TY  - JOUR
AU  - Ćurčić, Marijana
AU  - Durgo, Ksenija
AU  - Kopjar, Nevenka
AU  - Ancić, Mario
AU  - Vučinić, Slavica
AU  - Antonijević, Biljana
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2128
AB  - In order to look into the combined effects of Cd and BDE-209 in vitro, this study was aimed at examining cytotoxic and genotoxic effects using the human colon carcinoma cell line (SW 480) as a biological test system as well as to determine if ROS production was one of the possible mechanisms of their mixture action. This cell line was chosen since ingestion of contaminated food/water represents an important route of exposure to both Cd and BDE-209, which is why intestinal cells are a common target for the contaminants present in food and water. Cells were treated with single Cd in concentrations of 2.5, 7.5 or 15 mu g Cd/mL (corresponding to 22, 67 or 134 mu M), single BDE-209 in concentrations of 2.5, 5 or 10 mu g BDE209/mL (corresponding to 2.5, 5 or 10 mu M), and their mixtures (design 3 x 3). Mixture of Cd and BDE-209 has shown clear potential to reduce the viability of SW 480 cells, as evidenced by cytotoxicity associated with ROS generation. Factorial regression models used to identify type of interaction revealed synergism related to mixture citotoxicity and additive interaction for the effect on ROS production. The results from this introductory study could contribute to the issue of possible adverse effects associated with co-exposure and body burden with two persistent environmental pollutants, Cd and BDE-209.
PB  - Elsevier Science BV, Amsterdam
T2  - Environmental Toxicology and Pharmacology
T1  - Cadmium and decabrominated diphenyl ether mixture: In vitro evaluation of cytotoxic, prooxidative and genotoxic effects
VL  - 38
IS  - 2
SP  - 663
EP  - 671
DO  - 10.1016/j.etap.2014.07.021
ER  - 

@article{
author = "Ćurčić, Marijana and Durgo, Ksenija and Kopjar, Nevenka and Ancić, Mario and Vučinić, Slavica and Antonijević, Biljana",
year = "2014",
abstract = "In order to look into the combined effects of Cd and BDE-209 in vitro, this study was aimed at examining cytotoxic and genotoxic effects using the human colon carcinoma cell line (SW 480) as a biological test system as well as to determine if ROS production was one of the possible mechanisms of their mixture action. This cell line was chosen since ingestion of contaminated food/water represents an important route of exposure to both Cd and BDE-209, which is why intestinal cells are a common target for the contaminants present in food and water. Cells were treated with single Cd in concentrations of 2.5, 7.5 or 15 mu g Cd/mL (corresponding to 22, 67 or 134 mu M), single BDE-209 in concentrations of 2.5, 5 or 10 mu g BDE209/mL (corresponding to 2.5, 5 or 10 mu M), and their mixtures (design 3 x 3). Mixture of Cd and BDE-209 has shown clear potential to reduce the viability of SW 480 cells, as evidenced by cytotoxicity associated with ROS generation. Factorial regression models used to identify type of interaction revealed synergism related to mixture citotoxicity and additive interaction for the effect on ROS production. The results from this introductory study could contribute to the issue of possible adverse effects associated with co-exposure and body burden with two persistent environmental pollutants, Cd and BDE-209.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Environmental Toxicology and Pharmacology",
title = "Cadmium and decabrominated diphenyl ether mixture: In vitro evaluation of cytotoxic, prooxidative and genotoxic effects",
volume = "38",
number = "2",
pages = "663-671",
doi = "10.1016/j.etap.2014.07.021"
}

Ćurčić, M., Durgo, K., Kopjar, N., Ancić, M., Vučinić, S.,& Antonijević, B.. (2014). Cadmium and decabrominated diphenyl ether mixture: In vitro evaluation of cytotoxic, prooxidative and genotoxic effects. in Environmental Toxicology and Pharmacology
Elsevier Science BV, Amsterdam., 38(2), 663-671.
https://doi.org/10.1016/j.etap.2014.07.021

Ćurčić M, Durgo K, Kopjar N, Ancić M, Vučinić S, Antonijević B. Cadmium and decabrominated diphenyl ether mixture: In vitro evaluation of cytotoxic, prooxidative and genotoxic effects. in Environmental Toxicology and Pharmacology. 2014;38(2):663-671.
doi:10.1016/j.etap.2014.07.021 .

Ćurčić, Marijana, Durgo, Ksenija, Kopjar, Nevenka, Ancić, Mario, Vučinić, Slavica, Antonijević, Biljana, "Cadmium and decabrominated diphenyl ether mixture: In vitro evaluation of cytotoxic, prooxidative and genotoxic effects" in Environmental Toxicology and Pharmacology, 38, no. 2 (2014):663-671,
https://doi.org/10.1016/j.etap.2014.07.021 . .

TY  - CONF
AU  - Ćurčić, Marijana
AU  - Jaćević, Vesna
AU  - Janković, Saša
AU  - Vučinić, Slavica
AU  - Durgo, Ksenija
AU  - Kopjar, Nevenka
AU  - Antonijević, Biljana
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1711
PB  - Elsevier Ireland Ltd, Clare
C3  - Toxicology Letters
T1  - Morphological and histological changes in kidneys induced by BDE209 and Cd
VL  - 211
IS  - Supplement
SP  - S158
EP  - S158
DO  - 10.1016/j.toxlet.2012.03.573
ER  - 

@conference{
author = "Ćurčić, Marijana and Jaćević, Vesna and Janković, Saša and Vučinić, Slavica and Durgo, Ksenija and Kopjar, Nevenka and Antonijević, Biljana",
year = "2012",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Toxicology Letters",
title = "Morphological and histological changes in kidneys induced by BDE209 and Cd",
volume = "211",
number = "Supplement",
pages = "S158-S158",
doi = "10.1016/j.toxlet.2012.03.573"
}

Ćurčić, M., Jaćević, V., Janković, S., Vučinić, S., Durgo, K., Kopjar, N.,& Antonijević, B.. (2012). Morphological and histological changes in kidneys induced by BDE209 and Cd. in Toxicology Letters
Elsevier Ireland Ltd, Clare., 211(Supplement), S158-S158.
https://doi.org/10.1016/j.toxlet.2012.03.573

Ćurčić M, Jaćević V, Janković S, Vučinić S, Durgo K, Kopjar N, Antonijević B. Morphological and histological changes in kidneys induced by BDE209 and Cd. in Toxicology Letters. 2012;211(Supplement):S158-S158.
doi:10.1016/j.toxlet.2012.03.573 .

Ćurčić, Marijana, Jaćević, Vesna, Janković, Saša, Vučinić, Slavica, Durgo, Ksenija, Kopjar, Nevenka, Antonijević, Biljana, "Morphological and histological changes in kidneys induced by BDE209 and Cd" in Toxicology Letters, 211, no. Supplement (2012):S158-S158,
https://doi.org/10.1016/j.toxlet.2012.03.573 . .