, Marina and Dimić, Dejan and Dimić, Nemanja and Timotijević, Ljiljana and Sopić, Miron and Vekić, Jelena and Bogavac-Stanojević, Nataša and Kotur-Stevuljević, Jelena",
year = "2022",
abstract = "The pathogenesis of the COVID-19 infection caused by the SARS-CoV-2 coronavirus is
the subject of active research worldwide. As a complex disease, it is suspected that oxidative
stress plays a role in its pathogenesis and contributes to the progressive shortening of
telomeres. Patients aged 25–84 years (n=31) were monitored at the time of diagnosis, as
well as at control on the 14th and 21st days. Redox status parameters were determined: total
oxidant status (TOS), superoxide anion radical (O2.-), prooxidant-antioxidant balance (PAB),
advanced protein oxidation products (AOPP), malondialdehyde (MDA), and ischemia-
modified albumin (IMA) as prooxidants and total antioxidant status (TAS), superoxide-
dismutase (SOD) and paraoxonase 1 (PON1) enzyme activity, total antioxidant and total
oxidant status ratio (TAS/TOS), and total sulfhydryl groups (SHG) as antioxidants. Patients
have the shortest telomeres at diagnosis and their length increases during recovery. A
statistically significant difference in rTL was shown in patients at the time of diagnosis and
after 21 days (p=0.008). rTL has a statistically significant negative correlation with SHG in
patients at the time of diagnosis (ρ=-0.386, p=0.038), as well as in patients after 14 days (ρ =-
0.389, p=0.037). After 21 days, a statistically significant positive correlation was shown
between rTL and SOD (ρ =0.381, p=0.046). The obtained results indicate progressive
shortening of telomeres caused by COVID-19 infection, impaired redox status, as well as the
change of these parameters during recovery, which confirms the link between oxidative
stress and rTL, as well as the participation of these processes in the pathogenesis of COVID-
19., Patogeneza COVID-19 infekcije izazvane koronavirusom SARS-CoV-2 je predmet
aktivnog istraživanja širom sveta. Kako je u pitanju složena bolest, smatra se da i u njenoj
patogenezi leži oksidativni stres, koji doprinosi progesivnom skraćivanju telomera. Pacijenti
starosti 25-84 godina (n=31) praćeni su u trenutku postavljanja dijagnoze, kao i na kontroli
14. i 21. dana. Parametri redoks statusa određivani su iz seruma ili plazme odgovarajućim
spektrofotometrijskim metodama, dok je iz leukocita periferne krvi merena relativna dužina
telomera (rTL) pomoću qPCR metode. Od parametara oksidativnog statusa određivani su:
totalni oksidantni status (TOS), superoksidni anjon radikal (O2.- ), prooksidantno-
antioksidantni balans (PAB), uznapredovali produkti oksidacije proteina (AOPP),
malondialdehid (MDA), ishemijom modifikovan albumin (IMA). Kao parametri
antioksidativne zaštite određivani su: totalni antioksidantni status (TAS), aktivnost enzima
superoksid-dismutaze (SOD) i paraoksonaze 1 (PON1), odnos totalnog antioksidantnog i
totalnog oksidantnog statusa (TAS/TOS), kao i ukupne sulfhidrilne grupe (SHG). Pacijenti u
trenutku postavljanja dijagnoze imaju najkraće telomere i njihova dužina se povećava tokom
oporavka. Pokazana je statistički značajna razlika u rTL kod pacijenata u trenutku
postavljanja dijagnoze i nakon 21 dan (p=0,008). rTL je u statistički značajnoj negativnoj
korelaciji sa SHG kod pacijenata u trenutku postavljanja dijagnoze (ρ=-0,386, p=0,038), kao i
kod pacijenata nakon 14 dana oporavka (ρ=-0,389, p=0,037). Nakon 21 dan, pokazana je
statistički značajna pozitivna korelacija između rTL i SOD (ρ=0,381, p=0,046). Dobijeni
rezultati ukazuju na progresivno skraćenje telomera izazvano COVID-19 infekcijom, narušen
redoks status, kao i na promenu ovih parametara tokom oporavka, koja potvrđuje vezu
između oksidativnog stresa i rTL, kao i učešće ovih procesa u patogenezi COVID-19.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Oxidative stress and telomere length in COVID-19 patients, Oksidativni stres i dužina telomera kod COVID‐19 pacijenata",
volume = "72",
number = "4 suplement",
pages = "S231-S232",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4510"
}
Guzonjić, A., Roksandić Milenković, M., Dimić, D., Dimić, N., Timotijević, L., Sopić, M., Vekić, J., Bogavac-Stanojević, N.,& Kotur-Stevuljević, J.. (2022). Oxidative stress and telomere length in COVID-19 patients. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 72(4 suplement), S231-S232.
https://hdl.handle.net/21.15107/rcub_farfar_4510
Guzonjić A, Roksandić Milenković M, Dimić D, Dimić N, Timotijević L, Sopić M, Vekić J, Bogavac-Stanojević N, Kotur-Stevuljević J. Oxidative stress and telomere length in COVID-19 patients. in Arhiv za farmaciju. 2022;72(4 suplement):S231-S232.
https://hdl.handle.net/21.15107/rcub_farfar_4510 .
Guzonjić, Azra, Roksandić Milenković, Marina, Dimić, Dejan, Dimić, Nemanja, Timotijević, Ljiljana, Sopić, Miron, Vekić, Jelena, Bogavac-Stanojević, Nataša, Kotur-Stevuljević, Jelena, "Oxidative stress and telomere length in COVID-19 patients" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S231-S232,
https://hdl.handle.net/21.15107/rcub_farfar_4510 .

Association between cholesterol synthesis markers and biological sex in the healthy, middle-aged population

Vladimirov, Sandra; Gojković, Tamara; Zeljković, Aleksandra; Bogavac-Stanojević, Nataša; Spasojević-Kalimanovska, Vesna

(Elsevier Inc., 2022)

TY  - CONF
AU  - Vladimirov, Sandra
AU  - Gojković, Tamara
AU  - Zeljković, Aleksandra
AU  - Bogavac-Stanojević, Nataša
AU  - Spasojević-Kalimanovska, Vesna
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4359
PB  - Elsevier Inc.
C3  - Atherosclerosis
T1  - Association between cholesterol synthesis markers and biological sex in the healthy, middle-aged population
VL  - 355
SP  - E238
EP  - E238
DO  - 10.1016/j.atherosclerosis.2022.06.677
ER  - 
@conference{
author = "Vladimirov, Sandra and Gojković, Tamara and Zeljković, Aleksandra and Bogavac-Stanojević, Nataša and Spasojević-Kalimanovska, Vesna",
year = "2022",
publisher = "Elsevier Inc.",
journal = "Atherosclerosis",
title = "Association between cholesterol synthesis markers and biological sex in the healthy, middle-aged population",
volume = "355",
pages = "E238-E238",
doi = "10.1016/j.atherosclerosis.2022.06.677"
}
Vladimirov, S., Gojković, T., Zeljković, A., Bogavac-Stanojević, N.,& Spasojević-Kalimanovska, V.. (2022). Association between cholesterol synthesis markers and biological sex in the healthy, middle-aged population. in Atherosclerosis
Elsevier Inc.., 355, E238-E238.
https://doi.org/10.1016/j.atherosclerosis.2022.06.677
Vladimirov S, Gojković T, Zeljković A, Bogavac-Stanojević N, Spasojević-Kalimanovska V. Association between cholesterol synthesis markers and biological sex in the healthy, middle-aged population. in Atherosclerosis. 2022;355:E238-E238.
doi:10.1016/j.atherosclerosis.2022.06.677 .
Vladimirov, Sandra, Gojković, Tamara, Zeljković, Aleksandra, Bogavac-Stanojević, Nataša, Spasojević-Kalimanovska, Vesna, "Association between cholesterol synthesis markers and biological sex in the healthy, middle-aged population" in Atherosclerosis, 355 (2022):E238-E238,
https://doi.org/10.1016/j.atherosclerosis.2022.06.677 . .

Effects of monacolin K, and B1, C and K2 vitamins -Containing nutraceutical on cholesterol homeostasis re-establishment and CVD risk reduction in hypercholesterolemic subjects

Gojković, Tamara; Vladimirov, Sandra; Kotur-Stevuljević, Jelena; Bogavac-Stanojević, Nataša; Zeljković, Aleksandra; Vekić, Jelena; Antonić, Tamara; Spasojević-Kalimanovska, Vesna

(Elsevier B.V., 2022)

TY  - CONF
AU  - Gojković, Tamara
AU  - Vladimirov, Sandra
AU  - Kotur-Stevuljević, Jelena
AU  - Bogavac-Stanojević, Nataša
AU  - Zeljković, Aleksandra
AU  - Vekić, Jelena
AU  - Antonić, Tamara
AU  - Spasojević-Kalimanovska, Vesna
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4358
PB  - Elsevier B.V.
C3  - Clinica Chimica Acta
T1  - Effects of monacolin K, and B1, C and K2 vitamins -Containing nutraceutical on cholesterol homeostasis re-establishment and CVD risk reduction in hypercholesterolemic subjects
VL  - 530
IS  - Supplement 1
SP  - S24
EP  - S24
DO  - 10.1016/j.cca.2022.04.343
ER  - 
@conference{
author = "Gojković, Tamara and Vladimirov, Sandra and Kotur-Stevuljević, Jelena and Bogavac-Stanojević, Nataša and Zeljković, Aleksandra and Vekić, Jelena and Antonić, Tamara and Spasojević-Kalimanovska, Vesna",
year = "2022",
publisher = "Elsevier B.V.",
journal = "Clinica Chimica Acta",
title = "Effects of monacolin K, and B1, C and K2 vitamins -Containing nutraceutical on cholesterol homeostasis re-establishment and CVD risk reduction in hypercholesterolemic subjects",
volume = "530",
number = "Supplement 1",
pages = "S24-S24",
doi = "10.1016/j.cca.2022.04.343"
}
Gojković, T., Vladimirov, S., Kotur-Stevuljević, J., Bogavac-Stanojević, N., Zeljković, A., Vekić, J., Antonić, T.,& Spasojević-Kalimanovska, V.. (2022). Effects of monacolin K, and B1, C and K2 vitamins -Containing nutraceutical on cholesterol homeostasis re-establishment and CVD risk reduction in hypercholesterolemic subjects. in Clinica Chimica Acta
Elsevier B.V.., 530(Supplement 1), S24-S24.
https://doi.org/10.1016/j.cca.2022.04.343
Gojković T, Vladimirov S, Kotur-Stevuljević J, Bogavac-Stanojević N, Zeljković A, Vekić J, Antonić T, Spasojević-Kalimanovska V. Effects of monacolin K, and B1, C and K2 vitamins -Containing nutraceutical on cholesterol homeostasis re-establishment and CVD risk reduction in hypercholesterolemic subjects. in Clinica Chimica Acta. 2022;530(Supplement 1):S24-S24.
doi:10.1016/j.cca.2022.04.343 .
Gojković, Tamara, Vladimirov, Sandra, Kotur-Stevuljević, Jelena, Bogavac-Stanojević, Nataša, Zeljković, Aleksandra, Vekić, Jelena, Antonić, Tamara, Spasojević-Kalimanovska, Vesna, "Effects of monacolin K, and B1, C and K2 vitamins -Containing nutraceutical on cholesterol homeostasis re-establishment and CVD risk reduction in hypercholesterolemic subjects" in Clinica Chimica Acta, 530, no. Supplement 1 (2022):S24-S24,
https://doi.org/10.1016/j.cca.2022.04.343 . .

Alteration in Redox Status and Lipoprotein Profile in COVID-19 Patients with Mild, Moderate, and Severe Pneumonia

Lalosević, Miodrag; Kotur-Stevuljević, Jelena; Vekić, Jelena; Rizzo, Manfredi; Kosanović, Tijana; Blagojević-Perović, Ivana; Zeljković, Aleksandra; Jeremić, Danilo; Mihajlović, Marija; Petković, Aleksa; Hajdarpasić, Lejla; Đorđević, Marjana; Dobrilović, Violeta; Erceg, Sanja; Vujčić, Sanja; Marjanović, Jelena; Jovanović-Milijić, Jovana; Saponjski, Jovica; Bogavac-Stanojević, Nataša

(Hindawi Limited, 2022)

TY  - JOUR
AU  - Lalosević, Miodrag
AU  - Kotur-Stevuljević, Jelena
AU  - Vekić, Jelena
AU  - Rizzo, Manfredi
AU  - Kosanović, Tijana
AU  - Blagojević-Perović, Ivana
AU  - Zeljković, Aleksandra
AU  - Jeremić, Danilo
AU  - Mihajlović, Marija
AU  - Petković, Aleksa
AU  - Hajdarpasić, Lejla
AU  - Đorđević, Marjana
AU  - Dobrilović, Violeta
AU  - Erceg, Sanja
AU  - Vujčić, Sanja
AU  - Marjanović, Jelena
AU  - Jovanović-Milijić, Jovana
AU  - Saponjski, Jovica
AU  - Bogavac-Stanojević, Nataša
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4335
AB  - Background. Metabolic alterations, particularly disorders of lipoprotein metabolism in COVID-19, may affect the course and outcome of the disease. This study aims at evaluating the lipoprotein profile and redox status in SARS-CoV-2 infected patients with different pneumonia severity and their association with lethal outcomes. Methods. The prospective cohort study was performed on 98 COVID-19 patients with mild, moderate, and severe pneumonia. Lipid and inflammatory parameters, lipoprotein subclasses, and redox status biomarkers were determined at the study entry and after one week. Results. Compared to patients with mild and moderate pneumonia, severely ill patients had higher oxidised low-density lipoprotein (oxLDL) and malondialdehyde levels and lower high-density lipoprotein cholesterol (HDL-C) concentrations and paraoxonase 1 activity. Reduction in the proportion of large HDL 2a subclasses with a concomitant increase in the proportion of smallest HDL 3c and small dense LDL (sdLDL) particles was observed in patients with severe disease during the time. However, these changes were reversed in the mild and moderate groups. The results showed a positive association between changes in oxLDL and total antioxidative status. However, prooxidants and antioxidants in plasma were lower in patients with lethal outcomes. Conclusions. Increased levels of oxLDL and sdLDL particles may contribute to the severity of COVID-19. The role of oxidative stress should be clarified in further studies, mainly its association with lethal outcomes.
PB  - Hindawi Limited
T2  - Oxidative Medicine and Cellular Longevity
T1  - Alteration in Redox Status and Lipoprotein Profile in COVID-19 Patients with Mild, Moderate, and Severe Pneumonia
VL  - 2022
DO  - 10.1155/2022/8067857
ER  - 
@article{
author = "Lalosević, Miodrag and Kotur-Stevuljević, Jelena and Vekić, Jelena and Rizzo, Manfredi and Kosanović, Tijana and Blagojević-Perović, Ivana and Zeljković, Aleksandra and Jeremić, Danilo and Mihajlović, Marija and Petković, Aleksa and Hajdarpasić, Lejla and Đorđević, Marjana and Dobrilović, Violeta and Erceg, Sanja and Vujčić, Sanja and Marjanović, Jelena and Jovanović-Milijić, Jovana and Saponjski, Jovica and Bogavac-Stanojević, Nataša",
year = "2022",
abstract = "Background. Metabolic alterations, particularly disorders of lipoprotein metabolism in COVID-19, may affect the course and outcome of the disease. This study aims at evaluating the lipoprotein profile and redox status in SARS-CoV-2 infected patients with different pneumonia severity and their association with lethal outcomes. Methods. The prospective cohort study was performed on 98 COVID-19 patients with mild, moderate, and severe pneumonia. Lipid and inflammatory parameters, lipoprotein subclasses, and redox status biomarkers were determined at the study entry and after one week. Results. Compared to patients with mild and moderate pneumonia, severely ill patients had higher oxidised low-density lipoprotein (oxLDL) and malondialdehyde levels and lower high-density lipoprotein cholesterol (HDL-C) concentrations and paraoxonase 1 activity. Reduction in the proportion of large HDL 2a subclasses with a concomitant increase in the proportion of smallest HDL 3c and small dense LDL (sdLDL) particles was observed in patients with severe disease during the time. However, these changes were reversed in the mild and moderate groups. The results showed a positive association between changes in oxLDL and total antioxidative status. However, prooxidants and antioxidants in plasma were lower in patients with lethal outcomes. Conclusions. Increased levels of oxLDL and sdLDL particles may contribute to the severity of COVID-19. The role of oxidative stress should be clarified in further studies, mainly its association with lethal outcomes.",
publisher = "Hindawi Limited",
journal = "Oxidative Medicine and Cellular Longevity",
title = "Alteration in Redox Status and Lipoprotein Profile in COVID-19 Patients with Mild, Moderate, and Severe Pneumonia",
volume = "2022",
doi = "10.1155/2022/8067857"
}
Lalosević, M., Kotur-Stevuljević, J., Vekić, J., Rizzo, M., Kosanović, T., Blagojević-Perović, I., Zeljković, A., Jeremić, D., Mihajlović, M., Petković, A., Hajdarpasić, L., Đorđević, M., Dobrilović, V., Erceg, S., Vujčić, S., Marjanović, J., Jovanović-Milijić, J., Saponjski, J.,& Bogavac-Stanojević, N.. (2022). Alteration in Redox Status and Lipoprotein Profile in COVID-19 Patients with Mild, Moderate, and Severe Pneumonia. in Oxidative Medicine and Cellular Longevity
Hindawi Limited., 2022.
https://doi.org/10.1155/2022/8067857
Lalosević M, Kotur-Stevuljević J, Vekić J, Rizzo M, Kosanović T, Blagojević-Perović I, Zeljković A, Jeremić D, Mihajlović M, Petković A, Hajdarpasić L, Đorđević M, Dobrilović V, Erceg S, Vujčić S, Marjanović J, Jovanović-Milijić J, Saponjski J, Bogavac-Stanojević N. Alteration in Redox Status and Lipoprotein Profile in COVID-19 Patients with Mild, Moderate, and Severe Pneumonia. in Oxidative Medicine and Cellular Longevity. 2022;2022.
doi:10.1155/2022/8067857 .
Lalosević, Miodrag, Kotur-Stevuljević, Jelena, Vekić, Jelena, Rizzo, Manfredi, Kosanović, Tijana, Blagojević-Perović, Ivana, Zeljković, Aleksandra, Jeremić, Danilo, Mihajlović, Marija, Petković, Aleksa, Hajdarpasić, Lejla, Đorđević, Marjana, Dobrilović, Violeta, Erceg, Sanja, Vujčić, Sanja, Marjanović, Jelena, Jovanović-Milijić, Jovana, Saponjski, Jovica, Bogavac-Stanojević, Nataša, "Alteration in Redox Status and Lipoprotein Profile in COVID-19 Patients with Mild, Moderate, and Severe Pneumonia" in Oxidative Medicine and Cellular Longevity, 2022 (2022),
https://doi.org/10.1155/2022/8067857 . .
5
5

Association of Adiponectin Receptors with Metabolic and Immune Homeostasis Parameters in Colorectal Cancer: In Silico Analysis and Observational Findings

Mihajlović, Marija; Ninić, Ana; Ostojić, Marija; Sopić, Miron; Stefanović, Aleksandra; Vekić, Jelena; Antonić, Tamara; Zeljković, Dejan; Trifunović, Branislav; Spasojević-Kalimanovska, Vesna; Bogavac-Stanojević, Nataša; Jančić, Ivan; Zeljković, Aleksandra

(MDPI, 2022)

TY  - JOUR
AU  - Mihajlović, Marija
AU  - Ninić, Ana
AU  - Ostojić, Marija
AU  - Sopić, Miron
AU  - Stefanović, Aleksandra
AU  - Vekić, Jelena
AU  - Antonić, Tamara
AU  - Zeljković, Dejan
AU  - Trifunović, Branislav
AU  - Spasojević-Kalimanovska, Vesna
AU  - Bogavac-Stanojević, Nataša
AU  - Jančić, Ivan
AU  - Zeljković, Aleksandra
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4327
AB  - Adiponectin (ADIPOQ) as both a regulator of metabolic homeostasis and a protein involved in immune response might be of particular interest to contemporary laboratory medicine, especially in terms of minimally invasive diagnostics. The diverse roles of ADIPOQ with regard to the immune and metabolic aspects of colorectal carcinogenesis have been proposed. However, the expression of its receptors ADIPOR1 and ADIPOR2 is scarcely explored in peripheral blood mononuclear cells (PBMCs). Moreover, ADIPORs’ relationships with the immune response mediator TNF-α have not been previously investigated in the PBMCs of CRC patients. This study used both in silico and observational case–control analyses with the aim of exploring the association of ADIPOR gene expression and ADIPOQ single nucleotide polymorphisms (SNPs) with the inflammatory marker TNF-α and lipid status parameters in patients with CRC. Publicly available transcriptomic datasets (GSE47756, GSE44076) obtained from analyses of monocytes and CRC tissue samples were employed for the in silico evaluation of ADIPORs’ specific genetic traits. GSE47756 and GSE44076 datasets were processed with GSEA software to provide a genetic fingertip of different signaling pathways associated with ADIPORs’ mRNA levels. The case–control aspect of the study included the PBMC samples of 73 patients diagnosed with CRC and 80 healthy volunteers. The PCR method was carried out for the PBMC gene expression analysis (ADIPOR1, ADIPOR2, TNF-α mRNA levels) and for the subjects’ genotyping (ADIPOQ rs266729, ADIPOR1 rs7539542). GSEA showed significant associations of ADIPOR mRNA expression with gene sets related to metabolic and immune homeostasis in both datasets. The case–control study revealed the association of ADIPOR1 rs7539542 with reduced lipid status parameters in CRC. In addition, PBMC ADIPOR1 mRNA levels decreased in CRC (p < 0.001), whereas ADIPOR2 mRNA did not differ between the groups (p = 0.442). A reduction in PBMC TNF-α mRNA levels was noted in CRC (p < 0.05). Our results indicate that ADIPOR1 and ADIPOR2 play a significant role in the alteration of both metabolic and immune homeostasis during the progression of CRC. For the first time, ADIPOR1 is shown to be a specific receptor for mediating ADIPOQ’s effects in the PBMCs of CRC patients.
PB  - MDPI
T2  - International Journal of Environmental Research and Public Health
T1  - Association of Adiponectin Receptors with Metabolic and Immune Homeostasis Parameters in Colorectal Cancer: In Silico Analysis and Observational Findings
VL  - 19
IS  - 22
DO  - 10.3390/ijerph192214995
ER  - 
@article{
author = "Mihajlović, Marija and Ninić, Ana and Ostojić, Marija and Sopić, Miron and Stefanović, Aleksandra and Vekić, Jelena and Antonić, Tamara and Zeljković, Dejan and Trifunović, Branislav and Spasojević-Kalimanovska, Vesna and Bogavac-Stanojević, Nataša and Jančić, Ivan and Zeljković, Aleksandra",
year = "2022",
abstract = "Adiponectin (ADIPOQ) as both a regulator of metabolic homeostasis and a protein involved in immune response might be of particular interest to contemporary laboratory medicine, especially in terms of minimally invasive diagnostics. The diverse roles of ADIPOQ with regard to the immune and metabolic aspects of colorectal carcinogenesis have been proposed. However, the expression of its receptors ADIPOR1 and ADIPOR2 is scarcely explored in peripheral blood mononuclear cells (PBMCs). Moreover, ADIPORs’ relationships with the immune response mediator TNF-α have not been previously investigated in the PBMCs of CRC patients. This study used both in silico and observational case–control analyses with the aim of exploring the association of ADIPOR gene expression and ADIPOQ single nucleotide polymorphisms (SNPs) with the inflammatory marker TNF-α and lipid status parameters in patients with CRC. Publicly available transcriptomic datasets (GSE47756, GSE44076) obtained from analyses of monocytes and CRC tissue samples were employed for the in silico evaluation of ADIPORs’ specific genetic traits. GSE47756 and GSE44076 datasets were processed with GSEA software to provide a genetic fingertip of different signaling pathways associated with ADIPORs’ mRNA levels. The case–control aspect of the study included the PBMC samples of 73 patients diagnosed with CRC and 80 healthy volunteers. The PCR method was carried out for the PBMC gene expression analysis (ADIPOR1, ADIPOR2, TNF-α mRNA levels) and for the subjects’ genotyping (ADIPOQ rs266729, ADIPOR1 rs7539542). GSEA showed significant associations of ADIPOR mRNA expression with gene sets related to metabolic and immune homeostasis in both datasets. The case–control study revealed the association of ADIPOR1 rs7539542 with reduced lipid status parameters in CRC. In addition, PBMC ADIPOR1 mRNA levels decreased in CRC (p < 0.001), whereas ADIPOR2 mRNA did not differ between the groups (p = 0.442). A reduction in PBMC TNF-α mRNA levels was noted in CRC (p < 0.05). Our results indicate that ADIPOR1 and ADIPOR2 play a significant role in the alteration of both metabolic and immune homeostasis during the progression of CRC. For the first time, ADIPOR1 is shown to be a specific receptor for mediating ADIPOQ’s effects in the PBMCs of CRC patients.",
publisher = "MDPI",
journal = "International Journal of Environmental Research and Public Health",
title = "Association of Adiponectin Receptors with Metabolic and Immune Homeostasis Parameters in Colorectal Cancer: In Silico Analysis and Observational Findings",
volume = "19",
number = "22",
doi = "10.3390/ijerph192214995"
}
Mihajlović, M., Ninić, A., Ostojić, M., Sopić, M., Stefanović, A., Vekić, J., Antonić, T., Zeljković, D., Trifunović, B., Spasojević-Kalimanovska, V., Bogavac-Stanojević, N., Jančić, I.,& Zeljković, A.. (2022). Association of Adiponectin Receptors with Metabolic and Immune Homeostasis Parameters in Colorectal Cancer: In Silico Analysis and Observational Findings. in International Journal of Environmental Research and Public Health
MDPI., 19(22).
https://doi.org/10.3390/ijerph192214995
Mihajlović M, Ninić A, Ostojić M, Sopić M, Stefanović A, Vekić J, Antonić T, Zeljković D, Trifunović B, Spasojević-Kalimanovska V, Bogavac-Stanojević N, Jančić I, Zeljković A. Association of Adiponectin Receptors with Metabolic and Immune Homeostasis Parameters in Colorectal Cancer: In Silico Analysis and Observational Findings. in International Journal of Environmental Research and Public Health. 2022;19(22).
doi:10.3390/ijerph192214995 .
Mihajlović, Marija, Ninić, Ana, Ostojić, Marija, Sopić, Miron, Stefanović, Aleksandra, Vekić, Jelena, Antonić, Tamara, Zeljković, Dejan, Trifunović, Branislav, Spasojević-Kalimanovska, Vesna, Bogavac-Stanojević, Nataša, Jančić, Ivan, Zeljković, Aleksandra, "Association of Adiponectin Receptors with Metabolic and Immune Homeostasis Parameters in Colorectal Cancer: In Silico Analysis and Observational Findings" in International Journal of Environmental Research and Public Health, 19, no. 22 (2022),
https://doi.org/10.3390/ijerph192214995 . .
1
2
2

Cross-Cultural Adaptation and Validation of the Functional, Communicative and Critical Health Literacy Instrument (FCCHL-SR) for Diabetic Patients in Serbia

Lević, Marija; Bogavac-Stanojević, Nataša; Krajnović, Dušanka

(MDPI, 2022)

TY  - JOUR
AU  - Lević, Marija
AU  - Bogavac-Stanojević, Nataša
AU  - Krajnović, Dušanka
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4282
AB  - Thoroughly validated instruments can provide a more accurate and reliable picture of how the instrument works and of the level of health literacy in people with type 2 diabetes mellitus (T2DM). The present work aimed at cross-cultural adaptation and validation of the Functional, Communicative and Critical Health Literacy Instrument (FCCHL) in patients with T2DM in Serbia. After translation and back-translation, views from an expert group, one cognitive interview study (n = 10) and one survey study (n = 130) were conducted among samples of diabetic patients. Item analysis, internal consistency, content validity, confirmatory factor analysis (CFA) and reliability testing were performed. When all 14 items were analyzed, loading factors were above 0.55, but without adequate model fit. After removing two items with the lowest loadings FHL1 and IHL2 the fit indexes indicated a reasonable normed χ2 (SB scaled χ2/df = 1.90). CFI was 0.916 with SRMR = 0.0676 and RMSEA = 0.0831. To determine internal consistency, Cronbach’s alpha coefficient was 0.796 for the whole FCCHL-SR12. With only minor modifications compared to the English version, the 12-item FCCHL instrument is valid and reliable and can be used to measure health literacy among Serbian diabetic patients. However, future research on a larger population in Serbia is necessary for measuring the levels of HL and their relationship with other determinants in this country.
PB  - MDPI
T2  - Healthcare (Switzerland)
T1  - Cross-Cultural Adaptation and Validation of the Functional, Communicative and Critical Health Literacy Instrument (FCCHL-SR) for Diabetic Patients in Serbia
VL  - 10
IS  - 9
DO  - 10.3390/healthcare10091667
ER  - 
@article{
author = "Lević, Marija and Bogavac-Stanojević, Nataša and Krajnović, Dušanka",
year = "2022",
abstract = "Thoroughly validated instruments can provide a more accurate and reliable picture of how the instrument works and of the level of health literacy in people with type 2 diabetes mellitus (T2DM). The present work aimed at cross-cultural adaptation and validation of the Functional, Communicative and Critical Health Literacy Instrument (FCCHL) in patients with T2DM in Serbia. After translation and back-translation, views from an expert group, one cognitive interview study (n = 10) and one survey study (n = 130) were conducted among samples of diabetic patients. Item analysis, internal consistency, content validity, confirmatory factor analysis (CFA) and reliability testing were performed. When all 14 items were analyzed, loading factors were above 0.55, but without adequate model fit. After removing two items with the lowest loadings FHL1 and IHL2 the fit indexes indicated a reasonable normed χ2 (SB scaled χ2/df = 1.90). CFI was 0.916 with SRMR = 0.0676 and RMSEA = 0.0831. To determine internal consistency, Cronbach’s alpha coefficient was 0.796 for the whole FCCHL-SR12. With only minor modifications compared to the English version, the 12-item FCCHL instrument is valid and reliable and can be used to measure health literacy among Serbian diabetic patients. However, future research on a larger population in Serbia is necessary for measuring the levels of HL and their relationship with other determinants in this country.",
publisher = "MDPI",
journal = "Healthcare (Switzerland)",
title = "Cross-Cultural Adaptation and Validation of the Functional, Communicative and Critical Health Literacy Instrument (FCCHL-SR) for Diabetic Patients in Serbia",
volume = "10",
number = "9",
doi = "10.3390/healthcare10091667"
}
Lević, M., Bogavac-Stanojević, N.,& Krajnović, D.. (2022). Cross-Cultural Adaptation and Validation of the Functional, Communicative and Critical Health Literacy Instrument (FCCHL-SR) for Diabetic Patients in Serbia. in Healthcare (Switzerland)
MDPI., 10(9).
https://doi.org/10.3390/healthcare10091667
Lević M, Bogavac-Stanojević N, Krajnović D. Cross-Cultural Adaptation and Validation of the Functional, Communicative and Critical Health Literacy Instrument (FCCHL-SR) for Diabetic Patients in Serbia. in Healthcare (Switzerland). 2022;10(9).
doi:10.3390/healthcare10091667 .
Lević, Marija, Bogavac-Stanojević, Nataša, Krajnović, Dušanka, "Cross-Cultural Adaptation and Validation of the Functional, Communicative and Critical Health Literacy Instrument (FCCHL-SR) for Diabetic Patients in Serbia" in Healthcare (Switzerland), 10, no. 9 (2022),
https://doi.org/10.3390/healthcare10091667 . .
2
1

Does Pentraxin-3 contribute to the reduction of low-density lipoprotein levels by statin therapy?

Vuković-Dejanović, Vesna; Spasojević-Kalimanovska, Vesna; Kalimanovska-Oštrić, Dimitra; Bogavac-Stanojević, Nataša

(Pharmaceutical Association of Serbia, 2022)

TY  - JOUR
AU  - Vuković-Dejanović, Vesna
AU  - Spasojević-Kalimanovska, Vesna
AU  - Kalimanovska-Oštrić, Dimitra
AU  - Bogavac-Stanojević, Nataša
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4245
AB  - Statins have been shown to decrease inflammatory markers, especially high sensitivity C reactive protein (hsCRP), in a dose-dependent manner. Pentraxin-3 (PTX3) is another important inflammatory biomarker from the pentraxin family that provides useful prognostic information and facilitates diagnostics of cardiovascular diseases. This study investigated the effect of statin therapy on PTX3 and hsCRP concentrations and whether statins acted synergistically with PTX3 and hsCRP concentrations in lowering LDL-C. The study group consisted of 90 patients undergoing coronary angiography. The results showed that statins reduced PTX3 concentrations (p=0.031). PTX3 and hsCRP levels were significantly different between subclinical and severe stenosis groups (p=0.011 and p=0.009, respectively). Statin therapy was significantly associated with lower PTX3 and LDL-C levels in multiple logistic analyses. The probability that statin therapy would achieve target LDL-C values was highest in patients with low PTX3 values (OR=3.683, p=0.040), while multiplicative interaction was 23.3. The effect of statins on PTX3 reduction was higher than on hsCRP. It can be suggested that statin therapy was more successful in patients with low PTX3 values.
AB  - Pokazano je da statini snižavaju koncentracije inflamatornih markera, posebno visoko osetljivog C reaktivnog proteina (hsCRP), pri čemu je sniženje zavisno od doze leka. Pentraksin- 3 (PTX3) je još jedan važan inflamatorni biomarker iz porodice pentraksina koji ima prognostičke karakteristike i olakšava dijagnozu kardiovaskularnih bolesti. U ovoj studiji je ispitivan efekat terapije statinima na koncentracije PTX3 i hsCRP, kao i sinergistički efekat terapije, koncentracija PTX3 i hsCRP u snižavanju LDL-C. U studiju je uključeno 90 pacijenata kojima je koronarnom angiografijom procenjeno suženje koronarnih krvnih sudova. Rezultati su pokazali da statini smanjuju koncentraciju PTX3 (p=0,031). Koncentracije PTX3 i hsCRP značajno se razlikuju između grupa sa subkliničkim (p=0,011) i teškim oblikom stenoze (p=0,009). Primenom multiple logističke regresione analize uočena je veza između terapije statinima i niskih koncentracija PTX3 i LDL-C. Verovatnoća da će terapija statinima postići ciljne vrednosti LDL- C bila je najveća kod pacijenata sa niskim vrednostima PTX3 (OR=3,683, p=0,040), dok je multiplikativna interakcija bila 23,3. Efekat statina na sniženje PTX3 bio je veći u odnosu na efekat koji ostvaruje na hsCRP. Može se sugerisati da je terapija statinima bila uspešnija kod pacijenata sa niskim vrednostima PTX3.
PB  - Pharmaceutical Association of Serbia
T2  - Arhiv za farmaciju
T1  - Does Pentraxin-3 contribute to the reduction of low-density lipoprotein levels by statin therapy?
T1  - Da li pentraksin -3 doprinosi sniženju koncentracije lipoproteina niske gustine i terapiji statinima?
VL  - 72
IS  - 2
SP  - 247
EP  - 259
DO  - 10.5937/arhfarm72-36122
ER  - 
@article{
author = "Vuković-Dejanović, Vesna and Spasojević-Kalimanovska, Vesna and Kalimanovska-Oštrić, Dimitra and Bogavac-Stanojević, Nataša",
year = "2022",
abstract = "Statins have been shown to decrease inflammatory markers, especially high sensitivity C reactive protein (hsCRP), in a dose-dependent manner. Pentraxin-3 (PTX3) is another important inflammatory biomarker from the pentraxin family that provides useful prognostic information and facilitates diagnostics of cardiovascular diseases. This study investigated the effect of statin therapy on PTX3 and hsCRP concentrations and whether statins acted synergistically with PTX3 and hsCRP concentrations in lowering LDL-C. The study group consisted of 90 patients undergoing coronary angiography. The results showed that statins reduced PTX3 concentrations (p=0.031). PTX3 and hsCRP levels were significantly different between subclinical and severe stenosis groups (p=0.011 and p=0.009, respectively). Statin therapy was significantly associated with lower PTX3 and LDL-C levels in multiple logistic analyses. The probability that statin therapy would achieve target LDL-C values was highest in patients with low PTX3 values (OR=3.683, p=0.040), while multiplicative interaction was 23.3. The effect of statins on PTX3 reduction was higher than on hsCRP. It can be suggested that statin therapy was more successful in patients with low PTX3 values., Pokazano je da statini snižavaju koncentracije inflamatornih markera, posebno visoko osetljivog C reaktivnog proteina (hsCRP), pri čemu je sniženje zavisno od doze leka. Pentraksin- 3 (PTX3) je još jedan važan inflamatorni biomarker iz porodice pentraksina koji ima prognostičke karakteristike i olakšava dijagnozu kardiovaskularnih bolesti. U ovoj studiji je ispitivan efekat terapije statinima na koncentracije PTX3 i hsCRP, kao i sinergistički efekat terapije, koncentracija PTX3 i hsCRP u snižavanju LDL-C. U studiju je uključeno 90 pacijenata kojima je koronarnom angiografijom procenjeno suženje koronarnih krvnih sudova. Rezultati su pokazali da statini smanjuju koncentraciju PTX3 (p=0,031). Koncentracije PTX3 i hsCRP značajno se razlikuju između grupa sa subkliničkim (p=0,011) i teškim oblikom stenoze (p=0,009). Primenom multiple logističke regresione analize uočena je veza između terapije statinima i niskih koncentracija PTX3 i LDL-C. Verovatnoća da će terapija statinima postići ciljne vrednosti LDL- C bila je najveća kod pacijenata sa niskim vrednostima PTX3 (OR=3,683, p=0,040), dok je multiplikativna interakcija bila 23,3. Efekat statina na sniženje PTX3 bio je veći u odnosu na efekat koji ostvaruje na hsCRP. Može se sugerisati da je terapija statinima bila uspešnija kod pacijenata sa niskim vrednostima PTX3.",
publisher = "Pharmaceutical Association of Serbia",
journal = "Arhiv za farmaciju",
title = "Does Pentraxin-3 contribute to the reduction of low-density lipoprotein levels by statin therapy?, Da li pentraksin -3 doprinosi sniženju koncentracije lipoproteina niske gustine i terapiji statinima?",
volume = "72",
number = "2",
pages = "247-259",
doi = "10.5937/arhfarm72-36122"
}
Vuković-Dejanović, V., Spasojević-Kalimanovska, V., Kalimanovska-Oštrić, D.,& Bogavac-Stanojević, N.. (2022). Does Pentraxin-3 contribute to the reduction of low-density lipoprotein levels by statin therapy?. in Arhiv za farmaciju
Pharmaceutical Association of Serbia., 72(2), 247-259.
https://doi.org/10.5937/arhfarm72-36122
Vuković-Dejanović V, Spasojević-Kalimanovska V, Kalimanovska-Oštrić D, Bogavac-Stanojević N. Does Pentraxin-3 contribute to the reduction of low-density lipoprotein levels by statin therapy?. in Arhiv za farmaciju. 2022;72(2):247-259.
doi:10.5937/arhfarm72-36122 .
Vuković-Dejanović, Vesna, Spasojević-Kalimanovska, Vesna, Kalimanovska-Oštrić, Dimitra, Bogavac-Stanojević, Nataša, "Does Pentraxin-3 contribute to the reduction of low-density lipoprotein levels by statin therapy?" in Arhiv za farmaciju, 72, no. 2 (2022):247-259,
https://doi.org/10.5937/arhfarm72-36122 . .