TY  - JOUR
AU  - Stanojković, Ivana
AU  - Kotur-Stevuljević, Jelena
AU  - Spasić, Slavica
AU  - Milenković, Branislava
AU  - Vujić, Tatjana
AU  - Stefanović, Aleksandra
AU  - Ivanišević, Jasmina
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1922
AB  - Background: The natural course of chronic obstructive pulmonary disease (COPD) is complicated by the development of systemic consequences and co-morbidities. Increasing evidence indicates that COPD and osteoporosis are strongly linked. The common features in COPD pathology, history of smoking, age, inactivity, systemic inflammation, and use of systemic corticosteroids, are important risk factors for osteoporosis. Methods: Pulmonary function, matrix metalloproteinase, tissue inhibitor of metalloproteinases, oxidative stress parameters, inflammatory markers and bone resorption marker were measured in 85 COPD patients and 47 healthy subjects. In patients, all parameters were assessed at two time points: one day after admission during exacerbation and about 30 days after, in the stable state of disease. Results: In patients, bone resorption marker collagen type I p-isomerized C-terminal telopeptide (beta CL) was increased during exacerbation: geometric mean 0.521, compared with stable patients 0.408, p  lt  0.01, and control subjects 0.362 ng/ml, p  lt  0.001. During exacerbation high sensitivity C-reactive protein (hsCRP) and neutrophil count were significantly higher in COPD patients compared with the control group, p  lt  0.001. Matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) concentrations were significantly higher in COPD patients, stable state or exacerbation, compared with control subjects, p  lt  0.001. In patients during exacerbation, total oxidative status (TOS) was higher compared with the stable state, p  lt  0.05 and control group, p  lt  0.001. Multiple linear regression for the joint influence of inflammation, hypoxia and oxidative status during exacerbation showed almost 60% influence on the variability of beta CL concentrations. Conclusion: Intensification of disease characteristic symptoms such as inflammation, hypoxia, protease/antiprotease imbalance and oxidative stress, during exacerbation episodes in COPD patients may also contribute to increased bone resorption.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Clinical Biochemistry
T1  - Relationship between bone resorption, oxidative stress and inflammation in severe COPD exacerbation
VL  - 46
IS  - 16-17
SP  - 1678
EP  - 1682
DO  - 10.1016/j.clinbiochem.2013.08.003
ER  - 

@article{
author = "Stanojković, Ivana and Kotur-Stevuljević, Jelena and Spasić, Slavica and Milenković, Branislava and Vujić, Tatjana and Stefanović, Aleksandra and Ivanišević, Jasmina",
year = "2013",
abstract = "Background: The natural course of chronic obstructive pulmonary disease (COPD) is complicated by the development of systemic consequences and co-morbidities. Increasing evidence indicates that COPD and osteoporosis are strongly linked. The common features in COPD pathology, history of smoking, age, inactivity, systemic inflammation, and use of systemic corticosteroids, are important risk factors for osteoporosis. Methods: Pulmonary function, matrix metalloproteinase, tissue inhibitor of metalloproteinases, oxidative stress parameters, inflammatory markers and bone resorption marker were measured in 85 COPD patients and 47 healthy subjects. In patients, all parameters were assessed at two time points: one day after admission during exacerbation and about 30 days after, in the stable state of disease. Results: In patients, bone resorption marker collagen type I p-isomerized C-terminal telopeptide (beta CL) was increased during exacerbation: geometric mean 0.521, compared with stable patients 0.408, p  lt  0.01, and control subjects 0.362 ng/ml, p  lt  0.001. During exacerbation high sensitivity C-reactive protein (hsCRP) and neutrophil count were significantly higher in COPD patients compared with the control group, p  lt  0.001. Matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) concentrations were significantly higher in COPD patients, stable state or exacerbation, compared with control subjects, p  lt  0.001. In patients during exacerbation, total oxidative status (TOS) was higher compared with the stable state, p  lt  0.05 and control group, p  lt  0.001. Multiple linear regression for the joint influence of inflammation, hypoxia and oxidative status during exacerbation showed almost 60% influence on the variability of beta CL concentrations. Conclusion: Intensification of disease characteristic symptoms such as inflammation, hypoxia, protease/antiprotease imbalance and oxidative stress, during exacerbation episodes in COPD patients may also contribute to increased bone resorption.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Clinical Biochemistry",
title = "Relationship between bone resorption, oxidative stress and inflammation in severe COPD exacerbation",
volume = "46",
number = "16-17",
pages = "1678-1682",
doi = "10.1016/j.clinbiochem.2013.08.003"
}

Stanojković, I., Kotur-Stevuljević, J., Spasić, S., Milenković, B., Vujić, T., Stefanović, A.,& Ivanišević, J.. (2013). Relationship between bone resorption, oxidative stress and inflammation in severe COPD exacerbation. in Clinical Biochemistry
Pergamon-Elsevier Science Ltd, Oxford., 46(16-17), 1678-1682.
https://doi.org/10.1016/j.clinbiochem.2013.08.003

Stanojković I, Kotur-Stevuljević J, Spasić S, Milenković B, Vujić T, Stefanović A, Ivanišević J. Relationship between bone resorption, oxidative stress and inflammation in severe COPD exacerbation. in Clinical Biochemistry. 2013;46(16-17):1678-1682.
doi:10.1016/j.clinbiochem.2013.08.003 .

Stanojković, Ivana, Kotur-Stevuljević, Jelena, Spasić, Slavica, Milenković, Branislava, Vujić, Tatjana, Stefanović, Aleksandra, Ivanišević, Jasmina, "Relationship between bone resorption, oxidative stress and inflammation in severe COPD exacerbation" in Clinical Biochemistry, 46, no. 16-17 (2013):1678-1682,
https://doi.org/10.1016/j.clinbiochem.2013.08.003 . .

TY  - JOUR
AU  - Stanojković, Ivana
AU  - Kotur-Stevuljević, Jelena
AU  - Milenković, Branislava
AU  - Spasić, Slavica
AU  - Vujić, Tatjana
AU  - Stefanović, Aleksandra
AU  - Ilić, Aleksandra
AU  - Ivanišević, Jasmina
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1514
AB  - Background: Oxidative stress and inflammation play an important role in the pathogenesis of chronic: obstructive pulmonary disease (COPD). Objective: Pulmonary function, oxidative stress parameters and inflammatory markers were measured in 74 patients with severe COPD exacerbation and 41 healthy subjects. In patients all parameters were assessed at two time points: Firstly, one day after admission and secondly, after 7-10 days when they were clinically stable enough to be discharged. Patients were divided in two groups according the presence of ischemic heart disease (IHD): IHD positive (IHD+) patients and IHD negative (IHD-) patients. Methods and Results: During hospitalisation O(2)(center dot-), malondialdehyde (MDA), advanced oxidation protein products (AOPP) and total oxidant status (TOS) increased and were higher at discharge compared with admission and the control group. Superoxide dismutase (SOD) activity was significantly lower in COPD patients at both time points compared with the control group. Total antioxidant status (TAS) was significantly lower and the prooxidant-antioxidant balance (PAB) was higher at both time points in COPD patients compared with the control group. High sensitive C-reactive protein (hsCRP) and also the neutrophil count were significantly higher at admission compared with discharge. Paraoxonase 1 (PON1) enzymatic activities in COPD patients did not differ compared with the control group. IHD+ COPD patients had significantly lower PON1 activity but higher PAB levels and hsCRP concentrations, compared with IHD- COPD patients. Conclusion: The oxidant/antioxidant imbalance was significantly pronounced in patients with COPD exacerbation for at least 24 hours following their admission and when they were clinically stable enough to be discharged. Increased oxidative stress, elevated systemic inflammation and decreased antioxidant defence were common in end-stage disease and particularly COPD patients with ischemic heart disease.
PB  - W B Saunders Co Ltd, London
T2  - Revue Roumaine de Chimie
T1  - Pulmonary function, oxidative stress and inflammatory markers in severe COPD exacerbation
VL  - 105
DO  - 10.1016/S0954-6111(11)70008-7
ER  - 

@article{
author = "Stanojković, Ivana and Kotur-Stevuljević, Jelena and Milenković, Branislava and Spasić, Slavica and Vujić, Tatjana and Stefanović, Aleksandra and Ilić, Aleksandra and Ivanišević, Jasmina",
year = "2011",
abstract = "Background: Oxidative stress and inflammation play an important role in the pathogenesis of chronic: obstructive pulmonary disease (COPD). Objective: Pulmonary function, oxidative stress parameters and inflammatory markers were measured in 74 patients with severe COPD exacerbation and 41 healthy subjects. In patients all parameters were assessed at two time points: Firstly, one day after admission and secondly, after 7-10 days when they were clinically stable enough to be discharged. Patients were divided in two groups according the presence of ischemic heart disease (IHD): IHD positive (IHD+) patients and IHD negative (IHD-) patients. Methods and Results: During hospitalisation O(2)(center dot-), malondialdehyde (MDA), advanced oxidation protein products (AOPP) and total oxidant status (TOS) increased and were higher at discharge compared with admission and the control group. Superoxide dismutase (SOD) activity was significantly lower in COPD patients at both time points compared with the control group. Total antioxidant status (TAS) was significantly lower and the prooxidant-antioxidant balance (PAB) was higher at both time points in COPD patients compared with the control group. High sensitive C-reactive protein (hsCRP) and also the neutrophil count were significantly higher at admission compared with discharge. Paraoxonase 1 (PON1) enzymatic activities in COPD patients did not differ compared with the control group. IHD+ COPD patients had significantly lower PON1 activity but higher PAB levels and hsCRP concentrations, compared with IHD- COPD patients. Conclusion: The oxidant/antioxidant imbalance was significantly pronounced in patients with COPD exacerbation for at least 24 hours following their admission and when they were clinically stable enough to be discharged. Increased oxidative stress, elevated systemic inflammation and decreased antioxidant defence were common in end-stage disease and particularly COPD patients with ischemic heart disease.",
publisher = "W B Saunders Co Ltd, London",
journal = "Revue Roumaine de Chimie",
title = "Pulmonary function, oxidative stress and inflammatory markers in severe COPD exacerbation",
volume = "105",
doi = "10.1016/S0954-6111(11)70008-7"
}

Stanojković, I., Kotur-Stevuljević, J., Milenković, B., Spasić, S., Vujić, T., Stefanović, A., Ilić, A.,& Ivanišević, J.. (2011). Pulmonary function, oxidative stress and inflammatory markers in severe COPD exacerbation. in Revue Roumaine de Chimie
W B Saunders Co Ltd, London., 105.
https://doi.org/10.1016/S0954-6111(11)70008-7

Stanojković I, Kotur-Stevuljević J, Milenković B, Spasić S, Vujić T, Stefanović A, Ilić A, Ivanišević J. Pulmonary function, oxidative stress and inflammatory markers in severe COPD exacerbation. in Revue Roumaine de Chimie. 2011;105.
doi:10.1016/S0954-6111(11)70008-7 .

Stanojković, Ivana, Kotur-Stevuljević, Jelena, Milenković, Branislava, Spasić, Slavica, Vujić, Tatjana, Stefanović, Aleksandra, Ilić, Aleksandra, Ivanišević, Jasmina, "Pulmonary function, oxidative stress and inflammatory markers in severe COPD exacerbation" in Revue Roumaine de Chimie, 105 (2011),
https://doi.org/10.1016/S0954-6111(11)70008-7 . .