TY  - JOUR
AU  - Simić, Milena
AU  - Stanković, Miroslava
AU  - Mandić, Boris M.
AU  - Tešević, Vele
AU  - Savić, Vladimir
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2450
AB  - Cytoprotective compounds such as amifostine play an important role in chemo-and radiotherapy due to their ability to reduce the side effects of these treatments. Our work was initiated with the intention to design, synthesise and test a new class of heterocyclic compounds that would have an antioxidative profile with the potential to be further developed as cytoprotective agents. The design was based on the privileged tetrahydrobenzazepine scaffold found in many natural products with a wide range of biological properties. This structure was further functionalised with moieties known to possess antioxidative features such as tertiary amine and styrene double bond. A series of eight tetrahydrobenzazepine derivatives of isoquinoline, 3,4-dihydro-beta-carboline and pyridine were synthesised employing the Heck reaction as a key transformation. Some of the prepared compounds were tested for their in vitro effects on chromosome aberrations in peripheral human lymphocytes using the cytochalasin-B blocked micronucleus (MN) assay. Three tetrahydrobenzoazepine derivatives showed significant cytoprotective properties, comparable or even better to those of the radioprotective agent amifostine.
PB  - Wiley-VCH Verlag GMBH, Weinheim
T2  - Archiv der Pharmazie
T1  - Synthesis of Novel Tetrahydrobenzazepine Derivatives and Their Cytoprotective Effect on Human Lymphocytes
VL  - 348
IS  - 2
SP  - 100
EP  - 112
DO  - 10.1002/ardp.201400350
ER  - 

@article{
author = "Simić, Milena and Stanković, Miroslava and Mandić, Boris M. and Tešević, Vele and Savić, Vladimir",
year = "2015",
abstract = "Cytoprotective compounds such as amifostine play an important role in chemo-and radiotherapy due to their ability to reduce the side effects of these treatments. Our work was initiated with the intention to design, synthesise and test a new class of heterocyclic compounds that would have an antioxidative profile with the potential to be further developed as cytoprotective agents. The design was based on the privileged tetrahydrobenzazepine scaffold found in many natural products with a wide range of biological properties. This structure was further functionalised with moieties known to possess antioxidative features such as tertiary amine and styrene double bond. A series of eight tetrahydrobenzazepine derivatives of isoquinoline, 3,4-dihydro-beta-carboline and pyridine were synthesised employing the Heck reaction as a key transformation. Some of the prepared compounds were tested for their in vitro effects on chromosome aberrations in peripheral human lymphocytes using the cytochalasin-B blocked micronucleus (MN) assay. Three tetrahydrobenzoazepine derivatives showed significant cytoprotective properties, comparable or even better to those of the radioprotective agent amifostine.",
publisher = "Wiley-VCH Verlag GMBH, Weinheim",
journal = "Archiv der Pharmazie",
title = "Synthesis of Novel Tetrahydrobenzazepine Derivatives and Their Cytoprotective Effect on Human Lymphocytes",
volume = "348",
number = "2",
pages = "100-112",
doi = "10.1002/ardp.201400350"
}

Simić, M., Stanković, M., Mandić, B. M., Tešević, V.,& Savić, V.. (2015). Synthesis of Novel Tetrahydrobenzazepine Derivatives and Their Cytoprotective Effect on Human Lymphocytes. in Archiv der Pharmazie
Wiley-VCH Verlag GMBH, Weinheim., 348(2), 100-112.
https://doi.org/10.1002/ardp.201400350

Simić M, Stanković M, Mandić BM, Tešević V, Savić V. Synthesis of Novel Tetrahydrobenzazepine Derivatives and Their Cytoprotective Effect on Human Lymphocytes. in Archiv der Pharmazie. 2015;348(2):100-112.
doi:10.1002/ardp.201400350 .

Simić, Milena, Stanković, Miroslava, Mandić, Boris M., Tešević, Vele, Savić, Vladimir, "Synthesis of Novel Tetrahydrobenzazepine Derivatives and Their Cytoprotective Effect on Human Lymphocytes" in Archiv der Pharmazie, 348, no. 2 (2015):100-112,
https://doi.org/10.1002/ardp.201400350 . .

TY  - JOUR
AU  - Kuntić, Vesna
AU  - Stanković, Miroslava
AU  - Vujić, Zorica
AU  - Brborić, Jasmina
AU  - Uskoković-Marković, Snežana
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1910
AB  - To protect organisms from ionizing radiation (IR), and to reduce morbidity or mortality, various agents, called radioprotectors, have been utilized. Because radiation-induced cellular damage is attributed primarily to the harmful effects of free radicals, molecules with radical-scavenging properties are particularly promising as radioprotectors. Early development of such agents focused on thiol synthetic compounds, known as WR protectors, but only amifostine (WR-2721) has been used in clinical trials as an officially approved radioprotector. Besides thiol compounds, various compounds with different chemical structure were investigated, but an ideal radioprotector has not been found yet. Plants and natural products have been evaluated as promising sources of radioprotectors because of their low toxicity, although they exhibit an inferior protection level compared to synthetic thiol compounds. Active plant constituents seem to exert the radioprotection through antioxidant and free radical-scavenging activities. Our research established that plants containing polyphenolic compounds (raspberry, blueberry, strawberry, grape, etc.) exhibit antioxidative activities and protect genetic material from IR.
PB  - Wiley-VCH Verlag GMBH, Weinheim
T2  - Chemistry & Biodiversity
T1  - Radioprotectors - the Evergreen Topic
VL  - 10
IS  - 10
SP  - 1791
EP  - 1803
DO  - 10.1002/cbdv.201300054
ER  - 

@article{
author = "Kuntić, Vesna and Stanković, Miroslava and Vujić, Zorica and Brborić, Jasmina and Uskoković-Marković, Snežana",
year = "2013",
abstract = "To protect organisms from ionizing radiation (IR), and to reduce morbidity or mortality, various agents, called radioprotectors, have been utilized. Because radiation-induced cellular damage is attributed primarily to the harmful effects of free radicals, molecules with radical-scavenging properties are particularly promising as radioprotectors. Early development of such agents focused on thiol synthetic compounds, known as WR protectors, but only amifostine (WR-2721) has been used in clinical trials as an officially approved radioprotector. Besides thiol compounds, various compounds with different chemical structure were investigated, but an ideal radioprotector has not been found yet. Plants and natural products have been evaluated as promising sources of radioprotectors because of their low toxicity, although they exhibit an inferior protection level compared to synthetic thiol compounds. Active plant constituents seem to exert the radioprotection through antioxidant and free radical-scavenging activities. Our research established that plants containing polyphenolic compounds (raspberry, blueberry, strawberry, grape, etc.) exhibit antioxidative activities and protect genetic material from IR.",
publisher = "Wiley-VCH Verlag GMBH, Weinheim",
journal = "Chemistry & Biodiversity",
title = "Radioprotectors - the Evergreen Topic",
volume = "10",
number = "10",
pages = "1791-1803",
doi = "10.1002/cbdv.201300054"
}

Kuntić, V., Stanković, M., Vujić, Z., Brborić, J.,& Uskoković-Marković, S.. (2013). Radioprotectors - the Evergreen Topic. in Chemistry & Biodiversity
Wiley-VCH Verlag GMBH, Weinheim., 10(10), 1791-1803.
https://doi.org/10.1002/cbdv.201300054

Kuntić V, Stanković M, Vujić Z, Brborić J, Uskoković-Marković S. Radioprotectors - the Evergreen Topic. in Chemistry & Biodiversity. 2013;10(10):1791-1803.
doi:10.1002/cbdv.201300054 .

Kuntić, Vesna, Stanković, Miroslava, Vujić, Zorica, Brborić, Jasmina, Uskoković-Marković, Snežana, "Radioprotectors - the Evergreen Topic" in Chemistry & Biodiversity, 10, no. 10 (2013):1791-1803,
https://doi.org/10.1002/cbdv.201300054 . .