TY  - JOUR
AU  - Zečević, Mira
AU  - Minić, D
AU  - Stojšić, D.
AU  - Živanović, LJ
AU  - Ivanović, I
PY  - 2004
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/498
AB  - Ochratoxin A is a mycotoxin, a natural product of Aspergillus and Penicillium species. It can be present in grain from Triticum aestivum, (Graminae) and other starch-abundant cereals. This paper describes the investigation of ochratoxin A in grain from Triticum aestivum using a statistically optimized HPLC method. The assay was developed using two mathematical statistical models: factorial design and response surface mapping. The final step was to optimize the values of variables by response surface design. The analysis of variance 'ANOVA' method was applied to the analytical results in order to construct an adequate model. The optimal experimental conditions obtained by the response surface diagram method were: pH = 2.5, composition of the mobile phase acetonitrile: water 55:45 v/v and flow rate 1.0 ml/min. with a C18 column. Retention time and capacity factor for ochratotoxin A were 7.46 min. and 1.19, respectively.
PB  - Govi-Verlag Gmbh, Eschborn
T2  - Pharmazie
T1  - Application of experimental design to the development of an HPLC method for the analysis of ochratoxin A in Triticum aestivum grain
VL  - 59
IS  - 3
SP  - 175
EP  - 177
UR  - https://hdl.handle.net/21.15107/rcub_farfar_498
ER  - 

@article{
author = "Zečević, Mira and Minić, D and Stojšić, D. and Živanović, LJ and Ivanović, I",
year = "2004",
abstract = "Ochratoxin A is a mycotoxin, a natural product of Aspergillus and Penicillium species. It can be present in grain from Triticum aestivum, (Graminae) and other starch-abundant cereals. This paper describes the investigation of ochratoxin A in grain from Triticum aestivum using a statistically optimized HPLC method. The assay was developed using two mathematical statistical models: factorial design and response surface mapping. The final step was to optimize the values of variables by response surface design. The analysis of variance 'ANOVA' method was applied to the analytical results in order to construct an adequate model. The optimal experimental conditions obtained by the response surface diagram method were: pH = 2.5, composition of the mobile phase acetonitrile: water 55:45 v/v and flow rate 1.0 ml/min. with a C18 column. Retention time and capacity factor for ochratotoxin A were 7.46 min. and 1.19, respectively.",
publisher = "Govi-Verlag Gmbh, Eschborn",
journal = "Pharmazie",
title = "Application of experimental design to the development of an HPLC method for the analysis of ochratoxin A in Triticum aestivum grain",
volume = "59",
number = "3",
pages = "175-177",
url = "https://hdl.handle.net/21.15107/rcub_farfar_498"
}

Zečević, M., Minić, D., Stojšić, D., Živanović, L.,& Ivanović, I.. (2004). Application of experimental design to the development of an HPLC method for the analysis of ochratoxin A in Triticum aestivum grain. in Pharmazie
Govi-Verlag Gmbh, Eschborn., 59(3), 175-177.
https://hdl.handle.net/21.15107/rcub_farfar_498

Zečević M, Minić D, Stojšić D, Živanović L, Ivanović I. Application of experimental design to the development of an HPLC method for the analysis of ochratoxin A in Triticum aestivum grain. in Pharmazie. 2004;59(3):175-177.
https://hdl.handle.net/21.15107/rcub_farfar_498 .

Zečević, Mira, Minić, D, Stojšić, D., Živanović, LJ, Ivanović, I, "Application of experimental design to the development of an HPLC method for the analysis of ochratoxin A in Triticum aestivum grain" in Pharmazie, 59, no. 3 (2004):175-177,
https://hdl.handle.net/21.15107/rcub_farfar_498 .

TY  - JOUR
AU  - Zečević, Mira
AU  - Živanović, L
AU  - Agatonović-Kuštrin, Snežana
AU  - Minić, D
PY  - 2001
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/293
AB  - A multifactor optimisation technique is successfully applied to develop a new HPLC method in which methyldopa, hydrochlorothiazide and amiloride were analysed and determined on a C18 column with detection at 286 nm. The optimal conditions of HPLC separation were determined with the aid of the response surface diagram - 'window diagram'. The effect of simultaneously varying the pH, proportion aqueous acetic acidum and methanol in the mobile phase were studied to optimise the separation. The mobile phase composition that provides an acceptable resolution methyldopa, hydrochlorothiazide and amiloride in a short elution time is water-methanol (75:25) and pH 3.60. The k' values for methyldopa, hydrochlorothiazide and amiloride after optimisation were 1.40, 2.50 and 5.33, respectively. Relative retention (a) for ratio hydrochlorothiazide/methyldopa and amiloride/hydrochlorothiazide were 1.767 and 2.159, respectively. Correlation coefficients of the calibration curves for all analytes were greater than 0.995 and the R.S.D. values for the slope and the intercept with respect to the linearity were less than 2%. A method is applied for the quantitative analysis of Aatan(R) tablets (Lek-Ljubljana). The powdered tablets are extracted with methanol, containing caffeine as the internal standard and assayed by comparison of peak areas after liquid chromatography. The high recovery (for all analytes about 100%) and the low R.S.D. ( lt 2%) confirm good precision and reproducibility of the chromatographic method.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Journal of Pharmaceutical and Biomedical Analysis
T1  - The use of a response surface methodology on HPLC analysis of methyldopa, amiloride and hydrochlorothiazide in tablets
VL  - 24
IS  - 5-6
SP  - 1019
EP  - 1025
DO  - 10.1016/S0731-7085(00)00536-7
ER  - 

@article{
author = "Zečević, Mira and Živanović, L and Agatonović-Kuštrin, Snežana and Minić, D",
year = "2001",
abstract = "A multifactor optimisation technique is successfully applied to develop a new HPLC method in which methyldopa, hydrochlorothiazide and amiloride were analysed and determined on a C18 column with detection at 286 nm. The optimal conditions of HPLC separation were determined with the aid of the response surface diagram - 'window diagram'. The effect of simultaneously varying the pH, proportion aqueous acetic acidum and methanol in the mobile phase were studied to optimise the separation. The mobile phase composition that provides an acceptable resolution methyldopa, hydrochlorothiazide and amiloride in a short elution time is water-methanol (75:25) and pH 3.60. The k' values for methyldopa, hydrochlorothiazide and amiloride after optimisation were 1.40, 2.50 and 5.33, respectively. Relative retention (a) for ratio hydrochlorothiazide/methyldopa and amiloride/hydrochlorothiazide were 1.767 and 2.159, respectively. Correlation coefficients of the calibration curves for all analytes were greater than 0.995 and the R.S.D. values for the slope and the intercept with respect to the linearity were less than 2%. A method is applied for the quantitative analysis of Aatan(R) tablets (Lek-Ljubljana). The powdered tablets are extracted with methanol, containing caffeine as the internal standard and assayed by comparison of peak areas after liquid chromatography. The high recovery (for all analytes about 100%) and the low R.S.D. ( lt 2%) confirm good precision and reproducibility of the chromatographic method.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Journal of Pharmaceutical and Biomedical Analysis",
title = "The use of a response surface methodology on HPLC analysis of methyldopa, amiloride and hydrochlorothiazide in tablets",
volume = "24",
number = "5-6",
pages = "1019-1025",
doi = "10.1016/S0731-7085(00)00536-7"
}

Zečević, M., Živanović, L., Agatonović-Kuštrin, S.,& Minić, D.. (2001). The use of a response surface methodology on HPLC analysis of methyldopa, amiloride and hydrochlorothiazide in tablets. in Journal of Pharmaceutical and Biomedical Analysis
Pergamon-Elsevier Science Ltd, Oxford., 24(5-6), 1019-1025.
https://doi.org/10.1016/S0731-7085(00)00536-7

Zečević M, Živanović L, Agatonović-Kuštrin S, Minić D. The use of a response surface methodology on HPLC analysis of methyldopa, amiloride and hydrochlorothiazide in tablets. in Journal of Pharmaceutical and Biomedical Analysis. 2001;24(5-6):1019-1025.
doi:10.1016/S0731-7085(00)00536-7 .

Zečević, Mira, Živanović, L, Agatonović-Kuštrin, Snežana, Minić, D, "The use of a response surface methodology on HPLC analysis of methyldopa, amiloride and hydrochlorothiazide in tablets" in Journal of Pharmaceutical and Biomedical Analysis, 24, no. 5-6 (2001):1019-1025,
https://doi.org/10.1016/S0731-7085(00)00536-7 . .

TY  - JOUR
AU  - Karljiković-Rajić, Katarina
AU  - Jovanović, M
AU  - Korićanac, Zagorka
AU  - Stanković, B
AU  - Minić, D
PY  - 1991
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/82
AB  - The electrochemical behavior of 1‐(2‐phenyl‐2‐hydroxyiminoethyl)‐1‐quinolinium chloride (F‐1) and 1‐(2‐phenyl‐2‐hydroxyiminoethyl)‐1‐isoquinolinium chloride (F‐2) was investigated using dc and differential pulse polarography (DPP) and cyclic voltammetry. Well‐defined, diffusion‐controlled, cathodic waves were observed for F‐1 only in strong acidic solution (pH 1.25 HCl) and for F‐2 in the H range 1.25–5.33 (HCl and Britton–Robinson buffer). The overall reduction of the azomethine group to a primary amine, a process that involves the uptake of four electrons, is irreversible. For both oximes a mechanism of reduction has been proposed. The rapid and accurate determination of these quinolinium and isoquinolinium oximes is possible by dc polarography and by DPP. Limits of detection are 5 × 10−7 M for both oximes using DPP.
T2  - Electroanalysis
T1  - Electrochemical behavior and determination of quinolinium and isoquinolinium oximes
VL  - 3
IS  - 2
SP  - 139
EP  - 144
DO  - 10.1002/elan.1140030211
ER  - 

@article{
author = "Karljiković-Rajić, Katarina and Jovanović, M and Korićanac, Zagorka and Stanković, B and Minić, D",
year = "1991",
abstract = "The electrochemical behavior of 1‐(2‐phenyl‐2‐hydroxyiminoethyl)‐1‐quinolinium chloride (F‐1) and 1‐(2‐phenyl‐2‐hydroxyiminoethyl)‐1‐isoquinolinium chloride (F‐2) was investigated using dc and differential pulse polarography (DPP) and cyclic voltammetry. Well‐defined, diffusion‐controlled, cathodic waves were observed for F‐1 only in strong acidic solution (pH 1.25 HCl) and for F‐2 in the H range 1.25–5.33 (HCl and Britton–Robinson buffer). The overall reduction of the azomethine group to a primary amine, a process that involves the uptake of four electrons, is irreversible. For both oximes a mechanism of reduction has been proposed. The rapid and accurate determination of these quinolinium and isoquinolinium oximes is possible by dc polarography and by DPP. Limits of detection are 5 × 10−7 M for both oximes using DPP.",
journal = "Electroanalysis",
title = "Electrochemical behavior and determination of quinolinium and isoquinolinium oximes",
volume = "3",
number = "2",
pages = "139-144",
doi = "10.1002/elan.1140030211"
}

Karljiković-Rajić, K., Jovanović, M., Korićanac, Z., Stanković, B.,& Minić, D.. (1991). Electrochemical behavior and determination of quinolinium and isoquinolinium oximes. in Electroanalysis, 3(2), 139-144.
https://doi.org/10.1002/elan.1140030211

Karljiković-Rajić K, Jovanović M, Korićanac Z, Stanković B, Minić D. Electrochemical behavior and determination of quinolinium and isoquinolinium oximes. in Electroanalysis. 1991;3(2):139-144.
doi:10.1002/elan.1140030211 .

Karljiković-Rajić, Katarina, Jovanović, M, Korićanac, Zagorka, Stanković, B, Minić, D, "Electrochemical behavior and determination of quinolinium and isoquinolinium oximes" in Electroanalysis, 3, no. 2 (1991):139-144,
https://doi.org/10.1002/elan.1140030211 . .