TY  - JOUR
AU  - Bajić, Vladan
AU  - Salhi, Adil
AU  - Lakota, Katja
AU  - Radovanović, Aleksandar
AU  - Razali, Rozaimi
AU  - Živković, Lada
AU  - Spremo-Potparević, Biljana
AU  - Uludag, Mahmut
AU  - Tifratene, Faroug
AU  - Motwalli, Olaa
AU  - Marchand, Benoit
AU  - Bajić, Vladimir
AU  - Gojobori, Takashi
AU  - Isenović, Esma
AU  - Essack, Magbubah
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4249
AB  - More than 30 types of amyloids are linked to close to 50 diseases in humans, the most prom- inent being Alzheimer’s disease (AD). AD is brain-related local amyloidosis, while another amyloidosis, such as AA amyloidosis, tends to be more systemic. Therefore, we need to know more about the biological entities’ influencing these amyloidosis processes. However, there is currently no support system developed specifically to handle this extraordinarily complex and demanding task. To acquire a systematic view of amyloidosis and how this may be relevant to the brain and other organs, we needed a means to explore "amyloid net- work systems" that may underly processes that leads to an amyloid-related disease. In this regard, we developed the DES-Amyloidoses knowledgebase (KB) to obtain fast and rele- vant information regarding the biological network related to amyloid proteins/peptides and amyloid-related diseases. This KB contains information obtained through text and data min- ing of available scientific literature and other public repositories. The information compiled into the DES-Amyloidoses system based on 19 topic-specific dictionaries resulted in 796,409 associations between terms from these dictionaries. Users can explore this infor- mation through various options, including enriched concepts, enriched pairs, and semantic similarity. We show the usefulness of the KB using an example focused on inflammasome- amyloid associations. To our knowledge, this is the only KB dedicated to human amyloid- related diseases derived primarily through literature text mining and complemented by data mining that provides a novel way of exploring information relevant to amyloidoses.
PB  - Public Library of Science
T2  - PLoS ONE
T1  - DES-Amyloidoses “Amyloidoses through the
looking-glass”: A knowledgebase developed
for exploring and linking information related
to human amyloid-related diseases
VL  - 17
IS  - 7
DO  - 10.1371/journal.pone.0271737
ER  - 

@article{
author = "Bajić, Vladan and Salhi, Adil and Lakota, Katja and Radovanović, Aleksandar and Razali, Rozaimi and Živković, Lada and Spremo-Potparević, Biljana and Uludag, Mahmut and Tifratene, Faroug and Motwalli, Olaa and Marchand, Benoit and Bajić, Vladimir and Gojobori, Takashi and Isenović, Esma and Essack, Magbubah",
year = "2022",
abstract = "More than 30 types of amyloids are linked to close to 50 diseases in humans, the most prom- inent being Alzheimer’s disease (AD). AD is brain-related local amyloidosis, while another amyloidosis, such as AA amyloidosis, tends to be more systemic. Therefore, we need to know more about the biological entities’ influencing these amyloidosis processes. However, there is currently no support system developed specifically to handle this extraordinarily complex and demanding task. To acquire a systematic view of amyloidosis and how this may be relevant to the brain and other organs, we needed a means to explore "amyloid net- work systems" that may underly processes that leads to an amyloid-related disease. In this regard, we developed the DES-Amyloidoses knowledgebase (KB) to obtain fast and rele- vant information regarding the biological network related to amyloid proteins/peptides and amyloid-related diseases. This KB contains information obtained through text and data min- ing of available scientific literature and other public repositories. The information compiled into the DES-Amyloidoses system based on 19 topic-specific dictionaries resulted in 796,409 associations between terms from these dictionaries. Users can explore this infor- mation through various options, including enriched concepts, enriched pairs, and semantic similarity. We show the usefulness of the KB using an example focused on inflammasome- amyloid associations. To our knowledge, this is the only KB dedicated to human amyloid- related diseases derived primarily through literature text mining and complemented by data mining that provides a novel way of exploring information relevant to amyloidoses.",
publisher = "Public Library of Science",
journal = "PLoS ONE",
title = "DES-Amyloidoses “Amyloidoses through the
looking-glass”: A knowledgebase developed
for exploring and linking information related
to human amyloid-related diseases",
volume = "17",
number = "7",
doi = "10.1371/journal.pone.0271737"
}

Bajić, V., Salhi, A., Lakota, K., Radovanović, A., Razali, R., Živković, L., Spremo-Potparević, B., Uludag, M., Tifratene, F., Motwalli, O., Marchand, B., Bajić, V., Gojobori, T., Isenović, E.,& Essack, M.. (2022). DES-Amyloidoses “Amyloidoses through the
looking-glass”: A knowledgebase developed
for exploring and linking information related
to human amyloid-related diseases. in PLoS ONE
Public Library of Science., 17(7).
https://doi.org/10.1371/journal.pone.0271737

Bajić V, Salhi A, Lakota K, Radovanović A, Razali R, Živković L, Spremo-Potparević B, Uludag M, Tifratene F, Motwalli O, Marchand B, Bajić V, Gojobori T, Isenović E, Essack M. DES-Amyloidoses “Amyloidoses through the
looking-glass”: A knowledgebase developed
for exploring and linking information related
to human amyloid-related diseases. in PLoS ONE. 2022;17(7).
doi:10.1371/journal.pone.0271737 .

Bajić, Vladan, Salhi, Adil, Lakota, Katja, Radovanović, Aleksandar, Razali, Rozaimi, Živković, Lada, Spremo-Potparević, Biljana, Uludag, Mahmut, Tifratene, Faroug, Motwalli, Olaa, Marchand, Benoit, Bajić, Vladimir, Gojobori, Takashi, Isenović, Esma, Essack, Magbubah, "DES-Amyloidoses “Amyloidoses through the
looking-glass”: A knowledgebase developed
for exploring and linking information related
to human amyloid-related diseases" in PLoS ONE, 17, no. 7 (2022),
https://doi.org/10.1371/journal.pone.0271737 . .

TY  - CONF
AU  - Burja, Blaž
AU  - Topalović, Dijana
AU  - Kuret, Tadeja
AU  - Živković, Lada
AU  - Mrak-Poljšak, Katjuša
AU  - Janko, Tea
AU  - Spremo-Potparević, Biljana
AU  - Žigon, Polona
AU  - Čučnik, Saša
AU  - Sodin-Šemrl, Snežna
AU  - Lakota, Katja
AU  - Frank-Bertoncelj, Mojca
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5195
AB  - Background and Aims: Olive leaf extract (OLE) has been traditionally used due to its anti-inflammatory and anti-atherogenic effects.  ...
PB  - Elsevier
C3  - Atherosclerosis
T1  - Protective Effects Of Olive Leaf Extract On Inflammatory Activation Of Endothelial Cells
VL  - 287
SP  - e95
EP  - e95
DO  - 10.1016/j.atherosclerosis.2019.06.276
ER  - 

@conference{
author = "Burja, Blaž and Topalović, Dijana and Kuret, Tadeja and Živković, Lada and Mrak-Poljšak, Katjuša and Janko, Tea and Spremo-Potparević, Biljana and Žigon, Polona and Čučnik, Saša and Sodin-Šemrl, Snežna and Lakota, Katja and Frank-Bertoncelj, Mojca",
year = "2019",
abstract = "Background and Aims: Olive leaf extract (OLE) has been traditionally used due to its anti-inflammatory and anti-atherogenic effects.  ...",
publisher = "Elsevier",
journal = "Atherosclerosis",
title = "Protective Effects Of Olive Leaf Extract On Inflammatory Activation Of Endothelial Cells",
volume = "287",
pages = "e95-e95",
doi = "10.1016/j.atherosclerosis.2019.06.276"
}

Burja, B., Topalović, D., Kuret, T., Živković, L., Mrak-Poljšak, K., Janko, T., Spremo-Potparević, B., Žigon, P., Čučnik, S., Sodin-Šemrl, S., Lakota, K.,& Frank-Bertoncelj, M.. (2019). Protective Effects Of Olive Leaf Extract On Inflammatory Activation Of Endothelial Cells. in Atherosclerosis
Elsevier., 287, e95-e95.
https://doi.org/10.1016/j.atherosclerosis.2019.06.276

Burja B, Topalović D, Kuret T, Živković L, Mrak-Poljšak K, Janko T, Spremo-Potparević B, Žigon P, Čučnik S, Sodin-Šemrl S, Lakota K, Frank-Bertoncelj M. Protective Effects Of Olive Leaf Extract On Inflammatory Activation Of Endothelial Cells. in Atherosclerosis. 2019;287:e95-e95.
doi:10.1016/j.atherosclerosis.2019.06.276 .

Burja, Blaž, Topalović, Dijana, Kuret, Tadeja, Živković, Lada, Mrak-Poljšak, Katjuša, Janko, Tea, Spremo-Potparević, Biljana, Žigon, Polona, Čučnik, Saša, Sodin-Šemrl, Snežna, Lakota, Katja, Frank-Bertoncelj, Mojca, "Protective Effects Of Olive Leaf Extract On Inflammatory Activation Of Endothelial Cells" in Atherosclerosis, 287 (2019):e95-e95,
https://doi.org/10.1016/j.atherosclerosis.2019.06.276 . .

TY  - JOUR
AU  - Burja, Blaz
AU  - Kuret, Tadeja
AU  - Janko, Tea
AU  - Topalović, Dijana
AU  - Živković, Lada
AU  - Mrak-Poljsak, Katjusa
AU  - Potparević, Biljana
AU  - Zigon, Polona
AU  - Distler, Oliver
AU  - Cucnik, Sasa
AU  - Sodin-Semrl, Snezna
AU  - Lakota, Katja
AU  - Frank-Bertoncelj, Mojca
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3344
AB  - Olive leaf extract (OLE) is used in traditional medicine as a food supplement and as an over-the-counter drug for a variety of its effects, including anti-inflammatory and anti-atherosclerotic ones. Mechanisms through which OLE could modulate these pathways in human vasculature remain largely unknown. Serum amyloid A (SAA) plays a causal role in atherosclerosis and cardiovascular diseases and induces pro-inflammatory and pro-adhesive responses in human coronary artery endothelial cells (HCAEC). Within this study we explored whether OLE can attenuate SAA-driven responses in HCAEC. HCAEC were treated with SAA (1,000 nM) and/or OLE (0.5 and 1 mg/ml). The expression of adhesion molecules VCAM-1 and E-selectin, matrix metalloproteinases (MMP2 and MMP9) and microRNA 146a, let-7e, and let-7g (involved in the regulation of inflammation) was determined by qPCR. The amount of secreted IL-6, IL-8, MIF, and GRO-alpha in cell culture supernatants was quantified by ELISA. Phosphorylation of NF-kappa B was assessed by Western blot and DNA damage was measured using the COMET assay. OLE decreased significantly released protein levels of IL-6 and IL-8, as well as mRNA expression of E-selectin in SAA-stimulated HCAEC and reduced MMP2 levels in unstimulated cells. Phosphorylation of NF-kappa B (p65) was upregulated in the presence of SAA, with OLE significantly attenuating this SAA-induced effect. OLE stabilized SAA-induced upregulation of microRNA-146a and let-7e in HCAEC, suggesting that OLE could fine-tune the SAA-driven activity of NF-kappa B by changing the microRNA networks in HCAEC. SAA induced DNA damage and worsened the oxidative DNA damage in HCAEC, whereas OLE protected HCAEC from SAA- and H2O2-driven DNA damage. OLE significantly attenuated certain pro-inflammatory and pro-adhesive responses and decreased DNA damage in HCAEC upon stimulation with SAA. The reversal of SAA-driven endothelial activation by OLE might contribute to its anti-inflammatory and anti-atherogenic effects in HCAEC.
PB  - Frontiers Media Sa, Lausanne
T2  - Frontiers in Cardiovascular Medicine
T1  - Olive Leaf Extract Attenuates Inflammatory Activation and DNA Damage in Human Arterial Endothelial Cells
VL  - 6
DO  - 10.3389/fcvm.2019.00056
ER  - 

@article{
author = "Burja, Blaz and Kuret, Tadeja and Janko, Tea and Topalović, Dijana and Živković, Lada and Mrak-Poljsak, Katjusa and Potparević, Biljana and Zigon, Polona and Distler, Oliver and Cucnik, Sasa and Sodin-Semrl, Snezna and Lakota, Katja and Frank-Bertoncelj, Mojca",
year = "2019",
abstract = "Olive leaf extract (OLE) is used in traditional medicine as a food supplement and as an over-the-counter drug for a variety of its effects, including anti-inflammatory and anti-atherosclerotic ones. Mechanisms through which OLE could modulate these pathways in human vasculature remain largely unknown. Serum amyloid A (SAA) plays a causal role in atherosclerosis and cardiovascular diseases and induces pro-inflammatory and pro-adhesive responses in human coronary artery endothelial cells (HCAEC). Within this study we explored whether OLE can attenuate SAA-driven responses in HCAEC. HCAEC were treated with SAA (1,000 nM) and/or OLE (0.5 and 1 mg/ml). The expression of adhesion molecules VCAM-1 and E-selectin, matrix metalloproteinases (MMP2 and MMP9) and microRNA 146a, let-7e, and let-7g (involved in the regulation of inflammation) was determined by qPCR. The amount of secreted IL-6, IL-8, MIF, and GRO-alpha in cell culture supernatants was quantified by ELISA. Phosphorylation of NF-kappa B was assessed by Western blot and DNA damage was measured using the COMET assay. OLE decreased significantly released protein levels of IL-6 and IL-8, as well as mRNA expression of E-selectin in SAA-stimulated HCAEC and reduced MMP2 levels in unstimulated cells. Phosphorylation of NF-kappa B (p65) was upregulated in the presence of SAA, with OLE significantly attenuating this SAA-induced effect. OLE stabilized SAA-induced upregulation of microRNA-146a and let-7e in HCAEC, suggesting that OLE could fine-tune the SAA-driven activity of NF-kappa B by changing the microRNA networks in HCAEC. SAA induced DNA damage and worsened the oxidative DNA damage in HCAEC, whereas OLE protected HCAEC from SAA- and H2O2-driven DNA damage. OLE significantly attenuated certain pro-inflammatory and pro-adhesive responses and decreased DNA damage in HCAEC upon stimulation with SAA. The reversal of SAA-driven endothelial activation by OLE might contribute to its anti-inflammatory and anti-atherogenic effects in HCAEC.",
publisher = "Frontiers Media Sa, Lausanne",
journal = "Frontiers in Cardiovascular Medicine",
title = "Olive Leaf Extract Attenuates Inflammatory Activation and DNA Damage in Human Arterial Endothelial Cells",
volume = "6",
doi = "10.3389/fcvm.2019.00056"
}

Burja, B., Kuret, T., Janko, T., Topalović, D., Živković, L., Mrak-Poljsak, K., Potparević, B., Zigon, P., Distler, O., Cucnik, S., Sodin-Semrl, S., Lakota, K.,& Frank-Bertoncelj, M.. (2019). Olive Leaf Extract Attenuates Inflammatory Activation and DNA Damage in Human Arterial Endothelial Cells. in Frontiers in Cardiovascular Medicine
Frontiers Media Sa, Lausanne., 6.
https://doi.org/10.3389/fcvm.2019.00056

Burja B, Kuret T, Janko T, Topalović D, Živković L, Mrak-Poljsak K, Potparević B, Zigon P, Distler O, Cucnik S, Sodin-Semrl S, Lakota K, Frank-Bertoncelj M. Olive Leaf Extract Attenuates Inflammatory Activation and DNA Damage in Human Arterial Endothelial Cells. in Frontiers in Cardiovascular Medicine. 2019;6.
doi:10.3389/fcvm.2019.00056 .

Burja, Blaz, Kuret, Tadeja, Janko, Tea, Topalović, Dijana, Živković, Lada, Mrak-Poljsak, Katjusa, Potparević, Biljana, Zigon, Polona, Distler, Oliver, Cucnik, Sasa, Sodin-Semrl, Snezna, Lakota, Katja, Frank-Bertoncelj, Mojca, "Olive Leaf Extract Attenuates Inflammatory Activation and DNA Damage in Human Arterial Endothelial Cells" in Frontiers in Cardiovascular Medicine, 6 (2019),
https://doi.org/10.3389/fcvm.2019.00056 . .