TY  - JOUR
AU  - Savić, Snežana
AU  - Weber, Christian
AU  - Tamburić, Slobodanka
AU  - Savić, Miroslav
AU  - Mueller-Goymann, Christel
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1272
AB  - There is a growing need for in-depth research into new skill- and environment-friendly surfactants, such as alkylpolyglucosides. The aim of this study was to assess whether, to which extent and by what mechanism the two commonly used hydrophilic excipients, propylene glycol (PG) and glycerol (GL), affect the Colloidal structure of emulsions formed by a natural mixed emulsifier, cetearyl glucoside and cetearyl alcohol. Furthermore, the study was concerned with the effect of these changes on in vitro permeation profiles of two model drugs (diclofenac sodium and caffeine) and in vivo skin performance of the test samples. The results have shown that the emulsion vehicles consisted of a complex colloidal structure of lamellar liquid crystalline and lamellar gel crystalline type. PG addition produced a stronger hydrophilic lamellar gel phase than GL, which was independent on the model drug used. PG-containing vehicles have revealed a considerable amount of interlamellar PG/water mixture, with incorporated drug. In vitro permeation data obtained using artificial skill constructs (ASC) confirmed the relationship between rheological profiles of vehicles and the extent of skill delivery. Higher permeation profiles of both drugs from PG-containing formulations coincided with a higher increase in transepidermal water loss observed in in vivo study on human volunteers, which confirms the penetration/permeation enhancer effect of PG. It also indicates the existence of the vehicle/ASC interactions analogous to those between the vehicle and the skin, thus affirming the use of ASC as a reliable tool for permeation studies. Contrary to the effect of PG, the results obtained with GL suggest that it may have a permeation-retarding rather than a permeation-enhancing effect ill topical vehicles of this type.
PB  - Elsevier Science Inc, New York
T2  - Journal of Pharmaceutical Sciences
T1  - Topical Vehicles Based on Natural Surfactant/Fatty Alcohols Mixed Emulsifier: The Influence of Two Polyols on the Colloidal Structure and In Vitro/In Vivo Skin Performance
VL  - 98
IS  - 6
SP  - 2073
EP  - 2090
DO  - 10.1002/jps.21591
ER  - 

@article{
author = "Savić, Snežana and Weber, Christian and Tamburić, Slobodanka and Savić, Miroslav and Mueller-Goymann, Christel",
year = "2009",
abstract = "There is a growing need for in-depth research into new skill- and environment-friendly surfactants, such as alkylpolyglucosides. The aim of this study was to assess whether, to which extent and by what mechanism the two commonly used hydrophilic excipients, propylene glycol (PG) and glycerol (GL), affect the Colloidal structure of emulsions formed by a natural mixed emulsifier, cetearyl glucoside and cetearyl alcohol. Furthermore, the study was concerned with the effect of these changes on in vitro permeation profiles of two model drugs (diclofenac sodium and caffeine) and in vivo skin performance of the test samples. The results have shown that the emulsion vehicles consisted of a complex colloidal structure of lamellar liquid crystalline and lamellar gel crystalline type. PG addition produced a stronger hydrophilic lamellar gel phase than GL, which was independent on the model drug used. PG-containing vehicles have revealed a considerable amount of interlamellar PG/water mixture, with incorporated drug. In vitro permeation data obtained using artificial skill constructs (ASC) confirmed the relationship between rheological profiles of vehicles and the extent of skill delivery. Higher permeation profiles of both drugs from PG-containing formulations coincided with a higher increase in transepidermal water loss observed in in vivo study on human volunteers, which confirms the penetration/permeation enhancer effect of PG. It also indicates the existence of the vehicle/ASC interactions analogous to those between the vehicle and the skin, thus affirming the use of ASC as a reliable tool for permeation studies. Contrary to the effect of PG, the results obtained with GL suggest that it may have a permeation-retarding rather than a permeation-enhancing effect ill topical vehicles of this type.",
publisher = "Elsevier Science Inc, New York",
journal = "Journal of Pharmaceutical Sciences",
title = "Topical Vehicles Based on Natural Surfactant/Fatty Alcohols Mixed Emulsifier: The Influence of Two Polyols on the Colloidal Structure and In Vitro/In Vivo Skin Performance",
volume = "98",
number = "6",
pages = "2073-2090",
doi = "10.1002/jps.21591"
}

Savić, S., Weber, C., Tamburić, S., Savić, M.,& Mueller-Goymann, C.. (2009). Topical Vehicles Based on Natural Surfactant/Fatty Alcohols Mixed Emulsifier: The Influence of Two Polyols on the Colloidal Structure and In Vitro/In Vivo Skin Performance. in Journal of Pharmaceutical Sciences
Elsevier Science Inc, New York., 98(6), 2073-2090.
https://doi.org/10.1002/jps.21591

Savić S, Weber C, Tamburić S, Savić M, Mueller-Goymann C. Topical Vehicles Based on Natural Surfactant/Fatty Alcohols Mixed Emulsifier: The Influence of Two Polyols on the Colloidal Structure and In Vitro/In Vivo Skin Performance. in Journal of Pharmaceutical Sciences. 2009;98(6):2073-2090.
doi:10.1002/jps.21591 .

Savić, Snežana, Weber, Christian, Tamburić, Slobodanka, Savić, Miroslav, Mueller-Goymann, Christel, "Topical Vehicles Based on Natural Surfactant/Fatty Alcohols Mixed Emulsifier: The Influence of Two Polyols on the Colloidal Structure and In Vitro/In Vivo Skin Performance" in Journal of Pharmaceutical Sciences, 98, no. 6 (2009):2073-2090,
https://doi.org/10.1002/jps.21591 . .

TY  - JOUR
AU  - Savić, Snežana
AU  - Weber, Christian
AU  - Savić, Miroslav
AU  - Mueller-Goymann, Christel
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1207
AB  - This study focuses on the properties of topical vehicles based on alkylpolyglucoside natural surfactant-mixed emulsifier, cetearyl glucoside and cetearyl alcohol, in order to propose their use as "ready to use" pharmaceutical bases for a number of model drugs. We were interested to investigate how the alternative use of three lipophilic excipients (Ph. Eur. 6.0), differing in their polarity indexes (medium chain triglycerides (MG), decyl oleate (DO), and isopropyl myristate (IPM), respectively), affects the colloidal structure of the alkylpolyglucoside-based vehicles and in vitro permeation profiles of two model drugs: diclofenac sodium (DC) and caffeine (CF), both sparingly soluble in water. Finally, we aimed to evaluate the safety profile of such vehicles in vitro (acute skin irritation test using a cytotoxicity assay), comparing it with in vivo data obtained by the methods of skin bioengineering. The results have shown that the emulsion vehicles consisted of a complex colloidal structure of lamellar liquid crystalline and lamellar gel crystalline type. Varying of lipophilic excipient influenced noteworthy variations in the colloidal structure demonstrated as different theological profiles accompanied to the certain degree by different water distribution modes, but notably provoked by drug nature (an amphiphilic electrolyte drug vs. nonelectrolyte). In vitro permeation data obtained using ASC membranes in an infinite dose-type of experiment stressed the importance of the vehicle/solute interactions in case of small variation in formulation composition, asserting the drug properties in the first hours of permeation and theological profile of the vehicles in the later phase of experiment as decisive factors. In vitro skin irritation test demonstrated a mild nature of the emulsifying wax and the absence of negative effects of used oil phases on cell viability in formulation concentrations correspondent to the therapeutic need. This result alongside with data obtained from in vivo study, could additionally promote investigated topical vehicles as prospective "ready to use" pharmaceutical bases.
PB  - Elsevier Science BV, Amsterdam
T2  - International Journal of Pharmaceutics
T1  - Natural surfactant-based topical vehicles for two model drugs: Influence of different lipophilic excipients on in vitro/in vivo skin performance
VL  - 381
IS  - 2
SP  - 220
EP  - 230
DO  - 10.1016/j.ijpharm.2009.07.007
ER  - 

@article{
author = "Savić, Snežana and Weber, Christian and Savić, Miroslav and Mueller-Goymann, Christel",
year = "2009",
abstract = "This study focuses on the properties of topical vehicles based on alkylpolyglucoside natural surfactant-mixed emulsifier, cetearyl glucoside and cetearyl alcohol, in order to propose their use as "ready to use" pharmaceutical bases for a number of model drugs. We were interested to investigate how the alternative use of three lipophilic excipients (Ph. Eur. 6.0), differing in their polarity indexes (medium chain triglycerides (MG), decyl oleate (DO), and isopropyl myristate (IPM), respectively), affects the colloidal structure of the alkylpolyglucoside-based vehicles and in vitro permeation profiles of two model drugs: diclofenac sodium (DC) and caffeine (CF), both sparingly soluble in water. Finally, we aimed to evaluate the safety profile of such vehicles in vitro (acute skin irritation test using a cytotoxicity assay), comparing it with in vivo data obtained by the methods of skin bioengineering. The results have shown that the emulsion vehicles consisted of a complex colloidal structure of lamellar liquid crystalline and lamellar gel crystalline type. Varying of lipophilic excipient influenced noteworthy variations in the colloidal structure demonstrated as different theological profiles accompanied to the certain degree by different water distribution modes, but notably provoked by drug nature (an amphiphilic electrolyte drug vs. nonelectrolyte). In vitro permeation data obtained using ASC membranes in an infinite dose-type of experiment stressed the importance of the vehicle/solute interactions in case of small variation in formulation composition, asserting the drug properties in the first hours of permeation and theological profile of the vehicles in the later phase of experiment as decisive factors. In vitro skin irritation test demonstrated a mild nature of the emulsifying wax and the absence of negative effects of used oil phases on cell viability in formulation concentrations correspondent to the therapeutic need. This result alongside with data obtained from in vivo study, could additionally promote investigated topical vehicles as prospective "ready to use" pharmaceutical bases.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "International Journal of Pharmaceutics",
title = "Natural surfactant-based topical vehicles for two model drugs: Influence of different lipophilic excipients on in vitro/in vivo skin performance",
volume = "381",
number = "2",
pages = "220-230",
doi = "10.1016/j.ijpharm.2009.07.007"
}

Savić, S., Weber, C., Savić, M.,& Mueller-Goymann, C.. (2009). Natural surfactant-based topical vehicles for two model drugs: Influence of different lipophilic excipients on in vitro/in vivo skin performance. in International Journal of Pharmaceutics
Elsevier Science BV, Amsterdam., 381(2), 220-230.
https://doi.org/10.1016/j.ijpharm.2009.07.007

Savić S, Weber C, Savić M, Mueller-Goymann C. Natural surfactant-based topical vehicles for two model drugs: Influence of different lipophilic excipients on in vitro/in vivo skin performance. in International Journal of Pharmaceutics. 2009;381(2):220-230.
doi:10.1016/j.ijpharm.2009.07.007 .

Savić, Snežana, Weber, Christian, Savić, Miroslav, Mueller-Goymann, Christel, "Natural surfactant-based topical vehicles for two model drugs: Influence of different lipophilic excipients on in vitro/in vivo skin performance" in International Journal of Pharmaceutics, 381, no. 2 (2009):220-230,
https://doi.org/10.1016/j.ijpharm.2009.07.007 . .