@article{
author = "Jovanović, Marija and Petrović, Miloš and Stojanović, Dušica and Ibrić, Svetlana and Uskoković, Petar",
year = "2022",
abstract = "In this work, a blend of gelatin A (GA) and polyvinylpyrrolidone (PVP K30) was used for
semi-solid 3D printing of bone scaffold for ibuprofen (IBU) delivery. The cross-linking of the
obtained scaffold was performed with a 1% glutaraldehyde (GTA) solution, followed by
lyophilization. The thermal and mechanical properties, as well as drug release profiles, and drug
kinetics of prepared scaffolds were investigated. The cross-linked and lyophilized scaffold has
shown good thermal stability, mechanical properties, and prolonged release of IBU following the
Fickian diffusion process., Nosač za dostavu ibuprofena (IBU) u koštanom tkivu dobijen je metodom 3D štampe ekstruzijom iz paste uz korišćenje smeše polimera želatina A (GA) i polivinilpirolidona (PVP K30). Dobijeni nosač je umrežen sa 1% rastvorom glutaraldehida (GTA), nakon čega je usledio proces liofilizacije uzoraka. Ispitivana su mehanička i termička svojstva, profili i kinetika oslobađanja ibuprofena iz dobijenih nosača. Umrežen i liofilizovan nosač pokazao je dobru termičku stabilnost i mehanička svojstva, kao i produženo oslobađanje IBU-a koje prati kinetiku po Fikovom zakonu difuzije.",
publisher = "Pharmaceutical Association of Serbia",
journal = "Arhiv za farmaciju",
title = "Preparation and characterization of 3D printed bone scaffold for ibuprofen delivery, 3D štampa i karakterizacija nosača za dostavu ibuprofena u koštanom tkivu",
volume = "72",
number = "6",
pages = "661-673",
doi = "10.5937/arhfarm72-40262"
}