TY  - JOUR
AU  - Dražić, Branka
AU  - Antonijević-Nikolić, Mirjana
AU  - Marinović-Cincović, Milena
AU  - Živković-Radovanović, Vukosava
AU  - Borović, Branka
AU  - Tanasković, Slađana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4205
AB  - Two new cationic Cu(II) complexes of cyclam (1,4,8,11-tetraaza- cyclotetradecane) and aminocarboxylate coligands glycine or alanine have been synthesized. The complexes were characterized by elemental analysis (C, H and N), molar electrical conductivity, magnetic susceptibility measurement at room temperature, spectral methods (UV/Vis and Fourier transform infrared), as well as by thermogravimetric (TG) and differential thermal analysis (DTA). The analytical data of the complexes show the formation of mononuclear com- plexes with general formula [Cu(L)cyc](ClO4 )2⋅nH2 O, A) L = glycine, n = 1.5 and B) L = alanine, n = 2.5. The tetradentate ligand cyclam was coordinated to metals through four N donors. The spectroscopic data suggested that the amino carboxylate ligands coordinated via their carboxylate ion moieties. The six- -coordinate octahedral geometry around Cu(II) in both complexes was pre- sumed. TG-DTA analysis indicated that complex B decomposed exothermally in a single step in the range of 310–400 °C. The cytotoxic activity of Cu(II) complexes and the starting ligands were tested against human cervix adenocar- cinoma cell line (HeLa), human melanoma (FemX) and human colon carci- noma (LS174). The IC50 values for the Cu(II) complexes were from 48.35– –82.25 μM. Both complexes were tested for their antimicrobial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli and the yeast Candida albicans.
AB  - Синтетисана су два нова катјонска Cu(II) комплекса са цикламом (1,4,8,11-тетра- азациклотетрадекан) и аминокарбоксилатним колигандима: глицином или аланином. Комплекси су окарактерисани елементалном анализом (C, H, N), моларном електрич- ном проводљивошћу, мерењем магнетног момента на собној температури, спектралним методама (UV/Vis и Fourier трансфомисаном инфрацрвеном спектроскопијом) као и термогравиметријском (TG) и диференцијалном термијском (DTA) анализом. Анали- тички подаци комплекса показују формирање мононуклеарних комплекса опште фор- муле [Cu(L)cyc](ClO4) 2∙nH2O, A) L = глицин, n = 1,5 и B) L = аланин, n = 2,5. Тетра- дентатни лиганд циклам је координован са металима преко четири N донора. Спектро- скопски подаци сугеришу да су аминокарбоксилатни лиганди координовани преко својих карбоксилатних јона. У оба комплекса претпостављена је октаедарска геометрија око Cu(II). TG-DTA анализа показује да се комплекс B егзотермно разлаже у једном кораку у опсегу од 310–400 °C. Цитотоксична активност Cu(II) комплекса и почетних лиганада је тестирана na ћелијским линијама хуманог аденокарцинома грлића мате- рице (HeLa), хуманог меланома (FemiX) и хуманог карцинома дебелог црева (LS174). Вредности IC50 за комплексe Cu(II) биле су од 48,35 до 82,25 μМ. Антимикробна активност oба комплекса je тестирана према Staphylococcus aureus, Bacillus subtilis, Esche- richia coli и Candida albicans.
PB  - Serbian Chemical Society
T2  - Journal of the Serbian Chemical Society
T1  - New copper(II) cyclam complexes with aminocarboxylate co-ligands: Synthesis, characterization, and in vitro antiproliferative and antibacterial studies
T1  - Нови комплекси бакaр(ii)-циклама са аминокарбоксилатним
колигандима: синтеза, карактеризација и in vitro
антипролиферативна и антибактеријска анализа
VL  - 87
IS  - 4
SP  - 451
EP  - 464
DO  - 10.2298/JSC211107026D
ER  - 

@article{
author = "Dražić, Branka and Antonijević-Nikolić, Mirjana and Marinović-Cincović, Milena and Živković-Radovanović, Vukosava and Borović, Branka and Tanasković, Slađana",
year = "2022",
abstract = "Two new cationic Cu(II) complexes of cyclam (1,4,8,11-tetraaza- cyclotetradecane) and aminocarboxylate coligands glycine or alanine have been synthesized. The complexes were characterized by elemental analysis (C, H and N), molar electrical conductivity, magnetic susceptibility measurement at room temperature, spectral methods (UV/Vis and Fourier transform infrared), as well as by thermogravimetric (TG) and differential thermal analysis (DTA). The analytical data of the complexes show the formation of mononuclear com- plexes with general formula [Cu(L)cyc](ClO4 )2⋅nH2 O, A) L = glycine, n = 1.5 and B) L = alanine, n = 2.5. The tetradentate ligand cyclam was coordinated to metals through four N donors. The spectroscopic data suggested that the amino carboxylate ligands coordinated via their carboxylate ion moieties. The six- -coordinate octahedral geometry around Cu(II) in both complexes was pre- sumed. TG-DTA analysis indicated that complex B decomposed exothermally in a single step in the range of 310–400 °C. The cytotoxic activity of Cu(II) complexes and the starting ligands were tested against human cervix adenocar- cinoma cell line (HeLa), human melanoma (FemX) and human colon carci- noma (LS174). The IC50 values for the Cu(II) complexes were from 48.35– –82.25 μM. Both complexes were tested for their antimicrobial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli and the yeast Candida albicans., Синтетисана су два нова катјонска Cu(II) комплекса са цикламом (1,4,8,11-тетра- азациклотетрадекан) и аминокарбоксилатним колигандима: глицином или аланином. Комплекси су окарактерисани елементалном анализом (C, H, N), моларном електрич- ном проводљивошћу, мерењем магнетног момента на собној температури, спектралним методама (UV/Vis и Fourier трансфомисаном инфрацрвеном спектроскопијом) као и термогравиметријском (TG) и диференцијалном термијском (DTA) анализом. Анали- тички подаци комплекса показују формирање мононуклеарних комплекса опште фор- муле [Cu(L)cyc](ClO4) 2∙nH2O, A) L = глицин, n = 1,5 и B) L = аланин, n = 2,5. Тетра- дентатни лиганд циклам је координован са металима преко четири N донора. Спектро- скопски подаци сугеришу да су аминокарбоксилатни лиганди координовани преко својих карбоксилатних јона. У оба комплекса претпостављена је октаедарска геометрија око Cu(II). TG-DTA анализа показује да се комплекс B егзотермно разлаже у једном кораку у опсегу од 310–400 °C. Цитотоксична активност Cu(II) комплекса и почетних лиганада је тестирана na ћелијским линијама хуманог аденокарцинома грлића мате- рице (HeLa), хуманог меланома (FemiX) и хуманог карцинома дебелог црева (LS174). Вредности IC50 за комплексe Cu(II) биле су од 48,35 до 82,25 μМ. Антимикробна активност oба комплекса je тестирана према Staphylococcus aureus, Bacillus subtilis, Esche- richia coli и Candida albicans.",
publisher = "Serbian Chemical Society",
journal = "Journal of the Serbian Chemical Society",
title = "New copper(II) cyclam complexes with aminocarboxylate co-ligands: Synthesis, characterization, and in vitro antiproliferative and antibacterial studies, Нови комплекси бакaр(ii)-циклама са аминокарбоксилатним
колигандима: синтеза, карактеризација и in vitro
антипролиферативна и антибактеријска анализа",
volume = "87",
number = "4",
pages = "451-464",
doi = "10.2298/JSC211107026D"
}

Dražić, B., Antonijević-Nikolić, M., Marinović-Cincović, M., Živković-Radovanović, V., Borović, B.,& Tanasković, S.. (2022). New copper(II) cyclam complexes with aminocarboxylate co-ligands: Synthesis, characterization, and in vitro antiproliferative and antibacterial studies. in Journal of the Serbian Chemical Society
Serbian Chemical Society., 87(4), 451-464.
https://doi.org/10.2298/JSC211107026D

Dražić B, Antonijević-Nikolić M, Marinović-Cincović M, Živković-Radovanović V, Borović B, Tanasković S. New copper(II) cyclam complexes with aminocarboxylate co-ligands: Synthesis, characterization, and in vitro antiproliferative and antibacterial studies. in Journal of the Serbian Chemical Society. 2022;87(4):451-464.
doi:10.2298/JSC211107026D .

Dražić, Branka, Antonijević-Nikolić, Mirjana, Marinović-Cincović, Milena, Živković-Radovanović, Vukosava, Borović, Branka, Tanasković, Slađana, "New copper(II) cyclam complexes with aminocarboxylate co-ligands: Synthesis, characterization, and in vitro antiproliferative and antibacterial studies" in Journal of the Serbian Chemical Society, 87, no. 4 (2022):451-464,
https://doi.org/10.2298/JSC211107026D . .

TY  - JOUR
AU  - Tanasković, Slađana
AU  - Antonijević-Nikolić, Mirjana
AU  - Dražić, Branka
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4051
AB  - A large number of interesting Co (II) complexes with macrocyclicligands have been synthesized and the recognition of its complexes as important bioactive compounds in vitro and in vivo has aroused growing interest in these agents as potential drugs for therapeutic use in various diseases. Numerous available information on their bioinorganic properties and mode of action in several biological systems, combined with the new possibilities imposed by the development of medical chemistry, opens space for the development of a new generation of highly active drugs with minimized side effects which could add significantly to the current clinical research and practice. In this paper we attempt to present some properties of the earlier isolated the first Co(II)tpmc complex for which crystal structure confirmed chair conformation of macrocycle. Complex with formula [Co2(Cl)2tpmc](BF4)2 (tpmc = N,N',N'',N'''-tetrakis(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane), was studied on thermal behaviour and biological activity. TG-DTA analysis indicates that complex decomposition in a single step in the range of 365-435 °C. Investigated cytotoxic activity against two human cancer cell lines: HeLa (human cervix adenocarcinoma) and K562 (human myelogenous leukaemia). Complex was also preliminary assayed in vitro toward bacteria, fungi and mould together with the starting material for the synthesis (ligands, simple salts and solvents) as test substances. Investigated complex showed a moderate activity against strains of bacteria and were inactive against the tested fungi and mould. Minimal inhibitory concentration suppressing the visible growth of bacteria was determined. Biological investigations show the complex has significant cytotoxic potential.
AB  - Poznavanje biološke uloge kobalta i prepoznavanje njegovih kompleksa kao važnih bioaktivnih jedinjenja razlozi su sve veće zainteresovanosti za potencijalnu terapijsku primenu ovih kompleksa kod različitih bolesti. Brojne dostupne informacije o njihovim osobinama i načinu delovanja u nekoliko bioloških sistema, u kombinaciji sa novim mogućnostima koje nameće razvoj medicinske hemije, otvaraju prostor za razvoj nove generacije visoko aktivnih lekova sa minimalnim nuspojavama. U ovom radu smo ispitali neke osobine ranije izolovanog Co (II) tpmc kompleksa, prvog kod koga je rendgenska strukturna analiza potvrdila da se makrciklični ligand nalazi u konformaciji stolice. Ispitivane su termogravimetrijske I biološke osobine kompleksa [Co2(Cl)2tpmc](BF4)2 (tpmc = N, N', N'', N'''-tetrakis (2-piridilmetil) -1,4,8,11-tetraazaciklotetradekan). TG-DTA analiza ukazuje da je razlaganje kompleksa u jednom koraku u rasponu temperature od 365 -435 ° C. Ispitivana je citotoksična aktivnost na dve ljudske ćelijske linije karcinoma: HeLa (adenokarcinom grlića maternice) i K562 (mijelogena leukemija). Antimikrobno djelovanje kompleksa kvantifikovano je određivanjem minimalne inhibitorne koncentracije (MIC) korišćenjem bakterija Staphylococcus saprophyticus, Staphylococcus xylosus, Bacillus cereus, soja kvasca Candida albicans i plesni Aspergillus niger. Biološka ispitivanja su pokazala da kompleks ima značajan citotoksični potencijal I umerenu aktivnost prema bakterijama soja Staphylococcus.
PB  - Engineers Society for Corrosion
T2  - Materials Protection
T1  - Thermal behavior and biological activity of [Co2(Cl)2 tpmc](BF4)2 complex
T1  - Termičko ponašanje i biološka aktivnost [co2(cl)2 tpmc](bf4)2 kompleksa
VL  - 62
IS  - 4
SP  - 291
EP  - 296
DO  - 10.5937/zasmat2104291T
ER  - 

@article{
author = "Tanasković, Slađana and Antonijević-Nikolić, Mirjana and Dražić, Branka",
year = "2021",
abstract = "A large number of interesting Co (II) complexes with macrocyclicligands have been synthesized and the recognition of its complexes as important bioactive compounds in vitro and in vivo has aroused growing interest in these agents as potential drugs for therapeutic use in various diseases. Numerous available information on their bioinorganic properties and mode of action in several biological systems, combined with the new possibilities imposed by the development of medical chemistry, opens space for the development of a new generation of highly active drugs with minimized side effects which could add significantly to the current clinical research and practice. In this paper we attempt to present some properties of the earlier isolated the first Co(II)tpmc complex for which crystal structure confirmed chair conformation of macrocycle. Complex with formula [Co2(Cl)2tpmc](BF4)2 (tpmc = N,N',N'',N'''-tetrakis(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane), was studied on thermal behaviour and biological activity. TG-DTA analysis indicates that complex decomposition in a single step in the range of 365-435 °C. Investigated cytotoxic activity against two human cancer cell lines: HeLa (human cervix adenocarcinoma) and K562 (human myelogenous leukaemia). Complex was also preliminary assayed in vitro toward bacteria, fungi and mould together with the starting material for the synthesis (ligands, simple salts and solvents) as test substances. Investigated complex showed a moderate activity against strains of bacteria and were inactive against the tested fungi and mould. Minimal inhibitory concentration suppressing the visible growth of bacteria was determined. Biological investigations show the complex has significant cytotoxic potential., Poznavanje biološke uloge kobalta i prepoznavanje njegovih kompleksa kao važnih bioaktivnih jedinjenja razlozi su sve veće zainteresovanosti za potencijalnu terapijsku primenu ovih kompleksa kod različitih bolesti. Brojne dostupne informacije o njihovim osobinama i načinu delovanja u nekoliko bioloških sistema, u kombinaciji sa novim mogućnostima koje nameće razvoj medicinske hemije, otvaraju prostor za razvoj nove generacije visoko aktivnih lekova sa minimalnim nuspojavama. U ovom radu smo ispitali neke osobine ranije izolovanog Co (II) tpmc kompleksa, prvog kod koga je rendgenska strukturna analiza potvrdila da se makrciklični ligand nalazi u konformaciji stolice. Ispitivane su termogravimetrijske I biološke osobine kompleksa [Co2(Cl)2tpmc](BF4)2 (tpmc = N, N', N'', N'''-tetrakis (2-piridilmetil) -1,4,8,11-tetraazaciklotetradekan). TG-DTA analiza ukazuje da je razlaganje kompleksa u jednom koraku u rasponu temperature od 365 -435 ° C. Ispitivana je citotoksična aktivnost na dve ljudske ćelijske linije karcinoma: HeLa (adenokarcinom grlića maternice) i K562 (mijelogena leukemija). Antimikrobno djelovanje kompleksa kvantifikovano je određivanjem minimalne inhibitorne koncentracije (MIC) korišćenjem bakterija Staphylococcus saprophyticus, Staphylococcus xylosus, Bacillus cereus, soja kvasca Candida albicans i plesni Aspergillus niger. Biološka ispitivanja su pokazala da kompleks ima značajan citotoksični potencijal I umerenu aktivnost prema bakterijama soja Staphylococcus.",
publisher = "Engineers Society for Corrosion",
journal = "Materials Protection",
title = "Thermal behavior and biological activity of [Co2(Cl)2 tpmc](BF4)2 complex, Termičko ponašanje i biološka aktivnost [co2(cl)2 tpmc](bf4)2 kompleksa",
volume = "62",
number = "4",
pages = "291-296",
doi = "10.5937/zasmat2104291T"
}

Tanasković, S., Antonijević-Nikolić, M.,& Dražić, B.. (2021). Thermal behavior and biological activity of [Co2(Cl)2 tpmc](BF4)2 complex. in Materials Protection
Engineers Society for Corrosion., 62(4), 291-296.
https://doi.org/10.5937/zasmat2104291T

Tanasković S, Antonijević-Nikolić M, Dražić B. Thermal behavior and biological activity of [Co2(Cl)2 tpmc](BF4)2 complex. in Materials Protection. 2021;62(4):291-296.
doi:10.5937/zasmat2104291T .

Tanasković, Slađana, Antonijević-Nikolić, Mirjana, Dražić, Branka, "Thermal behavior and biological activity of [Co2(Cl)2 tpmc](BF4)2 complex" in Materials Protection, 62, no. 4 (2021):291-296,
https://doi.org/10.5937/zasmat2104291T . .

TY  - JOUR
AU  - Antonijević Nikolić, Mirjana
AU  - Mészáros Szécsényi, Katalin
AU  - Dražić, Branka
AU  - Rodić, Marko
AU  - Stanić, Vojislav
AU  - Tanasković, Slađana
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3811
AB  - In vitro cytotoxic evaluation, formation constants and thermal stability of four mixed-ligand Co(II) complexes with tpmc = N,N',N",N'"-tetrakis(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane and carboxylate/dicarboxylate co-ligands of formulas [Co2(benz)2tpmc](ClO4)2•3H2O (1), benz– = benzoate anion; [Co2(L)tpmc](ClO4)2•nH2O, L = pht2– (phthalate dianion), n=2 (2), L = ipht2– (isophthalate dianion), n=4 (3) and L = tpht2–(terephthalate dianion), n=4 (4) are reported. The stoichiometric composition of the compounds in the solution were determined spectrophotometrically using Job's methods. Formation constants, K and Gibbs free energy, ΔG values were calculated. The thermal behavior of the complexes was investigated by simultaneous TG/DSC and TG – MS measurements. The cytotoxic effect of the complexes, the free ligands, the DMSO solvent and cis-platin, as referent cytostatic drug, was evaluated on Human cervix adenocarcinoma (HeLa), human melanoma (Fem-x) and human colon carcinoma (LS174) cell lines. The IC50 values were between 12.7–42.3 μM. The first crystal structure determination of the Co(II) complex [Co2(µ-pht)tpmc](ClO4)2•H2O with boat conformation of tpmc ligand, was also done. The complex crystallizes in monoclinic crystal system, C2/c space group. The geometries around both Co(II) atoms are highly distorted octahedral. The Co(II) ions exhibit CoN4O2 coordination environments with the four nitrogen donor atoms of the tpmc ligand and two oxygen atoms belonging to the one carboxylate group of pht2− ligand. The carboxylate groups of pht2− are coordinated in an endo-bidentate mode. The tpmc ligand adopted a boat conformation in which the two coordinated Co(II) atoms are located on the same side of the ring, with Co•••Co distance amounting 5.4799(5) Å.
PB  - Elsevier B.V.
T2  - Journal of Molecular Structure
T1  - Binuclear Co(II) complexes with macrocycle and carboxylato ligands: structure, cytotoxicity and thermal behavior
VL  - 1236
DO  - 10.1016/j.molstruc.2021.130133
ER  - 

@article{
author = "Antonijević Nikolić, Mirjana and Mészáros Szécsényi, Katalin and Dražić, Branka and Rodić, Marko and Stanić, Vojislav and Tanasković, Slađana",
year = "2021",
abstract = "In vitro cytotoxic evaluation, formation constants and thermal stability of four mixed-ligand Co(II) complexes with tpmc = N,N',N",N'"-tetrakis(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane and carboxylate/dicarboxylate co-ligands of formulas [Co2(benz)2tpmc](ClO4)2•3H2O (1), benz– = benzoate anion; [Co2(L)tpmc](ClO4)2•nH2O, L = pht2– (phthalate dianion), n=2 (2), L = ipht2– (isophthalate dianion), n=4 (3) and L = tpht2–(terephthalate dianion), n=4 (4) are reported. The stoichiometric composition of the compounds in the solution were determined spectrophotometrically using Job's methods. Formation constants, K and Gibbs free energy, ΔG values were calculated. The thermal behavior of the complexes was investigated by simultaneous TG/DSC and TG – MS measurements. The cytotoxic effect of the complexes, the free ligands, the DMSO solvent and cis-platin, as referent cytostatic drug, was evaluated on Human cervix adenocarcinoma (HeLa), human melanoma (Fem-x) and human colon carcinoma (LS174) cell lines. The IC50 values were between 12.7–42.3 μM. The first crystal structure determination of the Co(II) complex [Co2(µ-pht)tpmc](ClO4)2•H2O with boat conformation of tpmc ligand, was also done. The complex crystallizes in monoclinic crystal system, C2/c space group. The geometries around both Co(II) atoms are highly distorted octahedral. The Co(II) ions exhibit CoN4O2 coordination environments with the four nitrogen donor atoms of the tpmc ligand and two oxygen atoms belonging to the one carboxylate group of pht2− ligand. The carboxylate groups of pht2− are coordinated in an endo-bidentate mode. The tpmc ligand adopted a boat conformation in which the two coordinated Co(II) atoms are located on the same side of the ring, with Co•••Co distance amounting 5.4799(5) Å.",
publisher = "Elsevier B.V.",
journal = "Journal of Molecular Structure",
title = "Binuclear Co(II) complexes with macrocycle and carboxylato ligands: structure, cytotoxicity and thermal behavior",
volume = "1236",
doi = "10.1016/j.molstruc.2021.130133"
}

Antonijević Nikolić, M., Mészáros Szécsényi, K., Dražić, B., Rodić, M., Stanić, V.,& Tanasković, S.. (2021). Binuclear Co(II) complexes with macrocycle and carboxylato ligands: structure, cytotoxicity and thermal behavior. in Journal of Molecular Structure
Elsevier B.V.., 1236.
https://doi.org/10.1016/j.molstruc.2021.130133

Antonijević Nikolić M, Mészáros Szécsényi K, Dražić B, Rodić M, Stanić V, Tanasković S. Binuclear Co(II) complexes with macrocycle and carboxylato ligands: structure, cytotoxicity and thermal behavior. in Journal of Molecular Structure. 2021;1236.
doi:10.1016/j.molstruc.2021.130133 .

Antonijević Nikolić, Mirjana, Mészáros Szécsényi, Katalin, Dražić, Branka, Rodić, Marko, Stanić, Vojislav, Tanasković, Slađana, "Binuclear Co(II) complexes with macrocycle and carboxylato ligands: structure, cytotoxicity and thermal behavior" in Journal of Molecular Structure, 1236 (2021),
https://doi.org/10.1016/j.molstruc.2021.130133 . .

TY  - JOUR
AU  - Dražić, Branka
AU  - Antonijević-Nikolić, Mirjana
AU  - Žižak, Željko
AU  - Tanasković, Slađana
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3650
AB  - Two   new   complexes   with   the   general   formula [Cu2(L)tpmc](ClO4)3·nH2O  (tpmc  = N,N′,N′′,N′′′-tetrakis(2-pyridylmethyl)- -1,4,8,11-tetraazacyclotetradecane,  L  = N-methylglycine, n =  3;  L  = N,N- -dimethylglycine, n = 2) were isolated and their composition, some physical and  chemical  properties  and  geometries  were  proposed  based  on  elemental analysis (C, H, N), conductometric and magnetic measurements and spectro-scopic data (UV–Vis, FTIR). It is evident that the complexes are binuclear and an exo coordination mode of the macrocyclic ligand in the boat conformation was proposed. The co-ligands are coordinated as a bridge using both oxygen atoms of the OCO- group. The cytotoxic activity of Cu(II) complexes as well as  their  Co(II)  analogs,  the  starting  ligands  and  the  free  salts  were  tested against human cervix adenocarcinoma cell line (HeLa), human chronic myelo-genous leukemia cells (K562), human breast cancer cell line (MDA-MB-453), and a non-cancerous cell line, human embryonic lung fibroblast (MRC-5). The IC50 values for the Cu(II) complexes were from 21.6±0.04 to 66.1±0.8, and for the Co(II) analogs were within the range from 8.8±0.74 to 15.40±1.52. All four complexes were tested for their antimicrobial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli and the yeast Candida albicans.
PB  - Belgrade : Serbian Chemical Society
T2  - Journal of the Serbian Chemical Society
T1  - Synthesis and characterization of copper(II) octaazamacrocyclic complexes with glycine derivatives. In vitro antiproliferative and antimicrobial evaluation of the Cu(II) and Co(II) analogous
VL  - 85
IS  - 5
SP  - 637
EP  - 649
DO  - 10.2298/JSC190710088D
ER  - 

@article{
author = "Dražić, Branka and Antonijević-Nikolić, Mirjana and Žižak, Željko and Tanasković, Slađana",
year = "2020",
abstract = "Two   new   complexes   with   the   general   formula [Cu2(L)tpmc](ClO4)3·nH2O  (tpmc  = N,N′,N′′,N′′′-tetrakis(2-pyridylmethyl)- -1,4,8,11-tetraazacyclotetradecane,  L  = N-methylglycine, n =  3;  L  = N,N- -dimethylglycine, n = 2) were isolated and their composition, some physical and  chemical  properties  and  geometries  were  proposed  based  on  elemental analysis (C, H, N), conductometric and magnetic measurements and spectro-scopic data (UV–Vis, FTIR). It is evident that the complexes are binuclear and an exo coordination mode of the macrocyclic ligand in the boat conformation was proposed. The co-ligands are coordinated as a bridge using both oxygen atoms of the OCO- group. The cytotoxic activity of Cu(II) complexes as well as  their  Co(II)  analogs,  the  starting  ligands  and  the  free  salts  were  tested against human cervix adenocarcinoma cell line (HeLa), human chronic myelo-genous leukemia cells (K562), human breast cancer cell line (MDA-MB-453), and a non-cancerous cell line, human embryonic lung fibroblast (MRC-5). The IC50 values for the Cu(II) complexes were from 21.6±0.04 to 66.1±0.8, and for the Co(II) analogs were within the range from 8.8±0.74 to 15.40±1.52. All four complexes were tested for their antimicrobial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli and the yeast Candida albicans.",
publisher = "Belgrade : Serbian Chemical Society",
journal = "Journal of the Serbian Chemical Society",
title = "Synthesis and characterization of copper(II) octaazamacrocyclic complexes with glycine derivatives. In vitro antiproliferative and antimicrobial evaluation of the Cu(II) and Co(II) analogous",
volume = "85",
number = "5",
pages = "637-649",
doi = "10.2298/JSC190710088D"
}

Dražić, B., Antonijević-Nikolić, M., Žižak, Ž.,& Tanasković, S.. (2020). Synthesis and characterization of copper(II) octaazamacrocyclic complexes with glycine derivatives. In vitro antiproliferative and antimicrobial evaluation of the Cu(II) and Co(II) analogous. in Journal of the Serbian Chemical Society
Belgrade : Serbian Chemical Society., 85(5), 637-649.
https://doi.org/10.2298/JSC190710088D

Dražić B, Antonijević-Nikolić M, Žižak Ž, Tanasković S. Synthesis and characterization of copper(II) octaazamacrocyclic complexes with glycine derivatives. In vitro antiproliferative and antimicrobial evaluation of the Cu(II) and Co(II) analogous. in Journal of the Serbian Chemical Society. 2020;85(5):637-649.
doi:10.2298/JSC190710088D .

Dražić, Branka, Antonijević-Nikolić, Mirjana, Žižak, Željko, Tanasković, Slađana, "Synthesis and characterization of copper(II) octaazamacrocyclic complexes with glycine derivatives. In vitro antiproliferative and antimicrobial evaluation of the Cu(II) and Co(II) analogous" in Journal of the Serbian Chemical Society, 85, no. 5 (2020):637-649,
https://doi.org/10.2298/JSC190710088D . .

TY  - JOUR
AU  - Antonijević-Nikolić, Mirjana
AU  - Antić-Stanković, Jelena
AU  - Dražić, Branka
AU  - Tanasković, Slađana
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3336
AB  - New cationic mixed-ligand tetranuclear complex [Cu-4(tpht) (tpmc)(2)](ClO4)(6)center dot 5H(2)O (tpmc = N, N', N '', N"'-tetrakis-(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane, H(2)tpht - terephthalic acid (benzene-1,4-dicarboxylic acid)) was prepared and characterized by elemental analysis (C, H, N, Cu), UV/Vis, IR, EPR (X-band) spectra, conductivity, cyclic voltammetry and magnetic measurements (SQUID). Five coordinated geometry for new Cu(II) complex is proposed. The central metal ion is coordinated with two pyridyl and two cyclam nitrogens and bridged with -N-(CH2)(3)-N- fragments of the cyclam ring and OCO- of the terephthalate anion. Copper (II) ions are coordinated out of cyclam rings and one OCO- group from tpht bridges two Cu(II) inside tpmc unit and two Cu(2)tpmc units are bridged by dicarboxylate tpht dianion engaging all four oxygen atoms. Weak ferromagnetic interaction between copper (II) ions in new tetranuclear complex is observed, Weiss constant theta = 0.21 K and C = 0.398 cm(3) Kmol(-1). The new complex, related Cu(II) complexes with bridged benzene carboxylate, [Cu-2(C6H5COO)tpmc](ClO4)(3)center dot CH3OH, [Cu-2(Hpht)tpmc](ClO4)(3)center dot 3H(2)O (H(2)pht = phthalic acid), [Cu-4(ipht) (tpmc)(2)](ClO4)(6)center dot NaClO4 center dot 2CH(3)CN (H(2)ipht = isophthalic acid), solvents, starting salts and ligands were in vitro evaluated for antiproliferative and antibacterial activity. Antiproliferative evaluation was carried out using tumour cell lines: HeLa (human adenocarcinoma) and K562 (chronic myelogenous leukaemia). Among all tested compounds, the ipht complex revealed the highest antiproliferative activity. According to antibacterial screening results, most active compound was the benzoate complex against Micrococcus lysodeikticus.
PB  - Elsevier Science BV, Amsterdam
T2  - Journal of Molecular Structure
T1  - New macrocyclic Cu(II) complex with bridge terephthalate: Synthesis, spectral properties, in vitro cytotoxic and antimicrobial activity. Comparison with related complexes
VL  - 1184
SP  - 41
EP  - 48
DO  - 10.1016/j.molstruc.2018.10.027
ER  - 

@article{
author = "Antonijević-Nikolić, Mirjana and Antić-Stanković, Jelena and Dražić, Branka and Tanasković, Slađana",
year = "2019",
abstract = "New cationic mixed-ligand tetranuclear complex [Cu-4(tpht) (tpmc)(2)](ClO4)(6)center dot 5H(2)O (tpmc = N, N', N '', N"'-tetrakis-(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane, H(2)tpht - terephthalic acid (benzene-1,4-dicarboxylic acid)) was prepared and characterized by elemental analysis (C, H, N, Cu), UV/Vis, IR, EPR (X-band) spectra, conductivity, cyclic voltammetry and magnetic measurements (SQUID). Five coordinated geometry for new Cu(II) complex is proposed. The central metal ion is coordinated with two pyridyl and two cyclam nitrogens and bridged with -N-(CH2)(3)-N- fragments of the cyclam ring and OCO- of the terephthalate anion. Copper (II) ions are coordinated out of cyclam rings and one OCO- group from tpht bridges two Cu(II) inside tpmc unit and two Cu(2)tpmc units are bridged by dicarboxylate tpht dianion engaging all four oxygen atoms. Weak ferromagnetic interaction between copper (II) ions in new tetranuclear complex is observed, Weiss constant theta = 0.21 K and C = 0.398 cm(3) Kmol(-1). The new complex, related Cu(II) complexes with bridged benzene carboxylate, [Cu-2(C6H5COO)tpmc](ClO4)(3)center dot CH3OH, [Cu-2(Hpht)tpmc](ClO4)(3)center dot 3H(2)O (H(2)pht = phthalic acid), [Cu-4(ipht) (tpmc)(2)](ClO4)(6)center dot NaClO4 center dot 2CH(3)CN (H(2)ipht = isophthalic acid), solvents, starting salts and ligands were in vitro evaluated for antiproliferative and antibacterial activity. Antiproliferative evaluation was carried out using tumour cell lines: HeLa (human adenocarcinoma) and K562 (chronic myelogenous leukaemia). Among all tested compounds, the ipht complex revealed the highest antiproliferative activity. According to antibacterial screening results, most active compound was the benzoate complex against Micrococcus lysodeikticus.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Journal of Molecular Structure",
title = "New macrocyclic Cu(II) complex with bridge terephthalate: Synthesis, spectral properties, in vitro cytotoxic and antimicrobial activity. Comparison with related complexes",
volume = "1184",
pages = "41-48",
doi = "10.1016/j.molstruc.2018.10.027"
}

Antonijević-Nikolić, M., Antić-Stanković, J., Dražić, B.,& Tanasković, S.. (2019). New macrocyclic Cu(II) complex with bridge terephthalate: Synthesis, spectral properties, in vitro cytotoxic and antimicrobial activity. Comparison with related complexes. in Journal of Molecular Structure
Elsevier Science BV, Amsterdam., 1184, 41-48.
https://doi.org/10.1016/j.molstruc.2018.10.027

Antonijević-Nikolić M, Antić-Stanković J, Dražić B, Tanasković S. New macrocyclic Cu(II) complex with bridge terephthalate: Synthesis, spectral properties, in vitro cytotoxic and antimicrobial activity. Comparison with related complexes. in Journal of Molecular Structure. 2019;1184:41-48.
doi:10.1016/j.molstruc.2018.10.027 .

Antonijević-Nikolić, Mirjana, Antić-Stanković, Jelena, Dražić, Branka, Tanasković, Slađana, "New macrocyclic Cu(II) complex with bridge terephthalate: Synthesis, spectral properties, in vitro cytotoxic and antimicrobial activity. Comparison with related complexes" in Journal of Molecular Structure, 1184 (2019):41-48,
https://doi.org/10.1016/j.molstruc.2018.10.027 . .

TY  - JOUR
AU  - Tanasković, Slađana
AU  - Antonijević-Nikolić, Mirjana
AU  - Dražić, Branka
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3113
AB  - A new complexes with general formula [Co2(X)2tpmc](BF4)2·Y (X= F-, Y=CH3CN; X= Br-, Y= H2O; tpmc = N,N',N'',N'''-tetrakis(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane), were isolated and their composition, some of physical and chemical properties and their tentative geometries were evaluated based on: elemental analysis (C, H, N), conductometric and magnetic measurements, spectroscopic data (UV/Vis, IR) respectively. Then, we compared synthesized complexes with early described chloro analogous. Both complexes are binuclear with proposed chair conformation of macrocycle. Complex compounds were also preliminary assayed in vitro toward some Gram (+) and Gram (-) bacteria, fungi and mould together with the starting material for the synthesis (ligands, simple salts and solvents) as test substances. In some cases certain antimicrobial activity of the complexes was detected. Minimal inhibitory concentration suppressing the visible growth of bacteria was determined. Both investigated complexes showed a moderate activity against strains of bacteria and were inactive against the tested fungi and mould. Under the same conditions and applied the same concentration of the control group did not show activity.
AB  - Pripremlljena su dva nova kompleksa opšte formule [Co2(X)2tpmc](BF4)2·Y (X= F-, Y=CH3CN; X= Br-, Y= H2O; tpmc = N,N',N'',N'''-tetrakis(2-piridilmetil)-1,4,8,11- tetraazaciklotetradekan), čiji su sastav, neke fizičke i hemijske osobine kao i približne geometrije određene na osnovu elementalne analize (C, H, N), konduktometrijskih i magnetnih merenja i spektroskopskih podataka (UV/Vis, IR). Podaci su upoređeni sa ranije sintetisanim i opisanim hloro analogom. Oba nova kompleksa Co(II) su dinuklearna sa pretpostavljenom egzo koordinacijom makrocikla u konformaciji stolice. Kompleksi su preliminarno testirani na neke Gram (+), Gram (-) bakterije, plesni i kvasce zajedno sa startnim supstancama za sintezu (ligandima, prostim solima i rastvaračima) koje su služile kao test supstance. Određivana je minimalna inhibitorna koncentracija koja sprečava rast bakterija. U nekim slučajevima je nađena izvesna antimikrobna aktivnost. Oba kompleksa su pokazala aktivnost prema bakterijama ali su inaktivni prema gljivicama i kvascima dok je pod istim uslovima i istim primenjenim koncentracijama kontrolna grupa bila neaktivna.
PB  - Inženjersko društvo za koroziju, Beograd
T2  - Zaštita materijala
T1  - New mixed ligand Co(II) complexes: Synthesis, characterization and antimicrobial activity
T1  - Novi mešovito-ligandni kompleksi Co (II)- sinteza, karakterizacija i antimikrobna aktivnost
VL  - 59
IS  - 1
SP  - 51
EP  - 55
DO  - 10.5937/ZasMat1801051T
ER  - 

@article{
author = "Tanasković, Slađana and Antonijević-Nikolić, Mirjana and Dražić, Branka",
year = "2018",
abstract = "A new complexes with general formula [Co2(X)2tpmc](BF4)2·Y (X= F-, Y=CH3CN; X= Br-, Y= H2O; tpmc = N,N',N'',N'''-tetrakis(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane), were isolated and their composition, some of physical and chemical properties and their tentative geometries were evaluated based on: elemental analysis (C, H, N), conductometric and magnetic measurements, spectroscopic data (UV/Vis, IR) respectively. Then, we compared synthesized complexes with early described chloro analogous. Both complexes are binuclear with proposed chair conformation of macrocycle. Complex compounds were also preliminary assayed in vitro toward some Gram (+) and Gram (-) bacteria, fungi and mould together with the starting material for the synthesis (ligands, simple salts and solvents) as test substances. In some cases certain antimicrobial activity of the complexes was detected. Minimal inhibitory concentration suppressing the visible growth of bacteria was determined. Both investigated complexes showed a moderate activity against strains of bacteria and were inactive against the tested fungi and mould. Under the same conditions and applied the same concentration of the control group did not show activity., Pripremlljena su dva nova kompleksa opšte formule [Co2(X)2tpmc](BF4)2·Y (X= F-, Y=CH3CN; X= Br-, Y= H2O; tpmc = N,N',N'',N'''-tetrakis(2-piridilmetil)-1,4,8,11- tetraazaciklotetradekan), čiji su sastav, neke fizičke i hemijske osobine kao i približne geometrije određene na osnovu elementalne analize (C, H, N), konduktometrijskih i magnetnih merenja i spektroskopskih podataka (UV/Vis, IR). Podaci su upoređeni sa ranije sintetisanim i opisanim hloro analogom. Oba nova kompleksa Co(II) su dinuklearna sa pretpostavljenom egzo koordinacijom makrocikla u konformaciji stolice. Kompleksi su preliminarno testirani na neke Gram (+), Gram (-) bakterije, plesni i kvasce zajedno sa startnim supstancama za sintezu (ligandima, prostim solima i rastvaračima) koje su služile kao test supstance. Određivana je minimalna inhibitorna koncentracija koja sprečava rast bakterija. U nekim slučajevima je nađena izvesna antimikrobna aktivnost. Oba kompleksa su pokazala aktivnost prema bakterijama ali su inaktivni prema gljivicama i kvascima dok je pod istim uslovima i istim primenjenim koncentracijama kontrolna grupa bila neaktivna.",
publisher = "Inženjersko društvo za koroziju, Beograd",
journal = "Zaštita materijala",
title = "New mixed ligand Co(II) complexes: Synthesis, characterization and antimicrobial activity, Novi mešovito-ligandni kompleksi Co (II)- sinteza, karakterizacija i antimikrobna aktivnost",
volume = "59",
number = "1",
pages = "51-55",
doi = "10.5937/ZasMat1801051T"
}

Tanasković, S., Antonijević-Nikolić, M.,& Dražić, B.. (2018). New mixed ligand Co(II) complexes: Synthesis, characterization and antimicrobial activity. in Zaštita materijala
Inženjersko društvo za koroziju, Beograd., 59(1), 51-55.
https://doi.org/10.5937/ZasMat1801051T

Tanasković S, Antonijević-Nikolić M, Dražić B. New mixed ligand Co(II) complexes: Synthesis, characterization and antimicrobial activity. in Zaštita materijala. 2018;59(1):51-55.
doi:10.5937/ZasMat1801051T .

Tanasković, Slađana, Antonijević-Nikolić, Mirjana, Dražić, Branka, "New mixed ligand Co(II) complexes: Synthesis, characterization and antimicrobial activity" in Zaštita materijala, 59, no. 1 (2018):51-55,
https://doi.org/10.5937/ZasMat1801051T . .

TY  - JOUR
AU  - Tanasković, Slađana
AU  - Antonijević-Nikolić, Mirjana
AU  - Dražić, Branka
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2834
AB  - The aim of this paper is to compare the efficiency of some analogue of Co (II) and Cu (II) complexes to bacteria pathogenic to humans, which can contaminate vegetables and fruit at any stage of its production. The complexes of Cu(II) and Co(II) with N, N’, N’’, N’’’ - tetrakis (2-pyridylmethyl) -1,4,8,11-tetraazacyclotetradecane (tpmc) and various additional ligands were tested against Gram (+) and Gram (-) bacteria and some strains of fungi. As a control group the free salts of Co(II) and Cu(II) which were used as starting substances in the synthesis, as well as ligands and solvents were tested. The minimum inhibition concentrations suppressing the visible growth of bacteria (MIC) were also screened. Investigated complexes showed a moderate activity against strains of bacteria. Complexes of Co(II) generally showed higher activity then Cu(II) analogues. Under the same conditions and the same concentrations, the control group showed no activity. No compound showed antifungal activity.
AB  - Cilj ovog rada je poređenje efikasnosti nekih analognih kompleksa Co(II) i Cu(II) na bakterijske vrste patogene za čoveka koje mogu kontaminirati povrće i voće u bilo kojoj fazi njegove proizvodnje. Kompleksi Cu (II) i Co (II) sa N, N’, N’’, N’’’ - tetrakis (2-piridilmetil) -1,4,8,11-tetraazaciklotetradekanom (tpmc) i različitim dodatnim ligandima su testirani na Gram (+) i Gram (-) bakterije i neke sojeve gljiva. Kao kontrolna grupa su testirane i proste soli Co(II) i Cu(II) koje su korišćene kao polazne supstance u sintezi kao i ligandi i rastvarači. Određene su minimalne inhibitorne koncentracije (MIC) koje sprečavaju rast mikroorganizama. Ispitivani kompleksi pokazuju umerenu aktivnost prema sojevima bakterija. Kompleksi Co(II) su pokazali generalno već u aktivnost u odnosu na Cu (II) analoge. Pod istim uslovima i u primenjenim istim koncentracijama kontrolne grupe nisu pokazale aktivnost. Nijedno jedinjenje nije ispoljilo antigljivično dejstvo.
PB  - Univerzitet u Novom Sadu - Poljoprivredni fakultet - Departman za zaštitu bilja i životne sredine "dr Pavla Vukasovića", Novi Sad
T2  - Biljni lekar
T1  - Comparison of the antimicrobial activity of related Co(II)/Cu(II) complexes
T1  - Uporedni prikaz antimikrobne aktivnosti srodnih Co(II)/Cu(II) kompleksa
VL  - 45
IS  - 3
SP  - 321
EP  - 325
UR  - https://hdl.handle.net/21.15107/rcub_farfar_2834
ER  - 

@article{
author = "Tanasković, Slađana and Antonijević-Nikolić, Mirjana and Dražić, Branka",
year = "2017",
abstract = "The aim of this paper is to compare the efficiency of some analogue of Co (II) and Cu (II) complexes to bacteria pathogenic to humans, which can contaminate vegetables and fruit at any stage of its production. The complexes of Cu(II) and Co(II) with N, N’, N’’, N’’’ - tetrakis (2-pyridylmethyl) -1,4,8,11-tetraazacyclotetradecane (tpmc) and various additional ligands were tested against Gram (+) and Gram (-) bacteria and some strains of fungi. As a control group the free salts of Co(II) and Cu(II) which were used as starting substances in the synthesis, as well as ligands and solvents were tested. The minimum inhibition concentrations suppressing the visible growth of bacteria (MIC) were also screened. Investigated complexes showed a moderate activity against strains of bacteria. Complexes of Co(II) generally showed higher activity then Cu(II) analogues. Under the same conditions and the same concentrations, the control group showed no activity. No compound showed antifungal activity., Cilj ovog rada je poređenje efikasnosti nekih analognih kompleksa Co(II) i Cu(II) na bakterijske vrste patogene za čoveka koje mogu kontaminirati povrće i voće u bilo kojoj fazi njegove proizvodnje. Kompleksi Cu (II) i Co (II) sa N, N’, N’’, N’’’ - tetrakis (2-piridilmetil) -1,4,8,11-tetraazaciklotetradekanom (tpmc) i različitim dodatnim ligandima su testirani na Gram (+) i Gram (-) bakterije i neke sojeve gljiva. Kao kontrolna grupa su testirane i proste soli Co(II) i Cu(II) koje su korišćene kao polazne supstance u sintezi kao i ligandi i rastvarači. Određene su minimalne inhibitorne koncentracije (MIC) koje sprečavaju rast mikroorganizama. Ispitivani kompleksi pokazuju umerenu aktivnost prema sojevima bakterija. Kompleksi Co(II) su pokazali generalno već u aktivnost u odnosu na Cu (II) analoge. Pod istim uslovima i u primenjenim istim koncentracijama kontrolne grupe nisu pokazale aktivnost. Nijedno jedinjenje nije ispoljilo antigljivično dejstvo.",
publisher = "Univerzitet u Novom Sadu - Poljoprivredni fakultet - Departman za zaštitu bilja i životne sredine "dr Pavla Vukasovića", Novi Sad",
journal = "Biljni lekar",
title = "Comparison of the antimicrobial activity of related Co(II)/Cu(II) complexes, Uporedni prikaz antimikrobne aktivnosti srodnih Co(II)/Cu(II) kompleksa",
volume = "45",
number = "3",
pages = "321-325",
url = "https://hdl.handle.net/21.15107/rcub_farfar_2834"
}

Tanasković, S., Antonijević-Nikolić, M.,& Dražić, B.. (2017). Comparison of the antimicrobial activity of related Co(II)/Cu(II) complexes. in Biljni lekar
Univerzitet u Novom Sadu - Poljoprivredni fakultet - Departman za zaštitu bilja i životne sredine "dr Pavla Vukasovića", Novi Sad., 45(3), 321-325.
https://hdl.handle.net/21.15107/rcub_farfar_2834

Tanasković S, Antonijević-Nikolić M, Dražić B. Comparison of the antimicrobial activity of related Co(II)/Cu(II) complexes. in Biljni lekar. 2017;45(3):321-325.
https://hdl.handle.net/21.15107/rcub_farfar_2834 .

Tanasković, Slađana, Antonijević-Nikolić, Mirjana, Dražić, Branka, "Comparison of the antimicrobial activity of related Co(II)/Cu(II) complexes" in Biljni lekar, 45, no. 3 (2017):321-325,
https://hdl.handle.net/21.15107/rcub_farfar_2834 .

TY  - JOUR
AU  - Tanasković, Slađana
AU  - Antonijević-Nikolić, Mirjana
AU  - Hollo, Berta Barta
AU  - Dražić, Branka
AU  - Stanojković, Tatjana
AU  - Meszaros-Szecsenyi, Katalin
AU  - Vucković, Gordana
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2131
AB  - Seven macrocyclic dinuclear Cu(II) complexes with tpmc = = N,N ',N '',N'''-tetrakis(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane of coordination formulae [Cu(2)tpmc](ClO4)(4) (1), [Cu-2(X)tpmc](ClO4)(3)center dot nH(2)O, X= F-, n = 0 (2), X = Cl-, n = 1 (3), X = Br-, n = 0 (4), X= I-, n = 1 (5), X = = NO2-, n = 0 (6), [Cu-2(NCS)(2)tpmc](ClO4)(2) (7) were evaluated for their cytotoxic activity against human cervix adenocarcinoma (HeLa), human melanoma (Fem-x) and human colon carcinoma (LS174) cell lines. The results were compared with the corresponding data for the cis-diamminedichloridoplafinum(H) (CDDP) as referent cytostatic, as well as with the free ligands and the solvent dimethyl sulfoxide (DMSO) as controls. The complexes showed considerable antiproliferative effect, although significantly less than CDDP. The thermal decomposition pattern of the complexes was determined by simultaneous TG/DSC measurements. The thermal stability of the compounds 2-7 followed the trend of their antiproliferative activity against the HeLa cell line, as well as their corresponding stability constants. The highest thermal stability and cytotoxicity belonged to complex [Cu(2)tpmc](ClO4)(4), with no anionic co-ligand. Complex [Cu-2(NO2)tpmc](ClO4)(3) exhibited a selective cytotoxicity against LS174 cells, at the level of the most active [Cu(2)tpmc](ClO4)(4).
PB  - Srpsko hemijsko društvo, Beograd
T2  - Journal of the Serbian Chemical Society
T1  - Correlations between the in vitro antiproliferative activity, structure and thermal stability of some macrocyclic dinuclear Cu(II) complexes
VL  - 79
IS  - 10
SP  - 1235
EP  - 1247
DO  - 10.2298/JSC140404044T
ER  - 

@article{
author = "Tanasković, Slađana and Antonijević-Nikolić, Mirjana and Hollo, Berta Barta and Dražić, Branka and Stanojković, Tatjana and Meszaros-Szecsenyi, Katalin and Vucković, Gordana",
year = "2014",
abstract = "Seven macrocyclic dinuclear Cu(II) complexes with tpmc = = N,N ',N '',N'''-tetrakis(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane of coordination formulae [Cu(2)tpmc](ClO4)(4) (1), [Cu-2(X)tpmc](ClO4)(3)center dot nH(2)O, X= F-, n = 0 (2), X = Cl-, n = 1 (3), X = Br-, n = 0 (4), X= I-, n = 1 (5), X = = NO2-, n = 0 (6), [Cu-2(NCS)(2)tpmc](ClO4)(2) (7) were evaluated for their cytotoxic activity against human cervix adenocarcinoma (HeLa), human melanoma (Fem-x) and human colon carcinoma (LS174) cell lines. The results were compared with the corresponding data for the cis-diamminedichloridoplafinum(H) (CDDP) as referent cytostatic, as well as with the free ligands and the solvent dimethyl sulfoxide (DMSO) as controls. The complexes showed considerable antiproliferative effect, although significantly less than CDDP. The thermal decomposition pattern of the complexes was determined by simultaneous TG/DSC measurements. The thermal stability of the compounds 2-7 followed the trend of their antiproliferative activity against the HeLa cell line, as well as their corresponding stability constants. The highest thermal stability and cytotoxicity belonged to complex [Cu(2)tpmc](ClO4)(4), with no anionic co-ligand. Complex [Cu-2(NO2)tpmc](ClO4)(3) exhibited a selective cytotoxicity against LS174 cells, at the level of the most active [Cu(2)tpmc](ClO4)(4).",
publisher = "Srpsko hemijsko društvo, Beograd",
journal = "Journal of the Serbian Chemical Society",
title = "Correlations between the in vitro antiproliferative activity, structure and thermal stability of some macrocyclic dinuclear Cu(II) complexes",
volume = "79",
number = "10",
pages = "1235-1247",
doi = "10.2298/JSC140404044T"
}

Tanasković, S., Antonijević-Nikolić, M., Hollo, B. B., Dražić, B., Stanojković, T., Meszaros-Szecsenyi, K.,& Vucković, G.. (2014). Correlations between the in vitro antiproliferative activity, structure and thermal stability of some macrocyclic dinuclear Cu(II) complexes. in Journal of the Serbian Chemical Society
Srpsko hemijsko društvo, Beograd., 79(10), 1235-1247.
https://doi.org/10.2298/JSC140404044T

Tanasković S, Antonijević-Nikolić M, Hollo BB, Dražić B, Stanojković T, Meszaros-Szecsenyi K, Vucković G. Correlations between the in vitro antiproliferative activity, structure and thermal stability of some macrocyclic dinuclear Cu(II) complexes. in Journal of the Serbian Chemical Society. 2014;79(10):1235-1247.
doi:10.2298/JSC140404044T .

Tanasković, Slađana, Antonijević-Nikolić, Mirjana, Hollo, Berta Barta, Dražić, Branka, Stanojković, Tatjana, Meszaros-Szecsenyi, Katalin, Vucković, Gordana, "Correlations between the in vitro antiproliferative activity, structure and thermal stability of some macrocyclic dinuclear Cu(II) complexes" in Journal of the Serbian Chemical Society, 79, no. 10 (2014):1235-1247,
https://doi.org/10.2298/JSC140404044T . .

TY  - JOUR
AU  - Dražić, Branka
AU  - Grgurić-Sipka, Sanja
AU  - Ivanović, Ivanka
AU  - Tešić, Živoslav
AU  - Popović, Gordana
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1723
AB  - Acid-base equilibria of the aqua adducts of Ru(II) arene complexes, general formulae [(eta(6)-p-cymene)Ru (L1-3)Cl-2] where L-1 = 3-acetylpyridine (1), L-2 = 4-acetylpyridine (2) and L-3 = 2-amino-5-chloropyridine (3), then [(eta(6)-p-cymene)Ru(HL4)Cl-2] with HL4 = isonicotinic acid (4); [(eta(6)-p-cymene)Ru(HL5-8)Cl] where H2L5 = 2,3-pyridine dicarboxylic acid (5), H2L6 = 2,4-pyridine dicarboxylic acid (6), H2L7 = 2,5-pyridine dicarboxylic acid (7) and H2L8 = 2,6-pyridine dicarboxylic acid (8) have been studied. pK (a) values were determined by potentiometry at 25 A degrees C and constant ionic strength of 0.1 M NaNO3. The assumed equilibria were confirmed by UV and H-1-NMR spectroscopy.
PB  - Springer, New York
T2  - Journal of the Iranian Chemical Society
T1  - Acid-base equilibria of the aqua adducts of Ru(II) arene complexes with functionalised pyridines
VL  - 9
IS  - 1
SP  - 7
EP  - 12
DO  - 10.1007/s13738-011-0001-3
ER  - 

@article{
author = "Dražić, Branka and Grgurić-Sipka, Sanja and Ivanović, Ivanka and Tešić, Živoslav and Popović, Gordana",
year = "2012",
abstract = "Acid-base equilibria of the aqua adducts of Ru(II) arene complexes, general formulae [(eta(6)-p-cymene)Ru (L1-3)Cl-2] where L-1 = 3-acetylpyridine (1), L-2 = 4-acetylpyridine (2) and L-3 = 2-amino-5-chloropyridine (3), then [(eta(6)-p-cymene)Ru(HL4)Cl-2] with HL4 = isonicotinic acid (4); [(eta(6)-p-cymene)Ru(HL5-8)Cl] where H2L5 = 2,3-pyridine dicarboxylic acid (5), H2L6 = 2,4-pyridine dicarboxylic acid (6), H2L7 = 2,5-pyridine dicarboxylic acid (7) and H2L8 = 2,6-pyridine dicarboxylic acid (8) have been studied. pK (a) values were determined by potentiometry at 25 A degrees C and constant ionic strength of 0.1 M NaNO3. The assumed equilibria were confirmed by UV and H-1-NMR spectroscopy.",
publisher = "Springer, New York",
journal = "Journal of the Iranian Chemical Society",
title = "Acid-base equilibria of the aqua adducts of Ru(II) arene complexes with functionalised pyridines",
volume = "9",
number = "1",
pages = "7-12",
doi = "10.1007/s13738-011-0001-3"
}

Dražić, B., Grgurić-Sipka, S., Ivanović, I., Tešić, Ž.,& Popović, G.. (2012). Acid-base equilibria of the aqua adducts of Ru(II) arene complexes with functionalised pyridines. in Journal of the Iranian Chemical Society
Springer, New York., 9(1), 7-12.
https://doi.org/10.1007/s13738-011-0001-3

Dražić B, Grgurić-Sipka S, Ivanović I, Tešić Ž, Popović G. Acid-base equilibria of the aqua adducts of Ru(II) arene complexes with functionalised pyridines. in Journal of the Iranian Chemical Society. 2012;9(1):7-12.
doi:10.1007/s13738-011-0001-3 .

Dražić, Branka, Grgurić-Sipka, Sanja, Ivanović, Ivanka, Tešić, Živoslav, Popović, Gordana, "Acid-base equilibria of the aqua adducts of Ru(II) arene complexes with functionalised pyridines" in Journal of the Iranian Chemical Society, 9, no. 1 (2012):7-12,
https://doi.org/10.1007/s13738-011-0001-3 . .

TY  - JOUR
AU  - Dražić, Branka
AU  - Popović, Gordana
AU  - Jelić, Ratomir
AU  - Sladić, Dušan
AU  - Mitić, Dragana
AU  - Anđelković, Katarina
AU  - Tešić, Živoslav
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1296
AB  - Acid-base equilibria of Zn(II) and Fe(III) complexes with N',N'2-bis- [(1E)-1-(2-pyridyl)ethylidene]ethanedihydrazide (ligand L1) and N',N'2-bis[(1E)- -1-(2-pyridyl)ethylidene]propanedihydrazide (ligand L2), i.e., [Fe(L1)Cl2(H2O)], [Fe(L2)Cl(H2O)]2+, [Zn(L1)(H2O)3]+ and [Zn(L2)(H2O)2]2+, which expressed cytotoxic activity, were investigated in aqueous media. The equilibrium constants were determined potentiometrically at 25°C at a constant ionic strength of 0.10 mol/dm3 (Na2SO4). The results showed that at pH  lt  8 both the Fe(III) complexes studied here have three, while [Zn(L1)(H2O)3]+ and [Zn(L2)(H2O)2]2+ have one and two titratable protons, respectively. Based on the obtained values for the equilibrium constants, protonation schemes of the examined complexes are proposed.
AB  - U ovom radu su proučavane kiselinsko-bazne ravnoteže u vodenim rastvorima kompleksa Zn(II) i Fe(III) sa N',N'2-bis[(1E)-1-(2-piridil)etiliden]etandihidrazidom (ligand L1) i N',N'2-bis[(1E)-1-(2-piridil)etiliden]propandihidrazidom (ligand L2), tj. [Fe(L1)Cl2(H2O)], [Fe(L2)Cl(H2O)]2+, [Zn(L1)(H2O)3]+, [Zn(L2)(H2O)2]2+, koji pokazuju citotoksičnu aktivnost. Ravnotežne konstante su određivane potenciometrijski, na temperaturi 25°C i pri konstantnoj jonskoj jačini 0,10 mol/dm3 Na2SO4. Utvrđeno je da u intervalu pH  lt  8 ispitivani Fe(III) kompleksi imaju tri, [Zn(L1)(H2O)3]+ jedan, a [Zn(L2)(H2O)2]2+ dva protona koji mogu da se titrišu. Na osnovu dobijenih vrednosti za konstante, pretpostavljene su i odgovarajuće protonacione sheme.
PB  - Srpsko hemijsko društvo, Beograd
T2  - Journal of the Serbian Chemical Society
T1  - Acid-base equilibria of the Zn(II) and Fe(III) complexes with condensation products of 2-acetylpyridine and the dihydrazide of oxalic and malonic acid
T1  - Kiselinsko-bazne ravnoteže kompleksa Fe(III) i Zn(II) sa kondenzacionim derivatima 2-acetilpiridina i hidrazida oksalne, odnosno malonske kiseline
VL  - 74
IS  - 3
SP  - 269
EP  - 277
DO  - 10.2298/JSC0903269D
ER  - 

@article{
author = "Dražić, Branka and Popović, Gordana and Jelić, Ratomir and Sladić, Dušan and Mitić, Dragana and Anđelković, Katarina and Tešić, Živoslav",
year = "2009",
abstract = "Acid-base equilibria of Zn(II) and Fe(III) complexes with N',N'2-bis- [(1E)-1-(2-pyridyl)ethylidene]ethanedihydrazide (ligand L1) and N',N'2-bis[(1E)- -1-(2-pyridyl)ethylidene]propanedihydrazide (ligand L2), i.e., [Fe(L1)Cl2(H2O)], [Fe(L2)Cl(H2O)]2+, [Zn(L1)(H2O)3]+ and [Zn(L2)(H2O)2]2+, which expressed cytotoxic activity, were investigated in aqueous media. The equilibrium constants were determined potentiometrically at 25°C at a constant ionic strength of 0.10 mol/dm3 (Na2SO4). The results showed that at pH  lt  8 both the Fe(III) complexes studied here have three, while [Zn(L1)(H2O)3]+ and [Zn(L2)(H2O)2]2+ have one and two titratable protons, respectively. Based on the obtained values for the equilibrium constants, protonation schemes of the examined complexes are proposed., U ovom radu su proučavane kiselinsko-bazne ravnoteže u vodenim rastvorima kompleksa Zn(II) i Fe(III) sa N',N'2-bis[(1E)-1-(2-piridil)etiliden]etandihidrazidom (ligand L1) i N',N'2-bis[(1E)-1-(2-piridil)etiliden]propandihidrazidom (ligand L2), tj. [Fe(L1)Cl2(H2O)], [Fe(L2)Cl(H2O)]2+, [Zn(L1)(H2O)3]+, [Zn(L2)(H2O)2]2+, koji pokazuju citotoksičnu aktivnost. Ravnotežne konstante su određivane potenciometrijski, na temperaturi 25°C i pri konstantnoj jonskoj jačini 0,10 mol/dm3 Na2SO4. Utvrđeno je da u intervalu pH  lt  8 ispitivani Fe(III) kompleksi imaju tri, [Zn(L1)(H2O)3]+ jedan, a [Zn(L2)(H2O)2]2+ dva protona koji mogu da se titrišu. Na osnovu dobijenih vrednosti za konstante, pretpostavljene su i odgovarajuće protonacione sheme.",
publisher = "Srpsko hemijsko društvo, Beograd",
journal = "Journal of the Serbian Chemical Society",
title = "Acid-base equilibria of the Zn(II) and Fe(III) complexes with condensation products of 2-acetylpyridine and the dihydrazide of oxalic and malonic acid, Kiselinsko-bazne ravnoteže kompleksa Fe(III) i Zn(II) sa kondenzacionim derivatima 2-acetilpiridina i hidrazida oksalne, odnosno malonske kiseline",
volume = "74",
number = "3",
pages = "269-277",
doi = "10.2298/JSC0903269D"
}

Dražić, B., Popović, G., Jelić, R., Sladić, D., Mitić, D., Anđelković, K.,& Tešić, Ž.. (2009). Acid-base equilibria of the Zn(II) and Fe(III) complexes with condensation products of 2-acetylpyridine and the dihydrazide of oxalic and malonic acid. in Journal of the Serbian Chemical Society
Srpsko hemijsko društvo, Beograd., 74(3), 269-277.
https://doi.org/10.2298/JSC0903269D

Dražić B, Popović G, Jelić R, Sladić D, Mitić D, Anđelković K, Tešić Ž. Acid-base equilibria of the Zn(II) and Fe(III) complexes with condensation products of 2-acetylpyridine and the dihydrazide of oxalic and malonic acid. in Journal of the Serbian Chemical Society. 2009;74(3):269-277.
doi:10.2298/JSC0903269D .

Dražić, Branka, Popović, Gordana, Jelić, Ratomir, Sladić, Dušan, Mitić, Dragana, Anđelković, Katarina, Tešić, Živoslav, "Acid-base equilibria of the Zn(II) and Fe(III) complexes with condensation products of 2-acetylpyridine and the dihydrazide of oxalic and malonic acid" in Journal of the Serbian Chemical Society, 74, no. 3 (2009):269-277,
https://doi.org/10.2298/JSC0903269D . .

TY  - JOUR
AU  - Pfendt, Lidija
AU  - Dražić, Branka
AU  - Popović, Gordana
AU  - Drakulić, Branko
AU  - Vitnik, Željko J.
AU  - Juranić, Ivan O.
PY  - 2003
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/457
AB  - For a series of seven unsaturated and seven epoxy di- and tricarboxylic acids, pK(a)(a) values were determined potentiometrically in aqueous media at 25 degreesC and an ionic strength of 0.1 M (NaCl). The thermodynamic pKaa values were correlated with the atomic charges of carboxylic group calculated by the MNDO-PM3 semiempirical MO method.
PB  - Scientific Reviews Ltd.
T2  - Journal of Chemical Research - Part S
T1  - Determination of all pK(a) values of some di- and tri-carboxylic unsaturated and epoxy acids and their polylinear correlation with the carboxylic group atomic charges
IS  - 5
SP  - 247
EP  - 248
UR  - https://hdl.handle.net/21.15107/rcub_farfar_457
ER  - 

@article{
author = "Pfendt, Lidija and Dražić, Branka and Popović, Gordana and Drakulić, Branko and Vitnik, Željko J. and Juranić, Ivan O.",
year = "2003",
abstract = "For a series of seven unsaturated and seven epoxy di- and tricarboxylic acids, pK(a)(a) values were determined potentiometrically in aqueous media at 25 degreesC and an ionic strength of 0.1 M (NaCl). The thermodynamic pKaa values were correlated with the atomic charges of carboxylic group calculated by the MNDO-PM3 semiempirical MO method.",
publisher = "Scientific Reviews Ltd.",
journal = "Journal of Chemical Research - Part S",
title = "Determination of all pK(a) values of some di- and tri-carboxylic unsaturated and epoxy acids and their polylinear correlation with the carboxylic group atomic charges",
number = "5",
pages = "247-248",
url = "https://hdl.handle.net/21.15107/rcub_farfar_457"
}

Pfendt, L., Dražić, B., Popović, G., Drakulić, B., Vitnik, Ž. J.,& Juranić, I. O.. (2003). Determination of all pK(a) values of some di- and tri-carboxylic unsaturated and epoxy acids and their polylinear correlation with the carboxylic group atomic charges. in Journal of Chemical Research - Part S
Scientific Reviews Ltd..(5), 247-248.
https://hdl.handle.net/21.15107/rcub_farfar_457

Pfendt L, Dražić B, Popović G, Drakulić B, Vitnik ŽJ, Juranić IO. Determination of all pK(a) values of some di- and tri-carboxylic unsaturated and epoxy acids and their polylinear correlation with the carboxylic group atomic charges. in Journal of Chemical Research - Part S. 2003;(5):247-248.
https://hdl.handle.net/21.15107/rcub_farfar_457 .

Pfendt, Lidija, Dražić, Branka, Popović, Gordana, Drakulić, Branko, Vitnik, Željko J., Juranić, Ivan O., "Determination of all pK(a) values of some di- and tri-carboxylic unsaturated and epoxy acids and their polylinear correlation with the carboxylic group atomic charges" in Journal of Chemical Research - Part S, no. 5 (2003):247-248,
https://hdl.handle.net/21.15107/rcub_farfar_457 .