TY  - JOUR
AU  - Cirković, Ivana
AU  - Jocić, Dario
AU  - Božić, Dragana
AU  - Đukić, Slobodanka
AU  - Konstantinović, Neda
AU  - Radak, Đorđe
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3225
AB  - Biofilm-associated wound infections are a major global health issue, and methicillin-resistant Staphylococcus aureus (MRSA) is among the greatest therapeutic challenges. Vacuum-assisted closure (VAC) therapy is now being revisited as an alternative treatment for both acute and chronic wounds. However, data supporting the concept of its antibiofilm effect remain limited. Using quantitative biofilm-forming assay and a range of genotypic methods (spa, SCCmec, and agr typing), study authors showed that VAC therapy can significantly prevent biofilm formation (P  lt  .01) of a range of MRSA wound isolates differing widely in their biofilm-forming abilities and genetic background. The best effect was presented on CC5-MRSA-SCCmecI-agrII, a dominant MRSA clone among wound isolates worldwide. An assessment of effects of different protocols on dressing changes (1 or 2 times per week) demonstrated significantly greater antibiofilm activity (P  lt  .05) of 3-day dressing changes. These findings support the use of VAC therapy as a topical antibiofilm treatment for the effective management of wound healing.
PB  - Lippincott Williams & Wilkins, Philadelphia
T2  - Advances in Skin & Wound Care
T1  - The Effect of Vacuum-Assisted Closure Therapy on Methicillin-Resistant Staphylococcus aureus Wound Biofilms
VL  - 31
IS  - 8
SP  - 361
EP  - 364
DO  - 10.1097/01.ASW.0000540070.07040.70
ER  - 

@article{
author = "Cirković, Ivana and Jocić, Dario and Božić, Dragana and Đukić, Slobodanka and Konstantinović, Neda and Radak, Đorđe",
year = "2018",
abstract = "Biofilm-associated wound infections are a major global health issue, and methicillin-resistant Staphylococcus aureus (MRSA) is among the greatest therapeutic challenges. Vacuum-assisted closure (VAC) therapy is now being revisited as an alternative treatment for both acute and chronic wounds. However, data supporting the concept of its antibiofilm effect remain limited. Using quantitative biofilm-forming assay and a range of genotypic methods (spa, SCCmec, and agr typing), study authors showed that VAC therapy can significantly prevent biofilm formation (P  lt  .01) of a range of MRSA wound isolates differing widely in their biofilm-forming abilities and genetic background. The best effect was presented on CC5-MRSA-SCCmecI-agrII, a dominant MRSA clone among wound isolates worldwide. An assessment of effects of different protocols on dressing changes (1 or 2 times per week) demonstrated significantly greater antibiofilm activity (P  lt  .05) of 3-day dressing changes. These findings support the use of VAC therapy as a topical antibiofilm treatment for the effective management of wound healing.",
publisher = "Lippincott Williams & Wilkins, Philadelphia",
journal = "Advances in Skin & Wound Care",
title = "The Effect of Vacuum-Assisted Closure Therapy on Methicillin-Resistant Staphylococcus aureus Wound Biofilms",
volume = "31",
number = "8",
pages = "361-364",
doi = "10.1097/01.ASW.0000540070.07040.70"
}

Cirković, I., Jocić, D., Božić, D., Đukić, S., Konstantinović, N.,& Radak, Đ.. (2018). The Effect of Vacuum-Assisted Closure Therapy on Methicillin-Resistant Staphylococcus aureus Wound Biofilms. in Advances in Skin & Wound Care
Lippincott Williams & Wilkins, Philadelphia., 31(8), 361-364.
https://doi.org/10.1097/01.ASW.0000540070.07040.70

Cirković I, Jocić D, Božić D, Đukić S, Konstantinović N, Radak Đ. The Effect of Vacuum-Assisted Closure Therapy on Methicillin-Resistant Staphylococcus aureus Wound Biofilms. in Advances in Skin & Wound Care. 2018;31(8):361-364.
doi:10.1097/01.ASW.0000540070.07040.70 .

Cirković, Ivana, Jocić, Dario, Božić, Dragana, Đukić, Slobodanka, Konstantinović, Neda, Radak, Đorđe, "The Effect of Vacuum-Assisted Closure Therapy on Methicillin-Resistant Staphylococcus aureus Wound Biofilms" in Advances in Skin & Wound Care, 31, no. 8 (2018):361-364,
https://doi.org/10.1097/01.ASW.0000540070.07040.70 . .

TY  - JOUR
AU  - Nenezić, Dragoslav
AU  - Radak, Đorđe
AU  - Jocić, Dario
AU  - Gajin, Predrag
AU  - Tanasković, Slobodan
AU  - Novaković, Aleksandra
AU  - Matić, Predrag
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2287
AB  - Introduction Acute lower limb ischemia results from thrombosis or embolization of diseased native artery or previously implanted bypass graft. When this occurs, several options are available to restore blood flow: catheter-directed thrombolysis, mechanical thrombectomy or open surgery. Fundamental reasons to apply percutaneous interventions are avoiding open procedures in high risk patients, and avoiding difficult dissection through scar tissue. Case Outline A 67-year-old male was admitted at our Institution for critical limb ischemia. After performed angiography the diagnosis of occluded femoropopliteal graft was established. Occlusion was resolved by catheter-directed thrombolysis with plasmin. Culprit lesions were treated by angioplasty. Conclusion Our patient underwent a successful thrombolysis of occluded femoropopliteal graft with locally-delivered human plasmin.
AB  - Uvod Ishemija donjih ekstremiteta je posledica tromboze ili embolizacije obolele nativne arterije ili implantiranog grafta. Postoji nekoliko načina lečenja ishemije: tromboliza kateterom, mehanička trombektomija i hirurško lečenje. Osnovni razlozi za primenu perkutanih intervencija jeste izbegavanje klasičnog hirurškog lečenja kod bolesnika s visokim rizikom, kao i izbegavanje preparisanja krvnog suda u ožiljku. Prikaz bolesnika Muškarac star 67 godina primljen je u bolnicu zbog kritične ishemije donjih ekstremiteta. Po učinjenoj angiografiji dijagnostikovana je tromboza femoropoplitealnog grafta. Okluzija je rešena primenom plazmina uz upotrebu intraarterijskog katetera. Stenoze koje su otkrivene posle trombolize lečene su angioplastikom. Zaključak Trombolizom uz primenu plazmina i intraarterijskog katetera uspešno je izlečena okluzija femoropoplitealnog grafta.
PB  - Srpsko lekarsko društvo, Beograd
T2  - Srpski arhiv za celokupno lekarstvo
T1  - Thrombolysis of occluded femoropopliteal graft with locally delivered human plasmin
T1  - Tromboliza okludiranog femoropoplitealnog grafta lokalno primenjenim humanim plazminom
VL  - 142
IS  - 5-6
SP  - 342
EP  - 346
DO  - 10.2298/SARH1406342N
ER  - 

@article{
author = "Nenezić, Dragoslav and Radak, Đorđe and Jocić, Dario and Gajin, Predrag and Tanasković, Slobodan and Novaković, Aleksandra and Matić, Predrag",
year = "2014",
abstract = "Introduction Acute lower limb ischemia results from thrombosis or embolization of diseased native artery or previously implanted bypass graft. When this occurs, several options are available to restore blood flow: catheter-directed thrombolysis, mechanical thrombectomy or open surgery. Fundamental reasons to apply percutaneous interventions are avoiding open procedures in high risk patients, and avoiding difficult dissection through scar tissue. Case Outline A 67-year-old male was admitted at our Institution for critical limb ischemia. After performed angiography the diagnosis of occluded femoropopliteal graft was established. Occlusion was resolved by catheter-directed thrombolysis with plasmin. Culprit lesions were treated by angioplasty. Conclusion Our patient underwent a successful thrombolysis of occluded femoropopliteal graft with locally-delivered human plasmin., Uvod Ishemija donjih ekstremiteta je posledica tromboze ili embolizacije obolele nativne arterije ili implantiranog grafta. Postoji nekoliko načina lečenja ishemije: tromboliza kateterom, mehanička trombektomija i hirurško lečenje. Osnovni razlozi za primenu perkutanih intervencija jeste izbegavanje klasičnog hirurškog lečenja kod bolesnika s visokim rizikom, kao i izbegavanje preparisanja krvnog suda u ožiljku. Prikaz bolesnika Muškarac star 67 godina primljen je u bolnicu zbog kritične ishemije donjih ekstremiteta. Po učinjenoj angiografiji dijagnostikovana je tromboza femoropoplitealnog grafta. Okluzija je rešena primenom plazmina uz upotrebu intraarterijskog katetera. Stenoze koje su otkrivene posle trombolize lečene su angioplastikom. Zaključak Trombolizom uz primenu plazmina i intraarterijskog katetera uspešno je izlečena okluzija femoropoplitealnog grafta.",
publisher = "Srpsko lekarsko društvo, Beograd",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "Thrombolysis of occluded femoropopliteal graft with locally delivered human plasmin, Tromboliza okludiranog femoropoplitealnog grafta lokalno primenjenim humanim plazminom",
volume = "142",
number = "5-6",
pages = "342-346",
doi = "10.2298/SARH1406342N"
}

Nenezić, D., Radak, Đ., Jocić, D., Gajin, P., Tanasković, S., Novaković, A.,& Matić, P.. (2014). Thrombolysis of occluded femoropopliteal graft with locally delivered human plasmin. in Srpski arhiv za celokupno lekarstvo
Srpsko lekarsko društvo, Beograd., 142(5-6), 342-346.
https://doi.org/10.2298/SARH1406342N

Nenezić D, Radak Đ, Jocić D, Gajin P, Tanasković S, Novaković A, Matić P. Thrombolysis of occluded femoropopliteal graft with locally delivered human plasmin. in Srpski arhiv za celokupno lekarstvo. 2014;142(5-6):342-346.
doi:10.2298/SARH1406342N .

Nenezić, Dragoslav, Radak, Đorđe, Jocić, Dario, Gajin, Predrag, Tanasković, Slobodan, Novaković, Aleksandra, Matić, Predrag, "Thrombolysis of occluded femoropopliteal graft with locally delivered human plasmin" in Srpski arhiv za celokupno lekarstvo, 142, no. 5-6 (2014):342-346,
https://doi.org/10.2298/SARH1406342N . .